Patents by Inventor Xiaoqi Chen

Xiaoqi Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER
    Publication number: 20140011796
    Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.
    Type: Application
    Filed: September 12, 2013
    Publication date: January 9, 2014
    Applicant: AMGEN INC.
    Inventors: Michael David BARTBERGER, Ana Gonzalez Buenrostro, Hilary Plake Beck, Xiaoqi Chen, Richard Victor Connors, Jeffrey Deignan, Jason Duquette, John Eksterwicz, Benjamin Fisher, Brian Matthew Fox, Jiasheng Fu, Zice Fu, Felix Gonzalez Lopez De Turiso, Michael William Gribble, Dann James Gustin, Julie Anne Heath, Xin Huang, Xianyun Jiao, Michael Johnson, Frank Kayser, David John Kopecky, Sujen Lai, Yihong Li, Zhihong Li, Jiwen Liu, Jonathan Dante Low, Brian Stuart Lucas, Zhihua Ma, Lawrence R. McGee, Joel McIntosh, Dustin McMinn, Julio Cesar Medina, Jeffrey Thomas Mihalic, Steven Howard Olson, Yosup Rew, Philip Marley Roveto, Daqing Sun, Xiaodong Wang, Yingcai Wang, Xuelei Yan, Ming Yu, Jiang Zhu
  • Fused tricyclic dual inhibitors of CDK 4/6 and FLT3
    Patent number: 8623885
    Abstract: Compounds of Formula I are useful inhibitors of CDK 4, CDK6, and FLT3. Such compounds are useful in treating cancer and various other disease conditions. Compounds of Formula I have the following structure: where R1 is a group of Formula IA, Formula IB, Formula IC, or Formula ID and the definitions of the other variables are provided herein.
    Type: Grant
    Filed: March 21, 2012
    Date of Patent: January 7, 2014
    Assignee: Amgen Inc.
    Inventors: Xiaoqi Chen, Kang Dai, Jason Duquette, Michael W. Gribble, Jr., Justin N. Huard, Kathleen S. Keegan, Zhihong Li, Sarah E. Lively, Lawrence R. McGee, Mark L. Ragains, Xianghong Wang, Margaret F. Weidner, Jian Zhang
  • TUNABLE VIBRATION ENERGY HARVESTER AND METHOD
    Publication number: 20130341936
    Abstract: In one embodiment, an energy harvester is provided. The energy harvester includes, an energy conversion device configured to convert vibrational energy to electrical energy, a mass coupled to the energy conversion device, and at least one biasing mechanism coupled to the mass. The biasing mechanism is selectively adjustable and selectively adjusting the biasing mechanism adjusts a resonance frequency of the energy conversion device and the mass.
    Type: Application
    Filed: June 21, 2012
    Publication date: December 26, 2013
    Inventors: Alan Ruthven Wood, Qing Ou, Nigel Trevor Leigh, XiaoQi Chen, Stefanie Gutschmidt
  • FUSED TRICYCLIC DUAL INHIBITORS OF CDK 4/6 AND FLT3
    Publication number: 20120244110
    Abstract: Compounds of Formula I are useful inhibitors of CDK 4, CDK6, and FLT3. Such compounds are useful in treating cancer and various other disease conditions. Compounds of Formula I have the following structure: where R1 is a group of Formula IA, Formula IB, Formula IC, or Formula ID and the definitions of the other variables are provided herein.
    Type: Application
    Filed: March 21, 2012
    Publication date: September 27, 2012
    Applicant: Amgen Inc.
    Inventors: Xiaoqi Chen, Kang Dai, Jason Duquette, Michael W. Gribble, JR., Justin N. Huard, Kathleen S. Keegan, Zhihong Li, Sarah E. Lively, Lawrence R. McGee, Mark L. Ragains, Xianghong Wang, Margaret F. Weidner, Jian Zhang
  • PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER
    Publication number: 20110319378
    Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.
    Type: Application
    Filed: June 3, 2011
    Publication date: December 29, 2011
    Applicant: AMGEN INC.
    Inventors: Michael David BARTBERGER, Ana GONZALEZ BUENROSTRO, Hilary Plake BECK, Xiaoqi CHEN, Richard Victor CONNORS, Jeffrey DEIGNAN, Jason DUQUETTE, John EKSTEROWICZ, Benjamin FISHER, Brian Matthew FOX, Jiasheng FU, Zice FU, Felix GONZALEZ LOPEZ DE TURISO, Michael GRIBBLE, JR., Darin James GUSTIN, Julie Anne HEATH, Xin HUANG, Xianyun JIAO, Michael G. JOHNSON, Frank KAYSER, David John KOPECKY, Sujen LAI, Yihong LI, Zhihong LI, Jiwen LIU, Jonathan Dante LOW, Brian Stuart LUCAS, Zhihua MA, Lawrence McGEE, Joel McINTOSH, Dustin McMINN, Julio Cesar MEDINA, Jeffrey Thomas MIHALIC, Steven Howard Olson, Yosup REW, Philip Marley ROVETO, Daqing SUN, Xiaodong WANG, Yingcai WANG, Xuelei YAN, Ming YU, Jiang ZHU
  • NON-CONTACT LIFTING AND LOCOMOTION DEVICE
    Publication number: 20110192665
    Abstract: A Bernoulli-type non-contact adhesion pad comprises a pad area which includes an outer section of the pad area and an inner section of the pad area which is undercut relative to the outer section, at least one aperture in the inner section of the pad area for introducing a pressurised fluid flow from the aperture in use between the pad area and a surface for non-contact adhesion of the pad to the surface, an element extending from the aperture beyond the periphery of the aperture, but not the outer section of the pad area, so that the flow of fluid from the aperture is between and around the element and the periphery of the aperture, the element including an edge around the element at or beyond the aperture. A wall climbing robot using the Bernoulli-type non-contact adhesion pads is also disclosed.
    Type: Application
    Filed: October 9, 2009
    Publication date: August 11, 2011
    Inventor: XiaoQi Chen
  • Retroviral protease inhibiting compounds
    Patent number: 7968707
    Abstract: A compound of the formula: is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
    Type: Grant
    Filed: February 27, 2007
    Date of Patent: June 28, 2011
    Assignee: Abbott Laboratories
    Inventors: Hing Leung Sham, Daniel W. Norbeck, Xiaoqi Chen, David A. Betebenner, Dale J. Kempf, Thomas R. Herrin, Gondi N. Kumar, Stephen L. Condon, Arthur J. Cooper, Daniel A. Dickman, Steven M. Hannick, Lawrence Kolaczkowski, Patricia A. Oliver, Daniel J. Plata, Peter J. Stengel, Eric J. Stoner, Jieh-Heh J. Tien, Jih-Hua Liu, Ketan M. Patel
  • Compounds, compositions and methods for prevention and treatment of inflammatory and immunoregulatory disorders and diseases
    Patent number: 7939538
    Abstract: Compounds are provided having the formula: wherein variables Ra, R1, R2, R3, R4, A1, A4, L, Q, X and subscript n as described herein. The subject compounds are useful for treatment of inflammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
    Type: Grant
    Filed: June 27, 2005
    Date of Patent: May 10, 2011
    Assignee: Amgen Inc.
    Inventors: Zice Fu, Michael G. Johnson, An-Rong Li, Andrew P. Marcus, Julio C. Medina, Philippe Bergeron, Xiaoqi Chen, Xiaohui Du, Jeffrey Deignan, Jason A. Duquette, Darin Gustin, Jeffrey T. Mihalic, Jiwen Liu
  • CXCR3 ANTAGONISTS
    Publication number: 20110034487
    Abstract: Compounds, compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of a chemokine receptor. The subject methods are useful for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis, transplant rejection and type I diabetes.
    Type: Application
    Filed: January 21, 2009
    Publication date: February 10, 2011
    Applicant: AMGEN INC.
    Inventors: Xiaoqi Chen, Kirk Henne, Julio C. Medina
  • Aryl nitrile compounds and compositions and their uses in treating inflammatory and related disorders
    Patent number: 7799795
    Abstract: Provided herein are compounds of the formula where A1, A2, A3, A4, L, Q, R1, R2, R3, R4, Rx, Ry, Rz, X, Y1, Y2, Y4 and Z are as described herein, and compositions thereof that are useful in the treatment of inflammatory and immune conditions and diseases. In particular, the invention provides aryl nitrile compounds which modulate the expression and/or function of a chemokine receptor.
    Type: Grant
    Filed: June 26, 2006
    Date of Patent: September 21, 2010
    Assignee: Amgen Inc.
    Inventors: Philippe Bergeron, Xiaoqi Chen, Xiaohui Du, Jeffrey Deignan, Jason A. Duquette, Darin Gustin, Julio C. Medina, Jeffrey T. Mihalic, George R. Tonn
  • Substituted benzofused heterocycles
    Patent number: 7572783
    Abstract: The present invention relates to the compounds of Formula I, their preparation and pharmaceutical compositions comprising them. The compounds and pharmaceutical compositions are useful, for example, for the treatment and prevention of obesity, obesity-related disorders and eating disorders.
    Type: Grant
    Filed: August 12, 2005
    Date of Patent: August 11, 2009
    Assignee: Amgen Inc.
    Inventors: Xi Chen, Xiaoqi Chen, Richard Victor Connors, Kang Dai, Ying Fu, Juan C. Jaen, Yong-Jae Kim, Leping Li, Mike E. Lizarzaburu, Jeffrey T. Mihalic, Stephen J. Shuttleworth
  • RETROVIRAL PROTEASE INHIBITING COMPOUNDS
    Publication number: 20080139811
    Abstract: A compound of the formula: is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
    Type: Application
    Filed: February 27, 2007
    Publication date: June 12, 2008
    Inventors: Hing Sham, Daniel Norbeck, Xiaoqi Chen, David Betebenner, Dale Kempf, Thomas Herrin, Gondi Kumar, Stephen Condon, Arthur Cooper, Daniel Dickman, Steven Hannick, Lawrence Kolaczkowski, Patricia Oliver, Daniel Plata, Peter Stengel, Eric Stoner, Jieh-Heh Tien, Jih-Hua Liu, Ketan Patel
  • Tetrahydroquinazolin-4(3H)-one-related and tetrahydropyrido[2,3-]pyrimidin-4(3H)-one-related compounds, compositions and methods for their use
    Patent number: 7375102
    Abstract: Compounds are provided having the formula: wherein variables A1, A2, A3, A4, R1, R2, R3, R4, Q and L are as described herein. The subject compounds are useful for treatment of inflammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
    Type: Grant
    Filed: June 27, 2005
    Date of Patent: May 20, 2008
    Assignee: AMGEN SF, LLC
    Inventors: Zice Fu, Michael G. Johnson, An-Rong Li, Andrew P. Marcus, Julio C. Medina, Philippe Bergeron, Xiaoqi Chen, Xiaohui Du, Jeffrey Deignan, Jason A. Duquette, Darin Gustin, Jeffrey T. Mihalic, Jiwen Liu
  • Fused heterocyclic compounds
    Publication number: 20080058365
    Abstract: Compounds, compositions and methods are provided that are useful in the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor. In particular, the compounds of the invention are useful in the treatment and/or prevention of eating disorders, obesity, anxiety disorders and mood disorders.
    Type: Application
    Filed: July 26, 2007
    Publication date: March 6, 2008
    Inventors: Xi Chen, Xiaoqi Chen, Pingchen Fan, Juan Jaen, Leping Li, Jeffrey Mihalic
  • Retroviral protease inhibiting compounds
    Patent number: 7279582
    Abstract: A compound of the formula: is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
    Type: Grant
    Filed: October 25, 2002
    Date of Patent: October 9, 2007
    Assignee: Abbott Laboratories
    Inventors: Eric J. Stoner, Arthur J. Cooper, Lawrence Kolaczkowski, Ketan M. Patel, Hing Leung Sham, Daniel W. Norbeck, Xiaoqi Chen, David A. Betebenner, Thomas R. Herrin, Gondi N. Kumar, Stephen L. Condon, Daniel A. Dickman, Patricia A. Oliver, Jien-Heh J. Tien
  • Imidazolo-related compounds, compositions and methods for their use
    Patent number: 7271271
    Abstract: Compounds are provided having the formula: wherein variables R0, R1, R2, R3, R4, Q, L and subscript n are as described herein. The subject compounds are useful for treatment of infammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
    Type: Grant
    Filed: June 27, 2005
    Date of Patent: September 18, 2007
    Assignee: Amgen SF, LLC
    Inventors: Zice Fu, Michael G. Johnson, An-Rong Li, Andrew P. Marcus, Julio C. Medina, Philippe Bergeron, Xiaoqi Chen, Xiaohui Du, Jeffrey Deignan, Jason A. Duquette, Darin Gustin, Jeffrey T. Mihalic
  • Fused heterocyclic compounds
    Patent number: 7253179
    Abstract: Compounds, compositions and methods are provided that are useful in the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor. In particular, the compounds of the invention are useful in the treatment and/or prevention of eating disorders, obesity, anxiety disorders and mood disorders.
    Type: Grant
    Filed: November 6, 2003
    Date of Patent: August 7, 2007
    Assignee: Amgen Inc.
    Inventors: Xi Chen, Xiaoqi Chen, Pingchen Fan, Juan Jaen, Leping Li, Jeffrey Thomas Mihalic
  • Fused heterocyclic compounds
    Publication number: 20070135425
    Abstract: Compounds, compositions and methods are provided that are useful in the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor. In particular, the compounds of the invention are useful in the treatment and/or prevention of eating disorders, obesity, anxiety disorders and mood disorders.
    Type: Application
    Filed: January 5, 2007
    Publication date: June 14, 2007
    Applicant: Amgen Inc.
    Inventors: Xiaoqi Chen, Kang Dai, Pingchen Fan, Shugui Huang, Leping Li, Jeffrey Mihalic
  • Piperidine derivatives
    Publication number: 20070078152
    Abstract: Compounds, compositions and methods are provided that are useful in the treatment or prevention of conditions or disorders associated with a neuropeptide receptor. The subject methods are particularly useful in the treatment and/or prevention of endocrine, metabolic, cardiovascular, neurologic, psychiatric, gastrointestinal, genitourinary and other disorders.
    Type: Application
    Filed: December 16, 2005
    Publication date: April 5, 2007
    Inventors: Xiaoqi Chen, Kang Dai, Pingchen Fan, Ying Fu, Leping Li, Jeffrey Mihalic
  • Aryl nitrile compounds and compositions and their uses in treating inflammatory and related disorders
    Publication number: 20070015773
    Abstract: Compounds, compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides aryl nitrile compounds which modulate the expression and/or function of a chemokine receptor. The subject methods are useful for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis, type I diabetes, asthma, psoriasis and inflammatory bowel disease.
    Type: Application
    Filed: June 26, 2006
    Publication date: January 18, 2007
    Inventors: Philippe Bergeron, Xiaoqi Chen, Xiaohui Du, Jeffrey Deignan, Jason Duquette, Darin Gustin, Julio Medina, Jeffrey Mihalic, George Tonn