Patents by Inventor Xiaoqi Chen

Xiaoqi Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aryl nitrile compounds and compositions and their uses in treating inflammatory and related disorders
    Publication number: 20070015773
    Abstract: Compounds, compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides aryl nitrile compounds which modulate the expression and/or function of a chemokine receptor. The subject methods are useful for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis, type I diabetes, asthma, psoriasis and inflammatory bowel disease.
    Type: Application
    Filed: June 26, 2006
    Publication date: January 18, 2007
    Inventors: Philippe Bergeron, Xiaoqi Chen, Xiaohui Du, Jeffrey Deignan, Jason Duquette, Darin Gustin, Julio Medina, Jeffrey Mihalic, George Tonn
  • Antibacterial agents
    Patent number: 7148259
    Abstract: Hydroxyamidines and related compounds are provided which are suitable as antibacterial agents.
    Type: Grant
    Filed: February 1, 2006
    Date of Patent: December 12, 2006
    Assignee: Amgen Inc.
    Inventors: Leping Li, Xiaoqi Chen, Pingchen Fan, Jeffrey Thomas Mihalic, Serena Cutler
  • ANTIBACTERIAL AGENTS
    Publication number: 20060270651
    Abstract: Hydroxyamidines and related compounds are provided which are suitable as antibacterial agents.
    Type: Application
    Filed: February 1, 2006
    Publication date: November 30, 2006
    Applicant: AMGEN INC.
    Inventors: Leping Li, Xiaoqi Chen, Pingchen Fan, Jeffrey Mihalic, Serena Cutler
  • Fused heterocyclic compounds
    Patent number: 7125885
    Abstract: The present invention provides compounds having the formula: wherein R1, R2, R, R? and the subscript p are described herein. The compounds are useful in the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor. Pharmaceutical compositions and methods of using these compounds for the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor, such as eating disorder, obesity, anxiety disorders and mood disorders are also provided.
    Type: Grant
    Filed: August 26, 2004
    Date of Patent: October 24, 2006
    Assignee: Amgen Inc.
    Inventors: Xiaoqi Chen, Pingchen Fan, Juan Jaen, Leping Li, Mike Lizarzaburu, Jeffrey Thomas Mihalic, Stephen Joseph Shuttleworth
  • Substituted benzofused heterocycles
    Publication number: 20060199796
    Abstract: The present invention relates to the compounds of Formula I, their preparation and pharmaceutical compositions comprising them. The compounds and pharmaceutical compositions are useful, for example, for the treatment and prevention of obesity, obesity-related disorders and eating disorders.
    Type: Application
    Filed: August 12, 2005
    Publication date: September 7, 2006
    Applicant: Amgen Inc.
    Inventors: Xi Chen, Xiaoqi Chen, Richard Connors, Kang Dai, Ying Fu, Juan Jaen, Yong-Jae Kim, Leping Li, Mike Lizarzaburu, Jeffrey Mihalic, Stephen Shuttleworth
  • Antibacterial agents
    Patent number: 7053234
    Abstract: Hydroxyamidines and related compounds are provided which are suitable as antibacterial agents.
    Type: Grant
    Filed: June 25, 2004
    Date of Patent: May 30, 2006
    Assignee: Amgen Inc.
    Inventors: Leping Li, Xiaoqi Chen, Pingchen Fan, Jeffrey Thomas Mihalic, Serena Cutler
  • Piperidine derivatives
    Patent number: 7045527
    Abstract: Compounds, compositions and methods are provided that are useful in the treatment or prevention of conditions or disorders associated with a neuropeptide receptor. The subject methods are particularly useful in the treatment and/or prevention of endocrine, metabolic, cardiovascular, neurologic, psychiatric, gastrointestinal, genitourinary and other disorders.
    Type: Grant
    Filed: September 23, 2003
    Date of Patent: May 16, 2006
    Assignee: Amgen Inc.
    Inventors: Xiaoqi Chen, Kang Dai, Pingchen Fan, Ying Fu, Leping Li, Jeffrey T. Mihalic
  • Tetrahydroquinazolin-4(3H)-one-related and tetrahydropyrido[2,3-D]pyrimidin-4(3H)-one-related compounds, compositions and methods for their use
    Publication number: 20060069106
    Abstract: Compounds are provided having the formula: wherein variables A1, A2, A3, A4, R1, R2, R3, R4, Q and L are as described herein. The subject compounds are useful for treatment of inflammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
    Type: Application
    Filed: June 27, 2005
    Publication date: March 30, 2006
    Inventors: Zice Fu, Michael Johnson, An-Rong Li, Andrew Marcus, Julio Medina, Philippe Bergeron, Xiaoqi Chen, Xiaohui Du, Jeffrey Deignan, Jason Duquette, Darin Gustin, Jeffrey Mihalic
  • Compounds, compositions and methods for prevention and treatment of inflammatory and immunoregulatory disorders and diseases
    Publication number: 20060069099
    Abstract: Compounds are provided having the formula: wherein variables Ra, R1, R2, R3, R4, A1, A4, L, Q, X and subscript n as described herein. The subject compounds are useful for treatment of inflammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
    Type: Application
    Filed: June 27, 2005
    Publication date: March 30, 2006
    Inventors: Zice Fu, Michael Johnson, An-Rong Li, Andrew Marcus, Julio Medina, Philippe Bergeron, Xiaoqi Chen, Xiaohui Du, Jeffrey Deignan, Jason Duquette, Darin Gustin, Jeffrey Mihalic
  • Imidazolo-related compounds, compositions and methods for their use
    Publication number: 20060069127
    Abstract: Compounds are provided having the formula: wherein variables R0, R1, R2, R3, R4, Q, L and subscript n are as described herein. The subject compounds are useful for treatment of infammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
    Type: Application
    Filed: June 27, 2005
    Publication date: March 30, 2006
    Inventors: Zice Fu, Michael Johnson, An-Rong Li, Andrew Marcus, Julio Medina, Philippe Bergeron, Xiaoqi Chen, Xiaohui Du, Jeffrey Deignan, Jason Duquette, Darin Gustin, Jeffrey Mihalic
  • Fused heterocyclic compounds
    Publication number: 20050148617
    Abstract: Compounds, compositions and methods are provided that are useful in the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor. In particular, the compounds of the invention are useful in the treatment and/or prevention of eating disorders, obesity, anxiety disorders and mood disorders.
    Type: Application
    Filed: August 26, 2004
    Publication date: July 7, 2005
    Inventors: Xiaoqi Chen, Pingchen Fan, Juan Jaen, Leping Li, Mike Lizarzaburu, Jeffrey Mihalic, Stephen Shuttleworth
  • Fused heterocyclic compounds
    Patent number: 6858619
    Abstract: Compounds useful in the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor are provided that have the formula: wherein A and B are CR?; V is either a bond and W is —N(R?)—, or else V is —N(R?)— and W is a bond; Z is —N(R)—CH2—; R1, R2, R3, R4, R?, R?, and R are as defined herein; the subscript n is an integer from 0 to 8; and ?is a benzene ring. Pharmaceutical compositions and methods of using these compounds for the treatment and/or prevention of eating disorders, obesity, anxiety disorders and mood disorders, are also provided.
    Type: Grant
    Filed: May 3, 2002
    Date of Patent: February 22, 2005
    Assignee: Amgen Inc.
    Inventors: Xiaoqi Chen, Kang Dai, Pingchen Fan, Shugui Huang, Leping Li, Jeffrey Thomas Mihalic
  • Pyrimidine derivatives
    Patent number: 6835726
    Abstract: Compounds and compositions are provided which are useful for the treatment of viral infections, particularly human Cytomegalovirus infection. The compounds include novel pyrimidine-based derivatives.
    Type: Grant
    Filed: January 24, 2003
    Date of Patent: December 28, 2004
    Assignee: Amgen Inc.
    Inventors: Timothy D. Cushing, Heather L. Mellon, Juan C. Jaen, John A. Flygare, Shi-Chang Miao, Xiaoqi Chen, Jay P. Powers
  • Antibacterial agents
    Publication number: 20040235911
    Abstract: Hydroxyamidines and related compounds are provided which are suitable as antibacterial agents.
    Type: Application
    Filed: June 25, 2004
    Publication date: November 25, 2004
    Applicant: Tularik Inc.
    Inventors: Leping Li, Xiaoqi Chen, Pingchen Fan, Jeffrey Thomas Mihalic, Serena Cutler
  • Fused heterocyclic compounds
    Patent number: 6809104
    Abstract: Compounds having the formula: wherein L is a bond or (C1-C4)alkylene, R″ is hydrogen or (C1-C8)alkyl, and R1, R2, R4, R, R′, and the subscript n are as described herein, are provided, which are useful in the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor. Pharmaceutical compositions and methods of using these compounds for the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor, such as eating disorders, obesity, anxiety disorders and mood disorders, are also provided.
    Type: Grant
    Filed: November 6, 2002
    Date of Patent: October 26, 2004
    Assignee: Tularik Inc.
    Inventors: Xiaoqi Chen, Pingchen Fan, Juan Jaen, Leping Li, Mike Lizarzaburu, Jeffrey Thomas Mihalic, Stephen Joseph Shuttleworth
  • Antibacterial agents
    Patent number: 6780858
    Abstract: Hydroxyamidines and related compounds are provided which are suitable as antibacterial agents.
    Type: Grant
    Filed: January 12, 2001
    Date of Patent: August 24, 2004
    Assignee: Tularik Inc.
    Inventors: Leping Li, Xiaoqi Chen, Pingchen Fan, Jeffrey Thomas Mihalic, Serena Cutler
  • Fused heterocyclic compounds
    Publication number: 20040147538
    Abstract: Compounds, compositions and methods are provided that are useful in the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor. In particular, the compounds of the invention are useful in the treatment and/or prevention of eating disorders, obesity, anxiety disorders and mood disorders.
    Type: Application
    Filed: November 6, 2003
    Publication date: July 29, 2004
    Inventors: Xi Chen, Xiaoqi Chen, Pingchen Fan, Juan Jaen, Leping Li, Jeffrey Thomas Mihalic
  • Piperidine derivatives
    Publication number: 20040142956
    Abstract: Compounds, compositions and methods are provided that are useful in the treatment or prevention of conditions or disorders associated with a neuropeptide receptor. The subject methods are particularly useful in the treatment and/or prevention of endocrine, metabolic, cardiovascular, neurologic, psychiatric, gastrointestinal, genitourinary and other disorders.
    Type: Application
    Filed: September 23, 2003
    Publication date: July 22, 2004
    Inventors: Xiaoqi Chen, Kang Dai, Pingchen Fan, Ying Fu, Leping Li, Jeffrey T. Mihalic
  • Pyrimidine derivatives
    Publication number: 20040006068
    Abstract: Compounds and compositions are provided which are useful for the treatment of viral infections, particularly human Cytomegalovirus infection. The compounds include novel pyrimidine-based derivatives.
    Type: Application
    Filed: January 24, 2003
    Publication date: January 8, 2004
    Applicant: Tularik Inc.
    Inventors: Timothy D. Cushing, Heather L. Mellon, Juan C. Jaen, John A. Flygare, Shi-Chang Miao, Xiaoqi Chen, Jay P. Powers
  • Pyrazole antimicrobial agents
    Patent number: 6673923
    Abstract: The present invention provides pyrazole and pyrazolone derivatives. Preferred compounds of the invention are useful as RNA polymerase inhibitors. Further preferred compounds of the invention are useful as antimicrobial agents.
    Type: Grant
    Filed: May 2, 2001
    Date of Patent: January 6, 2004
    Assignee: Tularik Inc.
    Inventors: Leping Li, Xiaoqi Chen, Serena T. Cutler