Patents by Inventor Xiaoyun Zhu

Xiaoyun Zhu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200292382
    Abstract: A single shot autocorrelator for measuring duration of an ultrashort laser pulse in the far field, having a beam splitter to form two beams from an input ultrashort pulse: the reflected beam is firstly reflected by two mirrors mounted on a translation stage for adjusting time delay and subsequently a third mirror, and after focused by a spherical convex lens, enters a naturally grown strontium barium niobate crystal along the crystal z axis; the transmitted beam is firstly focused by a spherical convex lens, and after reflected by two mirrors, enters the crystal along the crystal z axis from opposite direction. The crystal is in the common focal regions of two spherical convex lenses and generates the transverse second harmonic pulse beam that is the autocorrelation signal to be recorded, which is imaged with an optical microscope onto a charge coupled device camera mounted perpendicular to the beams.
    Type: Application
    Filed: March 15, 2019
    Publication date: September 17, 2020
    Inventors: Jianwei YU, Jianqiang ZHU, Xiaoping OUYANG, Baoqiang ZHU, Peiying ZENG, Xiaoyun TANG
  • Publication number: 20200283498
    Abstract: Featured is T cell receptor complexes designed to redirect the immune system against various diseases. The T cell receptor complexes of the invention have been engineered to recognize target antigen in a functionally bispecific nature. Fusion protein complexes and protein conjugate complexes are comprised of high affinity antigen-specific TCR and biologically active proteins and/or effector molecules. Also featured is methods of production of T cell receptor fusion and conjugate complexes as well as therapeutic compositions for use of the complexes.
    Type: Application
    Filed: March 30, 2020
    Publication date: September 10, 2020
    Inventors: Hing C. Wong, Peter Rhode, Xiaoyun Zhu
  • Patent number: 10719423
    Abstract: An apparatus and associated method are provided for application deployment assessment. In use, a plurality of deployment parameters associated with one or more applications, and a workload profile are received. Further, an application deployment specification is generated, based on the workload profile and the deployment parameters. Still yet, a type of one or more orchestrators on one or more systems is identified. The application deployment specification is processed, based on the identified type of the one or more orchestrators on the one or more systems. Further, the one or more processors execute the instructions to deploy, via an application program interface (API), the one or more applications to the one or more orchestrators on at least one of the one or more systems, and at least one workload generator to at least one of the one or more systems, utilizing the processed application deployment specification. Operational data is collected from one or more monitoring agents on the one or more systems.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: July 21, 2020
    Assignee: Futurewei Technologies, Inc.
    Inventors: Xiaoyun Zhu, Jinzhong Zhang, Huichao Zhao, Sid Askary, Daniel Chen, CJ Hersh, Yue Chen, Shu Zhang, Jing Ye
  • Publication number: 20200190164
    Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor a/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).
    Type: Application
    Filed: January 22, 2020
    Publication date: June 18, 2020
    Inventors: HING C. WONG, PETER RHODE, BAI LIU, XIAOYUN ZHU, KAI-PING HAN
  • Publication number: 20200181237
    Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor ?/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).
    Type: Application
    Filed: January 22, 2020
    Publication date: June 11, 2020
    Inventors: Hing C. Wong, Peter Rhode, Bai Liu, Xiaoyun Zhu, Kai-Ping Han
  • Publication number: 20200172594
    Abstract: Featured is T cell receptor complexes designed to redirect the immune system against various diseases. The T cell receptor complexes of the invention have been engineered to recognize target antigen in a functionally bispecific nature. Fusion protein complexes and protein conjugate complexes are comprised of high affinity antigen-specific TCR and biologically active proteins and/or effector molecules. Also featured is methods of production of T cell receptor fusion and conjugate complexes as well as therapeutic compositions for use of the complexes.
    Type: Application
    Filed: August 2, 2019
    Publication date: June 4, 2020
    Inventors: Hing C. Wong, Peter Rhode, Xiaoyun Zhu
  • Publication number: 20200140513
    Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the such proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.
    Type: Application
    Filed: October 16, 2019
    Publication date: May 7, 2020
    Inventors: Hing C. Wong, Peter Rhode, Xiaoyun Zhu, Kai-Ping Han
  • Publication number: 20200106034
    Abstract: A high dielectric constant composite material and method for preparing organic thin film transistor using the material as dielectric. The method includes: using sol-gel method, hydrolyzing terminal group-containing silane coupling agent to form functional terminal group-containing silica sol, cross-linked with organic polymer to form composite sol as material of dielectric of organic thin film transistor; forming film by solution method such as spin coating, dip coating, inkjet printing, 3D printing, etc., forming dielectric after curing; preparing semiconductor and electrode respectively to prepare organic thin film transistor device, which, based on composite dielectric material, has mobility of 5 cm2/V·s, exceeding that of using SiO2, having low threshold voltage and no hysteresis effect. Compared with traditional processes like SiO2 thermal oxidation, above method has advantages of simple process, low cost, suitable for large-area preparation, with great market application value.
    Type: Application
    Filed: September 6, 2017
    Publication date: April 2, 2020
    Applicant: PEKING UNIVERSITY SHENZHEN GRADUATE SCHOOL
    Inventors: Hong MENG, Jupeng CAO, Lijia YAN, Yu HE, Xiaoyun WEI, Yanan ZHU, Ting LI
  • Publication number: 20200021639
    Abstract: A system and method for performing an operational metric analysis for a virtual appliance uses application operational data from multiple instances of the virtual appliance. The application operational data is then used to generate an operational metric prediction for the virtual appliance.
    Type: Application
    Filed: September 25, 2019
    Publication date: January 16, 2020
    Inventors: Rean Griffith, Anne Holler, Shankari Kalyanaraman, Xiaoyun Zhu, Vijayaraghavan Soundararajan, Adarsh Jagadeeshwaran, Pradeep Padala, Pinar Yanardag Delul
  • Publication number: 20200002425
    Abstract: The invention features multi-specific protein complexes with one domain comprising IL-15 or a functional variant, a cytokine receptor or cytokine ligand, and a binding domain specific to a disease antigen, immune checkpoint or signaling molecule.
    Type: Application
    Filed: March 26, 2019
    Publication date: January 2, 2020
    Inventors: Qiongzhen Li, Xiaoyun Zhu, Hing C. Wong
  • Publication number: 20200008109
    Abstract: Provided are a method for base station handover, a system, and a computer storage medium, the method comprising a first access and mobility management function (AMF) receives handover request information sent by a first base station, the handover request information serving to request handover of a UE from the first base station to a second base station; when the UE does not need to carry out cross-AMF handover, the first AMF sends a handover preparation request to the second base station requesting target resources for the UE; in a cross-AMF handover process, the AMF of the UE changes from a first AMF to a second AMF; when a UE needs to carry out a cross-AMF handover process, the first AMF sends handover request information to a second AMF, and the second AMF sends a handover preparation request to the second base station requesting target resources for the UE.
    Type: Application
    Filed: March 22, 2018
    Publication date: January 2, 2020
    Inventors: ZHENDONG LI, JINGUO ZHU, SHUANG LIANG, XIAOYUN ZHOU
  • Publication number: 20190364458
    Abstract: Provided is a user equipment maximum bandwidth control method and device, and computer storage medium. The method includes that a gNodeB acquires a first user equipment-aggregated maximum bit rate (UE-AMBR) and an aggregated maximum bit rate (AMBR) corresponding to all established protocol data unit (PDU) sessions from a core network; the gNodeB calculates a second UE-AMBR based on the first UE-AMBR and the AMBR corresponding to all the established PDU sessions; and the gNodeB executes bandwidth control on a Non-Guaranteed Bit Rate (Non GBR) service of a user equipment (UE) in accordance with the second UE-AMBR.
    Type: Application
    Filed: August 5, 2019
    Publication date: November 28, 2019
    Inventors: Xiaoyun Zhou, Jinguo Zhu
  • Patent number: 10464633
    Abstract: A driving system for an electric vehicle comprises a motor (3) comprising a first output shaft (11) and a gearbox (17) comprising a second output shaft (27) attachable to a wheel (33) of the electric vehicle. The first output shaft (11) is capable of driving the second output shaft (27) to rotate by engagement of gears of the gearbox (17). The first output shaft (11) is hollow, and the second output shaft (27) extends through the first output shaft (11) so that the second output shaft (27) is disposed coaxially with the first output shaft (11). An electric vehicle comprising the driving system is disclosed. The driving system is possible to improve the balancing, the passing ability and the visual appearance of the electric vehicle.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: November 5, 2019
    Assignee: Robert Bosch GmbH
    Inventors: Tao Zhu, Weiya Li, Qilin Huang, Xiaoyun Zang
  • Publication number: 20190330309
    Abstract: Contemplated compositions and methods comprise chimeric molecule complexes that advantageously provide activating signaling to immune competent cells when bound to ALL cells. Furthermore, chimeric molecule complexes include an Fc portion to extend serum half live time and facilitate purification.
    Type: Application
    Filed: June 14, 2019
    Publication date: October 31, 2019
    Inventors: Patrick Soon-Shiong, Hing C. Wong, Peter Rhode, Bai Liu, Xiaoyun Zhu, Kai-Ping Han
  • Patent number: 10460254
    Abstract: An automatic scaling system and method for reducing state space in reinforced learning for automatic scaling of a multi-tier application uses a state decision tree that is updated with new states of the multi-tier application. When a new state of the multi-tier application is received, the new state is placed in an existing node of the state decision tree only if a first attribute of the new state is same as a first attribute of any state contained in the existing node and a second attribute of the new state is sufficiently similar to a second attribute of each existing state contained in the existing node based on a similarity measurement of the second attribute of each state contained in the existing node with the second attribute of the new state.
    Type: Grant
    Filed: March 17, 2015
    Date of Patent: October 29, 2019
    Assignee: VMware, Inc.
    Inventors: Lei Lu, Pradeep Padala, Anne Holler, Xiaoyun Zhu
  • Patent number: 10450359
    Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the such proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.
    Type: Grant
    Filed: September 1, 2016
    Date of Patent: October 22, 2019
    Assignee: Altor Bioscience Corporation
    Inventors: Hing C. Wong, Peter Rhode, Xiaoyun Zhu, Kai-ping Han
  • Patent number: 10432699
    Abstract: A system and method for performing an operational metric analysis for a virtual appliance uses application operational data from multiple instances of the virtual appliance. The application operational data is then used to generate an operational metric prediction for the virtual appliance.
    Type: Grant
    Filed: June 26, 2014
    Date of Patent: October 1, 2019
    Assignee: VMware, Inc.
    Inventors: Rean Griffith, Anne Holler, Shankari Kalyanaraman, Xiaoyun Zhu, Vijayaraghavan Soundararajan, Adarsh Jagadeeshwaran, Pradeep Padala, Pinar Yanardag Delul
  • Patent number: 10414756
    Abstract: Disclosed are a 2-(2,4,5-substituted aniline) pyrimidine derivative, a pharmaceutical composition and a use thereof. The pharmaceutical composition comprises a therapeutically effective amount of the 2-(2,4,5-substituted aniline) pyrimidine derivative, a solvate, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient. Also disclosed is a use of the 2-(2,4,5-substituted aniline) pyrimidine derivative, a solvate, or a pharmaceutically acceptable salt thereof in the preparation of drugs for treating cancers. The compounds of the present invention have a relatively high solubility in water and a relatively high permeability, and/or a relatively low binding ability to plasma proteins, and at the same time have a relatively low toxicity characteristic and a relatively high anti-tumor activity.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: September 17, 2019
    Assignee: NANJING DIANSU BIOLOGICAL TECHNOLOGY CO. LTD
    Inventors: Xiaoyun Zhu, Mingyu Jiang, Aining Ji
  • Publication number: 20190269807
    Abstract: Disclosed are compositions and methods for detecting cells or tissue comprising a peptide antigen presented in the context of an MHC or HLA complex. The invention has a wide range of applications including providing a highly sensitive method for detecting cancer cells.
    Type: Application
    Filed: April 29, 2019
    Publication date: September 5, 2019
    Inventors: Shari A. Price-Schiavi, Heather J. Belmont, Kimberlyn F. Card, Xiaoyun Zhu, Hing C. Wong
  • Patent number: 10358478
    Abstract: The invention provides soluble fusion protein complexes having at least two soluble fusion proteins. The first fusion protein is a biologically active polypeptide covalently linked to an interleukin-15 (IL-15) polypeptide or a functional fragment thereof. The second fusion protein is a second biologically active polypeptide covalently linked to a soluble interleukin-15 receptor alpha (IL-15R?) polypeptide or a functional fragment thereof. In the complexes of the invention, one or both of the first and second fusion proteins further includes an immunoglobulin Fc domain or a functional fragment thereof; and the first fusion protein binds to the soluble IL-15R? domain of the second fusion protein to form a soluble fusion protein complex. The invention further provides methods for making and using the complexes of the invention.
    Type: Grant
    Filed: July 19, 2016
    Date of Patent: July 23, 2019
    Assignee: Altor Bioscience Corporation
    Inventors: Hing C. Wong, Peter Rhode, Bai Liu, Xiaoyun Zhu, Kai-ping Han