Abstract: Techniques for dynamically managing the placement of blocks of a logical file between a flash storage tier and an HDD storage tier are provided. In one embodiment, a computer system can collect I/O statistics pertaining to the logical file, where a first subset of blocks of the logical file are stored on the flash storage tier and where a second subset of blocks of the logical file are stored on the HDD storage tier. The computer system can further generate a heat map for the logical file based on the I/O statistics, where the heat map indicates, for each block of the logical file, the number of times the block has been accessed. The computer system can then identify, using the heat map, one or more blocks of the logical file as being performance-critical blocks, and can move data between the flash and HDD storage tiers such that the performance-critical blocks are placed on the flash storage tier.

Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor ?/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).

Abstract: A system and method for performing an operational metric analysis for a virtual appliance uses application operational data from multiple instances of the virtual appliance. The application operational data is then used to generate an operational metric prediction for the virtual appliance.

Abstract: Exemplary embodiments of the present invention are directed towards a method for fabricating a semiconductor memory device comprising selectively depositing a material to form a cap above a recessed cell structure in order to prevent degradation of components inside the cell structure in oxidative or corrosive environments.

Abstract: A technique for controlling an output of a computing system having multiple adjustable inputs includes providing a set of adjustable inputs to the computing system, observing an output of the computing system while the system is in operation, and selecting a subset of adjustable inputs from the set of adjustable inputs based on the observation of the output. The inputs in the selected subset are then adjusted to achieve a desired output of the computing system.

Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making such proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.

Abstract: Featured is T cell receptor complexes designed to redirect the immune system against various diseases. The T cell receptor complexes of the invention have been engineered to recognize target antigen in a functionally bispecific nature. Fusion protein complexes and protein conjugate complexes are comprised of high affinity antigen-specific TCR and biologically active proteins and/or effector molecules. Also featured is methods of production of T cell receptor fusion and conjugate complexes as well as therapeutic compositions for use of the complexes.

Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making such proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.

Abstract: Techniques for dynamically managing the placement of blocks of a logical file between a flash storage tier and an HDD storage tier are provided. In one embodiment, a computer system can collect I/O statistics pertaining to the logical file, where a first subset of blocks of the logical file are stored on the flash storage tier and where a second subset of blocks of the logical file are stored on the HDD storage tier. The computer system can further generate a heat map for the logical file based on the I/O statistics, where the heat map indicates, for each block of the logical file, the number of times the block has been accessed. The computer system can then identify, using the heat map, one or more blocks of the logical file as being performance-critical blocks, and can move data between the flash and HDD storage tiers such that the performance-critical blocks are placed on the flash storage tier.

Abstract: Disclosed are compositions and methods for detecting cells or tissue comprising a peptide antigen presented in the context of an MHC or HLA complex. The invention has a wide range of applications including providing a highly sensitive method for detecting cancer cells.

Abstract: A system and method for managing resources in a distributed computer system that includes at least one resource pool for a set of virtual machines (VMs) utilizes a set of desired individual VM-level resource settings that corresponds to target resource allocations for observed performance of an application running in the distributed computer system. The set of desired individual VM-level resource settings are determined by constructing a model for the observed application performance as a function of current VM-level resource allocations and then inverting the function to compute the target resource allocations in order to meet at least one user-defined service level objective (SLO). The set of desired individual VM-level resource settings are used to determine final RP-level resource settings for a resource pool to which the application belongs and final VM-level resource settings for the VMs running under the resource pool, which are then selectively applied.

Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor ?/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).

Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making thesuch proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.

Abstract: The invention provides soluble fusion protein complexes having at least two soluble fusion proteins. The first fusion protein is a biologically active polypeptide covalently linked to an interleukin-15 (IL-15) polypeptide or a functional fragment thereof. The second fusion protein is a second biologically active polypeptide covalently linked to a soluble interleukin-15 receptor alpha (IL-15R?) polypeptide or a functional fragment thereof. In the complexes of the invention, one or both of the first and second fusion proteins further includes an immunoglobulin Fc domain or a functional fragment thereof; and the first fusion protein binds to the soluble IL-15R? domain of the second fusion protein to form a soluble fusion protein complex. The invention further provides methods for making and using the complexes of the invention.

Abstract: Disclosed are compositions and methods for detecting cells or tissue comprising a peptide antigen presented in the context of an MHC or HLA complex. The invention has a wide range of applications including providing a highly sensitive method for detecting cancer cells.

Abstract: A method for controlling resource allocation is provided. The method includes determining a service metric associated with a first application, wherein the first application is associated with one or more virtual machines. The method further includes comparing the service metric to an application specific service level goal associated with the first application and modifying a resource allocation associated with the first application at one or more of the virtual machines.

Abstract: A resource consumption of a resource compartment for a time interval is predicted. A resource entitlement for the resource compartment for the time interval is determined based on the predicted resource consumption.

Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor ?/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).

Abstract: Embodiments of the present invention pertain to dynamically resizing a virtual machine container. According to one embodiment, an optimal utilization is determined based on a desired performance for a multi-tiered application and transaction mix information that describes a mix of transactions that result from executing the multi-tiered application. Automatic modification of an amount of a physical resource a virtual machine container is entitled to for executing a particular application component associated with the multi-tiered application is enabled where the amount is automatically modified based on the optimal utilization.

Abstract: The invention provides soluble fusion protein complexes having at least two soluble fusion proteins. The first fusion protein is a biologically active polypeptide covalently linked to an interleukin-15 (IL-15) polypeptide or a functional fragment thereof. The second fusion protein is a second biologically active polypeptide covalently linked to a soluble interleukin-15 receptor alpha (IL-15R?) polypeptide or a functional fragment thereof. In the complexes of the invention, one or both of the first and second fusion proteins further includes an immunoglobulin Fc domain or a functional fragment thereof; and the first fusion protein binds to the soluble IL-15R? domain of the second fusion protein to form a soluble fusion protein complex. The invention further provides methods for making and using the complexes of the invention.