Patents by Inventor Xin Du

Xin Du has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250136718
    Abstract: Antibodies and antigen-binding fragments thereof that bind type II transmembrane serine protease 6 (TMPRSS6) on the surface of a cell and increase hepcidin expression, and methods for treating disorders of iron metabolism and myeloproliferative disorders using anti-TMPRSS6 antibodies and fragments, are provided.
    Type: Application
    Filed: May 24, 2024
    Publication date: May 1, 2025
    Inventors: XIN DU, BUXIN CHEN, YU JEAN WANG, William SAVAGE, Mahaney MILLER, Jonathan YU, Hua YANG
  • Patent number: 12215170
    Abstract: Antibodies and antigen-binding fragments thereof that bind type II transmembrane serine protease 6 (TMPRSS6) on the surface of a cell and increase hepcidin expression, and methods for treating disorders of iron metabolism using anti TMPRSS6 antibodies and fragments, are provided.
    Type: Grant
    Filed: April 5, 2021
    Date of Patent: February 4, 2025
    Assignee: MABWELL THERAPEUTICS INC.
    Inventors: Xin Du, Buxin Chen, Yu Jean Wang
  • Publication number: 20250034262
    Abstract: Provided herein are antibodies that specifically bind to MICA/B having heavy chain, light chain, variable heavy chain domains (VH), variable light chain domains (VL), and complementarity determining regions (CDRs) disclosed herein, as well as methods and uses thereof.
    Type: Application
    Filed: June 23, 2024
    Publication date: January 30, 2025
    Inventors: Neil Gibson, Justin Chapman, Xin Du
  • Publication number: 20240415778
    Abstract: An oral preparation containing a progestogen, and a preparation method and the use. The oral preparation does not contain or contains only benzyl benzoate in a weight percentage of less than 8%. The preparation contains 17-? hydroxyprogesterone caproate, propylene glycol monocaprylate, PEG35 castor oil, and propylene glycol monolaurate. The oral preparation provides good stability, dissolution performance, and bioavailability while ensuring high safety.
    Type: Application
    Filed: October 17, 2022
    Publication date: December 19, 2024
    Applicant: SHENZHEN EVERGREEN THERAPEUTICS CO., LTD.
    Inventors: Xin DU, Shanshan LI, Tao Tom DU
  • Publication number: 20240301046
    Abstract: The present disclosure provides anti-amyloid ? (A?) antibodies and antibody fragments that preferentially bind soluble amyloid A? protofibril/oligomer and trigger ADPC in microglial cells, anti-amyloid ? (A?) antibodies and antibody fragments that reduce soluble amyloid A? protofibril/oligomer levels and insoluble amyloid A? plaque in brain tissue, and the use of anti-A? protofibril/oligomer antibodies and antibody fragments in therapy, prophylaxis, diagnosis, screening, and monitoring of conditions associated with A? protein aggregation, in particular Alzheimer's disease (AD).
    Type: Application
    Filed: May 1, 2024
    Publication date: September 12, 2024
    Inventors: Yubin WANG, Lei HUANG, Xin DU
  • Publication number: 20240299415
    Abstract: A treatment method for interstitial pneumonia by means of hydroxyprogesterone caproate alone or in combination with other drugs, and corresponding pharmaceutical uses, and pharmaceutical compositions. Hydroxyprogesterone caproate can reduce pulmonary inflammation and fibrosis symptoms, reduce pulmonary collagen deposition, and reduce the levels of various inflammatory factors in bronchoalveolar lavage fluid and plasma. Hydroxyprogesterone caproate combined with dexamethasone can improve lipid metabolism abnormalities caused by dexamethasone treatment alone.
    Type: Application
    Filed: December 1, 2021
    Publication date: September 12, 2024
    Inventors: Tao Tom Du, Tao Hu, Xin Du
  • Patent number: 12084492
    Abstract: The present disclosure provides anti-amyloid ? (A?) antibodies and antibody fragments that preferentially bind soluble amyloid A? protofibril/oligomer and trigger ADPC in microglial cells, anti-amyloid ? (A?) antibodies and antibody fragments that reduce soluble amyloid A? protofibril/oligomer levels and insoluble amyloid A? plaque in brain tissue, and the use of anti-A? protofibril/oligomer antibodies and antibody fragments in therapy, prophylaxis, diagnosis, screening, and monitoring of conditions associated with A? protein aggregation, in particular Alzheimer's disease (AD).
    Type: Grant
    Filed: January 19, 2024
    Date of Patent: September 10, 2024
    Inventors: Yubin Wang, Lei Huang, Xin Du
  • Publication number: 20240285649
    Abstract: Disclosed herein, in certain embodiments, are compositions, solutions, and soft gelatin capsules comprising 17-alpha hydroxyprogesterone caproate (17-HPC). In certain embodiments, also disclosed herein are methods, dosing regimens, and kits for use in the treatment of a disease or condition.
    Type: Application
    Filed: May 6, 2021
    Publication date: August 29, 2024
    Inventors: Xin Du, Tao Tom Du, Weiwei Hua
  • Patent number: 12065493
    Abstract: Provided herein are antibodies that specifically bind to MICA/B having heavy chain, light chain, variable heavy chain domains (VH), variable light chain domains (VL), and complementarity determining regions (CDRs) disclosed herein, as well as methods and uses thereof.
    Type: Grant
    Filed: January 29, 2021
    Date of Patent: August 20, 2024
    Assignee: Cullinan Mica Corporation
    Inventors: Neil Gibson, Justin Chapman, Xin Du
  • Publication number: 20240247054
    Abstract: The present disclosure provides anti-amyloid ? (A?) antibodies and antibody fragments that preferentially bind soluble amyloid A? protofibril/oligomer and trigger ADPC in microglial cells, anti-amyloid ? (A?) antibodies and antibody fragments that reduce soluble amyloid A? protofibril/oligomer levels and insoluble amyloid A? plaque in brain tissue, and the use of anti-A? protofibril/oligomer antibodies and antibody fragments in therapy, prophylaxis, diagnosis, screening, and monitoring of conditions associated with A? protein aggregation, in particular Alzheimer's disease (AD).
    Type: Application
    Filed: January 19, 2024
    Publication date: July 25, 2024
    Inventors: Yubin WANG, Lei HUANG, Xin DU
  • Publication number: 20240158483
    Abstract: Antibodies and antigen-binding fragments thereof that bind C1s and inhibit C1s activity and modulate the activity of at least one component in the classical pathway (CP) of complement activation, and methods for treating complement-mediated disorders using anti-C1s antibodies and fragments, are provided.
    Type: Application
    Filed: February 1, 2024
    Publication date: May 16, 2024
    Inventors: Buxin CHEN, Lei HUANG, Xin DU
  • Patent number: 11958899
    Abstract: Antibodies and antigen-binding fragments thereof that bind C1s and inhibit C1s activity and modulate the activity of at least one component in the classical pathway (CP) of complement activation, and methods for treating complement-mediated disorders using anti-C1s antibodies and fragments, are provided.
    Type: Grant
    Filed: June 28, 2022
    Date of Patent: April 16, 2024
    Inventors: Buxin Chen, Lei Huang, Xin Du
  • Publication number: 20240067731
    Abstract: Provided herein are antibodies that specifically bind to MICA/B having variable heavy chain domains (VH), variable light chain domains (VL), and complementarity determining regions disclosed herein, as well as methods and uses thereof.
    Type: Application
    Filed: June 1, 2023
    Publication date: February 29, 2024
    Inventors: Neil Gibson, Justin Chapman, Xin Du
  • Publication number: 20240009166
    Abstract: This application provides the use of zanamivir in the preparation of drugs for the treatment or prevention of pre-eclampsia and the corresponding drugs and therapeutic methods; Zanamivir is effective in improving the symptoms of hypertension, proteinuria, elevated creatinine, neuraminidase and sialic acid in pre-eclampsia, increasing NO levels; and improving pregnancy outcomes. The combination of zanamivir and hydroxyprogesterone caproate showed superior results.
    Type: Application
    Filed: November 24, 2021
    Publication date: January 11, 2024
    Inventors: Tao Tom DU, Tao HU, XIN DU
  • Patent number: 11866513
    Abstract: Antibodies and antigen-binding fragments thereof that bind type II transmembrane serine protease 6 (TMPRSS6) on the surface of a cell and increase hepcidin expression, and methods for treating disorders of iron metabolism using anti TMPRSS6 antibodies and fragments, are provided.
    Type: Grant
    Filed: June 5, 2023
    Date of Patent: January 9, 2024
    Assignee: MABWELL THERAPEUTICS, INC.
    Inventors: Xin Du, Buxin Chen, Yu Jean Wang
  • Publication number: 20230348623
    Abstract: Antibodies and antigen-binding fragments thereof that bind type II transmembrane serine protease 6 (TMPRSS6) on the surface of a cell and increase hepcidin expression, and methods for treating disorders of iron metabolism using anti TMPRSS6 antibodies and fragments, are provided.
    Type: Application
    Filed: June 5, 2023
    Publication date: November 2, 2023
    Inventors: XIN DU, BUXIN CHEN, YU JEAN WANG
  • Publication number: 20230337679
    Abstract: A method of killing insects on or around an intact plant, comprising the step of depositing or suspending in the air a composition comprising synthetic amorphous silica (SAS) on or around the intact plant.
    Type: Application
    Filed: August 19, 2021
    Publication date: October 26, 2023
    Inventors: Manjree Agarwal, YongLin Ren, Xin Du, Hamish McKirdy
  • Publication number: 20230329238
    Abstract: A method of killing insects on or around stored products or in structures, comprising the step of depositing or suspending in the air a composition comprising a mixture of hydrophilic synthetic amorphous silica (SAS) and hydrophobic SAS on or around the stored products or structure.
    Type: Application
    Filed: August 19, 2021
    Publication date: October 19, 2023
    Inventors: Manjree Agarwal, YongLin Ren, Xin Du, Hamish McKirdy
  • Publication number: 20230295345
    Abstract: Antibodies and antigen-binding fragments thereof that bind type II transmembrane serine protease 6 (TMPRSS6) on the surface of a cell and increase hepcidin expression, and methods for treating disorders of iron metabolism and myeloproliferative disorders using anti TMPRSS6 antibodies and fragments, are provided.
    Type: Application
    Filed: November 25, 2022
    Publication date: September 21, 2023
    Inventors: XIN DU, BUXIN CHEN, YU JEAN WANG
  • Publication number: 20230203196
    Abstract: Antibodies and antigen-binding fragments thereof that bind type II transmembrane serine protease 6 (TMPRSS6) on the surface of a cell and increase hepcidin expression, and methods for treating disorders of iron metabolism using anti TMPRSS6 antibodies and fragments, are provided.
    Type: Application
    Filed: April 5, 2021
    Publication date: June 29, 2023
    Inventors: XIN DU, BUXIN CHEN, YU JEAN WANG