Abstract: There are proposed a method, device, apparatus, and medium for protecting sensitive data. In a method, to-be-processed data is received from a server device. A processing result of a user for the to-be-processed data is received, the processing result comprising sensitive data of the user for the processing of the to-be-processed data. A gradient for training a server model at the server device is determined based on a comparison between the processing result and a prediction result for the to-be-processed data. The gradient is updated in a change direction associated with the gradient so as to generate an updated gradient to be sent to the server device. Noise is added only in the change direction associated with the gradient. The corresponding overhead of processing noise in a plurality of directions can be reduced, and no excessive noise data interfering with training will be introduced to the updated gradient.

Abstract: A system and method for receiving secure data in a client device. In one embodiment, the method comprises (a) receiving a token having a token ID and a digital certificate generated by a certificate authority (CA) having client device fingerprint data generated from client device parameters, (b) accepting a request in the client device to provide secure data to the client device, (c) regenerating the client device fingerprint data from the client device parameters, (d) determining, in the client device, differences between the client device fingerprint data of the digital certificate from the regenerated client device fingerprint data, and (e) transmitting a request to a secure data service to provide secure data based upon the determination.

Abstract: The present disclosure describes techniques for determining performance of a classifier. A first machine learning model and a second machine learning model may be trained by aggregating updates to the first machine learning model and the second machine learning model received from a plurality of client computing devices. A cumulative distribution function (CDF) associated with a distribution of the positive samples in the user data may be estimated using the trained first machine learning model. A probability density function (PDF) associated with a distribution of the negative samples in the user data may be estimated using the trained second machine learning model. An integration-based computation of an area under the receiver operating characteristic curve (AUC) of the classifier may be performed using the PDF and the CDF.

Abstract: Chimeric antigen receptors targeting CD20 and preparation methods thereof are provided. The antigen binding region of the chimeric antigen receptor may include a heavy chain variable region shown in SEQ ID NOs: 7, 9 or 33 and a light chain variable region shown in SEQ ID NOs: 11, 13 or 35.

Abstract: The invention provides a Probiotic microcapsule and a preparation method thereof, relating to the technical field of Probiotic products. The method includes the following steps: (a) preparing a capsule core containing Probiotics: mixing the capsule core materials including Probiotic powder, microcrystalline cellulose and starch, then adding a hydroxypropyl methylcellulose solution thereinto, while mixing evenly, making the obtained mixture materials into spherical particulate capsule cores by the extrusion spherization method; (b) coating by atomization: coating the microcapsule cores with a coating material solution in a single layer or multiple layers by atomization, getting core-shell microcapsules. The Probiotic microcapsules prepared by the present invention have a large encapsulation, uniform microcapsule particles, controllable particle size, storage-resistance, targetability to intestinal tracts, resistance to gastric acids and high temperature stability.

Abstract: A projection display device and a projection display equipment are provided. The projection display device includes a display screen body, a photosensitive device, and a control module. The control module is electrically connected to the display screen body, the photosensitive device outputs a photosensitive signal when sensing a projection light beam, and the control module is electrically connected to the photosensitive device to receive the photosensitive signal and to control a section on the display screen body corresponding to a projection position of the projection light beam to be converted from a transparent state to an opaque state according to the photosensitive signal.

Abstract: The present disclosure relates to tricyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR enzyme and are useful in the treatment of FGFR-associated diseases such as cancer.

Abstract: An underwater and aerial vehicle includes a fixing frame, a core navigation system and an energy supply system. The fixing frame has a circular ring configuration in a middle part thereof, and the waterproof sealing cabin is fixed in the circular ring configuration, and multiple cantilever arms extend around the circular ring configuration. An underwater navigation control module and a relay are provided on an auxiliary fixing platform. A second brushless motor is provided on each of the cantilever arms. Each second brushless motor is provided with a marine propeller. A flight control module, a remote control receiver and a power management module are provided on a fixing platform. A first brushless motor is provided on each of the cantilever arms. Each first brushless motor is provided with a rotor via a coupling. The energy supply system is arranged in a lower part of the waterproof sealing cabin.

Abstract: The present disclosure provides a display panel, a manufacturing method thereof, and a display device. The display panel includes a first transistor. The first transistor includes a first semiconductor layer, and the first semiconductor layer includes bismuth selenium oxide materials to enhance mobility of the first transistor and improve electrical performance of the display panel, so that the display panel meets requirements of high refresh rate and high transmittance.

Abstract: A method for preparing Portland cement includes: respectively weighing iron slag, copper slag, vanadium slag, and nickel slag and grinding, to yield prefabricated iron slag, prefabricated copper slag, prefabricated vanadium slag, and prefabricated nickel slag; weighing mica and kaolinite, mixing, and grinding to obtain aluminous raw materials; evenly mixing the prefabricated iron slag and the aluminous raw materials, and calcining, to yield an iron-aluminum eutectic mineral; weighing the marble, fluorite, dolomite, and quartz, evenly mixing the marble, fluorite, dolomite, and quartz with the prefabricated copper slag, prefabricated vanadium slag, and prefabricated nickel slag to yield a first mixture; grinding the iron-aluminum eutectic mineral to yield powders, and calcining a second mixture of the first mixture and the powders, to yield the cement clinker; and cooling the cement clinker, and grinding a third mixture of the cooled cement clinker and the gypsum, to yield the Portland cement.

Abstract: The present disclosure describes techniques of performing machine unlearning in a recommendation model. An unlearning process of the recommendation model may be initiated in response to receiving a request for deleting a fraction of user data from any particular user. The recommendation model may be pre-trained to recommend content to users based at least in part on user data. Values of entries in a matrix corresponding to the fraction of user data may be configured as zero. The matrix may comprise entries denoting preferences of users with respect to content items. Confidence values associated with the fraction of user data may be configured as zero to block influence of the fraction of user data on performance of the recommendation model. The unlearning process may be implemented by performing a number of iterations until the recommendation model has converged.

Abstract: The present disclosure discloses a stable and high-capacity neutral aqueous redox flow lithium battery based on redox-targeting reaction and belongs to the technical field of flow lithium batteries. The present disclosure solves the technical problem that an existing flow battery can only work at low current density. The flow lithium battery of the present disclosure includes a positive electrode storage tank and a negative electrode storage tank; the positive electrode storage tank is filled with a positive electrolyte; and the negative electrode storage tank is filled with a negative electrolyte. The flow lithium battery is characterized in that the positive electrolyte includes a salt containing [Fe(CN)6]4? and/or [Fe(CN)6]3?, and the positive electrode storage tank is further filled with LFP particles and/or FP particles. The flow lithium battery of the present disclosure has wide application prospects in the field of large-scale energy storage.

Abstract: The present disclosure provides BCMA-targeted chimeric antigen receptors (CARs) as well as preparation methods and applications thereof. The CARs of the present disclosure targets BCMA-positive cells, and can be used for treating BCMA-positive B-cell lymphoma, multiple myeloma and plasma cell leukemia.

Abstract: A message display method and an electronic device related to the fields of human-computer interaction, foldable displays, and the like. The electronic device includes a foldable display. The foldable display includes a first region, a second region, and a third region. When the electronic device is in a folded form, the second region is bent. The message display method includes displaying a first interface of a first application in the first region; receiving a first message of a second application; displaying the first message in the first region; detecting a first flipping action; and displaying the first message in the second region.

Abstract: Provided are a chimeric antigen receptor targeting CD20 antigen and a preparation method thereof. The extracellular antigen binding domain of the chimeric antigen receptor includes an antibody heavy chain variable region shown in SEQ ID NO: 7 or 9 or 33 and an antibody light chain variable region shown in SEQ ID NO: 11 or 13 or 35, and is capable of killing tumor cells.

Abstract: A system for electronically and optically monitoring biological samples, the system including: a multi-well plate having a plurality of wells configured to receive a plurality of biological samples, each of the wells having a set of electrodes and a transparent window on a bottom surface of the well that is free of electrodes; an illumination module configured to illuminate the wells; a cradle configured to receive the multi-well plate, the cradle having an opening on the bottom that exposes the transparent windows of the wells; and an optical imaging module movable across different wells of a same multi-well plate to capture images through the windows.

Abstract: An optimization method, apparatus, computer device and storage medium for engine model. The method includes: setting an initial population according to a predetermined number of solutions; obtaining a first output set of the initial population on the engine model; determining a first fitness value; operating selection, crossover, and mutation on the initial population according to the first fitness value to obtain an evolved population, and the initial population and the evolved population constitute a to-be-selected population; obtaining a second output set of the evolved population on the engine model; determining a second fitness value; selecting engine model parameters in the to-be-selected population to form a new population according to the second fitness value; and optimizing the engine model by using the engine model parameters in the new population if a termination condition is met.

Abstract: A scheduling method includes controlling, by a terminal, a scheduling speed of broadcast scheduling events when a first preset condition is met. The first preset condition includes that a quantity of broadcast scheduling events in a preset time window is greater than or equal to a first preset value. The broadcast scheduling event is distributing a broadcast to a receiver. The receiver includes at least one of software, a component, or a program.

Abstract: The present invention provides a combined chimeric antigen receptor targeting CD19 and CD20 and application thereof. Specifically, the present invention provides a combined chimeric antigen receptor targeting CD19 and CD20, which comprises a scFv targeting CD19 and a scFv targeting CD20, a hinge region, a transmembrane region, and an intracellular signaling domain. The present invention provides a nucleic acid molecule encoding the chimeric antigen receptor and a corresponding expression vector, a CAR-T cell, and applications thereof. The experimental results show that the chimeric antigen receptor provided by the present invention shows extremely high killing ability against tumor cells. The chimeric antigen receptor of the present invention targets CD19 and/or CD20 positive cells and can be used to treat CD19 and/or CD20 positive B-cell lymphoma, leukemia and other diseases.

Abstract: The present disclosure provides systems, kits and methods for determining the copy number of a mouse TCR transgene. The primers are specific to the conserved regions of the mouse TCR gene. The primers/probes provide good amplification efficiency and can quickly and accurately determine the copy number of a mouse TCR transgene.