Abstract: The invention provides compositions and methods allowing for rapid, accurate, robust, and low-cost diagnosis of infectious diseases via extraction-free, direct PCR techniques.

Abstract: The present disclosure provides bispecific chimeric antigen receptors targeting CD20 and BCMA. The CAR may comprise an scFv targeting CD20 and an scFv targeting BCMA, a hinge region, a transmembrane domain, a co-stimulatory region, and a cytoplasmic signaling domain. The chimeric antigen receptors can be used to treat autoimmune disorders or cancer.

Abstract: Techniques for automated satellite device authentication to a portal for secure remote access are disclosed. In some embodiments, a system, a process, and/or a computer program product for automated satellite device authentication to a portal for secure remote access include receiving, at a portal, a serial number and an IP address associated with a new satellite for deployment in a large scale virtual private network (LSVPN) deployment; receiving, at the portal, the serial number and the IP address associated with the new satellite, wherein the new satellite is deployed at a remote location, and wherein the new satellite automatically sends the serial number and the IP address associated with the new satellite to the portal; and authenticating the new satellite at the portal using the serial number and the IP address associated with the new satellite.

Abstract: The present disclosure provides for improved methods for expanding tumor infiltrating lymphocytes (TILs) and producing therapeutic populations of TILs in a shorter time period than the traditional methods. TIL cell therapy products can be manufactured which easily meet the target cell dose while maintaining desired T cell phenotype.

Abstract: The present disclosure provides bispecific chimeric antigen receptors targeting CD20 and BCMA. The CAR may comprise an scFv targeting CD20 and an scFv targeting BCMA, a hinge region, a transmembrane domain, a co-stimulatory region, and a cytoplasmic signaling domain. The chimeric antigen receptors can be used to treat autoimmune disorders or cancer.

Abstract: The present disclosure provides bispecific chimeric antigen receptors targeting CD20 and BCMA. The CAR may comprise an scFv targeting CD20 and an scFv targeting BCMA, a hinge region, a transmembrane domain, a co-stimulatory region, and a cytoplasmic signaling domain. The chimeric antigen receptors can be used to treat autoimmune disorders or cancer.

Abstract: The present disclosure provides bispecific chimeric antigen receptors targeting CD20 and BCMA. The CAR may comprise an scFv targeting CD20 and an scFv targeting BCMA, a hinge region, a transmembrane domain, a co-stimulatory region, and a cytoplasmic signaling domain. The chimeric antigen receptors can be used to treat autoimmune disorders or cancer.

Abstract: A road network balanced drainage method aimed at reducing urban waterlogging is disclosed. According to the drainage demand, the existing intersection elevation is changed or the intersection elevation that meets the drainage requirement is designed and implemented in new construction so that the intersection drainage is distributed according to the desired proportion; the water flowing to the water accumulation position is transferred to reduce the waterlogging degree. Through the analysis of the depth of water accumulation in the whole road network, the method of water flow distribution at the intersection is used to make the precipitation flow evenly distributed in the whole road network. The method can be used for solving serious water accumulation of a certain road section, the balanced drainage of the whole road network, the technical transformation of existing intersections, and for the planned and designed roads. The method can effectively eliminate and prevent urban waterlogging.

Abstract: A system for electronically and optically monitoring biological samples, the system including: a multi-well plate having a plurality of wells configured to receive a plurality of biological samples, each of the wells having a set of electrodes and a transparent window on a bottom surface of the well that is free of electrodes; an illumination module configured to illuminate the wells; a cradle configured to receive the multi-well plate, the cradle having an opening on the bottom that exposes the transparent windows of the wells; and an optical imaging module movable across different wells of a same multi-well plate to capture images through the windows.

Abstract: The present disclosure provides a trench field effect transistor structure and a manufacturing method thereof. The manufacturing method includes: providing a substrate (100), forming an epitaxial layer (101), forming a device trench (102) in the epitaxial layer, and forming a shielding dielectric layer (107), a shielding gate layer (105), a first isolation dielectric layer (108), a gate dielectric layer (109), a gate layer (110), a second isolation dielectric layer (112), a body region (114), a source (115), a source contact hole (118), a source electrode structure (122), and a drain electrode structure (123). During manufacturing of a trench field effect transistor structure, a self-alignment process is adopted in a manufacturing process, so that a cell pitch is not limited by an exposure capability and alignment accuracy of a lithography machine, to further reduce the cell pitch of the device, improve a cell density, and reduce a device channel resistance.

Abstract: A task scheduling method and apparatus, a device, and a medium are provided. According to the task scheduling method, a target running category of an application is determined from a plurality of predefined running categories based on a running status of the application, where applications in different running categories in the plurality of predefined running categories have different importance levels. A target classification priority corresponding to the target running category is determined. A target scheduling priority of a target task in the application is determined based on at least the target classification priority. A resource of a processing system is scheduled to the target task based on the target scheduling priority, for running of the target task.

Abstract: Leveraging non-transient or persistent device identifiers to enforce device quarantine instead of IP addresses accommodates the transient associations of IP addresses to devices without compromising the effectiveness of quarantine. When a device has been determined to be compromised and is quarantined, the quarantine of the device is enforced using the IP address of the device. However, IP address assignment is transient. With each connection, a device can be assigned a different IP address. After a connection is established, a gateway can collect a device identifying value(s) that persists across network connections (e.g., host identifier (host ID) and device serial number). With a persistent device identifier, a quarantine list can be enforced in a data/forwarding plane regardless of a compromised device being assigned different network addresses.

Abstract: A system for electronically and optically monitoring biological samples, the system including: a multi-well plate having a plurality of wells configured to receive a plurality of biological samples, each of the wells having a set of electrodes and a transparent window on a bottom surface of the well that is free of electrodes; an illumination module configured to illuminate the wells; a cradle configured to receive the multi-well plate, the cradle having an opening on the bottom that exposes the transparent windows of the wells; and an optical imaging module movable across different wells of a same multi-well plate to capture images through the windows.

Abstract: A voice module of a television collects environmental volume Vr of an environment where a user is located; first current volume Vc of the television is obtained and compared with the environmental volume Vr, so as to determine whether the television volume needs to be adjusted; a desired volume value of the television requiring volume adjustment is calculated by means of a volume curve dynamic adjustment algorithm, and the television automatically adjusts its volume to the desired volume value.

Abstract: Leveraging non-transient or persistent device identifiers to enforce device quarantine instead of IP addresses accommodates the transient associations of IP addresses to devices without compromising the effectiveness of quarantine. When a device has been determined to be compromised and is quarantined, the quarantine of the device is enforced using the IP address of the device. However, IP address assignment is transient. With each connection, a device can be assigned a different IP address. After a connection is established, a gateway can collect a device identifying value(s) that persists across network connections (e.g., host identifier (hostid) and device serial number). With a persistent device identifier, a quarantine list can be enforced in a data/forwarding plane regardless of a compromised device being assigned different network addresses.

Abstract: Methods, systems, and devices related to light therapy using ophthalmic lenses are disclosed. In one example aspect, an optical device includes an ophthalmic lens and a frame comprising a frame front configured to support the ophthalmic lens. The frame includes two temples configured to allow a user to wear the optical device. The optical device includes a coating that is deposited in multiple sub-regions of the ophthalmic lens. The optical device includes a light source coupled to each of the two temples of the frame. The light source is controllable to emit light directed at the coating of the ophthalmic lens such that a portion of the light reflected by the multiple sub-regions of the ophthalmic lens forms a spectrum of light that has different wavelength bands corresponding to different therapeutical effects on the user.

Abstract: A bottle connection assembly is configured to seal a bottle and provide a fluidic path between the interior of the bottle and its exterior for drawing fluids therefrom. The fluids can be reagents used for preparing a sample for the identification of target molecules. A bottle cap for capping the bottle is positioned below the bottle interface assembly and includes a female fitting configured to engage with a male fitting of the bottle interface assembly to form a sealed fluidic connection.

Abstract: The present invention provides a combined chimeric antigen receptor targeting CD19 and CD20 and application thereof. Specifically, the present invention provides a combined chimeric antigen receptor targeting CD19 and CD20, which comprises a scFv targeting CD19 and CD20, a hinge region, a transmembrane region, and an intracellular signaling domain. The present invention provides a nucleic acid molecule encoding the chimeric antigen receptor and a corresponding expression vector, a CAR-T cell, and applications thereof. The experimental results show that the chimeric antigen receptor provided by the present invention shows extremely high killing ability against tumor cells. The chimeric antigen receptor of the present invention targets CD19 and/or CD20 positive cells and can be used to treat CD19 and/or CD20 positive B-cell lymphoma, leukemia and other diseases.

Abstract: Chimeric antigen receptors targeting CD20 and preparation methods thereof are provided. The antigen binding region of the chimeric antigen receptor may include a heavy chain variable region shown in SEQ ID NOs: 7, 9 or 33 and a light chain variable region shown in SEQ ID NOs: 11, 13 or 35.

Abstract: An underwater and aerial vehicle includes a fixing frame, a core navigation system and an energy supply system. The fixing frame has a circular ring configuration in a middle part thereof, and the waterproof sealing cabin is fixed in the circular ring configuration, and multiple cantilever arms extend around the circular ring configuration. An underwater navigation control module and a relay are provided on an auxiliary fixing platform. A second brushless motor is provided on each of the cantilever arms. Each second brushless motor is provided with a marine propeller. A flight control module, a remote control receiver and a power management module are provided on a fixing platform. A first brushless motor is provided on each of the cantilever arms. Each first brushless motor is provided with a rotor via a coupling. The energy supply system is arranged in a lower part of the waterproof sealing cabin.