Abstract: Provided are a chimeric antigen receptor targeting CD20 antigen and a preparation method thereof. The extracellular antigen binding domain of the chimeric antigen receptor includes an antibody heavy chain variable region shown in SEQ ID NO: 7 or 9 or 33 and an antibody light chain variable region shown in SEQ ID NO: 11 or 13 or 35, and is capable of killing tumor cells.

Abstract: Provided are a chimeric antigen receptor targeting CD20 antigen and a preparation method thereof. The extracellular antigen binding domain of the chimeric antigen receptor includes an antibody heavy chain variable region shown in SEQ ID NO: 7 or 9 or 33 and an antibody light chain variable region shown in SEQ ID NO: 11 or 13 or 35, and is capable of killing tumor cells.

Abstract: The present disclosure provides a trench field effect transistor structure and a manufacturing method thereof. The manufacturing method includes: providing a substrate (100), forming an epitaxial layer (101), forming a device trench (102) in the epitaxial layer, and forming a shielding dielectric layer (107), a shielding gate layer (105), a first isolation dielectric layer (108), a gate dielectric layer (109), a gate layer (110), a second isolation dielectric layer (112), a body region (114), a source (115), a source contact hole (118), a source electrode structure (122), and a drain electrode structure (123). During manufacturing of a trench field effect transistor structure, a self-alignment process is adopted in a manufacturing process, so that a cell pitch is not limited by an exposure capability and alignment accuracy of a lithography machine, to further reduce the cell pitch of the device, improve a cell density, and reduce a device channel resistance.

Abstract: An underwater and aerial vehicle includes a fixing frame, a core navigation system and an energy supply system. The fixing frame has a circular ring configuration in a middle part thereof, and the waterproof sealing cabin is fixed in the circular ring configuration, and multiple cantilever arms extend around the circular ring configuration. An underwater navigation control module and a relay are provided on an auxiliary fixing platform. A second brushless motor is provided on each of the cantilever arms. Each second brushless motor is provided with a marine propeller. A flight control module, a remote control receiver and a power management module are provided on a fixing platform. A first brushless motor is provided on each of the cantilever arms. Each first brushless motor is provided with a rotor via a coupling. The energy supply system is arranged in a lower part of the waterproof sealing cabin.

Abstract: A message display method and an electronic device related to the fields of human-computer interaction, foldable displays, and the like. The electronic device includes a foldable display. The foldable display includes a first region, a second region, and a third region. When the electronic device is in a folded form, the second region is bent. The message display method includes displaying a first interface of a first application in the first region; receiving a first message of a second application; displaying the first message in the first region; detecting a first flipping action; and displaying the first message in the second region.

Abstract: The present disclosure relates to a broadcast event processing method and an apparatus. In the broadcast event processing method, whether current user equipment satisfies a broadcast limiting condition is determined after a broadcast event is received, and after it is determined that the current user equipment satisfies the broadcast limiting condition, a first application is launched. The first application has subscribed to the broadcast event. According to a solution provided in this application, application launching triggered by the broadcast event can be flexibly controlled, thereby reducing power consumption of the user equipment and improving user experience.

Abstract: The present invention provides a combined chimeric antigen receptor targeting CD19 and CD20 and application thereof. Specifically, the present invention provides a combined chimeric antigen receptor targeting CD19 and CD20, which comprises a scFv targeting CD19 and CD20, a hinge region, a transmembrane region, and an intracellular signaling domain. The present invention provides a nucleic acid molecule encoding the chimeric antigen receptor and a corresponding expression vector, a CAR-T cell, and applications thereof. The experimental results show that the chimeric antigen receptor provided by the present invention shows extremely high killing ability against tumor cells. The chimeric antigen receptor of the present invention targets CD19 and/or CD20 positive cells and can be used to treat CD19 and/or CD20 positive B-cell lymphoma, leukemia and other diseases.

Abstract: The invention provides compositions and methods allowing for rapid, accurate, robust, and low-cost diagnosis of infectious diseases via extraction-free, direct PCR techniques.

Abstract: The present invention provides a combined chimeric antigen receptor targeting CD19 and CD20 and application thereof. Specifically, the present invention provides a combined chimeric antigen receptor targeting CD19 and CD20, which comprises a scFv targeting CD19 and CD20, a hinge region, a transmembrane region, and an intracellular signaling domain. The present invention provides a nucleic acid molecule encoding the chimeric antigen receptor and a corresponding expression vector, a CAR-T cell, and applications thereof. The experimental results show that the chimeric antigen receptor provided by the present invention shows extremely high killing ability against tumor cells. The chimeric antigen receptor of the present invention targets CD19 and/or CD20 positive cells and can be used to treat CD19 and/or CD20 positive B-cell lymphoma, leukemia and other diseases.

Abstract: Provided are a chimeric antigen receptor targeting CD20 antigen and a preparation method thereof. The extracellular antigen binding domain of the chimeric antigen receptor includes an antibody heavy chain variable region shown in SEQ ID NO: 7 or 9 or 33 and an antibody light chain variable region shown in SEQ ID NO: 11 or 13 or 35, and is capable of killing tumor cells.

Abstract: A voice module of a television collects environmental volume Vr of an environment where a user is located; first current volume Vc of the television is obtained and compared with the environmental volume Vr, so as to determine whether the television volume needs to be adjusted; a desired volume value of the television requiring volume adjustment is calculated by means of a volume curve dynamic adjustment algorithm, and the television automatically adjusts its volume to the desired volume value.

Abstract: A method comprises monitoring a drawing time of a first frame of image, obtaining a current state of a system on chip (SOC) when the drawing time exceeds a first drawing duration, where the current state comprises a current temperature of the SOC and/or a current load of the SOC, determining whether the current state exceeds a first preset threshold, when the current state does not exceed the first preset threshold, increasing an operating frequency of the SOC in a time range, and restoring the operating frequency after the increasing of the operating frequency ends, obtaining actual drawing duration of the first frame of the image when drawing of the first frame of the image is completed, and monitoring a drawing time of a second frame of the image when the actual drawing duration does not exceed second drawing.

Abstract: The present invention provides a combined chimeric antigen receptor targeting CD19 and CD20 and application thereof. Specifically, the present invention provides a combined chimeric antigen receptor targeting CD19 and CD20, which comprises a scFv targeting CD19 and CD20, a hinge region, a transmembrane region, and an intracellular signaling domain. The present invention provides a nucleic acid molecule encoding the chimeric antigen receptor and a corresponding expression vector, a CAR-T cell, and applications thereof. The experimental results show that the chimeric antigen receptor provided by the present invention shows extremely high killing ability against tumor cells. The chimeric antigen receptor of the present invention targets CD19 and/or CD20 positive cells and can be used to treat CD19 and/or CD20 positive B-cell lymphoma, leukemia and other diseases.

Abstract: A charging control method and a charging control apparatus are provided. The charging control method may be used to control a charging process of a secondary battery in a terminal device. According to the used charging control method, in the charging process, a battery voltage of the secondary battery may reach a voltage value greater than a limited charge voltage, so that a charging speed of the secondary battery may increase. In addition, in this method, overvoltage of the secondary battery is prevented by gradually reducing a current value of a charging current.

Abstract: A road network balanced drainage method aimed at reducing urban waterlogging is disclosed. According to the drainage demand, the existing intersection elevation is changed or the intersection elevation that meets the drainage requirement is designed and implemented in new construction so that the intersection drainage is distributed according to the desired proportion; the water flowing to the water accumulation position is transferred to reduce the waterlogging degree. Through the analysis of the depth of water accumulation in the whole road network, the method of water flow distribution at the intersection is used to make the precipitation flow evenly distributed in the whole road network. The method can be used for solving serious water accumulation of a certain road section, the balanced drainage of the whole road network, the technical transformation of existing intersections, and for the planned and designed roads. The method can effectively eliminate and prevent urban waterlogging.

Abstract: A method comprises monitoring a drawing time of a first frame of image, obtaining a current state of a system on chip (SOC) when the drawing time exceeds a first drawing duration, where the current state comprises a current temperature of the SOC and/or a current load of the SOC, determining whether the current state exceeds a first preset threshold, when the current state does not exceed the first preset threshold, increasing an operating frequency of the SOC in a time range, and restoring the operating frequency after the increasing of the operating frequency ends, obtaining actual drawing duration of the first frame of the image when drawing of the first frame of the image is completed, and monitoring a drawing time of a second frame of the image when the actual drawing duration does not exceed second drawing duration.

Abstract: Provided are a chimeric antigen receptor targeting CD20 antigen and a preparation method thereof. The extracellular antigen binding domain of the chimeric antigen receptor includes an antibody heavy chain variable region shown in SEQ ID NO: 7 or 9 or 33 and an antibody light chain variable region shown in SEQ ID NO: 11 or 13 or 35, and is capable of killing tumor cells.

Abstract: The present invention provides a combined chimeric antigen receptor targeting CD19 and CD20 and application thereof. Specifically, the present invention provides a combined chimeric antigen receptor targeting CD19 and CD20, which comprises a scFv targeting CD19 and CD20, a hinge region, a transmembrane region, and an intracellular signaling domain. The present invention provides a nucleic acid molecule encoding the chimeric antigen receptor and a corresponding expression vector, a CAR-T cell, and applications thereof. The experimental results show that the chimeric antigen receptor provided by the present invention shows extremely high killing ability against tumor cells. The chimeric antigen receptor of the present invention targets CD19 and/or CD20 positive cells and can be used to treat CD19 and/or CD20 positive B-cell lymphoma, leukemia and other diseases.

Abstract: A scheduling method includes controlling, by a terminal, a scheduling speed of broadcast scheduling events when a first preset condition is met. The first preset condition includes that a quantity of broadcast scheduling events in a preset time window is greater than or equal to a first preset value. The broadcast scheduling event is distributing a broadcast to a receiver. The receiver includes at least one of software, a component, or a program.

Abstract: The present invention provides a combined chimeric antigen receptor targeting CD19 and CD20 and application thereof. Specifically, the present invention provides a combined chimeric antigen receptor targeting CD19 and CD20, which comprises a scFv targeting CD19 and CD20, a hinge region, a transmembrane region, and an intracellular signaling domain. The present invention provides a nucleic acid molecule encoding the chimeric antigen receptor and a corresponding expression vector, a CAR-T cell, and applications thereof. The experimental results show that the chimeric antigen receptor provided by the present invention shows extremely high killing ability against tumor cells. The chimeric antigen receptor of the present invention targets CD19 and/or CD20 positive cells and can be used to treat CD19 and/or CD20 positive B-cell lymphoma, leukemia and other diseases.