Patents by Inventor Xin Ye

Xin Ye has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10344090
    Abstract: The present invention provides a human PD-1 antibody, an antigen-binding fragment thereof, and medical use thereof, and further provides a chimeric antibody and humanized antibodies comprising a complementarity-determining region (CDR) of the antibody, a pharmaceutical composition comprising the human PD-1 antibody and the antigen-binding fragment thereof, and use of the antibody in preparing medicines for treating diseases or disorders.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: July 9, 2019
    Assignees: Shanghai Hangrui Pharmaceutical Co., Ltd., Jiangsu Hangrui Medicine Co., Ltd.
    Inventors: Jijun Yuan, Xiangdong Qu, Jufang Lin, Xin Ye, Guoqing Cao, Weikang Tao, Lianshan Zhang, Lei Zhang, Li Yang
  • Publication number: 20190207950
    Abstract: A first electronic control unit (ECU) is in communication with a second ECU over a vehicle bus. The first ECU is configured to generate functional safety values and security protection values for a message, validate the security protection values for the message, and send the message to the second ECU including the security protection values but not the functional safety values.
    Type: Application
    Filed: January 3, 2018
    Publication date: July 4, 2019
    Inventors: Majed Samhan MOHAMMED, Xin YE, James Martin LAWLIS, Stephen Robert TRAICOFF
  • Publication number: 20190143517
    Abstract: Various embodiments of systems and methods for collision-free trajectory planning in human-robot interaction through hand movement prediction from vision are disclosed.
    Type: Application
    Filed: November 14, 2018
    Publication date: May 16, 2019
    Applicant: Arizona Board of Regents on Behalf of Arizona State University
    Inventors: Yezhou Yang, Wenlong Zhang, Yiwei Wang, Xin Ye
  • Publication number: 20190070264
    Abstract: An interleukin 15 (IL-15) protein complex is provided. The IL-15 protein complex includes soluble fusion proteins (I) and (II), wherein the fusion protein (I) is an IL-15 polypeptide or a functional fragment thereof, and the soluble fusion protein (II) is an IL-15R? polypeptide or a functional fragment thereof. The soluble fusion protein (I) has at least one amino acid residue mutated to a cysteine (Cys) residue, which pairs with a corresponding mutated Cys residue on the soluble fusion protein (II), or vice versa, to form one or more disulfide bonds. The IL-15 protein complex can be used for tumor therapy.
    Type: Application
    Filed: November 17, 2015
    Publication date: March 7, 2019
    Applicants: Jiangsu Hengrui Medicine Co., Ltd., Shanghai Hengrui Pharmaceutical Co., Ltd.
    Inventors: Xiangdong QU, Xin YE, Qiyue HU, Dongbing CUI, Weikang TAO, Lianshan ZHANG, Piaoyang SUN
  • Publication number: 20190068361
    Abstract: A gateway including a hardware security module (HSM) implementing a hardware random number generator and a non-transitory memory maintaining a key injection status table (KIST). The gateway is programmed to distribute keys generated using the random number generator to a plurality of electronic control units (ECUs) responsive to a trigger to begin key distribution received from an end-of-line (EOL) tool, and send the KIST to the EOL tool responsive to completion of the key distribution. A key generated using a hardware random number generator is sent in an encrypted message to a vehicle electronic control unit (ECU), responsive to receiving a unique identifier (UID) of the ECU over a vehicle bus. Responsive to an indication of success from the ECU in a second encrypted message, a key injection status table (KIST) is updated to indicate that the key was applied to the ECU.
    Type: Application
    Filed: August 30, 2017
    Publication date: February 28, 2019
    Inventors: Xin YE, Jason Michael MILLER, Piyush I. PATEL
  • Patent number: 10206980
    Abstract: Provided is an IL-15 heterodimeric protein, such as an IL-15/IL-15R? heterodimeric protein. The IL-15 heterodimeric protein contains protein (I) and protein (II). Protein (I) is recombinantly produced by combining IL-15 or a variant thereof with a first Fc variant, and protein (II) is a second Fc variant, or recombinantly produced by combining IL-15R? or a variant thereof with a second Fc variant. The first Fc variant and the second Fc variant are preferably linked via a “Knob-into-Hole” mode. Also provided are methods of using the IL-15 heterodimeric proteins to modulate an immune response. The provided IL-15 heterodimeric proteins have significant anti-tumor activity, better biological activity and prolonged in vivo half-life compared to the IL-15 molecule alone.
    Type: Grant
    Filed: December 25, 2014
    Date of Patent: February 19, 2019
    Assignees: Shanghai Hengrui Pharmaceutical Co., Ltd., Jiangsu Hengrui Medicine Co., Ltd.
    Inventors: Xiangdong Qu, Xin Ye, Jijun Yuan, Lei Zhang, Kan Chen, Lianshan Zhang, Guoqing Cao, Zhibin Xu, Weikang Tao
  • Patent number: 10211018
    Abstract: A pivot supporting structure for a circuit breaker and a circuit breaker. The pivot supporting structure includes: a supporting body having a supporting hole for receiving and pivotally supporting a pivot pin connected to an actuating mechanism of the circuit breaker, wherein at least one strain gauge are mounted to the supporting body for sensing the force acting on the pivot supporting structure by the actuating mechanism. This pivot supporting structure can accurately sense the characteristic force applied, such that the contact force and mechanical characteristics of the circuit breaker can be on-line monitored.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: February 19, 2019
    Assignee: ABB Schweiz AG
    Inventors: Zhijian Zhuang, Xin Ye, Luciano Chenet
  • Publication number: 20190016825
    Abstract: The present invention provides a PCSK9 antibody, an antigen-binding fragment thereof, and a medicinal application thereof. Provided in the invention is a chimeric antibody and a humanized antibody, both comprising a CDR of the PCSK9 antibody, and a pharmaceutical composition comprising the PCSK9 antibody and an antigen-binding fragment thereof, and an application of the PCSK9 antibody as a lipid-lowering agent. The invention specifically relates to an application of a humanized PCSK9 antibody for preparing a pharmaceutical drug to treat a PCSK9-induced disease or symptom.
    Type: Application
    Filed: December 20, 2016
    Publication date: January 17, 2019
    Inventors: Xiangdong QU, Xin YE, Shaoyu XU, Bei YUAN, Dongbing CUI, Qiyue HU, Lei ZHANG, Zhibin XU, Weikang TAO, Lianshan ZHANG, Piaoyang SUN
  • Patent number: 10137860
    Abstract: Method and apparatus are disclosed for remote keyless entry authentication. An example remote keyless entry system includes a key fob and a vehicle. The key fob generates a secured message with a plaintext space and a ciphertext space. The vehicle (i) determines whether the key fob may be authorized based on first information in the plaintext space, (ii) decrypts an encrypted value in the ciphertext space based on a predicted full counter value, and (iii) determines whether the key fob is authorized based on second information in the encrypted value.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: November 27, 2018
    Assignee: Ford Global Technologies, LLC
    Inventors: Mark Andre Zielinski, Kevin Thomas Hille, Xin Ye
  • Publication number: 20180254903
    Abstract: Method and apparatus are disclosed for end-to-end vehicle secure ECU unlock in a semi-offline environment. An example vehicle electronic control unit includes a first processor and a second processor. The first processor, when unlocked, provides diagnostic information. The second processor sends a seed value to a diagnostic tool. Additionally, the second processor, in response to receiving a second key, unlocks the first processor. The second processor, after receiving a first verifier, decrypts the first verifier to generate a new key, replaces a current key with the new key, and sends a second verifier to the diagnostic tool.
    Type: Application
    Filed: March 1, 2017
    Publication date: September 6, 2018
    Inventors: David Bardelski, Kevin Thomas Hille, Aldi Caushi, Xin Ye, Mohamad Yassine
  • Publication number: 20180217831
    Abstract: A system includes a processor controlling a vehicle module (VM) in communication with a telematics control unit (TCU) over a bus. In this embodiment, the processor is configured to receive an authentication request, including a counter value, from the TCU. The processor is also configured to respond to the authentication request based on comparison of the counter value to a stored counter value stored by the VM. The processor is further configured to receive a command corresponding to the authentication request and including the counter value, responsive to the approved authentication request and process the command based on comparison of the counter value to the stored counter value.
    Type: Application
    Filed: February 2, 2017
    Publication date: August 2, 2018
    Inventors: Daniel Joseph MADRID, Sangeetha SANGAMESWARAN, Jason Michael MILLER, Xin YE
  • Patent number: 9992821
    Abstract: A heating apparatus includes a power source, a heating unit, and a control unit. The control unit includes a transistor and a thermal resistor. The transistor is connected between the power source and the heating unit to control the power source to provide power to the heating unit. The thermal resistor is connected to the transistor. A resistance value of the thermal resistor changes along with ambient temperature to turn on or off the transistor to control the power source to provide power to the heating unit according the ambient temperature.
    Type: Grant
    Filed: April 24, 2015
    Date of Patent: June 5, 2018
    Assignees: HONG FU JIN PRECISION INDUSTRY (WuHan) CO., LTD, HON HAI PRECISION INDUSTRY CO., LTD.
    Inventors: Xin Ye, Chun-Sheng Chen
  • Publication number: 20180143809
    Abstract: The present disclosure generally describes computer-implemented methods, program products, and systems for providing an integrated visual code editor that generates code snippets based on input received through the graphical user interface and simultaneously displaying the generated code snippets along with a real-time preview of the runtime behavior of the code snippet through a graphical user interface. The method and system includes a novel graphical user interface of the visual code editor that is connected to a repository and can retrieve information for concurrently display to a developer of the application. The visual code editor may concurrently display a code snippet in particular area of the graphical user interface and the runtime behavior of the code snippet within another area of the graphical user interface.
    Type: Application
    Filed: November 21, 2016
    Publication date: May 24, 2018
    Inventors: Thomas Zang, Xin Ye
  • Publication number: 20180134253
    Abstract: Method and apparatus are disclosed for remote keyless entry authentication. An example remote keyless entry system includes a key fob and a vehicle. The key fob generates a secured message with a plaintext space and a ciphertext space. The vehicle (i) determines whether the key fob may be authorized based on first information in the plaintext space, (ii) decrypts an encrypted value in the ciphertext space based on a predicted full counter value, and (iii) determines whether the key fob is authorized based on second information in the encrypted value.
    Type: Application
    Filed: November 17, 2016
    Publication date: May 17, 2018
    Inventors: Mark Andre Zielinski, Kevin Thomas Hille, Xin Ye
  • Publication number: 20180131522
    Abstract: Method and apparatus are disclosed for controller area network message authentication. An example disclosed vehicle includes a data bus and a first control unit communicatively coupled to the data bus. The example first control unit generates a secured message by (a) calculating a message authentication code, (b) truncating the message authentication code, (c) truncating a freshness value used to generate the message authentication code, and (d) placing portions of the truncated message authentication code and the truncated freshness value in separate portions of the secured message.
    Type: Application
    Filed: November 7, 2016
    Publication date: May 10, 2018
    Inventors: James Martin Lawlis, Douglas A. Oliver, Xin Ye
  • Patent number: 9933922
    Abstract: Disclosed herein are technologies that give a disproportionate amount of screen real estate (or container real estate) to one of a group of user interface (UI) subcontainers to which a user is giving his or her attention. More particularly, in response to an indication that the user is focused and/or interested on a particular subcontainer, the device enlarges that subcontainer to occupy more (and perhaps all) of the available screen (or container) real estate. This Abstract is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.
    Type: Grant
    Filed: March 27, 2014
    Date of Patent: April 3, 2018
    Assignee: Sybase, Inc.
    Inventor: Xin Ye
  • Patent number: 9916151
    Abstract: A vehicle may receive a software update to be installed to a vehicle electronic control unit (ECU). The vehicle ECU may download a software update received from a server to a first storage; generate a nonce value associated with the software update; send to the server, a swap authorization request including the generated nonce value; receive a swap authorization including the nonce value and a command-and-control signature from the server; validate the signature and the nonce value from the swap authorization; and reboot using the first storage instead of a second storage when the recovered nonce value matches the generated nonce value.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: March 13, 2018
    Assignee: Ford Global Technologies, LLC
    Inventors: Xin Ye, Aldi Caushi, John R. Bielawski, Jr., Michael Raymond Westra
  • Publication number: 20180048473
    Abstract: A programming session may be initiated to a vehicle ECU by an update device. A software update for the ECU may be authenticated by the update device using an authentication key. When an authentication result indicates successful authentication, the ECU software update is sent by the update device over the in-vehicle network to the ECU. The ECU may then flash a memory with the ECU software update. The authentication key may be obtained from the ECU. The update device may be a vehicle telematics control unit or a service tool coupled to a connector of the vehicle.
    Type: Application
    Filed: August 10, 2016
    Publication date: February 15, 2018
    Inventors: Jason Michael MILLER, Xin YE, Aldi CAUSHI
  • Publication number: 20170289193
    Abstract: The invention discloses a secure smart terminal and an information processing method. The terminal includes a first operating system for processing sensitive logic, a secure storage module, a secure processing module. The secure storage module is for storing sensitive logic of the first operating system and an application. The secure processing module is for switching a current operating system into the first operating system and processing the sensitive logic in the first operating system in case that any sensitive logic is invoked. The first operating system is of functions of protecting information security and preventing invasion of a vicious software.
    Type: Application
    Filed: July 23, 2015
    Publication date: October 5, 2017
    Inventors: Xin YE, Tianqi ZHANG
  • Publication number: 20170250047
    Abstract: A pivot supporting structure for a circuit breaker and a circuit breaker. The pivot supporting structure comprises: a supporting body having a supporting hole for receiving and pivotally supporting a pivot pin connected to an actuating mechanism of the circuit breaker, wherein at least one strain gauge are mounted to the supporting body for sensing the force acting on the pivot supporting structure by the actuating mechanism. This pivot supporting structure can accurately sense the characteristic force applied, such that the contact force and mechanical characteristics of the circuit breaker can be on-line monitored.
    Type: Application
    Filed: May 12, 2017
    Publication date: August 31, 2017
    Inventors: Zhijian Zhuang, Xin Ye, Luciano Chenet