Abstract: The invention provides certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic double stranded siRNA to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).

Abstract: This disclosure relates to blockchain-based leasing. In some aspects, a leasing party node device of a blockchain network comprising a plurality of connected blockchain nodes acquires leasable state data of a target lease object based on a unique identifier that uniquely identifies the target lease object. The leasable state data is stored in a distributed database on the blockchain network and the leasable state data specifies a leasable state of the target lease object. Lease information of the target lease object is generated in response to acquiring the leasable state data. A first update transaction is transmitted to the blockchain network to update the leasable state of the target lease object. The first update transaction includes at least a portion of the lease information.

Abstract: A vehicle communication network is monitored to detect a plurality of electronic control units (ECUs). Upon identifying a new ECU in the plurality of ECUs, a highest ECU trip counter is determined from the plurality of ECUs. A global trip counter stored in the memory is updated based on the highest ECU trip counter. The updated trip global trip counter is greater than the highest ECU trip counter. Then a replacement synchronization message is provided to the plurality of ECUs on the vehicle communication network. The replacement synchronization message includes the updated global trip counter.

Abstract: A system for a vehicle includes a computer, a first electronic control module, and a wired vehicle communications network coupling the computer and the first electronic control module. The computer is programmed to transmit authentication keys to the first electronic control module and a plurality of second electronic control modules via the wired vehicle communications network, encrypt a table of the authentication keys using a first key, store the encrypted table, transmit the encrypted table to the first electronic control module via the wired vehicle communications network, and transmit the encrypted table and the first key to a remote server spaced from the wired vehicle communications network.

Abstract: Authorization of a user device is suspended based on determining, for a first predetermined time, a distance between the user device and a vehicle is greater than a threshold distance. Then a user input specifying a vehicle parameter is requested. Upon receiving the user input, the user input is validated based on the user input matching a stored vehicle parameter. The user device is deauthorized based on a) failing to receive a valid user input within a second predetermined time, or b) receiving a number of invalid user inputs equal to a threshold number.

Abstract: An onboard communication network of a vehicle is monitored to detect a request message that includes a first cipher based message authentication code (CMAC) and a request. A challenge message is determined based on the request message. The challenge message includes a counter and a random number output from a random number generator. A second CMAC is generated based on the challenge message and the request. The request message is authenticated based on determining that the second CMAC matches the first CMAC. The vehicle is operated based on the authenticated request message.

Abstract: The application relates to a fluidized adsorption device and a fluidized adsorption method for sewage treatment. The fluidized adsorption device comprises a fluidized adsorption column and a reflux device, wherein the fluidized adsorption column is consisted of a water outlet area, a fluidized adsorption area and a water inlet area from top to bottom; the reflux device includes top, middle and bottom reflux ports, and related reflux tubes; and the top reflux port and the bottom reflux port are activated during adsorption, and the middle reflux port and the bottom reflux port are activated during adsorbent replacement, such that the fluidized adsorption column can run continuously.

Abstract: A system includes a control module and a local server. The server is programmed to transmit a command to perform an operation to a plurality of vehicles including a vehicle including the control module. The command including a digital signature that is common across the vehicles. The control module is programmed to receive a temporary value; receive the command; decrypt the digital signature in the command with the temporary value; upon verifying the decrypted digital signature, perform the operation; and upon a metric incrementing to a threshold value, prevent decryption of the digital signature with the temporary value.

Abstract: A computer includes a processor and a memory storing instructions executable by the processor to, upon receiving an authorization message, transmit a plurality of new authentication keys to a respective plurality of control modules, the memory including an expiration time for the authorization message; update a listing of the control modules with respective statuses of the transmissions of the respective new authentication keys to the respective control modules, wherein each status is one of successful or unsuccessful; upon at least one status being unsuccessful, prevent the authorization message from expiring at the expiration time; after preventing the authorization message from expiring, retransmit the respective new authentication keys to each control module for which the respective status is unsuccessful; and then expire the authorization message.

Abstract: Systems and methods described herein provide for assigning classifications to signals and corresponding messages for prioritization and transmission across a vehicle CAN bus. The assigned classifications are used to prioritize messages, signals, and nodes of the vehicle CAN bus. The classifications are used to prioritize critical messages and high priority messages that control operations of the vehicle system.

Abstract: Disclosed are an electrocardiogram monitoring device (100) and an electrocardiogram monitoring system. The electrocardiogram monitoring device (100) comprises: a main body (10) and a bottom support, wherein the main body (10) is worn on a wrist, the main body (10) is provided with a controller and a first monitor (11) electrically connected to the controller, and the first monitor (11) is used for generating electrocardiosignals when abutting against two hands and sending the electrocardiosignals to the controller; and the bottom support is provided with a second monitor, the second monitor is in signal connection with the controller, and the second monitor is used for generating electrocardiosignals when being attached to the chest or a limb and sending the electrocardiosignals to the controller. The electrocardiogram monitoring device (100) may realize diverse detection and is easy to operate.

Abstract: The present invention provides a human PD-1 antibody, an antigen-binding fragment thereof, and medical use thereof, and further provides a chimeric antibody and humanized antibodies comprising a complementarity-determining region (CDR) of the antibody, a pharmaceutical composition comprising the human PD-1 antibody and the antigen-binding fragment thereof, and use of the antibody in preparing medicines for treating diseases or disorders.

Abstract: A mask includes a mask body and at least one sub-mask provided on the mask body. The sub-mask includes an evaporation zone and a shield portion. The shield portion is provided with at least one groove in a thickness direction of the sub-mask. The groove has a depth smaller than a thickness of the mask body. Since the shield portion is provided with the groove, and a single groove has a depth smaller than the thickness of the mask body, it not only ensures that there is no pixel evaporated onto a substrate at the shield portion, but also reduces the thickness of the shield portion, thereby reduces weight thereof, lowers the weight difference between the shield portion and the evaporation zone and reduces the stress concentration on the shield portion, resulting in that the mask body is evenly stressed during tensioning.

Abstract: The present disclosure provides a pixel structure, a mask and a display device. The pixel structure includes a number of pixel groups arranged in an array. Each of the pixel groups includes a first pixel sub-group and a second pixel sub-group disposed adjacent to each other in a first direction and misaligned with each other in a second direction perpendicular to the first direction. The first pixel sub-group and the second pixel sub-group include sub-pixel groups of three different colors including a first sub-pixel group, a second sub-pixel group, and a third sub-pixel group. Each sub-pixel group includes four sub-pixels of a same color, and the sub-pixel groups of a same color are alternately arranged in a regular manner.

Abstract: Systems and methods for social networking using augmented reality are disclosed. A network may receive, from a plurality of client devices, a request to connect to a server. The server may be associated with an object, such as a landmark or a product. The server may serialize an AR world including the object and content associated with the object and send, to the plurality of client devices, data indicative of the AR world. The server via network may receive, from a first client device among the plurality of client devices, an indication of user input associated with the AR world. The indication of user input may comprise text data, digital image data, or user feedback. The indication of user input may be broadcast to the plurality of client devices.

Abstract: Provided are an anti-PD-1 antibody, an antigen-binding fragment thereof, and a pharmaceutical use thereof. Specifically, provided are a humanized anti-PD-1 antibody containing a specific CDR region and an antigen-binding fragment thereof, a pharmaceutical composition containing the anti-PD-1 antibody and the antigen-binding fragment thereof, and a used thereof as medicament. In particular, provided is a use of the humanized anti-PD-1 antibody in the preparation of the medicament for treating PD-1 associated diseases or disorders.

Abstract: The present disclosure relates to a system that allows engagement of an electronic plug-in device (EPID) with an on-board diagnostic II (OBD-II) port of a vehicle. The EPID includes an accelerometer and a processor. The accelerometer detects vibrations associated with engine operation. The processor, in communication with the accelerometer, executes instructions to receive an input waveform from the accelerometer. The processor may determine whether the input waveform from the accelerometer is associated with the engine operation. The processor may transition the EPID from a sleep state to a wake state if the input waveform is detected to be associated with the engine operation. In contrast, the processor may transition the EPID from the wake state to the sleep state when the input waveform is not associated with the engine operation.

Abstract: A Digital Video Recorder (DVR) for storing video data received from an imaging device and a method thereof are provided in the present disclosure. The DVR includes a communication port configured to connect to the imaging device. The DVR also includes a processing module configured to determine whether the DVR receives video data from the imaging device through the communication port and a detection module configured to acquire an operating voltage of the imaging device. The DVR further includes a power supply switch configured to turn on or off a power supply to the imaging device based on a determination by the processing module and the operating voltage of the image device.

Abstract: Build-up of adhesive on process equipment is reduced or even eliminated by increasing the running temperature of process equipment used to guide substrates as they are conveyed along a system used to apply adhesive and form laminates. Preferably, the process equipment is heated to a temperature of at least about 5° C., preferably at least about 10° C., and most preferably at least about 15° C., above the crossover temperature of the adhesive, and at most about 60° C., preferably at most about 50° C., and most preferably at most about 45° C., above the crossover temperature. This method is particularly beneficial when using hot melt adhesives to form laminates with permeable substrates, such as low basis weight nonwovens, for use in disposable absorbent articles. A system for applying a hot melt adhesive to a substrate comprises a heater for providing heat to the process equipment and, optionally, a chiller for cooling the process equipment.

Abstract: Systems and methods described herein provide for assigning classifications to signals and corresponding messages for prioritization and transmission across a vehicle CAN bus. The assigned classifications are used to select authentication keys specific to each classification of message. Nodes of the CAN bus can include different sets of keys based on the classifications of messages handled at the nodes. Keys are distributed and localized to reduce any potential impact on critical functions of the vehicle system that may result from compromise of an authentication key.