Abstract: Disclosed are methods for treating or preventing or delaying outset of Alzheimer's disease (AD) in a subject by targeting the novel pathway STAT1-CH25H in AD pathogenesis, specifically by administering to the subject a pharmaceutically effective amount of a STAT1 inhibitor, a CH25H inhibitor, or a 25-OHC inhibitor, for example, a 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitor such as simvastatin.

Abstract: A pixel driving circuit, a display panel and a display device. The pixel driving circuit includes a driving and compensation sub-circuit; a data writing sub-circuit; and a coupling capacitance. A ratio of a capacitance value of the coupling capacitance to the sum of the capacitance value of the coupling capacitance and the capacitance value of the storage capacitance is configured to be greater than a preset value. The preset value is determined based on the preset maximum luminance fluctuation of the display panel. In the present application, the luminance fluctuation is adjusted by adjusting the correlation relationship between the capacitance value of the coupling capacitance and the capacitance value of the storage capacitance. Thus, a new capacitance configuration is provided, the panel can be adjusted at a capacitance level, and a better display effect is provided.

Abstract: A pixel driving circuit, a display panel, and a display device. The pixel driving circuit includes a driving transistor, a data-writing sub-circuit; and a voltage stabilization sub-circuit. The voltage stabilization sub-circuit is coupled to a first control terminal of the driving transistor and is configured to keep a voltage at the first control terminal of the driving transistor to be stable in a reset stage. The voltage at the first control terminal of the driving transistor is kept stable through the voltage stabilization sub-circuit in the reset stage, so that the voltage at the output of the driving transistor is relatively constant, characteristics of a switching element of the driving transistor is ensured, an effect of homogeneous luminance is realized, and a display effect and a stability of displaying of the display panel are improved.

Abstract: A pixel drive circuit, a display panel and a display device. In the pixel drive circuit, a voltage-stabilization transistor is arranged, and the voltage-stabilization transistor is provided with two control ends, each of the two control ends forms a voltage-stabilization capacitor with the active layer, thereby a new capacitor is added on the basis of the original parasitic capacitor. The new capacitor has a relatively large capacitance value. The potential variation at the control end of the drive transistor depends on the parasitic capacitor of the drive transistor, the storage capacitor at the control end of the drive transistor, and the capacitance value of the new capacitor, when the capacitive coupling effect occurs, the voltage at the control end of the drive transistor can be jointly maintained by the above three capacitors, thereby improving the effect of voltage stabilization.

Abstract: A pixel drive circuit, in which a second voltage-stabilization circuitry is configured that assists in maintaining the potential of the control end of the drive transistor during a transition from a compensation-and-writing phase to the light-emitting phase and in a light-emitting phase. During the transition from the compensation phase to the light-emitting phase, due to a decrease of the voltage output from the first voltage-stabilization circuitry, the node voltage between the first and second voltage-stabilization circuitries will be pulled down first. By providing the second voltage-stabilization circuitry, an influence on the node voltage at the control end of the drive transistor caused due to the voltage variation at the nodes between the two circuitries will be greatly reduced, the leakage current of the two circuitries connected in series is smaller than the leakage current of the one single first voltage-stabilization circuitry in the light-emitting phase.

Abstract: A pixel drive circuit, a display panel and a display device. The pixel drive circuit includes a drive transistor, a first compensation capacitor, and a second compensation capacitor. The drive transistor has a first control end, a second control end, an output end, and an input end. The drive transistor is configured as a four-terminal drive device having two control ends, and between each control end and the output end, a compensation element is arranged, so that the compensations to the threshold voltage of the front and rear channels are performed simultaneously when the drive transistor is driven. Meanwhile, each control end is equipped with a capacitor to eliminate the influence of a current difference caused by the threshold voltage of the secondary channel in the 4-terminal device.

Abstract: The present disclosure provides a display driving circuit and a display device. The display driving circuit includes multiple pixel circuits. A data end of each pixel circuit is connected to a data line, configured to provide a data signal; a gate end of each pixel circuit is connected to a gate line, configured to provide a gate signal; and a power supply end of each pixel circuit is connected to a same power supply common line. The multiple pixel circuits are divided into at least one first pixel circuit and at least one second pixel circuit, and a luminous efficiency of the first pixel circuit is less than that of the second pixel circuit; a width-to-length ratio of a channel of a thin-film field-effect transistor in a driving module of the first pixel circuit is greater than that of the second pixel circuit.

Abstract: A pixel drive circuit, a display panel and a display device. The pixel drive circuit includes a drive transistor, a first compensation capacitor, and a second compensation capacitor. The drive transistor has a first control end, a second control end, an output end, and an input end. The drive transistor is configured as a four-terminal drive device having two control ends, and between each control end and the output end, a compensation element is arranged, so that the compensations to the threshold voltage of the front and rear channels are performed simultaneously when the drive transistor is driven. Meanwhile, each control end is equipped with a capacitor to eliminate the influence of a current difference caused by the threshold voltage of the secondary channel in the 4-terminal device.

Abstract: A pixel driving circuit, a display panel and a display device. The pixel driving circuit includes a driving and compensation sub-circuit; a data writing sub-circuit; and a coupling capacitance. A ratio of a capacitance value of the coupling capacitance to the sum of the capacitance value of the coupling capacitance and the capacitance value of the storage capacitance is configured to be greater than a preset value. The preset value is determined based on the preset maximum luminance fluctuation of the display panel. In the present application, the luminance fluctuation is adjusted by adjusting the correlation relationship between the capacitance value of the coupling capacitance and the capacitance value of the storage capacitance. Thus, a new capacitance configuration is provided, the panel can be adjusted at a capacitance level, and a better display effect is provided.

Abstract: A custom tone and vocal synthesis method and apparatus, an electronic device, and a storage medium. The synthesis method comprises: training a first neural network by means of a speaker record sample to obtain a speaker recognition model, the output training result of the first neural network being a speaker vector sample (S102); training a second neural network by means of an unaccompanied vocal singing sample and the speaker vector sample to obtain an unaccompanied singing synthesis model (S104); inputting a speaker record to be synthesized into the speaker recognition model to obtain speaker information output by the intermediate hidden layer of the speaker recognition model (S106); and inputting unaccompanied singing music information to be synthesized and the speaker information into the unaccompanied singing synthesis model to obtain a synthesized custom tone and vocal (S108).

Abstract: A system and method for operating an ICE by (a) generating a running history of one or more-cylinder events per cylinder, and (b) using the running history to select a least-used non-rotating firing pattern, among a plurality of non-rotating firing patterns, provided for each firing fraction less than one (1). By making the least used selection based on the running history, unequal usage among cylinders of the ICE can be mitigated.

Abstract: A pixel driving circuit, a method for driving a display panel, and a display device are provided. The display panel includes pixel columns, each of the pixel columns includes pixel components. The pixel driving circuit includes pixel driving modules, a data line, first gating units, and second gating units. Each of the pixel driving modules is coupled to pixel components of adjacent two pixel columns of the pixel columns, any pixel component in each of the pixel columns is written in a driving voltage via a corresponding driving switch. A terminal of each of the first gating units and a terminal of each of the second gating units are respectively coupled to the data line, another terminal of each of the first gating units is coupled to a corresponding adjacent pixel component, another terminal of each of the second gating units is coupled to another corresponding adjacent pixel component.

Abstract: A system and method for operating an ICE by (a) generating a running history of one or more-cylinder events per cylinder, and (b) using the running history to select a least-used non-rotating firing pattern, among a plurality of non-rotating firing patterns, provided for each firing fraction less than one (1). By making the least used selection based on the running history, unequal usage among cylinders of the ICE can be mitigated.

Abstract: Disclosed are methods and compositions for treating ore preventing a STAT5-mediated medical condition, e.g., rheumatoid arthritis, in a subject by administering to the subject a therapeutically effective amount of a compound, the compound being a STAT5 inhibitor, or a pharmaceutically acceptable salt of the STATS inhibitor, or a solvate of the STATS inhibitor, or a prodrug of the STAT5 inhibitor. In one example, the compound used in the methods and compositions is pimozide. In another example, the compound used in the methods and compositions is nicotinohydrazide.

Abstract: A pixel driving circuit includes a driving transistor, a voltage stabilizing transistor, and a storage capacitance. A gate metal layer of a gate electrode of the voltage stabilizing transistor that serves as the control terminal of the voltage stabilizing transistor, and an active layer are constituted as a channel on-state capacitance, a ratio of an area of the channel on-state capacitance to a capacitance value of the storage capacitance is less than a preset value the area of the channel on-state capacitance is a directly opposite overlapping area between the gate metal layer and the active layer. This preset value is determined based on a ratio of a voltage fluctuation at a control terminal of the driving transistor to a potential voltage. A correlation between the channel on-state capacitance and the storage capacitance of the voltage stabilizing transistor is determined, so that a new capacitance configuration method is provided.

Abstract: The present disclosure relates to a display panel and a display device. The display panel comprises a thin film transistor and a plurality of voltage drain drain signal lines, the thin film transistor comprises a bottom gate and a top gate opposite to each other, the voltage drain drain signal lines are arranged on the same layer as a source electrode and a drain electrode, the display panel further comprises a plurality of voltage dividing wires arranged on the same layer as the bottom gate, the plurality of voltage dividing wires and the plurality of voltage drain drain signal lines intersect with one another to be in grid-shaped distribution, and at least part of intersecting positions of the voltage dividing wires and the voltage drain drain signal lines are electrically connected through via holes.

Abstract: Provided is a use of mesenchymal stem cells in the preparation of a drug for repairing lung damage caused by COVID-19. It is proved by clinical tests for the first time that mesenchymal stem cells have an excellent effect on repair of lung damage in subjects with viral pneumonia, especially severe pneumonia caused by SARS-CoV-2 infection, and can significantly reduce solid component lesion volume of the subjects, and repair lung tissue; moreover, it is proved by means of a six minute walking test that mesenchymal stem cells can significantly repair the subjects' cardiopulmonary function, so that the aerobic exercise capacity is significantly improved, thereby effectively alleviating sequelae of the subjects after the end of antiviral treatment, and improving health and quality of life of the subjects; in addition, mesenchymal stem cells are highly safe, and no obvious adverse reactions have been found.

Abstract: Described are a method, apparatus and computer program product are provided for block modulating video and image compression. Different masks may be imposed on different blocks of an image and then the blocks summed to one block. In some embodiments, an encoder complexity of the encoder may be O(1). A method can be carried out that includes dividing an input image into a plurality of blocks; assigning different masks to each respective image block of the plurality of image blocks, the different masks having a size equal to that of each respective image block of the plurality of image blocks; modulating each respective image block of the plurality of blocks the assigned different masks to generate a plurality of modulated image blocks; summing the modulated plurality of blocks to at least one summed block; and quantizing the at least one summed block.

Abstract: The present disclosure provides a display driving circuit and a display device. The display driving circuit includes multiple pixel circuits. A data terminal of each pixel circuit is connected to a corresponding data line. A scanning gate terminal of each pixel circuit is connected to a corresponding gate line. Power-supply terminals of N1 pixel circuits of the pixel circuits are all connected to a same first common line. N1 is greater than 2 and not greater than a first common number. The first common number is negatively correlated to any of a characteristic parameter of a thin-film field-effect transistor of each pixel circuit, and a current in one of the N1 pixel circuits, and a resistance of a power-supply voltage signal line between adjacent pixel circuits in the N1 pixel circuits, and the characteristic parameter is positively correlated to a channel width-to-length ratio of the thin-film field-effect transistor.

Abstract: Systems and methods for image generation are described. Embodiments of the present disclosure receive a text phrase that describes a target image to be generated; generate text features based on the text phrase; retrieve a search image based on the text phrase; and generate the target image using an image generation network based on the text features and the search image.