Abstract: Disclosed herein is a T-helper cell (“TH-GM” cell) that is regulated by IL-7/STAT5 and which secrete GM-CSF/IL-3. Also disclosed are methods and compositions for modulating TH-GM function for the treatment of, e.g., inflammatory disorders. Diagnostic and prognostic methods for specifically identifying TH-GM-mediated inflammatory disorders (e.g., rheumatoid arthritis), as distinct from and/or in addition to non-TH-GM-mediated (e.g., TNF-?-mediated) inflammatory disorders, are also provided.

Abstract: An image acquisition device compresses a media signal representative of a scene based on a sensing matrix that is a determined by a sensing matrix template and a set of template parameters. The image acquisition device provides the compressed media signal to a receiver and selectively provides a specification of a subset of the set of template parameters to the receiver. The receiver extracts one or more scene descriptors representative of one or more portions of the scene from the compressed media signal using the sensing matrix template without knowledge of the template parameters that are not included in the subset. The template parameters that are not included in the subset are not received by the receiver.

Abstract: In various aspects, internal combustion engines, engine controllers and methods of controlling engines are described. The engine includes a camshaft and a two cylinder sets. Cylinders in the first are deactivatable and cylinders in the second set may be fired at high or low output levels. The air charge for each fired working cycle is set based on whether a high or low torque output is selected. In some implementations, the camshaft is axially shiftable between first and second positions. First cam lobes are configured to cause their associated cylinders to intake a large air charge during intake strokes that occur when the camshaft is in the first position. Second cam lobes for cylinders in the second set cause their associated cylinders to intake a smaller air charge when the camshaft is in the second position. Second cam lobes for cylinders in the first set deactivate their associated cylinders.

Abstract: An alternating stack of insulating layers and spacer material layers is formed over a substrate. A staircase region having stepped surfaces is formed by patterning the alternating stack. Memory opening fill structures are formed in a memory array region, and support pillar structures are formed in the staircase region. Each of the memory stack structures includes a memory film and a vertical semiconductor channel. The support pillar structures include first support pillar structures and having a first maximum lateral dimension and second support pillar structures having a second maximum lateral dimension that is less than the first maximum lateral dimension and interlaced with the first support pillar structures. The sacrificial material layers are replaced with electrically conductive layers.

Abstract: A variety of methods and arrangements for reducing noise, vibration and harshness (NVH) in a skip fire engine control system are described. In one aspect, a firing sequence is used to operate the engine in a skip fire manner. A smoothing torque is determined that is applied to a powertrain by an energy storage/release device. The smoothing torque is arranged to at least partially cancel out variation in torque generated by the skip fire firing sequence. Various methods, powertrain controllers, arrangements and computer software related to the above operations are also described.

Abstract: The present disclosure generally discloses a three-dimensional (3D) image reconstruction capability. The 3D image reconstruction capability may be configured to support reconstruction of a 3D image of a scene. The 3D image reconstruction capability may be configured to support reconstruction of a 3D image of a scene based on lensless compressive image acquisition performed using a lensless compressive camera having a single aperture and a set of multiple sensors. The reconstructed 3D image of a scene may include (1) image data indicative of a set of multiple two-dimensional (2D) images reconstructed based on the set of multiple sensors of the lensless compressive camera (which may be represented as images) and (2) depth information indicative of depths at points or areas of an overlapping portion of the multiple images reconstructed based on the set of multiple sensors of the lensless compressive camera (which may be represented as a depth map).

Abstract: Disclosed are methods and compositions for treating ore preventing a STAT5-mediated medical condition, e.g., rheumatoid arthritis, in a subject by administering to the subject a therapeutically effective amount of a compound, the compound being a STAT5 inhibitor, or a pharmaceutically acceptable salt of the STAT5 inhibitor, or a solvate of the STAT5 inhibitor, or a prodrug of the STAT5 inhibitor. In one example, the compound used in the methods and compositions is pimozide. In another example, the compound used in the methods and compositions is nicotinohydrazide.

Abstract: An alternating stack of insulating layers and spacer material layers is formed over a substrate. A staircase region having stepped surfaces is formed by patterning the alternating stack. Memory opening fill structures are formed in a memory array region, and support pillar structures are formed in the staircase region. Each of the memory stack structures includes a memory film and a vertical semiconductor channel. The support pillar structures include first support pillar structures and having a first maximum lateral dimension and second support pillar structures having a second maximum lateral dimension that is less than the first maximum lateral dimension and interlaced with the first support pillar structures. The sacrificial material layers are replaced with electrically conductive layers.

Abstract: A linear titanium-oxide polymer, a nano-TiO2 coating structure, a glass fiber mat-nano-TiO2 photocatalytic coating structure and methods for preparing the same are disclosed. The linear titanium-oxide polymer has the following structural formula: The prepared materials can be used for photocatalysis, deodorizing filters, antibacterial filters, indoor air purifying filters, transport vehicle purifying filters, and household appliance purifiers and so on.

Abstract: Embodiments are directed to a trusted platform powered by a client-side company application that implements a Business Organizing Principle (“BOP”) for a company and distributed immutable ledger, which provides the company with secure transactions and transaction data. The application's Business Organizing Principle identifies the business components for a company (e.g., HR, marketing, suppliers, etc.) which the application identifies as core, medium-core, and non-core. The application can then suggest and link the business to other businesses on the network based on matching BOP components. The platform's scoring engine uses the ledger's trusted transactions to generate a BOP network score and “local score” to augment traditional thereby creating a quickly developed trusted ecosystem for horizontal B2B integration between not just businesses, but business components.

Abstract: The disclosure provides a method of inhibiting proliferation of a cell, inhibiting m3C formation in a cell, inhibiting activity of Mettl8 in a cell, or activating ATM and p53 in a cell, the method comprising contacting the cell with a Mettl8 inhibitor. The disclosure also provides a composition comprising a cell with a reduced expression or activity of Mettl8. In another aspect, the disclosure provides methods of rendering a tumor cell sensitive to a cancer therapy.

Abstract: A Total Loss Predictor Score assesses the risk of Total Loss of new credit applications by leveraging the most powerful insights from business databases. The Total Loss Predictor Score built on segmentation and algorithms that use the commercial information from business databases, powered by analytics, delivers a unique solution for credit risk management to help business creditors with origination decisions.

Abstract: Disclosed are methods for treating or preventing or delaying outset of Alzheimer's disease (AD) in a subject by targeting the novel pathway STAT1-CH25H in AD pathogenesis, specifically by administering to the subject a pharmaceutically effective amount of a STAT1 inhibitor, a CH25H inhibitor, or a 25-OHC inhibitor, for example, a 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitor such as simvastatin.

Abstract: Disclosed herein is a T-helper cell (“TH-GM” cell) that is regulated by IL-7/STAT5 and which secrete GM-CSF/IL-3. Also disclosed are methods and compositions for modulating TH-GM function for the treatment of, e.g., inflammatory disorders. Diagnostic and prognostic methods for specifically identifying TH-GM-mediated inflammatory disorders (e.g., rheumatoid arthritis), as distinct from and/or in addition to non-TH-GM-mediated (e.g., TNF-?-mediated) inflammatory disorders, are also provided.

Abstract: A variety of methods and arrangements for reducing noise, vibration and harshness (NVH) in a skip fire engine control system are described. In one aspect, a firing sequence is used to operate the engine in a dynamic firing level modulation manner. A smoothing torque is determined by adaptive control that is applied to a powertrain by an energy storage/release device. The smoothing torque is arranged to at least partially cancel out variation in torque generated by the firing sequence. Various methods, powertrain controllers, arrangements and computer software related to the above operations are also described.

Abstract: Memory dies on a wafer may include multiple memory blocks including bit lines extending along different directions. A memory die may include a first-type plane including first memory blocks and a second-type plane including second memory blocks. In this case, memory blocks having different bit line directions may be formed within a same memory die. An exposure field may include multiple types of memory dies that are oriented in different orientations. The bit line directions may be oriented differently in the multiple types of memory dies. Each lithographic exposure process may include a first step in which lithographic patterns in first exposure fields are oriented in one direction, and a second step in which lithographic patterns in second exposure fields are oriented in another direction. The different orientations of bit lines and word lines may change local directions of stress to reduce wafer distortion.

Abstract: A vehicle, engine controller and method for coordinating direct split injection of two or more pulses of fuel during a working cycle of a reactivated cylinder which was deactivated in a previous working cycle is described. By using split injection for the reactivated cylinder, the particulate matter and particulate number (“PM/PN”) generated by the reactivated cylinder is reduced.

Abstract: A variety of methods and arrangements for reducing noise, vibration and harshness (NVH) in a skip fire engine control system are described. In one aspect, a firing sequence is used to operate the engine in a dynamic firing level modulation manner. A smoothing torque is determined by adaptive control that is applied to a powertrain by an energy storage/release device. The smoothing torque is arranged to at least partially cancel out variation in torque generated by the firing sequence. Various methods, powertrain controllers, arrangements and computer software related to the above operations are also described.

Abstract: An encoder determines a compression ratio for compressive sensing and a quantization level used to quantize a media signal based on a target indicator. The encoder accesses compressive sensing measurements performed using the compression ratio and quantizes the compressive sensing measurements based on the quantization level. A decoder receives a compressed signal generated from the signal acquired by the signal acquisition device using the compression ratio and the quantization level. The decoder also receives information indicating the compression ratio or the quantization level. The decoder decompresses the compressed signal based on the compression ratio and the quantization level.

Abstract: Methods and arrangements for transitioning an engine between a deceleration cylinder cutoff (DCCO) state and an operational state are described. In one aspect, transitions from DCCO may begin with reactivating cylinders to pump air to reduce the pressure in the intake manifold prior to firing any cylinders. The number of pumping cycles, if any, is based on intake manifold absolute pressure (MAP).