Abstract: Embodiments relate to systems comprising Active Wearable Medical Device (AWMD) with an osmotic chamber containing or configured to receive an osmotic agent, a permeability module for fluid ingress, and a drug chamber holding a drug. A compressible piston, positioned between the chambers, moves longitudinally as a whole during operation. The compressible piston advances toward the drug chamber when a valve opens, enabling drug release through one or more outlets, and retracts when the valve closes, driven by osmotic pressure. A valve module regulates this flow. The system also comprises a fluid chamber containing fluid and a semipermeable membrane coupling it to the AWMD. A channel connected to the drug outlets delivers the drug externally.

Abstract: An embodiment relates to systems and methods to deliver medications precisely within body of a subject as prescribed and tailored to individual needs. The system comprises a miniaturized implantable drug delivery device that dispenses drugs subcutaneously with controlled precision; a stable drug formulation that remains effective at body temperature; a biosensor that continuously monitors at least one of a drug level and health markers; and an analytics platform that analyses data to optimize drug delivery in real-time, ensuring highly personalized and effective patient care.

Abstract: An embodiment relates to an active implantable medical device (AIMD), comprising: a) a permeability module to allow ingress of a fluid into an osmotic chamber, b) a drug chamber module comprising an osmotic agent chamber, a drug chamber comprising a drug or being provided to receive a drug, a piston sandwiched between the osmotic agent chamber and the drug chamber; and c) a valve module to allow unidirectional flow of the drug from the drug chamber to outside the AIMD through one or more drug outlet orifices present within the AIMD; wherein: (i) the AIMD is electrically powered; (ii) the permeability module allows ingress of a fluid into the osmotic agent chamber to establish an osmotic pressure; and (iii) the valve module is configured to open and close as per a predetermined program set within the AIMD to regulate flow of the drug from the drug chamber.

Abstract: A system is described. The system comprises an active wearable medical device (AWMD), a fluid chamber, and a channel for delivering a drug. The AWMD comprises a drug chamber, a motor chamber, a piston, an electronic module, and a permeability module. The motor chamber comprises a motor, and a driving component. The piston is affixed to an end of the driving component. The electronic module actuates the motor to operate the driving component and move the piston longitudinally to discharge a drug outside through orifices. The permeability module allows passive ingress of a fluid to an osmotic chamber from the fluid chamber through a semipermeable membrane and generates osmotic pressure to drive the piston longitudinally in addition to actuation by the motor. The AWMD is not implanted in a body of a mammal and is fluidically coupled to the fluid chamber via the semipermeable membrane.

Abstract: An active implantable medical device (AIMD) is described. The AIMD comprises: a drug chamber that comprises a drug; a motor chamber that comprises a housing, a motor, and a driving component; a piston that is affixed to a first end of the driving component; and an electronic module that actuates the motor to operate the driving component and move the piston longitudinally to discharge the drug outside the AIMD through one or more orifices.

Abstract: Light emitting diode, LED, controllers (110), light-emitting diode drive systems (10) and corresponding methods are provided. A LED arrangement (14) is switchable between a first set of active LEDs (15) and a second set of active LEDS (16). Upon switching, a series switch (13) between a power supply and the LED arrangement is switched off and on repeatedly during a transition period.

Abstract: Embodiments relate to systems comprising Active Wearable Medical Device (AWMD) with an osmotic chamber containing or configured to receive an osmotic agent, a permeability module for fluid ingress, and a drug chamber holding a drug. A compressible piston, positioned between the chambers, moves longitudinally as a whole during operation. The compressible piston advances toward the drug chamber when a valve opens, enabling drug release through one or more outlets, and retracts when the valve closes, driven by osmotic pressure. A valve module regulates this flow. The system also comprises a fluid chamber containing fluid and a semipermeable membrane coupling it to the AWMD. A channel connected to the drug outlets delivers the drug externally.

Abstract: An embodiment relates to systems and methods to deliver medications precisely within body of a subject as prescribed and tailored to individual needs. The system comprises a miniaturized implantable drug delivery device that dispenses drugs subcutaneously with controlled precision; a stable drug formulation that remains effective at body temperature; a biosensor that continuously monitors at least one of a drug level and health markers; and an analytics platform that analyses data to optimize drug delivery in real-time, ensuring highly personalized and effective patient care.

Abstract: Embodiments relate to devices, methods, and systems to assess the status of a bowel preparation in a subject. In an embodiment, the device, the methods, and the system assess the status of bowel preparation in a subject in real-time.

Abstract: An embodiment relates to a system comprising a fluid chamber containing a fluid; an Active Wearable Medical Device (AWMD) comprising a permeability module configured to allow ingress of fluid from the fluid chamber to an osmotic agent chamber via a semi-permeable membrane to generate osmotic pressure; a piston that moves longitudinally in response to the osmotic pressure; a drug chamber comprising a drug and a valve module configured to enable one-way drug flow from the chamber to outside the AWMD; a sensor module to measure piston displacement and provide real-time data; and an electronic module configured to regulate drug ejection based on the displacement data, ensuring dose-to-dose volume variation remains within ±25%. A machine learning model triggers alerts if dosing deviates from threshold limits. A channel is fluidically coupled to the AWMD and delivers the drug to the subject. The AWMD is externally worn and not implanted.

Abstract: Embodiments relate to systems comprising Active Wearable Medical Device (AWMD) with an osmotic chamber containing or configured to receive an osmotic agent, a permeability module for fluid ingress, and a drug chamber holding a drug. A compressible piston, positioned between the chambers, moves longitudinally as a whole during operation. The compressible piston advances toward the drug chamber when a valve opens, enabling drug release through one or more outlets, and retracts when the valve closes, driven by osmotic pressure. A valve module regulates this flow. The system also comprises a fluid chamber containing fluid and a semipermeable membrane coupling it to the AWMD. A channel connected to the drug outlets delivers the drug externally.

Abstract: An embodiment relates to an active implantable medical device (AIMD), comprising: a permeability module that allows ingress flow of a fluid to an osmotic agent chamber and generates osmotic pressure; a piston that moves longitudinally within the active implantable medical device (AIMD) in response to the osmotic pressure; a drug chamber that comprises a drug and a valve module to allow one-way flow of the drug from the drug chamber to outside the active implantable medical device (AIMD); a sensor module that measures a displacement of the piston in real-time; and an electronic module that communicates a signal to the valve module to control the valve module and regulate the one-way flow of the drug based on the displacement of the piston.

Abstract: Light emitting diode, LED, controllers (110), light-emitting diode drive systems (10) and corresponding methods are provided. A LED arrangement (14) is switchable between a first set of active LEDs (15) and a second set of active LEDS (16). Upon switching, a series switch (13) between a power supply and the LED arrangement is switched off and on repeatedly during a transition period.

Abstract: An embodiment relates to an active implantable medical device (AIMD) comprising: a permeability module to allow ingress of a fluid into an osmotic agent chamber of the AIMD, a compressible piston, a drug chamber comprising a drug or being provided to receive a drug and a valve module to allow flow of the drug from the drug chamber to outside the AIMD through one or more drug outlets present in the AIMD, wherein the AIMD has dimensions that allow the AIMD to be implanted, subcutaneously, in a human body.

Abstract: Embodiments relate to device, system and methods for personalised drug dosing via a device, the device comprising a first chamber comprising a drug reservoir unit; a second chamber comprising an electronic unit comprising a control component; a third chamber comprising a drug delivery unit and a flow control component controlled via the electronic unit; wherein the device is fully implanted in a subject during its intended operational modes, and wherein the device releases a body temperature stable drug formulation into the subject at a flow rate such that a variation in the flow rate is within ±15% by volume.

Abstract: The present invention relates to a homogeneous multiplex detection device, its operation and detection processes thereof. The device comprises, a reaction vessel, providing a reaction space with two ends opposite to each other, wherein the first end of the reaction vessel is an open end and the second end of the reaction vessel is a closed end, and being used for nucleic acid amplification reactions; a reaction chip, positioning inside the reaction space and on the first end of the reaction vessel, and having a reaction surface where a plurality of types of nucleic acid probes corresponding to a plurality of types of target molecules are immobilized, wherein a plurality of types of nucleic acid probes of the reaction chip are corresponding to the plurality of types of target molecules, and are used for detecting nucleic acid molecules produced by amplification of the target molecules inside the reaction vessel; and a lid, detachably arranged on the first end of the reaction vessel to close the reaction space.

Abstract: The invention relates to biochemical reactions, in particular to a detection device and a light guide detection method thereof. The detection device comprises: a reaction vessel providing a reaction space and having a first end and a second end opposite the first end, wherein the first end of the reaction vessel is an open end and the second end of the reaction vessel is a closed end; a reaction chip arranged inside the reaction space and located at a first end of the reaction vessel; a cover detachably provided on the first end of the reaction vessel to close the reaction space; and a light guide assembly passing through the cover from the outside of the reaction space into the inside of the reaction space and connected to the reaction chip.

Abstract: An embodiment relates to system comprising: (i) a reaction mixture comprises: a) a target nucleic acid molecule; b) a forward primer complementary to a strand of the target nucleic acid molecule, the forward primer comprises a first molecular moiety at a 3? end, wherein the first molecular moiety is non-complementary to the strand of the target nucleic acid molecule; c) a reverse primer complementary to a complementary sequence of the strand of the target nucleic acid molecule, the reverse primer comprises a second molecular moiety at a 3? end, wherein the second molecular moiety is non-complementary to the complementary sequence of the strand of the target nucleic acid molecule; d) a polymerase with 3?-5? exonuclease activity; and (ii a device suitable of detecting an amplification products.

Abstract: A database comprising a digital signature of a smell, the digital signature comprising a smell data, the smell data comprising a response signal that is a function of a first data corresponding to a generator generating the response signal and a second data corresponding to a predetermined stimulus for generating the response signal, wherein the digital signature comprises binary data, wherein the response signal is a measurable response of the generator to the predetermined stimulus that is a function of change in electrical properties of resistance or impedance in the generator. wherein the generator generating the smell-related response signal is a Metal Oxide Semiconductor (MOS) in a sensor or a sensor pixel of a sensor array having a plurality of MOS sensor pixels having an MOS active material exposed to an analyte in the gas environment and the predetermined stimulus is a sequence of predetermined temperatures.

Abstract: An anti-counterfeiting face detection method, device and multi-lens camera are disclosed. The anti-counterfeiting face detection method comprises: acquiring a depth image, an infrared image and an RGB image by using a TOF camera and an RGB camera; analyzing the RGB image through a preset face detection algorithm to determine an RGB face region of a face in the RGB image and position information of the RGB face region; determining a depth face region of the face in the depth image and an infrared face region of the face in the infrared image based on the position information of the RGB face region; determining that the face passes the detection when the depth face region, the infrared face region and the RGB face region meet corresponding preset rules respectively.