Abstract: Implantable modular hydrogels to aid in salivary gland restoration and associated methods are provided. In one embodiment, the present disclosure provides for a hydrogel network comprising: a hyaluronic acid macromer crosslinked with a multiblock copolymer.

Abstract: A camera adapted for taking pictures of a moving scene is disclosed. The camera includes an imaging array, a plurality of charge-coupled device (CCD) shift registers, and a controller. The imaging array includes a plurality of CMOS pixel sensors organized as a plurality of columns and rows. The image moves in the column direction. One CCD shift register corresponds to each of the columns. Each CMOS pixel sensor includes a first transfer gate that transfers charge accumulated in the pixel sensor to a corresponding cell in the CCD shift register. The controller controls the CCD shift registers such that charge stored in a first cell in a CCD shift register is moved to a second cell in the CCD shift register where the charge is combined with charge accumulated by the pixel sensor that is connected to the second cell, the combined charge being generated from the same image pixel.

Abstract: An apparatus and method for forming a digital image are disclosed. The apparatus includes a plurality of pixel sensors and a controller. Each sensor includes a photodiode, a floating diffusion node that can be selectively connected to said photodiode or a reset voltage, and an analog-to-digital converter (ADC) connected to the floating diffusion node, the ADC converting a voltage on the floating diffusion node to a digital value. Each pixel sensor also includes an output circuit that connects the ADC to a bus. The apparatus also includes a controller that causes the ADCs to operate in parallel to convert the voltages on the floating diffusion nodes to the digital values in a time that is less than the time needed for the floating diffusion node to acquire ten electron equivalents of noise. The optional apparatus includes circuitry that allows correlated double sampling to be performed in each sensor.

Abstract: A method for enhancing chondrogenesis in a subject in need thereof comprises administering to the subject an effective amount of a pharmaceutical composition comprising a growth factor bound to hyaluronic acid (HA)-based hydrogel particles (HGPs). The hyaluronic acid (HA)-based hydrogel particles (HGPs) are conjugated with a heparan sulfate proteoglycan (HSPG). Related medicaments and methods for preparing the medicaments are provided.

Abstract: An apparatus and method for forming a digital image are disclosed. The apparatus includes a plurality of pixel sensors and a controller. Each sensor includes a photodiode, a floating diffusion node that can be selectively connected to said photodiode or a reset voltage, and an analog-to-digital converter (ADC) connected to the floating diffusion node, the ADC converting a voltage on the floating diffusion node to a digital value. Each pixel sensor also includes an output circuit that connects the ADC to a bus. The apparatus also includes a controller that causes the ADCs to operate in parallel to convert the voltages on the floating diffusion nodes to the digital values in a time that is less than the time needed for the floating diffusion node to acquire ten electron equivalents of noise. The optional apparatus includes circuitry that allows correlated double sampling to be performed in each sensor.

Abstract: A camera adapted for taking pictures of a moving scene is disclosed. The camera includes an imaging array, a plurality of charge-coupled device (CCD) shift registers, and a controller. The imaging array includes a plurality of CMOS pixel sensors organized as a plurality of columns and rows. The image moves in the column direction. One CCD shift register corresponds to each of the columns. Each CMOS pixel sensor includes a first transfer gate that transfers charge accumulated in the pixel sensor to a corresponding cell in the CCD shift register. The controller controls the CCD shift registers such that charge stored in a first cell in a CCD shift register is moved to a second cell in the CCD shift register where the charge is combined with charge accumulated by the pixel sensor that is connected to the second cell, the combined charge being generated from the same image pixel.

Abstract: An imaging array and method for using the same to capture an image are disclosed. The imaging array includes an array of pixel sensors and a controller. Each pixel sensor includes a dual-ported photodiode characterized by ports having first and second gates, and a charge conversion circuit. The charge conversion circuit generates a signal that is a function of a charge on the dual-ported photodiode when the first gate in the dual-ported photodiode is activated to transfer a charge on the dual-ported photodiode to the charge conversion circuit. The controller applies a potential to the second gates and measures a current flowing out of the second gates, each second port passing charge stored in the photodiode connected to the second port when a potential in the photodiode exceeds the applied potential. The controller determines an average light intensity incident on the array of pixel sensors.

Abstract: A hybrid imaging array and method for using the same is disclosed. The image array includes a low-light imaging array and a color imaging array. The two imaging arrays can be utilized separately or in conjunction with one another. The low-light imaging array is optimized for night vision or situations in which the light levels are too low to allow a conventional color image to be formed by the color imaging array. The color imaging array is optimized for daylight or color photography. The low-light imaging array can be utilized in conjunction with the color imaging array to provide a color image with reduced noise.

Abstract: An imaging array and method for capturing an image utilizing the same are disclosed. The imaging array includes an array of pixel sensors in which each pixel includes a dual-ported photodiode or photogate and a charge conversion circuit. The charge conversion circuit generates a voltage signal that is a function of a charge on the dual-ported photodiode. The controller applies a potential that varies over the exposure to the second gates in the dual-ported photodiodes, each second port passing charge stored in the photodiode connected to the second port when a potential in the photodiode exceeds the applied potential. The potential is chosen such that charge flows through the second gates of pixel sensors that are exposed to light intensities greater than a first threshold intensity during the exposure.

Abstract: A light sensor having a light conversion element between first and second electrodes is disclosed. The light conversion element includes a body of semiconductor material having first and second surfaces. The body of semiconductor material is of a first conductivity type and has doping elements in a concentration gradient that creates a first electrostatic field having a magnitude that varies monotonically from the first surface to the second surface. A bias circuit applies a variable potential between the first and second electrodes to create a second electrostatic field having a direction opposite to that of the first electrostatic field and a magnitude determined by the potential. One of the electrodes is transparent to light in a predetermined band of wavelengths. The body of semiconductor material can include an epitaxial body having a monotonically increasing concentration of a doping element as a function of the distance from one the surfaces.

Abstract: A camera for forming an image of a scene that moves relative to the camera and the method of forming that image are disclosed. The camera includes an imaging array having a plurality of CMOS pixel sensors having a plurality of columns and rows, an imaging system, and a controller. The imaging system causes a portion of an image of a scene to be projected on the imaging array such that the image of the scene moves across the imaging array in the column direction. First and second images of the scene are formed at first and second times chosen such that the image of the scene moves a predetermined number of rows of the imaging array between the first and second times. The controller combines pixel values from rows in the first image with rows in the second image that are separated by the predetermined number of rows.

Abstract: A photosensor and an imaging array utilizing the same are disclosed. The photosensor includes a light conversion region that has separate charge storage regions. The light conversion region includes a plurality of separate charge storage regions within a doped region, each charge collection region being doped such that the mobile charges generated by light striking that charge storage region are prevented from moving to an adjacent charge storage region. The photosensor also includes a plurality of transfer gates, having a gate region adjacent to a corresponding one of the charge storage regions and disposed between that charge storage region and a drain region. The charge collection regions and the drain regions are doped such that the mobile charges collected in the charge storage region will flow to the drain region when a first electric field is applied to the gate region.

Abstract: Dynamic vibrational methods and devices for inducing differentiation of stem cells into vocal fold fibroblast-like cells or for generating vocal fold-like tissue from cultured cells. Also provided are matrices providing sustained release of growth factors, and bioreactors generating and delivering a high frequency vibration with in-plane shear stress to cultured cells.

Abstract: An image sensor and method for using the image sensor to capture an image are disclosed. The image sensor includes an imaging array, a first block amplifier and a controller. A first plurality of pixels in the imaging array includes pixels having a photodiode connected to a first node by a gate transistor, a reset transistor connected between the first node and a reset node, a pixel amplifier having an input connected to the first node and an output, and an output gate for connecting the pixel amplifier output to an output bus. The sensor has a monitoring mode and an image capture mode. In the monitoring mode the reset node is connected to the first block amplifier whose output is monitored and used to trigger the image capture mode when the output exceeds a predetermined threshold.

Abstract: An imaging array and method for capturing an image utilizing the same are disclosed. The imaging array includes an array of pixel sensors in which each pixel includes a dual-ported photodiode or photogate and a charge conversion circuit. The charge conversion circuit generates a voltage signal that is a function of a charge on the dual-ported photodiode. The controller applies a potential that varies over the exposure to the second gates in the dual-ported photodiodes, each second port passing charge stored in the photodiode connected to the second port when a potential in the photodiode exceeds the applied potential. The potential is chosen such that charge flows through the second gates of pixel sensors that are exposed to light intensities greater than a first threshold intensity during the exposure.

Abstract: An imaging array and method for using the same to capture an image are disclosed. The imaging array includes an array of pixel sensors and a controller. Each pixel sensor includes a dual-ported photodiode characterized by ports having first and second gates, and a charge conversion circuit. The charge conversion circuit generates a signal that is a function of a charge on the dual-ported photodiode when the first gate in the dual-ported photodiode is activated to transfer a charge on the dual-ported photodiode to the charge conversion circuit. The controller applies a potential to the second gates and measures a current flowing out of the second gates, each second port passing charge stored in the photodiode connected to the second port when a potential in the photodiode exceeds the applied potential. The controller determines an average light intensity incident on the array of pixel sensors.

Abstract: A light sensor having a light conversion element between first and second electrodes is disclosed. The light conversion element includes a body of semiconductor material having first and second surfaces. The body of semiconductor material is of a first conductivity type and has doping elements in a concentration gradient that creates a first electrostatic field having a magnitude that varies monotonically from the first surface to the second surface. A bias circuit applies a variable potential between the first and second electrodes to create a second electrostatic field having a direction opposite to that of the first electrostatic field and a magnitude determined by the potential. One of the electrodes is transparent to light in a predetermined band of wavelengths. The body of semiconductor material can include an epitaxial body having a monotonically increasing concentration of a doping element as a function of the distance from one the surfaces.

Abstract: A light sensor having a light conversion element between first and second electrodes is disclosed. The light conversion element includes a body of semiconductor material having first and second surfaces. The body of semiconductor material is of a first conductivity type and has doping elements in a concentration gradient that creates a first electrostatic field having a magnitude that varies monotonically from the first surface to the second surface. A bias circuit applies a variable potential between the first and second electrodes to create a second electrostatic field having a direction opposite to that of the first electrostatic field and a magnitude determined by the potential. One of the electrodes is transparent to light in a predetermined band of wavelengths. The body of semiconductor material can include an epitaxial body having a monotonically increasing concentration of a doping element as a function of the distance from one the surfaces.

Abstract: An image sensor having a two-dimensional array of CMOS pixel sensors, a row decoder and a column decoder is disclosed. The two-dimensional array of CMOS pixel sensors is organized as a plurality of rows and columns that are addressed with the aid of row and column decoders. At least one of the column decoder or the row decoder is located between two of the rows or two of the columns, respectively. X-rays are converted to light that is detected by the image sensor by a layer of scintillation material that overlies the two-dimensional array. The internally located decoder or decoders facilitate sensors in which the two-dimensional array includes a rectangular array having a chamfered corner such that rows or columns that extend into the chamfered corner have lengths that are less than rows or columns, respectively, that do not extend into the corners.

Abstract: A photodetector array and method for making the same are disclosed. The photodetector array includes a two-dimensional array of pixels and a controller. Each pixel includes a photodetector and a readout circuit, the readout circuit coupling that pixel to a corresponding bit line when a readout signal is received on a corresponding row line. The controller generates the row selection commands and processes signals on the bit lines. The photodetector array is divided into a plurality of sub-chips fabricated on a semiconductor substrate and having a plurality of metal conductors overlying the substrate. The sub-chips include a plurality of slave sub-chips, each slave sub-chip includes a row decode circuit, and a plurality of the rows of pixels, the row decode circuit in one of the slave-sub-chips providing the readout signals on row lines in that sub-chip in response to one of the row selection commands.