Abstract: Provided are salts of a compound of formula (I) having an ATX inhibitory activity. The salts comprises inorganic acid salts or organic acid salts, and solid forms of the salts, such as crystal forms. The salts of the compound of formula (I) and their crystal forms according to the present disclosure have a good solubility, stability and hygroscopicity, and are more suitable for medicinal use. Moreover, their preparation methods are simple and convenient, and are suitable for large-scale production.

Abstract: The present disclosure provides a ZSM-35 molecular sieve and a preparation method therefor, an isomerization catalyst and a preparation method therefor, and an isomerization method. The preparation method for a ZSM-35 molecular sieve comprises: mixing a silicon source, an aluminum source, an alkali, a template agent and water, then adding a polyacrylamide thereto, and performing crystallization on same twice to obtain a ZSM-35 molecular sieve. The present disclosure further provides an isomerization catalyst prepared from the ZSM-35 molecular sieve and a preparation method therefor, and an isomerization method.

Abstract: The present disclosure provides a driving video recorder for an automotive, which includes: a housing having a side wall, a top wall with an air outlet, and a bottom wall with an air inlet; a first electric fan arranged on the bottom wall above the air inlet and in a vertical middle plane of the housing for directing outside air into the housing; two sets of lenses for image capturing arranged at the side wall and positioned symmetrically on both sides of the vertical middle plane of the housing; and heat generating electrical components provided within the housing. The driving video recorder according to the present disclosure has a symmetrically distributed lens structure ensuring system stability, reliability, and enhanced functionality.

Abstract: Provided are a novel compound that effectively antagonizes P2X3 receptor, a preparation method thereof, and use thereof in the preparation of drugs. The compound is a compound represented by Formula I, or a tautomer, a stereoisomer, a hydrate, a solvate, a pharmaceutically acceptable salt, or a prodrug thereof.

Abstract: The present disclosure provides a precision calibrating device and a precision calibrating method for a magnetorheological polishing device, which realize an automatic and quick calibration process. It is ensured that a polishing gap is kept within an allowable error range when the magnetorheological polishing device processes surfaces of different optical elements, thereby effectively controlling a removal function, reducing or eliminating surface residual errors after processing and low frequency errors and medium frequency errors introduced by insufficient trajectory precision of a mechanical arm, and improving a processing precision of the magnetorheological polishing device based on the mechanical arm.

Abstract: The present disclosure provides a novel compound effective in antagonizing EP4, which is a compound represented by Formula I, or a tautomer, stereoisomer, hydrate, solvate, pharmaceutically acceptable salt or prodrug of the compound represented by Formula I: wherein: R1 is selected from —CH3, —CHF2, and —CF3; R2 is selected from C2-C6 alkyl, C3-C6 cycloalkyl, C2-C6 halogen-substituted alkyl, C3-C6 halogen-substituted cycloalkyl; R3 is selected from hydrogen, halogen, C1-C2 alkyl, C1-C2 fluorine- or chlorine-substituted alkyl; R4 is selected from hydrogen, halogen, C1-C6 alkyl, C1-C6 alkoxyl, C1-C6 halogen-substituted alkyl, C1-C6 halogen-substituted alkoxyl.

Abstract: A high anti-vibration gas density monitor is provided, including a monitor enclosure, a signal control mechanism, and an indication value display mechanism independent from the signal control mechanism which are provided in the monitor enclosure. The signal control mechanism includes at least one corrugated pipe, a sealed compensation chamber, a signal generator, and a signal regulation mechanism. The corrugated pipe is perpendicular to a side wall of a control casing. The monitor enclosure includes an independent sealed compartment used to mount the indication value display mechanism. The sealed compartment is filled with anti-vibration oil, or is hermetically filled with gas. The indication value display mechanism includes a Bourdon tube, a base, an end holder, a movement, a pointer, and a dial.

Abstract: The present invention provides a compound of formula or a pharmaceutical salt thereof, use, methods for its preparation are described.

Abstract: Disclosed are fall detection method and apparatus (400), and a wearable device (100). The method comprising: acquiring air pressure data of a position where a wearable device (100) is located, and performing first fall detection according to the air pressure data to obtain a first detection result (S2100); acquiring an attitude angle of the wearable device in the case that the first detection result is that fall has occurred, and performing second fall detection according to the attitude angle to obtain a second detection result (S2200); and determining a fall detection result according to the first detection result and the second detection result (S2300).

Abstract: The present disclosure relates to pyrimidine compounds, and more specifically, relates to pyrimidine compounds, preparation methods thereof, and uses thereof in manufacture of medicaments. Provided is a compound represented by Formula (I) or a tautomer, stereoisomer, hydrate, solvate, pharmaceutical acceptable salt, or prodrug of the compound represented by Formula (I). The compound has a significant inhibitory effect on ATX enzyme, exhibits excellent liver metabolism stability, is metabolized more slowly in the human body, and has higher exposure.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutical salt thereof, use, methods for its preparation are described.

Abstract: Provided is a new compound capable of effectively inhibiting ATX. The compound is represented by formula I, or the compound is a tautomer, a stereoisomer, a hydrate, a solvate, a salt, or a prodrug of the compound represented by formula I. In formula (I), R1 and R2 are independently selected from —H or —CH3, provided that: R1 and R2 are not —H at the same time or are not —CH3 at the same time.

Abstract: Provided is a compound. The compound is a compound represented by formula (A), or a tautomer, a stereoisomer, a hydrate, a solvate, a salt, or a prodrug of the compound represented by formula (A), where R is R1 and R2 are each independently selected from H, C1-C10 alkyl, C3-C10 cycloalkyl, C1-C10 alkoxyl, halogen, and —CN; and R3, R4, and R5 are each independently selected from C1-C10 alkyl, C3-C10 cycloalkyl, C1-C10 alkoxyl, halogen, and —CN, under a premise that: if R1 is —CH3, C1, or —CN, R2 is not H, and if R1 is H, R2 is not H, —CN, or —CH3.

Abstract: Provided is an earthworm protein peptide for preparing a medicine for treating a thrombotic disease. The earthworm protein peptide is any one selected from a group consisting of Leu-Val-Thr-Leu-Gly-Asn-Glu (SEQ ID NO.: 1), Leu-Leu-Ala-Pro-Pro (SEQ ID NO: 2), Leu-Leu-Pro-Ala-Pro (SEQ ID NO: 3) and Thr-Val-Ala-Pro-Phe (SEQ ID NO: 4). The earthworm protein peptide can significantly inhibit the thrombin activity, thus achieving the anticoagulant effect. In vivo, the earthworm protein peptide has a significant inhibitory effect on carrageenan-induced rat tail thrombosis; and in vitro and in vivo studies of rats with thrombus, the earthworm protein peptide provided by the present invention shows good anticoagulant effects. The earthworm protein peptide has effects of thrombosis inhibition, thrombolysis, anticoagulation and fibrinolysis promotion, and can effectively prevent and treat thrombotic disease.

Abstract: The present disclosure provides a driving video recorder for an automotive, which includes: a housing having a side wall, a top wall with an air outlet, and a bottom wall with an air inlet; a first electric fan arranged on the bottom wall above the air inlet and in a vertical middle plane of the housing for directing outside air into the housing; two sets of lenses for image capturing arranged at the side wall and positioned symmetrically on both sides of the vertical middle plane of the housing; and heat generating electrical components provided within the housing. The driving video recorder according to the present disclosure has a symmetrically distributed lens structure ensuring system stability, reliability, and enhanced functionality.

Abstract: A Region Merging image segmentation algorithm based on boundary extraction is disclosed, comprising the steps of calculating a gradient image, extracting a boundary and carrying out initial segmentation and Region Merging, wherein each pixel is regarded as one region when initial segmentation is not conducted. In the Region Merging process, the portion of the common boundary of two adjacent regions that lies on the boundary image is taken as the merging cost, the regions are merged according to the ascending order of the mean gradient value inside the region, and a texture difference evaluation mechanism is introduced to reduce the wrong segmentation. The algorithm solves the problems of the other current segmentation algorithms, such as over-segmentation, easy to be influenced by noise and illumination, large in computation and memory consumption, in need of a large number of samples being marked manually and the like.

Abstract: The present invention relates to application of an earthworm protein peptide in the preparation of a medicine for preventing and/or treating a thrombotic disease, which belongs to the technical field of prevention and treatment of cardiovascular and cerebrovascular diseases. The earthworm protein peptide is one or more members selected from a group consisting of Leu-Val-Thr-Leu-Gly-Asn-Glu, Leu-Leu-Ala-Pro-Pro, Leu-Leu-Pro-Ala-Pro and Thr-Val-Ala-Pro-Phe. The earthworm protein peptide provided by the present invention can significantly inhibit the thrombin activity, thus achieving the anticoagulant effect. In vivo, the earthworm protein peptide provided by the present invention has a significant inhibitory effect on carrageenan-induced rat tail thrombosis; and in vitro and in vivo studies of rats with thrombus, the earthworm protein peptide provided by the present invention shows good anticoagulant effects.

Abstract: A Region Merging image segmentation algorithm based on boundary extraction is disclosed, comprising the steps of calculating a gradient image, extracting a boundary and carrying out initial segmentation and Region Merging, wherein the initial segmentation can be omitted. In the Region Merging process, the ratio of the length of boundary extraction result lies on the adjacent edge between adjacent regions to the length of the adjacent edge is taken as the merging cost, the regions are merged according to the ascending order of the mean gradient value in the region, and a texture difference evaluation mechanism is introduced to remove the error segmentation. The algorithm solves the problems of the other current segmentation algorithms, such as over-segmentation, easy to be influenced by noise and illumination, large in computation and memory consumption, in need of a large number of samples being marked manually and the like.

Abstract: A sensing apparatus for detecting at least one target molecule in a gaseous medium is provided, comprising an optical fiber having a core with a tilted grating, and a coating assembly. The coating assembly has a composite film layer having an outer surface in direct contact with the gaseous medium, and contains at least two compositions mixed with one another therein, which include one or more surface plasmon resonance (SPR)-active compositions and one or more reacting compositions that are reversibly reactive to the at least one target molecule. Depending on different reacting compositions, the sensing apparatus can detect various target gas molecules such as hydrogen, ammonia, methane, and formaldehyde, etc. The sensing apparatus has relatively fast response time and high resistance to deactivation. A sensing system based on the sensing apparatus, a manufacturing method of the sensing apparatus, and a detection method using the sensing system, are further provided.

Abstract: A vehicle monitoring apparatus is described, comprising: a vehicle state detector detecting whether the vehicle is in a parking state; a motion detection sensor detecting whether an object is moving relative to the vehicle; an image recorder recording image data relating to the surrounding environment of the vehicle; a touch sensor sensing whether the object is touching the vehicle; a main control unit configured to: start the motion detection sensor when the vehicle state detector detects that the vehicle is in a parking state, turn on the image recorder and the touch sensor when the motion detection sensor detects that an object is moving with respect to the vehicle, and trim the image data recorded during a predetermined time period when the touch sensor senses that the object is touching the vehicle, the predetermined time period comprising the duration of the object being in touch with the vehicle; and a storage storing the trimmed image data.