Abstract: A light guide fixing assembly, a lighting or signal indicating device and a motor vehicle are provided. The light guide fixing assembly is used to fix two light guides, each light guide has an opposing first end and second end, and the first end has a mounting portion. The light guide fixing assembly includes a fixing base and a fastener, constructed to fix the mounting portions of the first ends of the two light guides to the fixing base by pressing them against the fixing base, so that the fastener separates the two mounting portions of the first ends of the two light guides in a first direction.

Abstract: A use of SRT2104 in preparation of a drug for treatment of bronchial asthma is provided, relating to the field of bronchial asthma treatment. The comprehensive analysis of the activation effect of SRT2104 on silent information regulator 1 (SIRT1) in the airway epithelium under asthma conditions and its alleviation effect on asthma airway inflammation is conducted. It is demonstrated that SRT2104 can be activated in the airway epithelium under asthma condition and effectively control asthma airway inflammation. A foundation is laid for the discovery of clinical drug targets and the development of drugs for the treatment of bronchial asthma.

Abstract: Systems may include a broadband light source device, which may include at least one processor programmed or configured to receive an electrical control signal for operating a component of a plurality of components of a spectrum control device of the broadband light source device, determine which component of the plurality of components of the spectrum control device to operate based on the electrical control signal, and operate a first component of the plurality of components of the spectrum control device based on determining to operate the first component. Methods and computer program products are also disclosed.

Abstract: A photonics integrated circuit chip includes first and second optical waveguides formed on a semiconductor substrate. Light input into the first optical waveguide passes through a first optical isolator and a coupler formed on the substrate. The coupler outputs light from the first optical isolator combined with light from an off-substrate pump light source to an off-substrate optical fiber which outputs the combined light into the second optical waveguide for passage through a second optical isolator formed on the substrate. The substrate may also include third and fourth optical waveguides. Light input into the third optical waveguide passes through a third optical isolator and a second coupler formed on the substrate. The second coupler outputs light from the second optical isolator combined with light from the pump light source to an off-substrate second optical fiber which outputs the combined light into the fourth optical waveguide for passage through a fourth optical isolator formed on the substrate.

Abstract: Systems may include a broadband light source device, which may include at least one processor programmed or configured to receive an electrical control signal for operating a component of a plurality of components of a spectrum control device of the broadband light source device, determine which component of the plurality of components of the spectrum control device to operate based on the electrical control signal, and operate a first component of the plurality of components of the spectrum control device based on determining to operate the first component. Methods and computer program products are also disclosed.

Abstract: An optical switching apparatus for optical switching of input beams from a plurality of optical fibers includes a plurality of digital switching blocks arranged in series or as a multi-dimensional array. The digital switching blocks include a plurality of liquid crystal (LC) cells arranged in series configured to control polarization of the input beams, and a plurality of birefringent wedges that direct the input beams based on polarization. The one or more of the plurality of birefringent wedges is disposed between adjacent LC cells of the plurality of LC cells. The digital switching blocks include 1×2N digital switching blocks, with N being an integer value equal to a number of the plurality of LC cells or a number of the plurality of birefringent wedges for one of the switching blocks.

Abstract: The present invention belongs to the technical field of biological catalysis and organic synthesis, and in particular, relates to an imine reductase mutant, application thereof and an application method therefor. The imine reductase mutant has an amino acid sequence derived by a mutation occurring to an amino acid sequence as set forth in SEQ ID NO. 1, and an mutation site includes one of the following sites: position 44 with G mutating into V, or position 89 with L mutating into V, or positions 44 and 89 with G and L simultaneously mutating into V, respectively. The imine reductase mutant of the present invention binds to glucose dehydrogenase to prepare an intermediate (S)-2-methyl-5-(pyrrol-2-yl)pyridine through asymmetric hydrogenation reduction by taking ?-nicotinamide adenine dinucleotide disodium salt as a coenzyme and 5-(3,4-dihydro-2H-pyrrol-5-yl)-2-methylpyridine as a substrate, with a chemical conversion rate up to above 99.5% and e.e. % up to 99.6%.

Abstract: The present invention relates to a CPR posture monitoring model and system, the model being configured to: based on human skeleton point data extracted from CPR moves, at least compute arm-posture angle data and GC matching angle data related to the CPR moves, and determine whether the CPR moves are qualified by comparing arm-posture angle data and GC matching angle data to a CCP qualification threshold; wherein human skeleton point data are extracted from first move data collected by a first optical component and second move data collected by a second optical component simultaneously, wherein an included angle between collection directions of the two optical components ranges between 30 and 90 degrees. By constructing and applying a CPR posture monitoring model defined by data like GC matching angle, evaluation result has higher accuracy.

Abstract: Embodiments of the disclosed technologies receive first event data associated with a first party application, receive second event data representing a click, in the first party application, on a link to a third party application, receive third event data from the third party application, convert the third event data to a label, map a compressed format of the labeled third event data to the first event data and the second event data to create multi-party attribution data, group multiple instances of the multi-party attribution data into a batch, add noise to the compressed format of the labeled third event data in the batch, and send the noisy batch to a second computing device. A debiasing algorithm can be applied to the noisy batch. The debiased noisy batch can be used to train at least one machine learning model.

Abstract: Disclosed is a nitrile derivative compound represented by formula (I), a stereoisomer, a deuterated product, a co-crystal, a solvate or a pharmaceutically acceptable salt thereof, wherein each group is as defined in the description. The compound has dipeptidyl peptidase 1 inhibitory activity and can be used to prepare a drug for treating diseases including obstructive airway diseases, bronchiectasis, cystic fibrosis, asthma, emphysema, and chronic obstructive pulmonary diseases.

Abstract: Methods for managing data associated with an optical communications network may include receiving data associated with an optical communications network, containerizing the data associated with the optical communications network according to a characteristic of the data to provide a data structure that includes containerized data, and providing access to the data structure for one or more application sessions. Systems and computer program products are also disclosed.

Abstract: Embodiments of the disclosed technologies receive first event data associated with a first party application, receive second event data representing a click, in the first party application, on a link to a third party application, receive third event data from the third party application, convert the third event data to a label, map a compressed format of the labeled third event data to the first event data and the second event data to create multi-party attribution data, group multiple instances of the multi-party attribution data into a batch, add noise to the compressed format of the labeled third event data in the batch, and send the noisy batch to a second computing device. A debiasing algorithm can be applied to the noisy batch. The debiased noisy batch can be used to train at least one machine learning model.

Abstract: Systems for recovery of transport system faults may include at least one processor programmed or configured to identify a presence of a reduction of power in an optical transmission band of a plurality of optical transmission bands of an optical communications network, determine a cause of the reduction of power in the optical transmission band based on identifying the presence of the reduction of power in the optical transmission band, and perform an action to rectify the reduction of power in the optical transmission band using an optical communications light source. Methods and computer program products are also disclosed.

Abstract: Systems may include a broadband light source device, which may include at least one processor programmed or configured to receive an electrical control signal for operating a component of a plurality of components of a spectrum control device of the broadband light source device, determine which component of the plurality of components of the spectrum control device to operate based on the electrical control signal, and operate a first component of the plurality of components of the spectrum control device based on determining to operate the first component. Methods and computer program products are also disclosed.

Abstract: A pluggable bidirectional optical amplifier module may include preamp and booster optical amplifiers and a housing. The preamp optical amplifier may be configured to amplify optical signals traveling in a first direction. The booster optical amplifier may be configured to amplify optical signals traveling in a second direction. The housing may at least partially enclose the preamp optical amplifier and the booster optical amplifier. The pluggable bidirectional optical amplifier module may have a mechanical form factor that is compliant with a pluggable communication module form factor MSA. A colorless mux/demux cable assembly may be operated with the pluggable bidirectional optical amplifier. The colorless mux/demux cable assembly may include a 1:N optical splitter a N:1 optical combiner coupled side-by-side to the 1:N optical splitter, a first fiber optic cable optic cable, and a second fiber optic cable.

Abstract: Efforts to use RNA-cleaving DIMA enzymes (DNAzymes) as gene silencing agents in therapeutic applications have stalled due to their low efficacy in clinical trials. Here the present invention reports a xeno-nucleic acid (XNA) modified version of the classic DNAzyme 10-23 that achieves multiple turnover activity under cellular conditions and resists nuclease digestion. The new reagent overcomes the problem of product inhibition limiting previous 10-23 designs using molecular chemotypes with DNA. FANA, and TNA backbone architectures that balance the effects of enhanced biological stability with RNA hybridization and divalent metal ion coordination. In cultured mammalian cells. X 10-23 facilitates persistent gene silencing by efficiently degrading exogenous and endogenous mRNA transcripts. Together, these results demonstrate that new molecular chemotypes can improve the activity and stability of DNAzymes, and may provide a new route for nucleic acid enzymes to reach the clinic.

Abstract: An optical channel monitor is formed to include the capability to sense real-time changes in optical power across signal bands (optical power changes including, for example, a complete drop out of the signal band) and quickly measure the resulting spectrum, thus enabling the host to initiate advanced power balancing solutions that mitigate the extent of the power change until a permanent fix is provided. A set of signal band sensors is included with a conventional OCM, where each sensor includes a photodetector that is able to detect changes in operation along its associated incoming signal band. Control electronics are used to monitor the states of the photodetectors, with the ability to invoke an OCM scan of the complete wavelength range when a power change condition is flagged.

Abstract: A colorless mux/demux cable assembly, including a first fiber optic cable, a second fiber optic cable, and a main body that includes an N:1 optical combiner and a 1:N optical splitter. The N:1 optical combiner is configured to combine individual optical signals received by each of N input fibers of the second fiber optic cable and provide a combined output signal to an output fiber of the first fiber optic cable. The 1:N optical splitter is configured to split a combined input optical signal (having N wavelength channels) received via an input fiber of the first fiber optic cable and provide a split output signal comprising each of the N wavelength channels to each of N output fibers of the second fiber optic cable.

Abstract: A photonics integrated circuit chip includes first and second optical waveguides formed on a semiconductor substrate. Light input into the first optical waveguide passes through a first optical isolator and a coupler formed on the substrate. The coupler outputs light from the first optical isolator combined with light from an off-substrate pump light source to an off-substrate optical fiber which outputs the combined light into the second optical waveguide for passage through a second optical isolator formed on the substrate. The substrate may also include third and fourth optical waveguides. Light input into the third optical waveguide passes through a third optical isolator and a second coupler formed on the substrate. The second coupler outputs light from the second optical isolator combined with light from the pump light source to an off-substrate second optical fiber which outputs the combined light into the fourth optical waveguide for passage through a fourth optical isolator formed on the substrate.

Abstract: An optical channel monitor is formed to include the capability to sense real-time changes in optical power across signal bands (optical power changes including, for example, a complete drop out of the signal band) and quickly measure the resulting spectrum, thus enabling the host to initiate advanced power balancing solutions that mitigate the extent of the power change until a permanent fix is provided. A set of signal band sensors is included with a conventional OCM, where each sensor includes a photodetector that is able to detect changes in operation along its associated incoming signal band. Control electronics are used to monitor the states of the photodetectors, with the ability to invoke an OCM scan of the complete wavelength range when a power change condition is flagged.