Abstract: A humanized antibody, or a binding fragment thereof, wherein the humanized antibody binds human ENO1 (GenBank: AAH50642.1), wherein the antibody comprises a light chain variable region (VL) domain comprising a CDR1 having the amino acid sequence LCDR1 (RASENIYSYLT; SEQ ID NO: 6) and a CDR2 having the amino acid sequence LCDR2 (NAKTLPE; SEQ ID NO: 7) and a CDR3 having the amino acid sequence LCDR3 (QHHYGTPYT; SEQ ID NO: 8) and an antibody heavy chain variable region (VH) domain comprising a CDR1 having the amino acid sequence HCDR1 (GYTFTSCVMN; SEQ ID NO: 3), a CDR2 having the amino acid sequence HCDR2 (YINPYNDGTKYNEKFKG; SEQ ID NO: 4) and a CDR3 having the amino acid sequence HCDR3 (EGFYYGNFDN; SEQ ID NO: 5), wherein framework regions in the light chain variable region (VL) domain and the heavy chain variable region (VH) domain comprise amino acid sequences from a human immunoglobulin.

Abstract: A display device and an assembly method of the display device are provided. The display device includes a backlight module, a display panel, a cover lens, and an alignment mark. The backlight module has a supporting frame, and at least one alignment hole is formed on the supporting frame. The display panel is disposed on the backlight module and has a first substrate. The cover lens covers an outer side of the display panel opposite to the backlight module and protrudes outside a side edge of the first substrate. The alignment mark is formed on the first substrate or on the cover lens. The alignment mark at least partially overlaps the alignment hole within a vertical projecting region of the supporting frame. The relative positions along each part of the display device are ensured by using the alignment mark and the alignment hole.

Abstract: The present invention is drawn to understanding lytic bone diseases. In this regard, the present invention discloses mechanism by which Wnt signaling antagonist inhibits bone differentiation. Also disclosed herein are methods for treating multiple myeloma, for restoring osteoprotegerin (OPG) expression in a cell, for inhibiting receptor activator of nuclear factor kappa B ligand (RANKL) expression in a cell, and for increasing bone mass in a subject. These methods utilize a DKK1 neutralizing antibody, an anti-sense oligonucleotide against a DKK1 gene, or a shRNA against a DKK1 gene to inhibit the activity of the DKK1 protein.

Abstract: The present invention is drawn to understanding lytic bone diseases. In this regard, the present invention discloses mechanism by which Wnt signaling antagonist inhibits bone differentiation. Also disclosed herein are methods to control bone loss, treat bone disease and prevent tumor growth in bones of individual.

Abstract: A touch display panel includes a substrate, touch sensing elements, a light-shielding layer, a first patterned light-shielding layer, and a display module. The substrate has a display zone and a non-display zone. The non-display zone includes at least one first patterned transparent region. The touch sensing elements is disposed in the display zone. The light-shielding layer covers the first patterned transparent region and has a first transmittance rate. The first patterned light-shielding layer partially covers the light-shielding layer and is not disposed in the first patterned transparent region. The first patterned light-shielding layer has a second transmittance rate. The second transmittance rate is substantially less than the first transmittance rate.

Abstract: A system for diagnosing autism comprises a measuring device, a movie display, a speaker, and a computer connected with the measuring device and the speaker. The computer contains a control program therein, the control program being capable of arranging a sequence of human-voiced syllables in a pseudo-random order and allowing the sequence of the human-voiced syllables to be played from the speaker while a silent subtitled movie being played on the movie display. The measuring device can measure brain response of a patient to obtain an averaged MMN value, which can be compared with a cut-off point by the control program, whereby, if the averaged MMN value is less than the cut-off point, the patient is deemed to have suffered from an autism. The present invention can provide objective data for quantitative analysis for autism, and provide an easy way to diagnose autism.

Abstract: The present invention is drawn to methods of repairing lytic bone lesions and tumor growth in an individual. In this regard, the present invention discloses use of a Wnt ligand either alone or in combination with anti-Wnt signaling antagonist therapy. The individuals who might benefit from such method may include but are not limited to the ones with multiple myeloma, osteoporosis, post-menopausal osteoporosis, fractures, metastatic breast cancer or metastatic prostate cancer.

Abstract: The present invention is drawn to understanding lytic bone diseases. In this regard, the present invention discloses mechanism by which Wnt signaling antagonist inhibits bone differentiation. Also disclosed herein are methods to control bone loss, treat bone disease and prevent tumor growth in bones of individual.

Abstract: The present invention is drawn to understanding lytic bone diseases. In this regard, the present invention discloses mechanism by which Wnt signaling antagonist inhibits bone differentiation. Also disclosed herein are methods to control bone loss, treat bone disease and prevent tumor growth in bones of individual.

Abstract: A backlight module structure including a light guide plate and a plurality of light emitting diodes is provided. A plurality of first micro-structures and a plurality of second micro-structures are formed on the light incident surface of the light guide plate, and the first micro-structure and the second micro-structure are respectively disposed on two sides of the light incident surface and distributed along the light incident surface. The first micro-structure has a first receiving surface and the second micro-structure has a second receiving surface. The first and second receiving surfaces are faced oppositely and incline at least one inclined angle, such that the normal lines thereof are deflected to the imaginational center of the light guide plate, respectively.

Abstract: The present invention is drawn to understanding lytic bone diseases. In this regard, the present invention discloses mechanism by which Wnt signaling antagonist inhibits bone differentiation. Also disclosed herein are methods to control bone loss, treat bone disease and prevent tumor growth in bones of individual.

Abstract: The present invention is drawn to methods of repairing lytic bone lesions and tumor growth in an individual. In this regard, the present invention discloses use of a Wnt ligand either alone or in combination with anti-Wnt signaling antagonist therapy. The individuals who might benefit from such method may include but are not limited to the ones with multiple myeloma, osteoporosis, post-menopausal osteoporosis, fractures, metastatic breast cancer or metastatic prostate cancer.

Abstract: A coplanar transformer with a capacitor that has the advantage of high space utilization is provided. The coplanar transformer comprises a primary coil and a secondary coil constructed by many conductor segments in a first metal layer and connectors in a second metal layer. The upper plate and lower plate of the capacitor are electrically coupled with the two terminals of the primary coil separately. The upper plate comprises the extended plate from the connected terminal toward the other terminal and the connected conductor segment in the first metal layer, and the lower plate locates in the second metal layer corresponding to the upper plate.

Abstract: An electromagnetic clutch-controlled electric blind is constructed to include a blind body formed of a headrail defining a receiving chamber, a set of slats, and a bottom rail, a power drive, the power drive including a reversible motor and electromagnetic clutch apparatus connectable to the motor, an amplitude modulation set coupled to the motor for rotation with the motor to lift/lower the slats to the desired elevation, a frequency modulation set coupled to the motor through the electromagnetic clutch apparatus and adapted for controlling tilting angle of the slats.

Abstract: The present invention refers to a kind of deNOx catalyst without the reducing agent to decompose the NO, wherein it is to mix the Zeolite with Al2O3, then they were dried, calcined, and powdered to make the catalyst carrier, after adding the Pt/Rh or Pd/Rh noble metal solutions, again dry and calcine, then the deNOx catalyst without the usage of reducing agent such as ammonia, propane could be thus obtained, wherein its optimum conversion of stripping deNOx is within 250-500° C., besides, at the condition that there is CO except NO for that polluted air, the rate of stripping for the present invention could also achieves a fine results.

Abstract: An upper frame for a vertical Venetian blind includes a horizontal rod and a slide rail. The horizontal rod is formed axially with at least two rod portions, and the slide rail is axially formed with at least two slide rail portions. The rod portions can be connected together to make up the horizontal rod and the slide rail portions can be connected together to make up the slide rail. The rod portions and the slide rail portions are separable or collapsible before they are assembled, able to be packed with less space to save cost in packing, storing and transporting.

Abstract: A coplanar transformer with a capacitor that has the advantage of high space utilization is provided. The coplanar transformer comprises a primary coil and a secondary coil constructed by many conductor segments in a first metal layer and connectors in a second metal layer. The upper plate and lower plate of the capacitor are electrically coupled with the two terminals of the primary coil separately. The upper plate comprises the extended plate from the connected terminal toward the other terminal and the connected conductor segment in the first metal layer, and the lower plate locates in the second metal layer corresponding to the upper plate.

Abstract: A friction transmission mechanism for a motor-driven blind is constructed to include a driving unit, and at least one cord roll-up unit controlled to the driving unit to lift/lower or tilt the slats of the motor-driven Venetian blind. Each cord roll-up unit includes an amplitude modulation wheel controlled by the driving unit to lift/lower the slats and bottom rail of the Venetian blind, a frequency modulation wheel for rotation with the amplitude modulation set to tilt the slats of the Venetian blind, spring means, which forces the frequency modulation wheel into friction-engagement with the amplitude modulation wheel, and a support supporting the amplitude modulation wheel, the support having a shoulder adapted to act with a protruding block of the frequency modulation wheel and to further limit angle of rotation of the frequency modulation wheel.

Abstract: An electromagnetic clutch-controlled electric blind is constructed to include a blind body formed of a headrail defining a receiving chamber, a set of slats, and a bottom rail, a power drive, the power drive including a reversible motor and electromagnetic clutch apparatus connectable to the motor, an amplitude modulation set coupled to the motor for rotation with the motor to lift/lower the slats to the desired elevation, a frequency modulation set coupled to the motor through the electromagnetic clutch apparatus and adapted for controlling tilting angle of the slats.

Abstract: An integrated circuit with electrostatic discharge (ESD) protection is disclosed. The integrated circuit with electrostatic discharge protection comprises an inductor and a capacitor which can cancel the reactance induced by electrostatic discharge protection elements at an operating radio frequency. By choosing the combination of ESD protection elements, the inductor and the capacitor with proper equivalent reactance values, the mismatch caused by ESD protection elements can be eliminated at an operating radio frequency.