Abstract: Systems may include a broadband light source device, which may include at least one processor programmed or configured to receive an electrical control signal for operating a component of a plurality of components of a spectrum control device of the broadband light source device, determine which component of the plurality of components of the spectrum control device to operate based on the electrical control signal, and operate a first component of the plurality of components of the spectrum control device based on determining to operate the first component. Methods and computer program products are also disclosed.

Abstract: A pluggable bidirectional optical amplifier module may include preamp and booster optical amplifiers and a housing. The preamp optical amplifier may be configured to amplify optical signals traveling in a first direction. The booster optical amplifier may be configured to amplify optical signals traveling in a second direction. The housing may at least partially enclose the preamp optical amplifier and the booster optical amplifier. The pluggable bidirectional optical amplifier module may have a mechanical form factor that is compliant with a pluggable communication module form factor MSA. A colorless mux/demux cable assembly may be operated with the pluggable bidirectional optical amplifier. The colorless mux/demux cable assembly may include a 1:N optical splitter a N:1 optical combiner coupled side-by-side to the 1:N optical splitter, a first fiber optic cable optic cable, and a second fiber optic cable.

Abstract: Efforts to use RNA-cleaving DIMA enzymes (DNAzymes) as gene silencing agents in therapeutic applications have stalled due to their low efficacy in clinical trials. Here the present invention reports a xeno-nucleic acid (XNA) modified version of the classic DNAzyme 10-23 that achieves multiple turnover activity under cellular conditions and resists nuclease digestion. The new reagent overcomes the problem of product inhibition limiting previous 10-23 designs using molecular chemotypes with DNA. FANA, and TNA backbone architectures that balance the effects of enhanced biological stability with RNA hybridization and divalent metal ion coordination. In cultured mammalian cells. X 10-23 facilitates persistent gene silencing by efficiently degrading exogenous and endogenous mRNA transcripts. Together, these results demonstrate that new molecular chemotypes can improve the activity and stability of DNAzymes, and may provide a new route for nucleic acid enzymes to reach the clinic.

Abstract: An optical channel monitor is formed to include the capability to sense real-time changes in optical power across signal bands (optical power changes including, for example, a complete drop out of the signal band) and quickly measure the resulting spectrum, thus enabling the host to initiate advanced power balancing solutions that mitigate the extent of the power change until a permanent fix is provided. A set of signal band sensors is included with a conventional OCM, where each sensor includes a photodetector that is able to detect changes in operation along its associated incoming signal band. Control electronics are used to monitor the states of the photodetectors, with the ability to invoke an OCM scan of the complete wavelength range when a power change condition is flagged.

Abstract: A colorless mux/demux cable assembly, including a first fiber optic cable, a second fiber optic cable, and a main body that includes an N:1 optical combiner and a 1:N optical splitter. The N:1 optical combiner is configured to combine individual optical signals received by each of N input fibers of the second fiber optic cable and provide a combined output signal to an output fiber of the first fiber optic cable. The 1:N optical splitter is configured to split a combined input optical signal (having N wavelength channels) received via an input fiber of the first fiber optic cable and provide a split output signal comprising each of the N wavelength channels to each of N output fibers of the second fiber optic cable.

Abstract: A photonics integrated circuit chip includes first and second optical waveguides formed on a semiconductor substrate. Light input into the first optical waveguide passes through a first optical isolator and a coupler formed on the substrate. The coupler outputs light from the first optical isolator combined with light from an off-substrate pump light source to an off-substrate optical fiber which outputs the combined light into the second optical waveguide for passage through a second optical isolator formed on the substrate. The substrate may also include third and fourth optical waveguides. Light input into the third optical waveguide passes through a third optical isolator and a second coupler formed on the substrate. The second coupler outputs light from the second optical isolator combined with light from the pump light source to an off-substrate second optical fiber which outputs the combined light into the fourth optical waveguide for passage through a fourth optical isolator formed on the substrate.

Abstract: An optical channel monitor is formed to include the capability to sense real-time changes in optical power across signal bands (optical power changes including, for example, a complete drop out of the signal band) and quickly measure the resulting spectrum, thus enabling the host to initiate advanced power balancing solutions that mitigate the extent of the power change until a permanent fix is provided. A set of signal band sensors is included with a conventional OCM, where each sensor includes a photodetector that is able to detect changes in operation along its associated incoming signal band. Control electronics are used to monitor the states of the photodetectors, with the ability to invoke an OCM scan of the complete wavelength range when a power change condition is flagged.

Abstract: The present disclosure relates to systems and methods for providing personalized retrievals of items. The systems and methods create a user-specific morph operator for a user that captures learned user preferences for the user. The systems and methods use the user-specific morph operator to transform a generic embedding for a query into a personalized embedding for the query. The systems and method use the personalized embedding to retrieve items based on the user preferences to present in response to the query.

Abstract: Embodiments of the disclosed technologies receive first event data associated with a first party application, receive second event data representing a click, in the first party application, on a link to a third party application, receive third event data from the third party application, convert the third event data to a label, map a compressed format of the labeled third event data to the first event data and the second event data to create multi-party attribution data, group multiple instances of the multi-party attribution data into a batch, add noise to the compressed format of the labeled third event data in the batch, and send the noisy batch to a second computing device. A debiasing algorithm can be applied to the noisy batch. The debiased noisy batch can be used to train at least one machine learning model.

Abstract: Provided are a compound of formula (I), a stereoisomer, a deuterated compound, a solvate, a prodrug, a metabolite, a pharmaceutically acceptable salt or a eutectic thereof, or a pharmaceutical composition comprising same, and use thereof as a ketohexokinase inhibitor in the preparation of drugs for treating related diseases. Each group in formula (I) is as defined in the description.

Abstract: Disclosed is a nitrile derivative compound represented by formula (I), a stereoisomer, a deuterated product, a co-crystal, a solvate or a pharmaceutically acceptable salt thereof, wherein each group is as defined in the description. The compound has dipeptidyl peptidase 1 inhibitory activity and can be used to prepare a drug for treating diseases including obstructive airway diseases, bronchiectasis, cystic fibrosis, asthma, emphysema, and chronic obstructive pulmonary diseases.

Abstract: Coherent optical multiplexing 1+1 protection disclosed herein uses multiplexers, each having multiplexing and demultiplexing sub-units. Relay ports of a node are connected with the multiplexers, and each relay port is configured to input and output optical signals with the corresponding multiplexer. Two transmission ports of the node are connected with disjoint paths and are configured to input and output optical signals therewith. The node includes: a first optical splitter having input ports connected with the relay ports and two output ports connected with the two transmission ports; an optical switch connected with the transmission ports respectively via two input interfaces; a second optical splitter, which is a 1×N optical splitter, having one input port connected with an output interface of the optical switch and having output ports connected with the relay ports. The solution is reliable in implementation, has low insertion loss, and has good transmission performance.

Abstract: The present disclosure provides a substrate, a maintenance method thereof and a display device. The substrate includes a base substrate, the base substrate is provided with at least one conductive pattern, and at least one of the at least one conductive pattern is interrupted and divided into a first conductive sub-pattern and a second conductive sub-pattern. The maintenance method includes: coating a conductive material in an interruption region in such a manner as to cover both the first conductive sub-pattern and the second conductive sub-pattern; and coating an organic insulation material at a side of the conductive material away from the base substrate, and curing the organic insulation material to form an organic protection film covering the conductive material.

Abstract: Disclosed is a nitrile derivative compound represented by formula (I), a stereoisomer, a deuterated product, a co-crystal, a solvate or a pharmaceutically acceptable salt thereof, wherein each group is as defined in the description. The compound has dipeptidyl peptidase 1 inhibitory activity and can be used to prepare a drug for treating diseases including obstructive airway diseases, bronchiectasis, cystic fibrosis, asthma, emphysema, and chronic obstructive pulmonary diseases.

Abstract: The present invention relates to a CPR posture monitoring model and system, the model being configured to: based on human skeleton point data extracted from CPR moves, at least compute arm-posture angle data and GC matching angle data related to the CPR moves, and determine whether the CPR moves are qualified by comparing arm-posture angle data and GC matching angle data to a CCP qualification threshold; wherein human skeleton point data are extracted from first move data collected by a first optical component and second move data collected by a second optical component simultaneously, wherein an included angle between collection directions of the two optical components ranges between 30 and 90 degrees. By constructing and applying a CPR posture monitoring model defined by data like GC matching angle, evaluation result has higher accuracy.

Abstract: Coherent optical multiplexing 1+1 protection disclosed herein uses multiplexers, each having multiplexing and demultiplexing sub-units. Relay ports of a node are connected with the multiplexers, and each relay port is configured to input and output optical signals with the corresponding multiplexer. Two transmission ports of the node are connected with disjoint paths and are configured to input and output optical signals therewith. The node includes: a first optical splitter having input ports connected with the relay ports and two output ports connected with the two transmission ports; an optical switch connected with the transmission ports respectively via two input interfaces; a second optical splitter, which is a 1×N optical splitter, having one input port connected with an output interface of the optical switch and having output ports connected with the relay ports. The solution is reliable in implementation, has low insertion loss, and has good transmission performance.

Abstract: The present disclosure discloses a wheel rim finishing device. A motor is fixedly mounted on a stand through a shaft sleeve I. A supporting body is arranged on the stand. The side, close to a locating disk, of the supporting body is provided with an outer roller. An inner driving roller body and an inner driven roller body are arranged at a position, close to the outer roller, on the inner side of the locating disk. The wheel rim finishing device is simple in structure and high in universality, and may adapt to wheel types with different rim structures.

Abstract: A drive circuit, a drive method, a shift register, and a display device are provided. The drive circuit includes a control module, an output module, and a protect module. The control module is electrically connected to a start signal line, first and second clock signal lines, first and second potential signal lines, and first and second nodes, and is configured to transmit a voltage signal to the first and the second nodes in response to first and second clock signals. The output module is electrically connected to the first and second potential signal lines, an output wire, and the first and second nodes. The protect module is configured to transmit an effective voltage signal to the first node in response to a control signal in a first state of the drive circuit such that the output module transmits an ineffective voltage signal to the output wire.

Abstract: Coherent optical multiplexing 1+1 protection disclosed herein uses multiplexers, each having multiplexing and demultiplexing sub-units. Relay ports of a node are connected with the multiplexers, and each relay port is configured to input and output optical signals with the corresponding multiplexer. Two transmission ports of the node are connected with disjoint paths and are configured to input and output optical signals therewith. The node includes: a first optical splitter having input ports connected with the relay ports and two output ports connected with the two transmission ports; an optical switch connected with the transmission ports respectively via two input interfaces; a second optical splitter, which is a 1×N optical splitter, having one input port connected with an output interface of the optical switch and having output ports connected with the relay ports. The solution is reliable in implementation, has low insertion loss, and has good transmission performance.