Abstract: The present disclosure provides a preparation method of setmelanotide by cyclization of a disulfide bond in a solid phase. By using different solvents or mixed solvents to carry out a cyclization reaction in a solid phase, the reaction concentration can be greatly increased in comparison with a cyclization reaction in a liquid phase, and the production of impurities can also be reduced, so that the effects of reducing the use of the solvents and increasing the production capacity are achieved.

Abstract: The present technology can include a semiconductor device assembly comprising an RDL with a top surface and a side surface intersecting the top surface. The assembly can further comprise a semiconductor device coupled to the top surfaces, and a mold material encasing the semiconductor device (when included) and directly coupled to at least a portion of the top surface and the side surface of the RDL. In other embodiments, the assembly can comprise an RDL with a top surface, a bottom surface opposite thereto, and a sloped side surface extending between the top surface and the bottom surface. The assembly similarly can further comprise a semiconductor device coupled to the top surface, and a mold material encasing the semiconductor device and directly coupled to at least a portion of the top surface and the side surface of the RDL.

Abstract: Disclosed herein is a method for alleviating depression, which includes administering to a subject in need thereof a composition containing TNFAIP3-interacting protein (TNIP) 1. The composition is administered to the CA3 region of the subject's hippocampus.

Abstract: A method for switching a power mode of a computer device is adapted to a computer accessory. The method comprises setting a power management mode of the computer device to be awakened when connected to the external power; connecting the computer accessory to a host connector of the computer device to establish a power connection and a communication connection through a host signal pin set of the host connector; through the power connection and the communication connection, detecting and determining the power mode of the computer device; and executing one of following steps upon receiving the switch signal: when the power mode is the normal operation state, transmitting a communication signal; when the power mode is the Suspend-To-RAM state, transmitting a wake up signal; and when the power mode is the Suspend-To-Disk state or the shutdown state, temporarily cutting off the external power and then restoring the external power.

Abstract: A power-governing method is for a USB docking station. The USB docking station includes a connector, ports, output-monitoring circuits, and a control circuit. The connector connects to a master device and has a power supply channel. The ports connect to power-receiving devices. The output-monitoring circuits correspond to the ports. The output-monitoring circuits selectively connect the power supply channel to the corresponding ports. Each the output-monitoring circuit has an upper limit power value. Each the output-monitoring circuit obtains a current output power of the corresponding port. The output-monitoring circuit disconnects the connection between the corresponding port and the power supply channel when the current output power is greater than its upper limit power value. The control circuit has rated power values corresponding to the ports. The control circuit sets upper limit power values according to the rated power values, current output powers, and a power supply option of the master device.

Abstract: A method for switching a power mode of a computer device is adapted to a computer accessory. The method comprises setting a power management mode of the computer device to be awakened when connected to the external power; connecting the computer accessory to a host connector of the computer device to establish a power connection and a communication connection through a host signal pin set of the host connector; through the power connection and the communication connection, detecting and determining the power mode of the computer device; and executing one of following steps upon receiving the switch signal: when the power mode is the normal operation state, transmitting a communication signal; when the power mode is the Suspend-To-RAM state, transmitting a wake up signal; and when the power mode is the Suspend-To-Disk state or the shutdown state, temporarily cutting off the external power and then restoring the external power.

Abstract: A power-governing method is for a USB docking station. The USB docking station includes a connector, ports, output-monitoring circuits, and a control circuit. The connector connects to a master device and has a power supply channel. The ports connect to power-receiving devices. The output-monitoring circuits correspond to the ports. The output-monitoring circuits selectively connect the power supply channel to the corresponding ports. Each the output-monitoring circuit has an upper limit power value. Each the output-monitoring circuit obtains a current output power of the corresponding port. The output-monitoring circuit disconnects the connection between the corresponding port and the power supply channel when the current output power is greater than its upper limit power value. The control circuit has rated power values corresponding to the ports. The control circuit sets upper limit power values according to the rated power values, current output powers, and a power supply option of the master device.

Abstract: A method for waking up a notebook computer is adapted to a computer accessory. The notebook computer includes a host connector including a power receiving. The method includes setting a power management mode of the notebook computer to be awakened when connected to the external power, to switch a power state of the notebook computer from a waiting to be awakened state to a normal operation state; connecting the computer accessory to the host connector to establish a power connection through the power receiving pin and deliver an external power to the notebook computer; temporarily cutting off the external power by the computer accessory and then restoring the external power; when the power state of the notebook computer is the waiting to be awakened state, performing a wake-up operation with the notebook computer to switch to the power state to be the normal operation.

Abstract: The present invention provides a method for synthesizing etelcalcetide or salts thereof, comprising the steps of: (a) synthesizing the D-amino acids in the formula (I) sequentially by Fmoc solid-phase synthesis, using a solid support as a starting material in solid phase peptide synthesis and sequentially synthesizing a D-form amino acid of formula (I) by Fmoc chemistry; deprotecting Fmoc group and acetylating the amino group to obtain a sequence A comprising protecting groups (PG) in the side chain of D-Cys and D-Arg; (b) removing the protecting group in the side-chain of D-Cys of the sequence A to form a sequence B; (c) disulfide formation at D-Cys of the sequence B by (PG)-L-Cys-OH to obtain a sequence C; (d) using a cleavage solution to remove the protecting groups of the sequence C to give etelcalcetide as formula (I). The present invention can shorten the steps and time for preparing Etelcalcetide.

Abstract: The present invention provides a method for synthesizing etelcalcetide or salts thereof, comprising the steps of: (a) synthesizing the D-amino acids in the formula (I) sequentially by Fmoc solid-phase synthesis, using a solid support as a starting material in solid phase peptide synthesis and sequentially synthesizing a D-form amino acid of formula (I) by Fmoc chemistry; deprotecting Fmoc group and acetylating the amino group to obtain a sequence A comprising protecting groups (PG) in the side chain of D-Cys and D-Arg; (b) removing the protecting group in the side-chain of D-Cys of the sequence A to form a sequence B; (c) disulfide formation at D-Cys of the sequence B by (PG)-L-Cys-OH to obtain a sequence C; (d) using a cleavage solution to remove the protecting groups of the sequence C to give etelcalcetide as formula (I). The present invention can shorten the steps and time for preparing Etelcalcetide.

Abstract: Provided is a strategy for generating transgenic plants with concurrent resistance to DNA and RNA viruses at one construction, so as to develop an RNA-directed DNA methylation (RdDM) transgenic system using a hairpin construct of Ageratum yellow vein virus (AYVV) promoter region residing in an intron to resist DNA virus infection by RdDM. Furthermore, the hairpin construct of the AYVV promoter region coupled with an untranslatable nucleocapsid protein (NP) fragment of Melon yellow sport virus (MYSV) is created to induce post-transcriptional gene silencing (PTGS) against MYSV. A method for providing transgenic plants conferring concurrent resistance to both AYVV and MYSV for control of DNA and RNA virus at the same time, and underlying RdDM and PTGS mechanisms, respectively, is also provided.

Abstract: A cord-winding device for a blind assembly having no pull cord includes a base seat defining a slide channel and having a bottom side configured to removably mount the blind assembly thereto, and an adjustment unit including a slide seat mounted slidably in the slide channel, a plurality of rollers mounted on the base seat and the slide seat, respectively, and a constant force spring having first and second ends respectively fixed to the base seat and the slide seat. A lift cord winds around the rollers and extends through the base seat. The lift cord is configured to extend through the blind assembly after extending through the base seat so as to be positioned to the base seat and the blind assembly.

Abstract: Provided is a strategy for generating transgenic plants with concurrent resistance to DNA and RNA viruses at one construction, so as to develop an RNA-directed DNA methylation (RdDM) transgenic system using a hairpin construct of Ageratum yellow vein virus (AYVV) promoter region residing in an intron to resist DNA virus infection by RdDM. Furthermore, the hairpin construct of the AYVV promoter region coupled with an untranslatable nucleocapsid protein (NP) fragment of Melon yellow sport virus (MYSV) is created to induce post-transcriptional gene silencing (PTGS) against MYSV. A method for providing transgenic plants conferring concurrent resistance to both AYVV and MYSV for control of DNA and RNA virus at the same time, and underlying RdDM and PTGS mechanisms, respectively, is also provided.

Abstract: A cord-winding device for a window blind includes a base unit having a base defining a slide channel. An adjustment unit includes two slide seats mounted in the slide channel and slidable toward or away from each other, two sets of pulleys mounted respectively and rotatably on the slide seats, at least one elastic unit disposed on one of the slide seats, and an adjustment cord winding around the sets of pulleys and then extending through the base. The adjustment cord is configured to be connected to the window blind after extending through the base, and is configured to support the weight of the window blind to thereby generate a pulling force to pull the slide seats.

Abstract: A cord-winding device for a blind assembly having no pull cord includes a base seat defining a slide channel and having a bottom side configured to removably mount the blind, assembly thereto, and an adjustment unit including a slide seat mounted slidably in the slide channel, a plurality of rollers mounted on the base seat and the slide seat, respectively, and a constant force spring having first and second ends respectively fixed to the base seat and the slide seat. A lift cord winds around the rollers and extends through the base seat. The lift cord is configured to extend through the blind assembly after extending through the base seat so as to fee positioned to the base seat and the blind assembly.

Abstract: A computer-based method for checking signal transmission lines of a printed circuit board (PCB) layout is provided. A design rules is set according to different length requirements and the quantity of storage devices input by users. A group of transmission line from a displayed PCB layout is selected. The quantity of branch lines of each transmission line to be checked and the length of each branch line of the group of transmission lines to be checked are computed. The design of which branch lines does not satisfy the design rules is determined according to the computed quantity of the branch lines of each transmission line to be checked, the length of each branch line of the group of transmission lines, and the design rules.

Abstract: A method for checking signal transmission lines of a printed circuit board (PCB) layout includes determining differential pairs to be checked and dividing the differential pairs to be checked into a first group and a second group. A first reference distance between differential pairs belonging to the same group and a second reference distance between differential pairs belonging to different groups are set. A first box surrounding each line section of one to be checked signal differential line of the first group and a second box surrounding the first box are created. One first box surrounding each line section of the to be checked differential line of the second group is created. Whether or not in the first box and the second box there are differential lines which do not satisfy design standards is determined.

Abstract: A method for checking signal transmission lines of a printed circuit board (PCB) layout includes determining differential pairs to be checked and dividing the differential pairs to be checked into a first group and a second group. A first reference distance between differential pairs belonging to the same group and a second reference distance between differential pairs belonging to different groups are set. A first box surrounding each line section of one to be checked signal differential line of the first group and a second box surrounding the first box are created. One first box surrounding each line section of the to be checked differential line of the second group is created. Whether or not in the first box and the second box there are differential lines which do not satisfy design standards is determined.

Abstract: A signal transmission line check method to be executed by a computing device is described. A to-be-checked signal transmission line group in a displayed printed circuit board (PCB) layout is determined. Whether all signal transmission lines of the to-be-checked signal transmission line group are laid out in a same layer of the displayed PCB layout is checked according to an input serial number of a chipset and layer properties of the to-be-checked signal transmission lines. The signal transmission lines that do not satisfy design standards are determined when not all of the to-be-checked signal transmission lines are laid out in a same layer. A related computing device is also disclosed.

Abstract: In a method for checking a wiring diagram in a printed circuit board (PCB) design, a pair of differential signal lines in a PCB file is located according to a designation of a user. Components connected by the differential signal lines and vias which the differential signal lines pass through are obtained from the PCB file. A determination of whether obtained components and the obtained vias meet predetermined requirements is made by checking whether copper foils between each pair of the obtained vias or between pins of the obtained components in ground layers and power layers of the PCB file are hollowed.