Abstract: Provided is a composition and an application thereof. The composition is used to prepare a medium for inducing differentiation of human pluripotent stem cells to liver precursor cells. By means of screening active components, optimizing the composition ratio and adding a GSK3-beta inhibitor, a Nodal activator, a BMP activator, a BMP inhibitor and a Hedgehog activator, human pluripotent stem cells are induced to differentiate to liver precursor cells. The process is simple and efficient, the content of positive cells is high, and the cost of cell differentiation is reduced. The invention can be used for research and application in drug development and regenerative medicinal treatment, and has broad application prospects.

Abstract: Multilayer polymer sheets are provided, as well as related methods, systems, and appliances.

Abstract: Embodiments of this application provide a data transmission method, a network device, and a terminal device. The method may include detecting, by a network device, a first signal in an uplink signal. The method may also include determining, by the network device, a signal structure of the uplink signal based on a result of detecting the first signal. Furthermore, the method may include receiving, by the network device, the uplink signal based on the signal structure, and/or responding to the uplink signal based on the signal structure. According to the data transmission method in the embodiments of this application, before receiving data, the network device can determine the signal structure, used by the terminal device, of the uplink signal, and then use a corresponding receiving method to avoid complexity and a reliability risk that are caused by completely blind detection performed by the network device.

Abstract: Multilayer polymer sheets are provided, as well as related methods, systems, and appliances.

Abstract: A suspension bushing for a powertrain of an electric vehicle includes amandrel, an outer sleeve and a rubber mainspring connected between the mandrel and the outer sleeve. The rubber main spring includes multiple main parts arranged at intervals and surrounding the outer contour of the mandrel. At least one side of each of the main parts is provided with an extending part. An end surface of the extending part and an end surfaceof each main part form a stepped structure.

Abstract: Control logic in a memory device initiates, subsequent to a program verify phase of a program operation, a new program operation on the memory array, the new program operation comprising a pre-boosting phase occurring prior to a program phase. The control logic causing one or more positive pre-boosting voltages to be applied to corresponding subsets of a plurality of word lines of a block of the memory array during the pre-boosting phase and causes the one or more positive pre-boosting voltages to be ramped down to a ground voltage during the pre-boosting phase in a designated order based on a location of the corresponding subsets of the plurality of word lines to which the one or more positive pre-boosting voltages were applied.

Abstract: The manufacturing method of titanium dioxide solution includes: mixing choline chloride, urea, boric acid, and titanium tetrachloride to form a first solution, wherein a molar concentration ratio of choline chloride to urea is 1:2, a molar concentration of titanium tetrachloride is 0.2 M to 0.4 M, and weight/volume of boric acid is 5 g/300 ml to 15 g/300 ml; and heating the first solute ion to form a second solution, wherein the second solution contains carbon/nitrogen doped titanium dioxide. In the manufacturing method of the present disclosure, the deep eutectic solution formed by choline chloride and urea may be used as a solvent, and may also be used as a carbon source and/or a nitrogen source. Therefore, titanium dioxide may be doped with carbon and/or nitrogen during the formation process.

Abstract: A lens assembly includes a first lens, a second lens, a third lens, and a fourth lens. The first lens is with positive refractive power and includes a concave surface facing an object side and a convex surface facing an image side. The second lens is with negative refractive power and includes a concave surface facing the object side. The third lens is with positive refractive power. The fourth lens is with refractive power and includes a concave surface facing the image side. The first lens, the second lens, the third lens, and the fourth lens are arranged in order from the object side to the image side along an optical axis. The lens assembly satisfies: TTL/f>1.2; wherein TTL is a total length of optical system of the lens assembly and f is an effective focal length of the lens assembly.

Abstract: The present invention belongs to the technical field of biological pharmacy, and particularly relates to a long-acting HM-3 fusion protein molecule and an application thereof. In the present invention, on the basis of the sequence of HM-3 molecule, an active polypeptide HM-3 and derivatives thereof are linked to a human Fc (IgG) fragment or a fragment of an Fc (IgG) mutant directly or by a linker peptide (Linker), thus forming a novel molecular entity. The general formula of the molecular entity is (HM-3)n-Linker-Fc(IgG), Fc(IgG)-Linker-(HM-3)n, or (HM-3)n-Linker-Fc(IgG)-Linker-(HM-3)n. The fusion protein effectively prolongs the half-life of HM-3, is low in cost and overcomes the major problem of druggability of small peptides. Therefore, the fusion protein of the present invention may serve as a potential drug for the treatment of autoimmune diseases, neovascular diseases, osteoarthritis and the like.

Abstract: An information transmission method includes sending, by a terminal, second information and uplink data. The uplink data is sent in a second access mode. The second information indicates a first access mode. The first access mode is useable by the terminal to send the uplink data before the terminal sends the uplink data in the second access mode.

Abstract: A method for predicting and optimizing an ROP for oil and gas drilling based on Bayesian optimization includes: acquiring raw drilling data according to a preset sampling period, constructing an initial sample data set based on the raw drilling data, constructing an ROP prediction model based on the initial sample data set, and predicting an ROP at a next sample point through a Gaussian process regression based on the ROP prediction model. The present invention realizes rapid analysis of historical drilling data and accurate prediction of an ROP range at a sample point in a feasible domain. The method can obtain an optimized ROP and an optimized engineering parameter through Bayesian optimization, and obtain an engineering parameter corresponding to an optimal ROP. The method has few restrictions on the drilling engineering parameter and the raw formation parameter, improves prediction accuracy, and avoids the problem of blurred parameter value boundaries.

Abstract: Multilayer polymer sheets are provided, as well as related methods, systems, and appliances.

Abstract: Multilayer polymer sheets are provided, as well as related methods, systems, and appliances.

Abstract: Disclosed herein are kinase inhibitory compounds, such as a receptor-interacting protein-1 (RIP1) kinase inhibitor compounds, as well as pharmaceutical compositions and combinations comprising such inhibitory compounds. The compounds may have a structure according to Formula I The disclosed compounds, pharmaceutical compositions, and/or combinations may be used to treat or prevent a kinase-associated disease or condition, particularly a RIP1-associated disease or condition.

Abstract: An orthodontic appliance may include an outer shell having a plurality of cavities shaped to receive the patient's teeth and generate one or more of a force or a torque in response to the appliance being worn on the patient's teeth. The orthodontic appliance may also include an inner structure having a stiffness different than a stiffness of the outer shell. The inner structure can be positioned on an inner surface of the outer shell in order to distribute the one or more of a force or a torque to at least one tooth received within the plurality of cavities.

Abstract: This disclosure relates to a system and method for monitoring a sheave bearing condition, and in particular relates to passenger conveyer systems, such as elevator systems, employing the system and method. An example passenger conveyer system includes a suspension member, and a sheave configured to rotate on a bearing. The suspension member is wrapped around at least a portion of the sheave. Further, the system includes a sensor mounted adjacent an end of the suspension member, and a controller configured to determine a condition of the bearing based on an output of the sensor.

Abstract: A process for producing high octane bio-based alkylate is provided. The process involves reacting isobutane and bio-ethylene using an ionic liquid catalyst. Reaction conditions can be chosen to assist in attaining, or to optimize, desirable alkylate yields and/or properties.

Abstract: A HARQ-ACK transmission method and an apparatus. A network device configures at least two common PUCCH resource sets for a terminal device, and sends, to the terminal device, configuration information indicating the at least two common PUCCH resource sets. After receiving the configuration information from the network device, the terminal device determines, from the at least two common PUCCH resource sets, a first PUCCH resource used to send HARQ-ACK information, and sends the HARQ-ACK information to the network device based on the first PUCCH resource. Available PUCCH frequency domain resources are able to be added for the terminal device in a same slot. PUCCH frequency domain resource collision is reduced, and a transmission delay that is increased to avoid the PUCCH frequency domain resource collision is reduced.

Abstract: A method for predicting and optimizing an ROP for oil and gas drilling based on Bayesian optimization includes: acquiring raw drilling data according to a preset sampling period, constructing an initial sample data set based on the raw drilling data, constructing an ROP prediction model based on the initial sample data set, and predicting an ROP at a next sample point through a Gaussian process regression based on the ROP prediction model. The present invention realizes rapid analysis of historical drilling data and accurate prediction of an ROP range at a sample point in a feasible domain. The method can obtain an optimized ROP and an optimized engineering parameter through Bayesian optimization, and obtain an engineering parameter corresponding to an optimal ROP. The method has few restrictions on the drilling engineering parameter and the raw formation parameter, improves prediction accuracy, and avoids the problem of blurred parameter value boundaries.

Abstract: A method is disclosed for producing small crystal, high aluminum content zincoaluminosilicate crystalline materials having the SSZ-41 framework structure. The compositions made according to that method, as well as uses of the same, are also disclosed.