Patents by Inventor Yan Chen

Yan Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BLADE VIBRATION MITIGATION OF INTEGRALLY BLADED ROTOR BY DAMPING ON DISK
    Publication number: 20230117555
    Abstract: A vibration mitigation coating for an integrally bladed rotor including a disk including an interior radius proximate an axis and an exterior radius distal from the axis, the disk including a substrate with an external surface, said external surface extends from the interior radius to the exterior radius; and a damping material disposed directly onto the external surface of the substrate.
    Type: Application
    Filed: October 15, 2021
    Publication date: April 20, 2023
    Applicant: Raytheon Technologies Corporation
    Inventors: Yan Chen, Zaffir A. Chaudhry
  • Antibody screening methods
    Patent number: 11629434
    Abstract: Provided are methods and compositions for the production of novel antibodies that bind specifically to a target antigen. These methods and compositions are particularly useful for producing antibodies having the antigen binding specificity of a reference antibody but with improved properties (e.g., binding affinity, immunogenicity, and thermodynamic stability) relative to the reference antibody.
    Type: Grant
    Filed: April 30, 2020
    Date of Patent: April 18, 2023
    Assignee: X-BODY, INC.
    Inventors: Yan Chen, Tod M. Woolf, Richard W. Wagner
  • AMIDE COMPOUNDS AND METHOD FOR MAKING AND USING
    Publication number: 20230115275
    Abstract: Disclosed embodiments concern novel interleukin receptor associated kinases (IRAK) inhibitors and compositions comprising such inhibitors. Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/or compositions may be used to treat or prevent an IRAK-associated disease or condition.
    Type: Application
    Filed: November 9, 2022
    Publication date: April 13, 2023
    Applicant: Rigel Pharmaceuticals, Inc.
    Inventors: Kin Tso, Hui Li, Yan Chen, Rose Yen, Vanessa Taylor, Thilo Heckrodt, Rajinder Singh, Simon Shaw
  • RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME
    Publication number: 20230112865
    Abstract: Disclosed herein are kinase inhibitory compounds, such as a receptor-interacting protein-1 (RIP1) kinase inhibitor compounds, as well as pharmaceutical compositions and combinations comprising such inhibitory compounds. The disclosed compounds, pharmaceutical compositions, and/or combinations may be used to treat or prevent a kinase-associated disease or condition, particularly a RIP1-associated disease or condition.
    Type: Application
    Filed: June 17, 2022
    Publication date: April 13, 2023
    Inventors: Yan CHEN, Jiaxin YU, Simon SHAW, Ihab DARWISH, Vanessa TAYLOR, Somasekhar BHAMIDIPATI, Zhushou LUO, Rao KOLLURI
  • Antibodies and chimeric antigen receptors specific for B-cell maturation antigen
    Patent number: 11623961
    Abstract: Provided herein are BCMA-binding molecules, including anti-BCMA antibodies and antigen-binding fragments thereof such as heavy chain variable (VH) regions and single-chain antibody fragments, and chimeric receptors comprising the anti-BCMA binding molecules such as chimeric antigen receptors (CARs). In some embodiments, the anti-BCMA antibodies or antigen-binding fragments thereof specifically bind to BCMA-1. Among the anti-BCMA antibodies are human antibodies, including those that compete for binding to BCMA with reference antibodies, such as a non-human reference antibody. Also provided are genetically engineered cells expressing the CARs or BCMA-binding molecules and uses thereof such as in adoptive cell therapy.
    Type: Grant
    Filed: November 1, 2018
    Date of Patent: April 11, 2023
    Assignee: Juno Therapeutics, Inc.
    Inventors: Blythe D. Sather, Steven M. Shamah, Yan Chen, Rebecca Wu, Collin Hauskins, Csaba Pazmany, Jui Dutta-Simmons, Kimberly Harrington
  • MOLECULAR SIEVE SSZ-116, ITS SYNTHESIS AND USE
    Publication number: 20230109602
    Abstract: A novel synthetic crystalline aluminogermanosilicate molecular sieve material, designated SSZ-116, is provided. SSZ-116 can be synthesized using 3-[(3,5-di-tert-butylphenyl)methyl]-1,2-dimethyl-1H-imidazolium cations as a structure directing agent. SSZ-116 may be used in organic compound conversion reactions and/or sorptive processes.
    Type: Application
    Filed: December 12, 2022
    Publication date: April 6, 2023
    Inventors: Stacey Ian ZONES, Jesus PASCUAL, Dan XIE, Cong-Yan CHEN
  • 2,4-DIAMINO-PYRIMIDINE COMPOUNDS AND METHOD FOR MAKING AND USING THE COMPOUNDS
    Publication number: 20230095835
    Abstract: Compounds within the scope of the present invention have a Formula 1 or a salt or produg thereof, where ring A is selected from cycloaliphatic; ring B is aryl; R1 is selected from (C1-C10)alkyl, (C3-C10)cycloalkyl, halo, aryl, and heteroaryl; and R2 and R3 are independently selected from hydrogen and (C1-C6)alkyl. Disclosed compounds may have an IRAK4 IC50 of from 0.003 ?M to 3.7 ?M; a TAK1 IC50 of from 0.008 ?M to 132 ?M; and/or an IRAK4/TAK1 selectivity of from 1 to 450. Particular compounds may have an IRAK4/TAK1 selectivity of from 100 to 500. Disclosed compositions may be formulated as pharmaceutical compositions. A method for using the compounds and/or compositions also are disclosed. The method may comprise administering to a subject an effective amount of a compound within the scope of the present invention, particularly to selectively inhibit IRAK 1 and/or IRAK4 over TAK1.
    Type: Application
    Filed: November 16, 2022
    Publication date: March 30, 2023
    Applicant: Rigel Pharmaceuticals, Inc.
    Inventors: Yan Chen, Rose Yen, Jiaxin Yu, Vanessa Taylor, Rajinder Singh
  • OPTICAL DIAGNOSTICS OF SEMICONDUCTOR PROCESS USING HYPERSPECTRAL IMAGING
    Publication number: 20230097892
    Abstract: Disclosed are embodiments of an improved apparatus and system, and associated methods for optically diagnosing a semiconductor manufacturing process. A hyperspectral imaging system is used to acquire spectrally-resolved images of emissions from the plasma, in a plasma processing system. Acquired hyperspectral images may be used to determine the chemical composition of the plasma and the plasma process endpoint. Alternatively, a hyperspectral imaging system is used to acquire spectrally-resolved images of a substrate before, during, or after processing, to determine properties of the substrate or layers and features formed on the substrate, including whether a process endpoint has been reached; or before or after processing, for inspecting the substrate condition.
    Type: Application
    Filed: December 5, 2022
    Publication date: March 30, 2023
    Applicant: Tokyo Electron Limited
    Inventors: Yan CHEN, Xinkang TIAN
  • Baffle plate for controlling wafer uniformity and methods for making the same
    Patent number: 11615946
    Abstract: Devices and methods for controlling wafer uniformity using a gas baffle plate are disclosed. In one example, a device for plasma-based processes is disclosed. The device includes: a housing defining a process chamber and a baffle plate arranged above a wafer in the process chamber. The baffle plate is configured to control plasma distribution on the wafer. The baffle plate has a shape of an annulus that comprises a first annulus sector and a second annulus sector. The first annulus sector has a first inner radius. The second annulus sector has a second inner radius that is different from the first inner radius.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: March 28, 2023
    Assignee: Taiwan Semiconductor Manufacturing Co., Ltd.
    Inventors: Jr-Sheng Chen, An-Chi Li, Shih-Che Huang, Chih-Hsien Hsu, Zhi-Hao Huang, Alex Wang, Yu-Pei Chiang, Chun Yan Chen
  • Bus communication signal conversion method and device, medium, and numerical control machine tool control equipment
    Patent number: 11615046
    Abstract: The present application relates to a bus communication signal conversion method and device, a medium, and a numerical control machine tool control equipment. The bus communication signal conversion method comprises: acquiring an interface type of a bus interface of a first equipment end; receiving an output signal sent by a communication interface of a second equipment end; extracting a working parameter value of the second equipment end from the output signal; and sending the working parameter value of the second equipment end to the bus interface of the first equipment end according to a communication protocol corresponding to the interface type. The use of the present method can achieve signal conversion between different types of interfaces, thereby ensuring effectiveness of communication.
    Type: Grant
    Filed: July 17, 2018
    Date of Patent: March 28, 2023
    Assignees: HAN'S LASER TECHNOLOGY INDUSTRY GROUP CO., LTD., SHENZHEN HAN'S SMART CONTROLTECHNOLOGY CO., LTD.
    Inventors: Yuxin Feng, Yan Chen, Yunfeng Gao
  • COMMUNICATION METHOD AND APPARATUS
    Publication number: 20230088910
    Abstract: Embodiments of this application provide a communication method and apparatus. The method includes: receiving indication information that is of a target reference signal and that is sent by a cluster head terminal; and measuring the target reference signal based on the indication information, to obtain a coverage level of a cluster member terminal in a target cell. In comparison with a conventional technology, in embodiments of this application, the cluster head terminal indicates, by sending the indication information of the target reference signal to the cluster member terminal, the cluster member terminal to measure the target reference signal, so that the cluster head terminal learns of the coverage level of the cluster member terminal in the target cell, and further, a network device can perform different RRC configuration based on different coverage levels of the cluster member terminal.
    Type: Application
    Filed: November 25, 2022
    Publication date: March 23, 2023
    Inventors: Yunhao ZHANG, Xiuqiang XU, Yiqun WU, Yan CHEN
  • Scrambling-based data transmission method
    Patent number: 11611967
    Abstract: This application provides example scrambling-based data transmission methods and apparatuses. A scrambling manner is determined based on a sending waveform. The scrambling manner can include frequency domain scrambling, time domain scrambling, or time-frequency domain scrambling. To-be-scrambled data can be scrambled based on the scrambling manner, to obtain scrambled output data. The scrambled output data can be sent. The sending waveform can be a discrete Fourier transform spreading orthogonal frequency division multiplexing (DFT-s-OFDM) waveform or a cyclic prefix orthogonal frequency division multiplexing (CP-OFDM) waveform.
    Type: Grant
    Filed: July 22, 2020
    Date of Patent: March 21, 2023
    Assignee: Huawei Technologies Co., Ltd.
    Inventors: Yiqun Wu, Yan Chen, Lei Wang
  • PREPARATION METHOD, PRODUCT, AND APPLICATION OF CIRCULATING TUMOR DNA REFERENCE SAMPLES
    Publication number: 20230079748
    Abstract: The present disclosure relates to methods of preparing circulating tumor DNA (ctDNA) reference samples including: inducing apoptosis in tumor cells to obtain DNA fragments and then extracting DNA from the tumor cells to obtain the circulating tumor DNA reference samples. The methods to prepare ctDNA reference samples disclosed herein are simple and easy to use, suitable for various tumor cells, and the variant information can be retained to simulate the ctDNA in animals. In some embodiments, the reference samples can facilitate assay calibration and evaluation.
    Type: Application
    Filed: September 1, 2022
    Publication date: March 16, 2023
    Inventors: Guolin Zhong, Mao Mao, Shiyong Li, Dandan Zhu, Yan Chen, Yumin Feng, Wei Wu
  • Laser marking of dental appliances
    Patent number: 11602413
    Abstract: Dental appliances, materials, and methods of forming such appliances and materials for improved laser marking are provided herein including the use of textured and/or roughened surfaces to enhance laser marking.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: March 14, 2023
    Assignee: Align Technology, Inc.
    Inventors: Yan Chen, Fangxiao Guan, Kwan Ho, Shiva P. Sambu
  • TARGET ANTIGEN DISCOVERY, PHENOTYPIC SCREENS AND USE THEREOF FOR IDENTIFICATION OF TARGET CELL SPECIFIC TARGET EPITOPES
    Publication number: 20230074705
    Abstract: The invention provides methods and compositions for identifying binding polypeptides (e.g., antibodies or antigen binding fragments thereof) that specifically binds to a cell-surface antigen. The methods of the invention generally comprise contacting a variegated nucleic acid-display library of binding polypeptides with a cell-surface antigen displayed on the exterior surface of a cell; and isolating from the library at least one library member that specifically binds to the cell-surface antigen on the exterior surface of the cell.
    Type: Application
    Filed: July 29, 2022
    Publication date: March 9, 2023
    Inventors: Yan Chen, Steven M. Shamah
  • IRAK INHIBITORS AND METHOD FOR MAKING AND USING
    Publication number: 20230062818
    Abstract: Disclosed embodiments concern interleukin receptor associated kinases (IRAK) inhibitors, such as oxazole compounds, and compositions comprising such inhibitors. Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/or compositions may be used to treat or prevent an IRAK-associated disease or condition.
    Type: Application
    Filed: September 27, 2022
    Publication date: March 2, 2023
    Applicant: Rigel Pharmaceuticals, Inc.
    Inventors: Hui Li, Thilo Heckrodt, Yan Chen, Ryan Kelley, Darren McMurtrie, Kin Tso, Vanessa Taylor, Rajinder Singh, Rose Yen, Jack Maung
  • FOCUS RING FOR A PLASMA-BASED SEMICONDUCTOR PROCESSING TOOL
    Publication number: 20230066418
    Abstract: A focus ring for a plasma-based semiconductor processing tool is designed to provide and/or ensure etch rate uniformity across a wafer during a plasma etch process. The focus ring may include an angled inner wall that is angled away from a center of the focus ring to direct a plasma toward the wafer. The angle of the angled inner wall may be greater than approximately 130 degrees relative to the top surface of the wafer and/or may be less than approximately 50 degrees relative to an adjacent lower surface of the focus ring to reduce and/or eliminate areas of overlapping plasma on the wafer (which would otherwise cause non-uniform etch rates). Moreover, an inner diameter may be configured to be in a range of approximately 209 millimeters to 214 millimeters to further reduce and/or eliminate areas of overlapping plasma on the wafer.
    Type: Application
    Filed: August 30, 2021
    Publication date: March 2, 2023
    Inventors: Sheng Chieh HUANG, Cheng Kuang TSO, Chou-Feng LEE, Chung-Hsiu CHENG, Jr-Sheng CHEN, Chun Yan CHEN, Chih-Hsien HSU, Chin-Tai HUNG
  • DEVICES, SYSTEMS, AND COMPUTER-IMPLEMENTED METHODS FOR DENTAL ATTACHMENT TEMPLATES
    Publication number: 20230069617
    Abstract: The present disclosure provides methods, devices, systems, and computer-implemented methods for forming and placing attachments for use with dental appliances, and more particularly to the design, manufacture, and use of three-dimensionally printed attachment templates for use with orthodontic devices. Dental attachment templates include a cavity with one or more openings for injecting and bonding attachment material directly on a patient's tooth, which allow accurate placement of the attachments while providing the dental practitioner flexibility during the attachment forming process. Digital dental attachment template model techniques can be used to accurately place the cavity and opening.
    Type: Application
    Filed: November 7, 2022
    Publication date: March 2, 2023
    Inventors: Fuming WU, Jihua CHENG, Chunhua LI, Yan CHEN, Norman C. SU
  • Organotemplate-free synthesis of a zeolite of ton framework type
    Patent number: 11591231
    Abstract: An organotemplate-free synthetic process for the production of a zeolite of TON framework type structure is provided. The process includes the steps of: (1) preparing a mixture comprising: (a) an alumina-coated silica; (b) a source of an alkali metal; (c) an alcohol; (d) a source of hydroxide ions; (e) seed crystals comprising a zeolitic material having a TON framework type structure; and (f) water; and (2) crystallizing the mixture obtained in step (1).
    Type: Grant
    Filed: June 25, 2021
    Date of Patent: February 28, 2023
    Assignee: CHEVRON U.S.A. INC.
    Inventors: Joel Edward Schmidt, Adeola Florence Ojo, Cong-Yan Chen
  • Camera
    Patent number: D979629
    Type: Grant
    Filed: March 17, 2021
    Date of Patent: February 28, 2023
    Inventor: Yan Chen