Abstract: Disclosed embodiments concern novel interleukin receptor associated kinases (IRAK) inhibitor compounds and compositions comprising such compounds. The compounds may have a structure according to Formula I Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/or compositions may be used to treat or prevent an IRAK-associated disease or condition.

Abstract: The invention relates to a multi-layer, preferably co-extruded, plastic film with improved modulus properties, which is suitable, in particular, for producing three-dimensionally shaped articles.

Abstract: Devices and methods for controlling wafer uniformity in plasma-based process is disclosed. In one example, a device for plasma-based processes is disclosed. The device includes: a housing defining a process chamber and a gas distribution plate (GDP) arranged in the process chamber. The housing comprises: a gas inlet configured to receive a process gas, and a gas outlet configured to expel processed gas. The GDP is configured to distribute the process gas within the process chamber. The GDP has a plurality of holes evenly distributed thereon. The GDP comprises a first zone and a second zone. The first zone is closer to the gas outlet than the second zone. At least one hole in the first zone is closed.

Abstract: A multilayer sheet comprising first and second layers is provided. The first layer consists of a co-polyester. The second layer consists of a thermoplastic polyurethane elastomer having an elongation at break of greater than 200%, a hardness of 60A to 85D, an ultimate tensile strength of greater than about 5000 psi, and a light transmission between 400 nm and 800 nm of greater than about 75%. A mold is provided and the multilayer sheet is thermoformed over the mold to form a plurality of tooth-receiving cavities configured to receive and reposition a patient's teeth from a first arrangement toward a second arrangement. Excess material is trimmed from the thermoformed multilayer sheet to form a multilayer dental aligner.

Abstract: An internal combustion engine for neutron diffraction analysis is provided. The engine includes an elongated piston chamber formed from an aluminum alloy to ensure maximum neutron visibility into the combustion chamber. An elongated piston assembly reciprocates within the elongated piston chamber, the piston assembly including an upper piston joined to a lower piston. The upper piston and the lower piston are hollow, thereby reducing the reciprocating mass and increasing neutron access to the combustion chamber. The upper piston is lubricated with a neutron-transparent fluorocarbon lubricant such as perfluoropolyether (PFPE), while the lower piston and the crankcase are lubricated with hydrocarbon lubricant. The engine enables 3D and time-resolved measurements of strain, stress, and temperature, as well as phase transformation, texture, and microstructure.

Abstract: An uplink transmission methods and apparatuses to reduce a probability that a collision between a user equipment (UE) and another UE occurs when the UE sends uplink data, thereby improving network performance are described. A plurality of different preamble signals are sent to a network device by a user equipment (UE). A feedback signal of the network device in response to the plurality of preamble signals is received by the UE. The feedback signal in response to each preamble signal carries a timing advance (TA) corresponding to the preamble signal. A valid TA is determined by the UE from the plurality of received TAs. A parameter used for uplink transmission is determined by the UE based on a feedback signal carrying the valid TA or a preamble signal corresponding to the valid TA. Uplink data are sent according to the parameter by the UE.

Abstract: A multilayer sheet comprising first, second, and third layers is provided. The first layer consists of a co-polyester having an elongation at break of greater than 70%. The second layer consists of a thermoplastic polyurethane elastomer having an elongation at break of greater than 200% and a hardness of about 60 A to about 85 D. The first layer has a hardness greater than the hardness of the second layer. A mold is provided and the multilayer sheet is thermoformed over the mold to form a plurality of tooth-receiving cavities configured to receive and position a patient's teeth from a first arrangement toward a second arrangement. Excess material is trimmed from the thermoformed multilayer sheet to form the multilayer dental aligner.

Abstract: A centrifugal heat dissipation fan including a housing and an impeller is provided. The housing has at least one inlet disposed along an axis and at least one first outlet and a second outlet located in different radial directions, wherein the first outlet and the second outlet are opposite to and separated from each other. The impeller is disposed in the housing along the axis. A heat dissipation system of an electronic device is also provided.

Abstract: Provided is an implant material, an implant suitable for implantation in bone defect repair and in spinal fusion, and a preparation method thereof. The implant material is used for filling in an internal cavity of a titanium cage/titanium stent (10) or a bone defect site, and is consisted of an upper layer (21), a lower layer (22) and an intermediate layer between the upper layer (21) and lower layer (22), wherein the intermediate layer is composed of an annular coating region (23) located at the periphery and a central region (24) located inside the annular coating region. The central region (24) is filled with a first filling material, which is a gel material having a pro-osteogenic effect. The annular coating region (23) is filled with a second filling material, which is a gel material regulating epigenetics. The upper layer (21) and lower layer (22) are filled with a third filling material, which is a gel material regulating immuno-inflammatory response and stress response.

Abstract: Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I: These compounds are useful for the treatment of HIV and AIDS.

Abstract: A data set is stored in memory circuitry that is indicative of a state of a semiconductor fabrication process or of semiconductor structure fabricated thereby. Features in the data set are discernable to an extent limited by a data resolution. A machine-learning model comprising parameters having respective values assigned thereto as constrained by a model training process is also stored in the memory circuitry. Processor circuitry communicatively coupled to the memory circuitry generates an output data set from the data set in accordance with the machine-learning model such that features in the output data set are discernable to an extent limited by an output data resolution that is finer than the data resolution of the data set.

Abstract: A method for manufacturing a semiconductor structure includes forming a fin over a substrate, wherein the fin includes first semiconductor layers and second semiconductor layers alternating stacked. The method also includes forming an isolation feature around the fin, forming a dielectric feature over the isolation feature, forming a cap layer over the fin and the dielectric feature, oxidizing the cap layer to form an oxidized cap layer, forming source/drain features passing through the cap layer and in the fin, removing the second semiconductor layers in the fin to form nanostructures, and forming a gate structure wrapping around the nanostructures.

Abstract: A dental appliance includes a first segment comprising a first plurality of tooth receiving cavities shaped to receive and to impart a first distalization force in a distal direction on a first part of a patient dentition on a first jaw. The dental appliance further includes a second segment comprising a second plurality of tooth receiving cavities shaped to receive and to impart a second distalization force in the distal direction on a second part of the patient dentition. The dental appliance further includes a connector shaped to span a plurality of anterior teeth of the patient dentition and to leave open a labial side of the plurality of anterior teeth. The connector operates to decrease transmission of one or more forces between the first segment and the second segment to limit transmission of at least one of the first distalization force or the second distalization force to the plurality of anterior teeth.

Abstract: A processing device in a memory system receives an erase request to erase data stored at a data block of a memory device, the erase request identifying a selected sub-block of a plurality of sub-blocks of the data block for erase, each of the plurality of sub-blocks comprising select gate devices (SGDs) and data storage devices. For each sub-block of the plurality of sub-blocks not selected for erase, the processing device applies an input voltage at a bitline of the respective sub-block and applies a plurality of gate voltages to a plurality of wordlines of the respective sub-block, the plurality of wordlines are coupled to the SGDs and to the data storage devices, each voltage of the plurality of voltages applied to a successive wordline of the plurality of wordlines is less than a previous voltage applied to a previous wordline.

Abstract: Control logic in a memory device initiates a program operation on the memory device, and causes a program voltage to be applied to a selected wordline of the memory array during a program phase of the program operation. The control logic further causes a select gate drain coupled with a string of memory cells in the memory array to deactivate during a recovery phase after applying the program voltage, wherein the string of memory cells comprises a plurality of memory cells, and wherein each memory cell of the plurality of memory cells is coupled to a corresponding wordline of a plurality of wordlines in the memory array.

Abstract: This application provides a coding method and a communication apparatus, which may be applied to wireless data transmission. The method includes: A sending apparatus sends indication information to a receiving apparatus, where the indication information indicates first information and second information. The first information indicates a coding scheme of to-be-encoded data, and the coding scheme includes a coding matrix for channel coding and a channel coding mode. The second information indicates a distribution feature of the to-be-encoded data. The sending apparatus performs channel coding on the to-be-encoded data based on the coding scheme, to obtain encoded data. The receiving apparatus receives the indication information sent by the sending apparatus, and the receiving apparatus performs channel decoding on received data based on the indication information, to obtain decoded data.

Abstract: Embodiments include a method for retrieving atmospheric aerosol based on statistical segmentation. Firstly a multi-band remote sensing image including an apparent reflectance and an aerosol optical thickness look-up table corresponding to a retrieval band is obtained, then pixels are partitioned and screened according to apparent reflectance segments of a mid-infrared 2.1 micrometer band. After that the retained pixel sets are further partitioned and screened according to the apparent reflectance segments of the mid-infrared 1.6 micrometer band. Finally the obtained pixel sets are partitioned into two categories according to the pixel number, one category including pixels having more pixels, the other including those with less pixels. The category with more pixels is taken as the reference part for retrieval.

Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein R1, R2, R4, R6, m, and n are defined herein. Also disclosed are methods of using such compounds to inhibit Helios protein, and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.

Abstract: A data transmission method, a terminal, and a network device are provided. In embodiments of the present disclosure, a terminal sends, in a grant-free mode, first data to a network device by using a grant-free resource, and if the terminal needs to switch from the grant-free mode to a grant mode, the terminal sends, in the grant mode, second data to the network device by using a grant resource. When the terminal initially transmits the first data in the grant-free mode, if the terminal needs to switch from the grant-free mode to the grant mode, the terminal may fall back to the grant mode and transmit data in the grant mode.

Abstract: A fan adapted for being disposed in an electronic device is provided. The fan includes a hub and a plurality of metal blades respectively extending from the hub. Each of the metal blades has a root portion connected to the hub and an end portion away from the hub, and a mass of the end portion is greater than a mass of the root portion, such that the metal blade is elongated while the fan is rotated.