Abstract: An implantable device is configured to be positioned within a native heart valve to allow the native heart valve to form a more effective seal. The implantable device includes a cover. The cover can be attached to one or more sleeves, can have a portion that has a lower coefficient of friction, and/or can have separate pieces that cover different portions of the implantable device.

Abstract: Provided herein are BCMA-binding molecules, including anti-BCMA antibodies and antigen-binding fragments thereof such as heavy chain variable (VH) regions and single-chain antibody fragments, and chimeric receptors comprising the anti-BCMA binding molecules such as chimeric antigen receptors (CARs). In some embodiments, the anti-BCMA antibodies or antigen-binding fragments thereof specifically bind to BCMA-1. Among the anti-BCMA antibodies are human antibodies, including those that compete for binding to BCMA with reference antibodies, such as a non-human reference antibody. Also provided are genetically engineered cells expressing the CARs or BCMA-binding molecules and uses thereof such as in adoptive cell therapy.

Abstract: The disclosure discloses a large-aperture infrared metalens camera, which belongs to the technical field of infrared imaging and micro-nano photonics, including a large-aperture metalens, an infrared focal plane array detector, a metalens mechanical assembly and a housing. The large-aperture metalens has an aperture greater than 50 mm and a thickness less than 2 mm, and the distance between the large-aperture metalens and the infrared focal plane array detector is greater than 30 mm. The disclosure adopts strict electromagnetic field values, diffraction design algorithm and large-area semiconductor process manufacturing method to increase the aperture of metalens to 50 mm or more, and considerably improves the focal length and magnification of the camera while ensuring that the F-number of the metalens meets the requirements of signal-to-noise ratio of image. The problems of short focal length, small magnification, and insufficient imaging range of conventional metalens cameras are overcome.

Abstract: Methods for designing orthodontic appliances for repositioning a patient's teeth are provided. In some embodiments, a method includes determining a movement path to move one or more teeth from an initial arrangement to a target arrangement, determining a force system to produce movement of the one or more teeth along the movement path, and determining an appliance geometry for an orthodontic appliance configured to produce the force system. The orthodontic appliance can include an outer shell comprising a plurality of teeth-receiving cavities and an inner structure positioned on an inner surface of the outer shell. The inner structure can have an elastic modulus different than an elastic modulus of the outer shell. The method can also include generating instructions for directly fabricating the orthodontic appliance using a layer-by-layer additive manufacturing technique.

Abstract: The present invention provides antigen-binding polypeptides, including bi-specific antigen-binding polypeptides, that specifically bind to a first and a second target antigen with high affinity. The present invention also provides novel antigen-binding polypeptides that specifically bind to HER2 and antagonize HER2 activation. The invention also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen binding polypeptides. Methods of using antigen-binding polypeptide of the invention to treat disease, including cancer, are also encompassed by the invention.

Abstract: Embodiments of this application provide a data transmission method, a network device, and a terminal device. The method may include detecting, by a network device, a first signal in an uplink signal. The method may also include determining, by the network device, a signal structure of the uplink signal based on a result of detecting the first signal. Furthermore, the method may include receiving, by the network device, the uplink signal based on the signal structure, and/or responding to the uplink signal based on the signal structure. According to the data transmission method in the embodiments of this application, before receiving data, the network device can determine the signal structure, used by the terminal device, of the uplink signal, and then use a corresponding receiving method to avoid complexity and a reliability risk that are caused by completely blind detection performed by the network device.

Abstract: A processing device in a memory system connects a first data block of the memory device to a second data block of the memory device to generate a combined data block comprising a first plurality of sub-blocks of the first data block and a second plurality of sub-blocks of the second data block, wherein the connecting includes: for each wordline of a first plurality of wordlines of the first data block, creating a wordline connection short between the respective wordline of the first data block and a corresponding wordline of a second plurality of wordlines of the second data block, wherein the first plurality of wordlines and the second plurality of wordlines comprise data wordlines; and driving a first data wordline of the first data block and a second wordline of the second data block using a single string driver of the memory device.

Abstract: This application provides a transmit power control method, a terminal, a chip system, and a system. The method includes: A terminal connects to a 4G network device over an LTE link and connects to a 5G network device over an NR link, where transmit power of the NR link is first transmit power; determines to send a first data packet over the NR link, where the first data packet is a preset data packet; adjusts the first transmit power to second transmit power, where the second transmit power is greater than the first transmit power; and sends the first data packet at the second transmit power over the NR link.

Abstract: This application provides example methods for controlling an output power of an antenna for user equipment. One example method includes, during a sounding reference signal (SRS) transmission period, transmitting, by a first antenna of at least one antenna of the user equipment, a first SRS signal to a base station at a first SRS output power, where the first SRS output power is equal to a maximum output power (Pcmax) of the first antenna. During the SRS period, a non-SRS signal is transmitted to the base station at a non-SRS output power, where the non-SRS output power is less than a difference between the maximum output power of the first antenna and a maximum output power reduction of the first antenna, and the maximum output power reduction of the first antenna is set to meet an electromagnetic power density exposure requirement of the first antenna.

Abstract: A graphitization furnace with a rapid active cooling system is disclosed, including a furnace body and an active cooling system. The active cooling system is provided with at least one medium loop unit and a control unit for controlling a flow velocity of a medium in the medium loop unit, each medium loop unit includes a plurality of heat removal pipes pre-embedded in a furnace cavity of the furnace body, and each heat removal pipe is provided with a medium flow channel communicated with the medium loop unit. The graphitization furnace with a rapid active cooling system can realize rapid active cooling, short turnover time and high energy utilization efficiency of the graphitization furnace, and has wide applicability, which is not only suitable for construction of a new graphitization furnace, but also suitable for transformation of the existing Acheson graphitization furnace.

Abstract: The present disclosure relates to the field of the preparation of high purity sodium and the safe treatment of sodium calcium slag, and discloses a method and apparatus for sodium slag recovery by using gravity separation—controllable combustion—alkaline liquor leaching process for the preparation of high purity sodium and safe treatment of sodium calcium slag. The method comprises the following steps: (1) subjecting a liquid sodium slag to a gravity stratification to obtain pure metallic sodium and high calcium content sodium slag; (2) roasting the high calcium content sodium slag to obtain a roasting slag; and (3) leaching the roasting slag by using an alkaline liquor to obtain the sodium hydroxide solution and calcium hydroxide.

Abstract: Provided is a centrifugal heat dissipation fan including a housing and an impeller. The impeller is disposed in the housing. The impeller has a hub and multiple blades disposed surrounding the hub. Every two adjacent blades have different blade structures relative to the housing such that the blade structures pass by a fixed position of the housing and generate blade tones of varying frequencies when the impeller rotates.

Abstract: An integrated teaching system for interaction and examination of ear acupoints includes a placement table, and a mounting plate rotatably mounted on the placement table by a first connecting shaft. Two ear acupoint models are symmetrically mounted on two sides of the mounting plate, respectively. The system further includes a support frame and a second connecting shaft fixed on the support frame, the second connecting shaft is connected to the first connecting shaft by a gear set, the second connecting shaft is rotatably connected to a mounting frame fixed on the placement table, an end of the support frame away from the placement table is inserted into a fixing sleeve and is slidable along the fixing sleeve, a lifting drive part is disposed in the support frame and connected to the fixing sleeve, and the lifting drive part is connected to the mounting frame by a transmission part.

Abstract: The present disclosure relates to the field of non-ferrous metal and chemical industries for the production of metal sodium, and discloses a process for the preparation of high purity metallic sodium and the safe treatment of high calcium content sodium slag, the process comprises the following steps: (1) subjecting a liquid sodium obtained from electrolysis to a supergravity separation to obtain a high purity metallic sodium and a high calcium content sodium slag; (2) subjecting said high calcium content sodium slag to at least one roasting process to obtain a roasting slag; (3) leaching said roasting slag with an alkaline liquor to produce sodium hydroxide solution and calcium hydroxide. The process provided by the present disclosure not only greatly reduces the amount of generated sodium slag, but also implements the safe recovery of calcium and sodium resources from the sodium slag.

Abstract: The disclosure relates to a method for separating circulating free nucleic acid (e.g., circulating free DNA, cfDNA) from capillary blood sample (e.g., capillary blood plasma) and methods of determining and/or assessing the risk of cancer in a subject.

Abstract: The invention discloses an intelligent mobile patrol method, which comprises the following steps: an intelligent mobile device bound with NFC is used to identify the patrol task process; a patrol display point calls and displays the progress of the patrol task and the items inspected; according to the patrol items of the patrol display point, a mobile terminal is used to collect on-site photos, recordings, videos and other information to accumulate on-site visual data; the visual data obtained are uploaded for intelligent processing and analysis, and the historical patrol records are queried in real time to analyze the maintenance rate, missing inspection rate and equipment availability rate; and the patrol records of WIFI or network real-time record points are used to automatically import equipment exceptions into the missing library.

Abstract: Disclosed are a mercury cadmium telluride-black phosphorus van der Waals heterojunction infrared polarization detector and a preparation method thereof. The structure of the detector from bottom to top comprises a substrate, a mercury cadmium telluride material, an insulating layer, a two-dimensional semiconductor black phosphorus, and metal electrodes.

Abstract: Disclosed herein are kinase inhibitory compounds, such as a receptor-interacting protein-1 (RIP1) kinase inhibitor compounds, as well as pharmaceutical compositions and combinations comprising such inhibitory compounds. The disclosed compounds, pharmaceutical compositions, and/or combinations may be used to treat or prevent a kinase-associated disease or condition, particularly a RIP1-associated disease or condition.

Abstract: The disclosure discloses a large-aperture infrared metalens camera, which belongs to the technical field of infrared imaging and micro-nano photonics, including a large-aperture metalens, an infrared focal plane array detector, a metalens mechanical assembly and a housing. The large-aperture metalens has an aperture greater than 50 mm and a thickness less than 2 mm, and the distance between the large-aperture metalens and the infrared focal plane array detector is greater than 30 mm. The metalens mechanical assembly uses a buffer structure to fix, adjust and protect the metalens from shocks. The housing is sealed through a thermal insulation coating, thus providing heat insulation and waterproof protection for the lens.