Abstract: Provided are tumor-targeted protein degradation chimeras, termed chaperone-mediated protein degraders (CHAMPs) comprising a first moiety that is capable of binding to a target protein (e.g., KRAS(G12D) or proteins and a second moiety that is capable of binding a chaperone protein or proteins or protein component of chaperone complexes (e.g., HSP90). Pharmaceutical compositions comprising the disclosed CHAMPs and their uses for treating thereof, which are useful for treating cancers and related conditions are also provided.

Abstract: The provided is a temperature measurement method based on laser deflection induced by ultrasonic pulse. The method includes the following steps: S1, emitting a continuous laser beam by a continuous laser, and collimating the laser beam by a collimator; S2, the laser beam passes through a high-temperature gas to be measured; S3, the laser beam folds back and again passes through the high-temperature gas to be measured, and then received by a quadrant photodiode; S4, arranging a pulse ultrasonic generator in a vertical direction of the laser beam, and carrying out control by an ultrasonic generator control box; S5, the ultrasonic successively passes through the laser beams at different distances from the pulse ultrasonic generator, and obtaining a generated deflection position information of the laser beams by the quadrant photodiode; S6, analyzing the voltage signal of the quadrant photodiode obtained by step S5.

Abstract: The present invention provides a high-efficient magnesium ion removal system for salt lake brine based on in situ alkali production using bipolar membrane electrochemical process, it is constructed with cathode, cathode cell, anode, anode cell, and anion exchange membranes, bipolar membranes, acid cells, alkali cells, mesh materials for precipitate aggregation, acid-washing cells.

Abstract: Provided are small molecule inhibitors of the KRAS(G12D) mutant oncoprotein having the structural formula: and pharmaceutically acceptable salts and compositions thereof, which are useful for treating cancers and related conditions.

Abstract: The present invention belongs to the field of alkaline polymer electrolyte membranes, and relates to a comb-shaped structure polybenzimidazole anion exchange membrane with high conductivity and preparation method thereof. In the invention, firstly, polybenzimidazole is grafted with the non-cationic side chains to the max grafting rate to synthesize the de-protonated comb-shaped polybenzimidazole material, avoiding the N—H in benzimidazole forms ionic binding with cationic functional groups, which will reduce the reactivity and mobility of cationic groups; then react de-protonated comb-shaped polybenzimidazole with quaternization reagent to attach the pendent side chain with cationic functional groups, making it easy to aggregate to form ion clusters and hydrophilic/hydrophobic microphase separation. The anion exchange membrane prepared in this invention has excellent conductivity, mechanical properties and alkaline stability.

Abstract: Provided are small molecule inhibitors of the KRAS(G12D) mutant oncoprotein having the structural formula: R00F2C—L—R0 and pharmaceutically acceptable salts and compositions thereof, which are useful for treating cancers and related conditions.

Abstract: A separation and purification coupled process with a high helium yield and diversified products is provided. The process is as follows. Firstly, a low-concentration helium-containing gas after being pressurized and pre-treated enters a two-stage and two-section membrane separation unit to produce a helium product with a medium concentration by concentrating stage by stage through the membrane separation unit. A part of the helium with medium concentration enters an adsorption unit for further concentration to produce a helium product above grade A.

Abstract: A separation and purification coupled process with a high helium yield and diversified products is provided The process is as follows. Firstly, a low-concentration helium-containing gas after being pressurized and pre-treated enters a two-stage and two-section membrane separation unit to produce a helium product with a medium concentration by concentrating stage by stage through the membrane separation unit. A part of the helium with medium concentration enters an adsorption unit for further concentration to produce a helium product above grade A.

Abstract: The present invention belongs to the field of alkaline polymer electrolyte membranes, and relates to a comb-shaped structure polybenzimidazole anion exchange membrane with high conductivity and preparation method thereof. In the invention, firstly, polybenzimidazole is grafted with the non-cationic side chains to the max grafting rate to synthesize the de-protonated comb-shaped polybenzimidazole material, avoiding the N—H in benzimidazole forms ionic binding with cationic functional groups, which will reduce the reactivity and mobility of cationic groups; then react de-protonated comb-shaped polybenzimidazole with quaternization reagent to attach the pendent side chain with cationic functional groups, making it easy to aggregate to form ion clusters and hydrophilic/hydrophobic microphase separation. The anion exchange membrane prepared in this invention has excellent conductivity, mechanical properties and alkaline stability.

Abstract: A method for transmitting feed stream may include receiving, over a network, a request for transmitting feed stream to a user interface of an application installed in a terminal device, wherein the request is associated with one or more users of the terminal device and the user interface is to be displayed to the one or more users. The method may also include determining at least one operating control element to be displayed in the user interface, wherein the operating control element is selected from one or more pre-arranged control elements based on historical behavior data of the one or more users. The method may further include transmitting feed stream to the terminal device over the network, wherein the feed stream is configured to prompt the application to display the operating control element in the user interface of the application.

Abstract: The present invention provides a surface modification method based on the polymerization and cross-linking solidification of dopamine and/or its derivatives, which belongs to the technical field about composite material fabrication. The principle of dopamine polymerization and the formation process of polydopamine coating layer are the foundation of the present invention. This innovative method is established after deeply analyzing the failure mechanism of polydopamine coating layer in severe environments, such as organic solvents and acidic/alkalic environments. The critical work is finding out an eligible cross-linking agent which could react with the active functional groups in polydopamine. After cross-linking reaction, the soluble low-molecular-weight dopamine oligomers could be transformed into the insoluble three-dimensional stereographic networks.

Abstract: Embodiments of this application provide a near-field wireless communication service processing method performed at a first computing device associated with a social networking application. While running a social networking application, the first computing device detects a near-field wireless communication signal broadcasted by a second computing device associated with a service provider account registered with the social networking application.

Abstract: Embodiments of this application provide a near-field wireless communication service processing method performed at a first computing device associated with a social networking application. While running a social networking application, the first computing device detects a near-field wireless communication signal broadcasted by a second computing device associated with a service provider account registered with the social networking application.

Abstract: Embodiments of this application provide a near-field wireless communication service processing method performed at a first computing device. While running a social networking application, the first computing device listens to a near-field wireless communication signal broadcasted by a second computing device. After detecting the near-field wireless communication signal broadcasted by the second computing device, first computing device processes the near-field wireless communication signal to obtain identification information associated with the second computing device. The first computing device sends the identification information associated with the second computing device to a remote server supporting the social networking application and obtains a preset service page corresponding to the identification information associated with the second computing device from the server, and displays the preset service page within the social networking application on the first computing device.

Abstract: The present invention provides a surface modification method based on the polymerization and cross-linking solidification of dopamine and/or its derivatives, which belongs to the technical field about composite material fabrication. The principle of dopamine polymerization and the formation process of polydopamine coating layer are the foundation of the present invention. This innovative method is established after deeply analyzing the failure mechanism of polydopamine coating layer in severe environments, such as organic solvents and acidic/alkalic environments. The critical work is finding out an eligible cross-linking agent which could react with the active functional groups in polydopamine. After cross-linking reaction, the soluble low-molecular-weight dopamine oligomers could be transformed into the insoluble three-dimensional stereographic networks.

Abstract: Embodiments of this application provide a near-field wireless communication service processing method performed at a first computing device. While running a social networking application, the first computing device listens to a near-field wireless communication signal broadcasted by a second computing device. After detecting the near-field wireless communication signal broadcasted by the second computing device, first computing device processes the near-field wireless communication signal to obtain identification information associated with the second computing device. The first computing device sends the identification information associated with the second computing device to a remote server supporting the social networking application and obtains a preset service page corresponding to the identification information associated with the second computing device from the server, and displays the preset service page within the social networking application on the first computing device.

Abstract: A method of forming a keyword based search query that uses a plurality of keywords, in which the keywords of the query are arranged into groups of purpose-related keywords, in which each keyword is associated with a designation of its relative importance. The keywords of a group may be identified manually by the searcher, or existing keywords in a group may be used to suggest or automatically add additional related keywords to the group. The keywords of a group need not be semantically related, but only related to a common purpose of the keyword group. Additional keywords can be suggested to the searcher, or automatically added to the groups. Suitable additional keywords may be identified by reference to previous searches in which the existing keywords were grouped with those additional keywords. Keywords may also be derived from text designated by the searcher, using all or portions of one or more documents or text blocks that the user identifies as describing a concept of interest to the searcher.

Abstract: The invention discloses an information processing method, the method including: obtaining by the first sensor a first movement input of a first operating body located on the side of the frame structural body and a second movement input of a second operating body located on the side of the frame structural body; determining whether the first movement input and the second movement input satisfy a predetermined condition, wherein the predetermined condition is that a movement direction of the first operating body and a movement direction of the second operating body are consistent with respect to the sensing area; generating a control instruction when the first movement input and the second movement input satisfy the predetermined condition; and controlling a display interface on the display screen in response to the control instruction.

Abstract: The present disclosure provides information processing methods and electronic devices in view of the problem in the conventional technology that accuracy of adjusting parameters via voice input is low. The information processing method is applied in an electronic device comprising an output unit.

Abstract: A spindle motor component of hard disk with composite coating layer and a composite coating method hereof. The spindle motor component of hard disk includes a motor component base (1) and the composite coating layer which is coated on the base (1). The composite coating layer consists of an electrodepositing coating layer (2) and a spraying coating layer (3). The composite coating method includes a step of coating the electrodepositing coating layer (2) on the surface of the motor component base (1) and coating the spraying coating layer (3) on the electrodepositing coating layer (2), wherein the weight ratio of tin in the electrodepositing coating layer (2) is between 60 ppm to 300 ppm and the weight ratio of tin in the spraying coating layer (3) is no more than 50 ppm.