Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

Abstract: A scene-based beam generation method for ground-to-air coverage based on convex polygon subdivision is provided and includes: obtaining a collection of base station positions by using a method of universal transverse mercator projection; constructing a three-dimensional (3D) low altitude signal coverage area; performing convex polygon subdivision on the area to be covered; and generating a beam configuration of each base station. The method realizes generation of beam configurations of base stations in the 3D low altitude signal coverage area, overcomes a problem that the existing 17 kind of scene-based beams cannot realize the coverage of 3D area, overcomes a problem of mismatch between network state information and beam configuration caused by dynamic adjustment of beam configurations. The beam configurations generated by the method does not need to obtain the number of users in real time to adjust the beam, and has a good coverage ability.

Abstract: The present invention relates to a monitoring apparatus for monitoring an ablation procedure. The monitoring apparatus comprises an ultrasound signal providing unit for providing an ultrasound signal that depends on received echo series of an object that is ablated. The monitoring apparatus further comprises an ablation depth determination unit for determining an ablation depth from the provided ultrasound signal. The ablation depth can be determined directly from the ultrasound signal and is an important parameter while performing an ablation procedure. For example, it can be used for determining the progress of ablation within the object and for determining when the ablation has reached a desired progression.

Abstract: An online trimming device and method for a micro-shell resonator gyroscope is provided. A micro-shell resonator gyroscope fixing fixture and a mode test circuit in the device are placed in a vacuum test cavity provided with a circuit interface. The mode test circuit and a host computer are connected through a circuit interface on the vacuum test cavity. The gyroscope fixing fixture is provided with a signal interface, and the electrodes on the gyroscope substrate are connected to the signal interface. The signal interface on the fixture is connected to the mode test circuit. The laser etching module is located at the top of the device. An opening is formed in the gyroscope fixing fixture. The vacuum test cavity is provided with a transparent trimming window. The laser acts on the edge of the resonant structure of the gyroscope through the trimming window and the through hole of the fixture.

Abstract: Provided are a T cell deleting the Ryr2 gene and a preparation method. Also provided are an Ryr2 antagonist, an Ryr2 overexpressing T cell, a method and applications for regulating Ryr2 expression, regulating basal Ca2+ oscillation, regulating m-Calpain activity, and increasing bonding strength between T cells and DC cells, applications of a reagent implementing the functions in preparing a medicament for treating an infectious disease, inflammation, or tumor, and a method for transforming Tconv cells into being functionally similar to Treg cells.

Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

Abstract: A method for making a soft carbon includes providing a coke, and subjecting the coke to a carbonization process. The carbonization process includes a preliminary calcination treatment conducted by calcining the coke at a first temperature ranging from 800° C. to 1000° C. to obtain a pre-calcinated coke, followed by a main calcination treatment conducted by calcining the pre-calcinated coke at a second temperature ranging from 1000° C. to 1200° C., and/or a surface-modifying calcination treatment conducted by calcining the pre-calcinated coke in the presence of a carbonaceous material for modifying surfaces thereof at a third temperature ranging from 1000° C. to 1200° C. A soft carbon made by the method is also disclosed.

Abstract: A large-scale network node simulation method based on Linux container is provided, which solves problems of low packet transmission efficiency and multi-thread creation in real-time simulation in a large-scale network scenario. The method includes: scheduling all container nodes in a scenario; managing, by a container node, a dynamic thread through an idle thread management queue, and setting a finite state machine and a function pointer for the dynamic thread; registering, by a source container node, an output queue with a next-hop container node, and informing the next-hop container node to allocate a dynamic thread for receiving and processing the output queue. Packet transmission is realized between the container nodes through data units created in a shared memory. The sending thread and the receiving thread dynamically adjust the number of dynamic threads by checking the state of the output queue.

Abstract: A scene-based beam generation method for ground-to-air coverage based on convex polygon subdivision is provided and includes: obtaining a collection of base station positions by using a method of universal transverse mercator projection; constructing a three-dimensional (3D) low altitude signal coverage area; performing convex polygon subdivision on the area to be covered; and generating a beam configuration of each base station. The method realizes generation of beam configurations of base stations in the 3D low altitude signal coverage area, overcomes a problem that the existing 17 kind of scene-based beams cannot realize the coverage of 3D area, overcomes a problem of mismatch between network state information and beam configuration caused by dynamic adjustment of beam configurations. The beam configurations generated by the method does not need to obtain the number of users in real time to adjust the beam, and has a good coverage ability.

Abstract: A method for inducing reprogramming of a cell of a first type which is not a non-hepatocyte (non-hepatocyte cell), into a cell with functional hepatic drug metabolizing and transporting capabilities, is disclosed. The non-hepatocyte is induced to express or overexpress hepatic fate conversion and maturation factors, cultured in somatic cell culture medium, hepatocyte cell culture medium and hepatocyte maturation medium for a sufficient period of time to convert the non-hepatocyte cell into a cell with hepatocyte-like properties. The iHeps induced according to the methods disclosed herein are functional induced hepatocytes (iHeps) in that they express I and II drug-metabolizing enzymes and phase III drug transporters and show superior drug metabolizing activity compared to iHeps obtained by prior art methods. The iHeps thus provide a cell resource for pharmaceutical applications.

Abstract: The present disclosure relates to a device configured to move within a body cavity, such as the gastrointestinal tract, in particular, the small intestine, and methods of using the device. The presently disclosed device may be self-driving, e.g., through the use of one or more traction-motion element, and the articulation of a tip of the device may be controlled and fine tuned. The presently disclosed device may be used in a variety of body cavities such as a vascular body lumen, a digestive body lumen, a respiratory body lumen, or a urinary body lumen, for example, for endoscopic purposes, for delivering a substance into the body cavity, for removing a substance or tissue from the body cavity, for capturing an image of the body cavity, and/or for performing an operation of a tissue or organ using the device.

Abstract: Use of a TNFR1-FADD-caspase8-caspase3 pathway inhibitor in preparation of a medicament for treating an immune system related disease caused by autoinducer, a method for screening a medicament for treating an immune system related disease caused by autoinducer and a method for treating an immune system related disease.

Abstract: The present invention discloses a method for enhancing the recovery factor of heavy oil by in-situ oil-water emulsion with high phase inversion point, and the method is aimed at the development of heavy oil reservoir by water injection under the condition that the performance parameters of crude oil emulsion meet the following three specific requirements: (A) The viscosity of the crude oil is less than 6,000 mPa·s; (B) At the reservoir temperature, the phase inversion point of the crude oil emulsion is greater than or equal to 70%, and the emulsion viscosity corresponding to the phase inversion point is 2-6 times of the crude oil viscosity; (C) At the reservoir temperature, when the water cut is less than or equal to the phase inversion point, the flow rate ratio of crude oil emulsion to crude oil is 0.2 to 0.9.

Abstract: The present invention discloses a method for enhancing the recovery factor of heavy oil by in-situ oil-water emulsion with high phase inversion point, and the method is aimed at the development of heavy oil reservoir by water injection under the condition that the performance parameters of crude oil emulsion meet the following three specific requirements: (A) The viscosity of the crude oil is less than 6,000 mPa·s; (B) At the reservoir temperature, the phase inversion point of the crude oil emulsion is greater than or equal to 70%, and the emulsion viscosity corresponding to the phase inversion point is 2-6 times of the crude oil viscosity; (C) At the reservoir temperature, when the water cut is less than or equal to the phase inversion point, the flow rate ratio of crude oil emulsion to crude oil is 0.2 to 0.9.

Abstract: The disclosure relates to an apparatus and a method for controlling an image sensor, a storage medium, and a movable object. The apparatus for controlling an image sensor includes: a data obtaining unit configured to obtain parameter data related to one or more moving scenarios; and an instruction generation unit configured to generate, based on the parameter data, an instruction for controlling operation modes of the image sensor, where the moving scenarios are scenarios in which a movable object with the image sensor is located; and the operation modes correspond to setting manners of active pixels of the image sensor. According to the solutions of one or more embodiments of the disclosure, different operation modes are set for the image sensor in different scenarios, so that while sensing requirements in different scenarios are met, the power consumption can be reduced and requirements for a system can be lowered as far as possible.

Abstract: Hierarchical network operation and resource control system and method for a mega satellite constellation, belonging to the field of spatial information technology, are provided. The hierarchical network operation and resource control system includes a service layer, a global organization layer, a local coordination layer and a resource layer. The service layer is used as an input to drive operation of whole system. The global organization layer is to realize “operation, measurement and control” integrated control and decision of whole network. The local coordination layer is to realize local management decision and management slice generation. The resource layer is to provide physical resource and physical device and realize resource virtualization.

Abstract: Lightweight inter-satellite handover device and method for a mega LEO satellite network are provided. An attribute extraction sub-module extracts attributes of handover users in a user information storage unit. Based on the attributes of the handover users, a cluster sub-module clusters the handover users into user clusters. A decision set generator sub-module generates target satellite sets of the user clusters, determines each target satellite of the target satellite sets of the user clusters of each LEO satellite whether belongs to LEO satellites in a management domain of a handover decision point of managing the LEO satellite based on management domain information in a LEO satellite information storage unit, and if YES, performing inter-satellite handover by a centralized decision unit, otherwise performing inter-satellite handover by a distributed decision unit.

Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

Abstract: An ultrasonic diagnostic imaging system produces an image of shear wave velocities by transmitting push pulses to generate shear waves. A plurality of tracking lines are transmitted and echoes received by a focusing beamformer adjacent to the location of the push pulses. The tracking lines are sampled in a time-interleaved manner. The echo data acquired along each tracking line is processed to determine the time of peak tissue displacement caused by the shear waves at points along the tracking line, and the times of peaks at adjacent tracking lines compared to compute a local shear wave velocity. The resultant map of shear wave velocity values is color-coded and displayed over an anatomical image of the region of interest.

Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.