Patents by Inventor Yan Shi
Yan Shi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9018018Abstract: The invention relates to a method and a device for determining the cell activation of a target cell by an activator, said method having the following steps: provision of a probe measuring device with a probe sample arrangement having a measuring probe and a sample holder; loading of the probe sample arrangement with a target cell and with an activator assigned to the target cell, the measuring probe being loaded with the activator, and the sample holder being loaded with the target cell, or vice versa; relative mutual displacement of the measuring probe and the sample holder until contact is made between the target cell and the activator by means of a displacement apparatus of the probe measuring device; recording of measurement values, indicating binding between the target cell and the activator, for the measuring probe with the probe measuring device during the relative displacement of the measuring probe and the sample holder; and determination of a dimension for the cell activation of the target cell fromType: GrantFiled: June 17, 2009Date of Patent: April 28, 2015Assignee: JPK Instruments AGInventors: Matthias Amrein, Yan Shi
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Publication number: 20140088418Abstract: Functional imaging for localization in biological tissue entails measuring a response in the tissue (240) to electromagnetic radiation. A catheter (200) for real-time monitoring of cardiac ablation is employed to distinguish a hemorrhage zone (232) from the sandwiching necrotic and healthy tissue, or to distinguish exogenous photoacoustic contrast agent from bordering native tissue. A pair of wavelengths is selected for differential absorption (244) of the radiation in, correspondingly, the hemorrhage zone or where the contrast agent exists, and relatively similar absorption elsewhere. Near infrared laser or LED light may be used photoacoustically to serially acquire (S310, S320) the two datasets to be compared, each representative of a time waveform. Alternatively, acquisition is for a pair of wavelength bands of microwave-induced thermoacoustic data.Type: ApplicationFiled: March 27, 2012Publication date: March 27, 2014Applicant: KONINKLIJKE PHILIPS N.V.Inventors: Emil Radulescu, Sheng-Wen Huang, Ramon Erkamp, Ladislav Jankovic, Yan Shi, Khalid Shahzad
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Patent number: 8614332Abstract: Compounds are provided which are phosphonate and phosphinate activators and thus are useful in treating diabetes and related diseases and have the structure is a heteroaryl ring; R4 is —(CH2)n—Z—(CH2)m—PO(OR7)(OR8), —(CH2)nZ—(CH2)m—PO(OR7)R9, —(CH2)n—Z—(CH2)m—OPO(OR7)R9, —(CH2)nZ—(CH2)m—OPO(R9)(R10), or —(CH2)nZ—(CH2)m—PO(R9)(R10); R5 and R6 are independently selected from H, alkyl and halogen; Y is R7(CH2)s or is absent; and X, n, Z, m, R4, R5, R6, R7, and s are as defined herein; or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.Type: GrantFiled: February 15, 2012Date of Patent: December 24, 2013Assignee: Bristol-Myers Squibb CompanyInventors: Denis E. Ryono, Peter T. W. Cheng, Scott A. Bolton, Sean Chen, Yan Shi, Wei Meng, Joseph A. Tino, Richard B. Sulsky
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Patent number: 8597664Abstract: Methods of modulating the immune response using pharmaceutical compositions containing crystalline adjuvants are described. In various embodiments the crystalline adjuvants are selected from the group consisting of monosodium urate (MSU), xanthine, basic calcium phosphate (BCP), calcium pyrophosphate dihydrate (CPPD), hydroxyapatite, calcium oxalate, cholesterol, lipid liquid, other crystalline lipids, lithium heparin, talc, and starch.Type: GrantFiled: September 10, 2010Date of Patent: December 3, 2013Assignee: University of MassachusettsInventors: Kenneth L. Rock, Yan Shi
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Publication number: 20130317362Abstract: The weighted-average-based position (244) in the temporal domain is computed based on the sampling of shear wave displacement (226) along the propagation path. The weighting is, for example, by displacement observed at times (230) corresponding to sampling and represents the time of arrival of the shear wave at the shear-wave propagation path location being sampled. In some embodiments, the computed shear-wave times of arrival at respective locations are functionally related to known inter-location distances (250) to derive shear-wave group velocity. The derived velocity can serve as input into known algorithms for estimating shear elasticity of the medium, such as body tissue, for purposes of clinical diagnosis and therapy assessment.Type: ApplicationFiled: December 19, 2011Publication date: November 28, 2013Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Yan Shi, Hua Xie, Roy Peterson, Jean-Luc Robert, Vijay Shamdasani
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Publication number: 20130273536Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.Type: ApplicationFiled: March 14, 2013Publication date: October 17, 2013Inventors: Yan Shi, Caroline Desponts, Sheng Ding, Hongyan Zhou, Tongxiang Lin, Wenlin Li, Saiyong Zhu
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Publication number: 20130131511Abstract: An ultrasonic diagnostic imaging system produces an image of shear wave velocities by transmitting push pulses to generate shear waves. A plurality of tracking lines are transmitted and echoes received by a focusing beamformer adjacent to the location of the push pulses. The tracking lines are sampled in a time-interleaved manner. The echo data acquired along each tracking line is processed to determine the time of peak tissue displacement caused by the shear waves at points along the tracking line, and the times of peaks at adjacent tracking lines compared to compute a local shear wave velocity. The resultant map of shear wave velocity values is color-coded and displayed over an anatomical image of the region of interest.Type: ApplicationFiled: November 15, 2010Publication date: May 23, 2013Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Roy Beck Peterson, Yan Shi, Hua Xie, Jean-Luc Robert, Vijay Shamdasani, Robert Randall Entrekin, Anna Teresa Fernandez
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Patent number: 8410782Abstract: A switch testing circuit is configured for testing a switch. The switch testing circuit includes a switch element, a first light emitting diode, and a control chip. The first light emitting diode, the switch element, and the switch are connected in series. The first light emitting diode is configured for indicating connection condition between the switch and the switch testing circuit. The control chip is configured for acquiring a voltage from one terminal of the switch element and comparing the acquired voltage with a comparison voltage to judge whether the switch is qualified or disqualified according to the comparison result.Type: GrantFiled: June 21, 2010Date of Patent: April 2, 2013Assignees: Hong Fu Jin Precision Industry (ShenZhen) Co., Ltd., Hon Hai Precision Industry Co., Ltd.Inventor: Yan Shi
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Publication number: 20120287750Abstract: The invention relates to an imaging apparatus (1) for imaging an interior of an object (2). The imaging apparatus (1) comprises a first ultrasound sensor and a second ultrasound sensor for sensing the interior of the object at different frequencies, wherein the ultrasound sensing signals from the first ultrasound sensor are used for generating a first ultrasound image and a the ultrasound sensing signals from the second ultrasound sensor are used for generating a second ultrasound image. A larger frequency generally provides a smaller depth of penetrating the interior of the object and a larger spatial resolution than a smaller frequency. The imaging apparatus (1) can therefore provide the capability of simultaneously imaging the interior of the object with different spatial resolutions and at different penetration depths. This allows the imaging apparatus to improve the quality of imaging the interior of the object.Type: ApplicationFiled: January 12, 2011Publication date: November 15, 2012Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Szabolcs Deladi, Nenad Mihajlovic, Drazenko Babic, Jan Suijver, Yan Shi
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Patent number: 8273777Abstract: Compounds are provided which are activators of the enzyme glucokinase and thus are useful in treating diabetes and related diseases, which compounds have the structure where Q is and R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.Type: GrantFiled: August 30, 2010Date of Patent: September 25, 2012Assignee: Bristol-Meyer Squibb CompanyInventors: Yan Shi, Peter T. W. Cheng, Ying Wang, Denis E. Ryono
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Patent number: 8233221Abstract: An adjustable fluid type lens system is provided that allows e.g. ultrasound imaging through the lens during adjustment of the lens. The lens includes a container enclosing two immiscible fluids, e.g. water and oil, being in contact with each other at an interface. Incoming waves are then refracted at this interface. The shape of the interface, and thereby the refraction property, is adjustable by adjusting a voltage applied to the lens. The two fluids are selected such that they together exhibit a mechanical damping which is critical or near critical. A control circuit generates the electric voltage for adjusting the refraction from one value to another, the control circuit being arranged to change the electric voltage such that a rate of voltage change is limited to avoid oscillation of the interface, thereby adjusting refraction of incoming waves at the interface in a continuous manner.Type: GrantFiled: December 10, 2008Date of Patent: July 31, 2012Assignee: Koninklijke Philips Electronics N.V.Inventors: Jan Frederik Suijver, Christopher Stephen Hall, Anna Teresa Fernandez, Stein Kuiper, Yan Shi
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Publication number: 20120142636Abstract: Compounds are provided which are phosphonate and phosphinate activators and thus are useful in treating diabetes and related diseases and have the structure is a heteroaryl ring; R4 is —(CH2)n—Z—(CH2)m—PO(OR7)(OR8), —(CH2)nZ—(CH2)m—PO(OR7)R9, —(CH2)n—Z—(CH2)m—OPO(OR7)R9, —(CH2)nZ—(CH2)m—OPO(R9)(R10), or —(CH2)nZ—(CH2)m—PO(R9)(R10); R5 and R6 are independently selected from H, alkyl and halogen; Y is R7(CH2)s or is absent; and X, n, Z, m, R4, R5, R6, R7, and s are as defined herein; or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.Type: ApplicationFiled: February 15, 2012Publication date: June 7, 2012Inventors: Denis E. Ryono, Peter T.W. Cheng, Scott A. Bolton, Sean Chen, Yan Shi, Wei Meng, Joseph A. Tino, Richard B. Sulsky
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Patent number: 8153677Abstract: Compounds are provided which are phosphonate and phosphinate activators and thus are useful in treating diabetes and related diseases and have the structure wherein is a heteroaryl ring; R4 is —(CH2)n—Z—(CH2)m—PO(OR7)(OR8), —(CH2)nZ—(CH2)m—OPO(OR7)R9, —(CH2)nZ—(CH2)m—OPO(R9)(R10), or —(CH2)nZ—(CH2)m—PO(R9)(R10); R5 and R6 are independently selected from hydrogen, alkyl and halogen; Y is R7(CH2)s or is absent; and X, n, Z, m, R4, R5, R6, R7, and s are as defined herein; or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.Type: GrantFiled: January 24, 2011Date of Patent: April 10, 2012Assignee: Bristol-Myers Squibb CompanyInventors: Denis E. Ryono, Peter T. W. Cheng, Scott A. Bolton, Sean Chen, Yan Shi, Wei Meng, Joseph A. Tino, Richard B. Sulsky
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Publication number: 20120004547Abstract: The present invention relates to a monitoring apparatus (101) for monitoring an ablation procedure. The monitoring apparatus (101) comprises an ultrasound signal providing unit for providing an ultrasound signal that depends on received echo series of an object (4) that is ablated. The monitoring apparatus (101) further comprises an ablation depth determination unit (103) for determining an ablation depth from the provided ultrasound signal. The ablation depth can be determined directly from the ultrasound signal and is an important parameter while performing an ablation procedure. For example, it can be used for determining the progress of ablation within the object (4) and for determining when the ablation has reached a desired progression.Type: ApplicationFiled: January 8, 2010Publication date: January 5, 2012Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Erik Harks, Szabolcs Deladi, Jan Frederik Suijver, Ladislav Jankovic, Yan Shi, Wouter Harry Jacinth Rensen, Maya Barley, Nijs Cornelis Van Der Vaart
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Publication number: 20110269336Abstract: An electrical equipment system may include a battery for an electrical power tool, an electrical equipment except for the electrical power tool, and an adapter that is capable of electrically and mechanically connecting the battery and the electrical equipment. The adapter has a battery side connecting portion that is capable of being detachably connected to the battery and an electrical equipment side connecting portion that is capable of being connected to the electrical equipment.Type: ApplicationFiled: April 18, 2011Publication date: November 3, 2011Applicant: MAKITA CORPORATIONInventors: Tomonobu NASHIMOTO, Yan SHI, Kenji ABE, Munetoshi GOTO
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Publication number: 20110254556Abstract: A switch testing circuit is configured for testing a switch. The switch testing circuit includes a switch element, a first light emitting diode, and a control chip. The first light emitting diode, the switch element, and the switch are connected in series. The first light emitting diode is configured for indicating connection condition between the switch and the switch testing circuit. The control chip is configured for acquiring a voltage from one terminal of the switch element and comparing the acquired voltage with a comparison voltage to judge whether the switch is qualified or disqualified according to the comparison result.Type: ApplicationFiled: June 21, 2010Publication date: October 20, 2011Applicants: HON HAI PRECISION INDUSTRY CO., LTD., HONG FU JIN PRECISION INDUSTRY (ShenZhen) CO., LTD.Inventor: YAN SHI
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Publication number: 20110123566Abstract: Methods of modulating the immune response using pharmaceutical compositions containing crystalline adjuvants are described. In various embodiments the crystalline adjuvants are selected from the group consisting of monosodium urate (MSU), xanthine, basic calcium phosphate (BCP), calcium pyrophosphate dihydrate (CPPD), hydroxyapatite, calcium oxalate, cholesterol, lipid liquid, other crystalline lipids, lithium heparin, talc, and starch.Type: ApplicationFiled: September 10, 2010Publication date: May 26, 2011Applicant: The University of Massachusetts an agency of the Commonwealth of MassachusettsInventors: Kenneth L. ROCK, Yan SHI
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Publication number: 20110118211Abstract: Compounds are provided which are phosphonate and phosphinate activators and thus are useful in treating diabetes and related diseases and have the structure wherein is a heteroaryl ring; R4 is —(CH2)n—Z—(CH2)mPO(OR7)(OR8), —(CH2)nZ—(CH2)m—PO(OR7)R9, —(CH2)n—Z—(CH2)m—OPO(OR7)R9, —(CH2)nZ—(CH2)m—OPO(R9)(R10), or —(CH2)nZ—(CH2)m—PO(R9)(R10); R5 and R6 are independently selected from H, alkyl and halogen; Y is R7(CH2)s or is absent; and X, n, Z, m, R4, R5, R6, R7, and s are as defined herein; or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.Type: ApplicationFiled: January 24, 2011Publication date: May 19, 2011Inventors: Denis E. Ryono, Peter T.W. Cheng, Scott A. Bolton, Sean Chen, Yan Shi, Wei Meng, Joseph A. Tino, Richard B. Sulsky
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Publication number: 20110110899Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.Type: ApplicationFiled: March 17, 2009Publication date: May 12, 2011Applicant: SCRIPPS RESEARCH INSTITUTEInventors: Yan Shi, Caroline Desponts, Sheng Ding, Hongyan zhou, Tongxiang Lin, Wenlin Li, Saiyong Zhu
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Patent number: 7910747Abstract: Pyrazoloamides are provided which are phosphonate and phosphinate glucokinase activators that are useful in treating diabetes and related diseases and have the structure wherein is a pyrazoyl ring; R4 is —(CH2)n—Z—(CH2)m—PO(OR7)(OR8), —(CH2)nZ—(CH2)m—PO(OR7)R9, or —(CH2)nZ—(CH2)m—PO(R9)(R10); R5 and R6 are independently selected from H, alkyl and halogen; Y is R3(CH2)s, wherein R3 is aryl , s is 0, X is a bond; and n, Z, m, R4, R5, R6, and R7 are as defined herein; or a pharmaceutically acceptable salt thereof.Type: GrantFiled: June 28, 2007Date of Patent: March 22, 2011Assignee: Bristol-Myers Squibb CompanyInventors: Denis E. Ryono, Peter T. W. Cheng, Scott A. Bolton, Sean Chen, Yan Shi, Wei Meng, Joseph A. Tino