Abstract: A method and device for displacing fluid from a reagent cartridge (310) into a microfluidic device (320) and for loading the fluid into the reagent cartridge (310). The reagent cartridge (310) may include a cartridge body and a pipette array with pipette tips (315) to engage inlets of a microfluidics or other cartridge, wherein the pipette tips (315) correspond in position to the plurality of inlets (325) of the microfluidic device (320). Fluid may be loaded into or displaced from the microfluidic device (320) by a system of plungers (615). The reagent cartridge may alternatively include blisters (925) having fluid reservoirs and dispensing tips (930), each dispensing tip (930) including a pathway (927) that is fluidly coupled to a blister (925). The fluid may be displaced from or loaded into the blister (925) via the dispensing tip (930). A deformable seal (910) may be overlaid on the blisters (925) to seal the volumes of fluid within the blisters (925), and may be deformed to displace the fluid.

Abstract: Implementations of a method for seeding sequence libraries on a surface of a sequencing flow cell that allow for spatial segregation of the libraries on the surface are provided. The spatial segregation can be used to index sequence reads from individual sequencing libraries to increase efficiency of subsequent data analysis. In some examples, hydrogel beads containing encapsulated sequencing libraries are captured on a sequencing flow cell and degraded in the presence of a liquid diffusion barrier to allow for the spatial segregation and seeding of the sequencing libraries on the surface of the flow cell. Additionally, examples of systems, methods and compositions are provided relating to flow cell devices configured for nucleic acid library preparation and single cell sequencing. Some examples include flow cell devices having a hydrogel with genetic material disposed therein, and which is retained within the hydrogel during nucleic acid processing.

Abstract: An electrophoretic display able to operate on a reduced power supply includes a display panel and a driving circuit electrically connected to the display panel. The display panel includes a plurality of first electrophoretic particles and a plurality of second electrophoretic particles. The driving circuit is configured to provide a balance signal to the display panel during a balance period, provide a mixed signal to the display panel during a mixing period, and provide a driving signal to the display panel during a coloring period. The balance period, the mixing period, and the coloring period are sequential in time, and a preset time interval is between each of the periods.

Abstract: The present disclosure provides an electromagnetic imaging device for an active microwave and millimeter wave security inspection apparatus, including: a two-dimensional multiple-input multiple-output array panel including at least one sub-array, wherein each sub-array includes a plurality of transmitting antennas arranged linearly and a plurality of receiving antennas arranged linearly, the plurality of transmitting antennas arranged linearly being intersected with the plurality of receiving antennas arranged linearly; a signal processing device; a display device; and a ranging radar. In each sub-array, a midpoint of a connection line between each transmitting antenna and a corresponding receiving antenna serves as a virtual equivalent phase center of a pair of the each transmitting antenna and the corresponding receiving antenna, and the plurality of transmitting antennas and the plurality of receiving antennas are arranged to generate an equivalent phase center web.

Abstract: A method for forming sequencing flow cells can include providing a semiconductor wafer covered with a dielectric layer, and forming a patterned layer on the dielectric layer. The patterned layer has a differential surface that includes alternating first surface regions and second surface regions. The method can also include attaching a cover wafer to the semiconductor wafer to form a composite wafer structure including a plurality of flow cells. The composite wafer structure can then be singulated to form a plurality of dies. Each die forms a sequencing flow cell. The sequencing flow cell can include a flow channel between a portion of the patterned layer and a portion of the cover wafer, an inlet, and an outlet. Further, the method can include functionalizing the sequencing flow cell to create differential surfaces.

Abstract: A keyboard overlay film forming a plurality of keycap accommodating cavities and a key-gap space, the key-gap space surrounding the keycap accommodating cavities, and the keycap accommodating cavities respectively including a key projection surface, wherein the keyboard overlay film includes a top protective layer; a character layer located on a side of the top protective layer forming the keycap accommodating cavities, and the character layer includes a plurality of light-transparent characters respectively corresponding to the key projection surface of the keycap accommodating cavities; a set of touch electrodes located on a side of the character layer opposite to the top protective layer; and a lower protective layer located on a side of the set of touch electrodes opposite to the character layer.

Abstract: In accordance with embodiments herein a method for capturing cells of interest in a digital microfluidic system is provided, comprising utilizing a droplet actuator to transport a sample droplet to a microwell device. The microwell device includes a substrate having a plurality of microwells that open onto a droplet operations surface of the microwell device. The sample droplet includes cells of interest that enter the microwells. The method introduces capture beads to the microwells, and the capture elements are immobilized on the capture beads. The method utilizes the droplet actuator to transport a cell lysis reagent droplet to the microwell device. Portions of the cell lysis reagent droplet enter the microwells and, during an incubation period, cause the cells of interest to release analyte that is captured by the capture elements on the capture beads.

Abstract: Implementations of a method for seeding sequence libraries on a surface of a sequencing flow cell that allow for spatial segregation of the libraries on the surface are provided. The spatial segregation can be used to index sequence reads from individual sequencing libraries to increase efficiency of subsequent data analysis. In some examples, hydrogel beads containing encapsulated sequencing libraries are captured on a sequencing flow cell and degraded in the presence of a liquid diffusion barrier to allow for the spatial segregation and seeding of the sequencing libraries on the surface of the flow cell. Additionally, examples of systems, methods and compositions are provided relating to flow cell devices configured for nucleic acid library preparation and single cell sequencing. Some examples include flow cell devices having a hydrogel with genetic material disposed therein, and which is retained within the hydrogel during nucleic acid processing.

Abstract: Embodiments provided herewith are directed to self-assembled methods of preparing a patterned surface for sequencing applications including, for example, a patterned flow cell or a patterned surface for digital fluidic devices. The methods utilize photolithography to create a patterned surface with a plurality of microscale or nanoscale contours, separated by hydrophobic interstitial regions, without the need of oxygen plasma treatment during the photolithography process. In addition, the methods avoid the use of any chemical or mechanical polishing steps after the deposition of a gel material to the contours.

Abstract: An apparatus (100) including multiple biological chips (110,120) includes a substrate (101), a first adhesive layer (134) disposed on the substrate (101), a first biological chip (110) and a second biological chip (120) disposed on the first adhesive layer (134) and attached to the substrate (101) by the adhesive layer (134). The apparatus (100) further includes a filler (130) disposed between the first biological chip (110) and the second biological chip (120). The filler (130) includes a second adhesive layer (135) extending between a side surface (114) of the first biological chip (110) and a side surface (124) of the second biological chip (120), the second adhesive layer (135) attaching the first biological chip (110) to the second biological chip (120). The filler (130) also includes a surface layer (132) disposed over the second adhesive layer (135).

Abstract: A terahertz security inspection robot is provided, including: a housing including a main housing and a head housing rotatably connected to the main housing; a terahertz wave imaging mechanism including a mirror assembly arranged in the head housing and a detector array arranged in the main housing; and a rotating mechanism configured to cause the head housing and the mirror assembly located in the head housing to rotate with respect to the main housing, so that the mirror assembly of the terahertz wave imaging mechanism is oriented in different directions to respectively perform terahertz scanning and imaging on objects to be inspected in different inspection regions in a security inspection scene.

Abstract: In accordance with embodiments herein a method for capturing cells of interest in a digital microfluidic system is provided, comprising utilizing a droplet actuator to transport a sample droplet to a microwell device. The microwell device includes a substrate having a plurality of microwells that open onto a droplet operations surface of the microwell device. The sample droplet includes cells of interest that enter the microwells. The method introduces capture beads to the microwells, and the capture elements are immobilized on the capture beads. The method utilizes the droplet actuator to transport a cell lysis reagent droplet to the microwell device. Portions of the cell lysis reagent droplet enter the microwells and, during an incubation period, cause the cells of interest to release analyte that is captured by the capture elements on the capture beads.

Abstract: An apparatus for forming a plurality of microdroplets from a droplet includes a substrate, a dielectric layer on the substrate and having a plurality of hydrophilic surface regions spaced apart from each other by a hydrophobic surface, and a plurality of electrodes covered by the dielectric layer. The electrodes are configured to form an electric field across the droplet in response to voltages provided by a control circuit to move the droplet across the dielectric layer in a lateral direction while leaving portions of the droplet on the hydrophilic surface regions to form the plurality of microdroplets on the hydrophilic surface regions.

Abstract: A stack of fluidics layers of a microfluidic cartridge for sequencing nucleic acid molecules includes a sequencing chamber layer having a sequencing chamber area configured for carrying out clustering and sequencing reactions, and a sequencing chamber bottom layer disposed under the sequencing chamber layer. The sequencing chamber bottom layer has an opening configured to hold an image sensor with the image sensor having an active area disposed under the sequencing chamber area. The sequencing chamber area spans substantially all of the active area of the image sensor. The stack of fluidics layers includes a flexible printed circuit board (PCB) layer under the sequencing chamber bottom layer, and a fluidics channels layer disposed under the flexible PCB layer. The fluidics channels layer includes fluidics channels that are configured to deliver reactants to the sequencing chamber area. The fluidics channels do not substantially overlap with the active area of the image sensor.

Abstract: A touch keyboard includes a keyboard touch electrode module and keyswitches arranged along lengthwise and widthwise directions. The keyboard touch electrode module includes plural key electrode matrixes one-to-one corresponding to plural key projection areas for the keyswitches. The key electrode matrixes are arranged along the lengthwise direction and the widthwise direction. At least two key electrode matrixes unaligned in the widthwise direction are identical to each other. The key electrode matrix includes plural electrodes arranged alternately at an electrode interval. A size of the electrode in the widthwise direction is defined by a function of the electrode interval, a key pitch between two widthwise-adjacent ones of the key projection areas, and an electrode row number covered within the key pitch.

Abstract: A luminous touch keyboard includes a baseplate, a plurality of keycaps, a plurality of support mechanisms connected between the baseplate and the keycaps, and a keyboard composite electrode module disposed between the baseplate and the keycaps and configured to sense a non-pressing movement over the keycaps and to provide light emitting through the keycaps. The support mechanism supports the keycap to move relative to the baseplate and the keyboard composite electrode module. The keyboard composite electrode module includes a light source circuit and a plurality of electrode matrices arranged along a first direction and a second direction. Two of the electrode matrices adjacent in the second direction are mis-aligned. The light source circuit includes a plurality of light sources disposed in the plurality of electrode matrices in a one-to-one manner, and the position of the light source in the electrode matrix is correspondingly the same.

Abstract: A keyboard touch electrode module includes a plurality of same electrode matrices, which are arranged along a lengthwise direction and a widthwise direction and formed by a plurality of series of first electrodes and a plurality of series of second electrodes which interlace with each other. Adjacent two of the electrode matrices in the widthwise direction are mis-aligned. The electrode matrices thereon define a plurality of key projection areas, each of which covers a same key-face electrode pattern. A touch keyboard includes a base, a plurality of keycaps, a plurality of supporting structures connected to and between the base and the keycaps, and the keyboard touch electrode module disposed between the base and the keycaps. The keyboard touch electrode module can senses a non-pressing movement on the keycaps. The keycap can move up and down relative to the base and the keyboard touch electrode module through the corresponding supporting structure.

Abstract: A security inspection apparatus and a method of controlling the same are described. An example security inspection apparatus includes a bottom plate configured to carry an inspected object and a two-dimensional multi-input multi-output array panel, including at least one two-dimensional multi-input multi-output sub-array. Each two-dimensional multi-input multi-output sub-array includes transmitting antennas and receiving antennas arranged such that equivalent phase centers are arranged in a two-dimensional array. The security inspection apparatus includes a control circuit configured to control the transmitting antennas to transmit a detection signal in a form of an electromagnetic wave to the inspected object in a preset order, and to control the receiving antennas to receive an echo signal from the inspected object.

Abstract: The application describes a security inspection apparatus and a method of controlling the same. An example security inspection apparatus includes a body fixed in the field and an electromagnetic imaging device installed on the body. The electromagnetic imaging device includes a two-dimensional multi-input multi-output array panel, including at least one two-dimensional multi-input multi-output sub-array and a control circuit. Each two-dimensional multi-input multi-output sub-array includes transmitting antennas and receiving antennas, with the transmitting antennas and the transmitting antennas being arranged such that equivalent phase centers are arranged in a two-dimensional array. The electromagnetic imaging device further includes a signal processing device configured to reconstruct an image of an inspected object based on an echo signal received and a display device configured to display the reconstructed image of the inspected object.

Abstract: Embodiments provided herewith are directed to self-assembled methods of preparing a patterned surface for sequencing applications including, for example, a patterned flow cell or a patterned surface for digital fluidic devices. The methods utilize photolithography to create a patterned surface with a plurality of microscale or nanoscale contours, separated by hydrophobic interstitial regions, without the need of oxygen plasma treatment during the photolithography process. In addition, the methods avoid the use of any chemical or mechanical polishing steps after the deposition of a gel material to the contours.