Abstract: Disclosed are a tricyclic fused heterocyclic compound having a PDE3/4 dual inhibitory effect represented by formula (I), a stereoisomer, a solvate, or a pharmaceutically acceptable salt thereof, and the use thereof in the preparation of a drug for treating/preventing PDE3/4-mediated diseases. Each group in formula (I) is as defined in the description.

Abstract: The present invention provides a method for generating a droplet array on a microfluidic chip, comprising the following steps: assembling an upper chip and a lower chip to an initial position, a fluid channel of the upper chip partially or completely covering a microporous array of the lower chip; injecting a solution into a chip, the solution being partially or fully filled in the microporous array of the lower chip; and relatively moving the upper chip and the lower chip to a liquid dividing position, the fluid channel of the upper chip and the microporous array of the lower chip being overlapped no longer, and the solution being dispersed into the microporous array to form a droplet array. A contact surface between the upper chip and the lower chip is hydrophobic, and the microporous array sufficiently separates the generated droplets physically, thereby avoiding cross-contamination. The present invention can effectively control the size and shape of the generated droplet.

Abstract: A calcium-magnesium composite fireproof and flame-retardant material, a preparation method and applications thereof, and a flame-resistant optical/electrical cable and a preparation method thereof are provided. The present disclosure only uses water as a solvent, VAE latex as a polymer matrix, a biomass calcium material and magnesium hydroxide as fillers, and the raw materials have low price and are easy to obtain. The calcium-magnesium composite fireproof and flame-retardant material has excellent flame retardancy and mechanical strength. The present disclosure utilizes the layered structure of the biomass calcium material, a gas generation mechanism, stable thermal decomposition products, and excellent mechanical properties, and can effectively enhance the flame retardancy and mechanical properties of the calcium-magnesium composite fireproof and flame-retardant material.

Abstract: A fireproof and flame-retardant material based on waste slag of aluminum factory, a preparation method and applications thereof, and a flame-retardant cable and a preparation method thereof are provided. The present disclosure provides a fireproof and flame-retardant material based on waste slag of aluminum factory, measured by weight parts, including raw materials: waste slag of aluminum factory (dry weight) 1-6 phr, inorganic hydroxide 0-6 phr, VAE latex 3-8 phr, and water 20-50 phr. The present disclosure only uses water as a solvent, VAE latex as a polymer matrix, the waste slag of aluminum factory and inorganic hydroxide as fillers. The price of raw materials is low and easy to obtain. The fireproof and flame-retardant material based on the waste slag of aluminum factory has excellent flame retardant, tensile strength, elongation and gram weight.

Abstract: The present disclosure provides a growth method of a high-temperature phase lanthanum borosilicate crystal, where the high-temperature phase lanthanum borosilicate crystal is a ?-La1-yLnyBSiO5 crystal prepared by a high-temperature flux method; a composite flux system is (La1-yLny)BO3—LiMoO4—SiO2—B2O3, and (La1-yLny)BO3, LiMoO4, SiO2, and B2O3 in the system have molar percentages of x1, x2, x3, and x4, respectively; 0<x1<0.3, 0.7?x2<1, 0<x3<0.3, x1+x2+x3=1, x1:x4=2:1 to 4:1. In the present disclosure, a difficulty is overcome in the crystal growth of ?-LaBSiO5 due to phase transition. The crystal is an optical function material that does not undergo the phase transition during annealing and can exist stably at room temperature. The crystal is widely used in laser, terahertz, and other fields.

Abstract: Provided are a compound as shown in general formula (I), or a stereoisomer, deuterate, solvate, prodrug, metabolite, pharmaceutically acceptable salt or co-crystal thereof, an intermediate thereof, a preparation method therefor, and the use thereof in the preparation of a drug for treating a disease associated with the activity or expression quantity of complement factor B.

Abstract: The present application provides an audio previewing method, an apparatus and a storage medium. The method plays, on a target audio file set interface, an audio preview clip of at least one audio file in a target audio file set in response to a previewing request of previewing the target audio file set without entering a target audio file set detailed interface, so that a user can quickly preview the target audio file set through auditory sense, and the user can preview the at least one audio file in the target audio file set at a time, which is simple in operation. In addition, embodiments of the present application further display, on the target audio file set interface, information of an audio file corresponding to the audio preview clip that is currently played during previewing, such as name and/or singer.

Abstract: Antimicrobial Janus nanoparticles (NPs) having distinct hydrophobic and polycationic surfaces are embedded in crosslinked polymers. These encapsulated Janus NPs have increased stabilization, to allow for long-term effectiveness. The encapsulated Janus NPs enhance traditional antibiotics and reduce the necessary dosage of those traditional antibiotics to inhibit growth of muti-drug resistant bacteria.

Abstract: Provided are a compound as shown in general formula (I), or a stereoisomer, deuterate, solvate, prodrug, metabolite, pharmaceutically acceptable salt or co-crystal thereof, an intermediate thereof, a preparation method therefor, and the use thereof in the preparation of a drug for treating a disease associated with the activity or expression quantity of complement factor B.

Abstract: Methods and apparatuses are described for generating a domain-specific knowledge graph from unstructured computer text. A computing device extracts unstructured computer text associated with pairs of entities from domain-independent documents, and trains an entity relationship classification model using a domain-independent knowledge graph and the extracted text. The computing device extracts other unstructured text associated with a first domain from domain-specific documents. The computing device identifies pairs of entities contained within the text for the first domain, and executes the trained model to determine a relationship between the entities in each pair of entities identified from the text for the first domain. The computing device generates a domain-specific knowledge graph using (i) the pairs of entities identified from the text for the first domain and (ii) the relationships between the entities in each pair of entities identified from the text for the first domain.

Abstract: A pharmaceutical composition or a pharmaceutical preparation, the pharmaceutical composition or the pharmaceutical preparation comprising a therapeutically effective amount of an active ingredient M and a pharmaceutically acceptable excipient; the active ingredient M is selected from among a compound having general formula (I) or a stereoisomer, a tautomer, a deuterated substance, a solvate, a prodrug, a metabolite, a pharmaceutically acceptable salt or a co-crystal thereof; and the pharmaceutical composition or the pharmaceutical preparation comprises 1-600 mg of the active ingredient M. Further provided is a use of the pharmaceutical composition or pharmaceutical preparation in preparing a pharmaceutical for treating cancer.

Abstract: An ion generator, a fan coil unit and an air conditioning system. The ion generator includes: a power module; a negative plate connected to the power module; a ground plate spaced apart from a first side of the negative plate, the first side of the negative plate includes a plurality of plasma needles extending toward the ground plate; a positive plate spaced apart from a second side of the negative plate, the positive plate is connected to the power module and has a polarity opposite to that of the negative plate, and the respective sides of the negative plate and the positive plate that are facing toward each other are respectively provided with a plurality of carbon fiber brushes at corresponding positions.

Abstract: Music pushing method, apparatus, electronic device, and storage medium are provided by the embodiments of the present disclosure, for the method, firstly, a user end displays user information that satisfies a preset association relationship with music currently on a music playing interface in response to an operation acting on the music playing interface. In the present embodiments, upon inputting an operation instruction on target music by a user, information of other users who have taken an associated operation instruction to the target music and have an unrestricted friend relationship with the user is displayed, and by presenting music lists corresponding to other users, the user is guided to acquire music pushing information, and thus, ways for the user to acquire the music pushing information are expanded, and problems that music pushing is single and centralized as well as the pushing depends on a friend relationship are overcome.

Abstract: The present invention relates to the compound shown in general formula (I) or to a stereoisomer, tautomer, deuterated substance, solvate, prodrug, metabolite, pharmaceutically acceptable salt or eutectic crystal thereof, and to an intermediate and a preparation method thereof, and also to an application thereof in the preparation of a medicine for treating diseases related to USP1 activity or expression.

Abstract: Described herein are biomimetic Janus particles useful as artificial antigen presenting cells capable of activating T cells in vitro. “Bull's eye” ligand patterns mimicking either the native or reverse organization of the T cell immunological synapse are provided on the surface of nano- or micro-sized particles. Methods for activating T cells in vitro using biomimetic Janus particles described herein are also provided. T cells activated by the biomimetic Janus particles can be used in adoptive immunotherapies for treating cancer, tolerance induction in autoimmune disease, autologous immune enhancement therapy, and viral infection immunotherapy. Also described herein are methods for producing a biomimetic Janus particle.

Abstract: Disclosed are a tricyclic fused heterocyclic compound having a PDE3/4 dual inhibitory effect represented by formula (I), a stereoisomer, a solvate, or a pharmaceutically acceptable salt thereof, and the use thereof in the preparation of a drug for treating/preventing PDE3/4-mediated diseases. Each group in formula (I) is as defined in the description.

Abstract: The present invention relates to a compound represented by general formula (I) or a stereoisomer, a deuterated form, a solvate, a prodrug, a metabolite, a pharmaceutically acceptable salt or a eutectic thereof, and an intermediate and a pharmaceutical composition thereof, and use thereof in Bcl6-related diseases such as cancer. B-L-K (I).

Abstract: A system, method and device for determining concentration of a target gas. The system comprises a sensing chamber comprising at least one sampling bag configured to receive the target gas. Further, a testing paper module having at least one testing paper that is configured to change color based at least on concentration of the target gas. A detecting device operationally coupled to the sensing chamber, comprising a housing having at least one testing chamber configured to receive the testing paper module. Further, at least one controller is configured to facilitate flow of the target gas through the testing paper module by actuating at least one pump. The flow of the target gas facilitates color change of the at least one testing paper. Further, the concentration of the target gas is determined via at least one detector, based on color change of the at least one testing paper.