Abstract: The present invention relates to polyisocyanate compositions comprising two different types of polyisocyanate, their use in the manufacture of prepregs and polyisocyanurate composited made from said prepregs.

Abstract: The present application provides compounds as shown in Formula (I) and uses thereof. The compounds shown in Formula (I) provided by the present application may serve as effective glucagon-like peptide-1 (GLP-1) receptor agonists. They have excellent GLP-1R receptor agonist activity and significant blood glucose-reducing effect, have better pharmacokinetic characteristics, represent more options for the prevention and/or treatment of GLP-1 activity-related diseases, conditions, or disorders, and thereby have better clinical application prospects.

Abstract: A glycosyltransferase mutant and a method for catalytic synthesis of rebaudioside M using the glycosyltransferase mutant are provided. The glycosyltransferase mutant is obtained through mutation based on a glycosyltransferase amino acid sequence shown in SEQ ID NO: 1, and can be produced by inducing expression in a mutant strain. The glycosyltransferase mutant can be used as a catalyst for enzymatic catalytic synthesis of 12.8 g/LRebM from 20 g/LRebE. Michaelis constants (a kinetic parameter) of the glycosyltransferase mutant S195Q for rebaudioside E and rebaudioside D are 56.34±2.02 ?M and 214.48±14.54 ?M, respectively, which are ? and ? of a Michaelis constant of a wild-type (WT) glycosyltransferase, respectively.

Abstract: Disclosed is a medium to large-sized cable peeling device, including a main component having a base, a cable support positioned on top of the base and a positioning frame positioned in the middle of the cable support; and a cutting assembly positioned below the positioning frame and in the middle of the cable support, the cutting assembly has an adjustment component positioned below the positioning frame, a cutting blade positioned at the bottom of the adjustment component, a locking component positioned inside the cutting blade and a rotating component positioned below the adjustment component and in the middle of the cable support. The invention achieves adjustment of cable peeling based on the thickness of the cable insulation by setting up a main component and a cutting assembly, which prevents damage to cable core during the cutting process and enables the blade to cut at an angle, thereby improving cutting efficiency.

Abstract: A processing device in a memory system connects a first data block of the memory device to a second data block of the memory device to generate a combined data block comprising a first plurality of sub-blocks of the first data block and a second plurality of sub-blocks of the second data block, wherein the connecting includes: for each wordline of a first plurality of wordlines of the first data block, creating a wordline connection short between the respective wordline of the first data block and a corresponding wordline of a second plurality of wordlines of the second data block, wherein the first plurality of wordlines and the second plurality of wordlines comprise data wordlines; and driving a first data wordline of the first data block and a second wordline of the second data block using a single string driver of the memory device.

Abstract: Anti-IL-6 antibodies and antirheumatics are useful to treat and suppress IL-6 related conditions, such as rheumatoid arthritis.

Abstract: A drug conjugate, such as an antibody drug conjugate, and the use thereof, belonging to the field of biomedicine. In some embodiments, the drug conjugate is a compound of Formula I or a pharmaceutically acceptable salt or a solvate thereof, and can be used for treating cancers, autoimmune diseases, inflammatory diseases or infectious diseases.

Abstract: Provided are the compound shown in general formula (I) or a stereoisomer, a deuterated compound, a solvate, a prodrug, a metabolite, a pharmaceutically acceptable salt, or co-crystal thereof, an intermediate thereof, and a use thereof in EGFR-related diseases such as cancer.

Abstract: Disclosed is a prefabricated laminated slab made in accordance with a pretensioning fibermesh anti-cracking process and a manufacturing method thereof, and belongs to the technical field of fabricated structure engineering. The prefabricated laminated slab comprises a concrete layer, fiber grids, distribution bars and truss bars. The fiber grids are subjected to prestress tensioning and pouring to form a novel laminated slab with the pretensioning process, an overall pouring process of layered formworks is adopted, the construction problem during prestress tensioning of the fiber grids of the component can be effectively solved, the crack resistance of the laminated slab can be improved by adopting the prestress grids, the rigidity is increased, and the crack width under normal use conditions is reduced.

Abstract: An SMF network element determines, according to a PCC rule of a flow, a third latency of transmitting the flow from a UPF network element to UE, so that a second latency of transmitting the flow from a flow service provider in a TSN to the UE can be determined based on the third latency and a first latency of transmitting the flow from the flow service provider in the TSN to the UPF network element.

Abstract: A planting machine, comprising a planting water tank which is opened at the upper surface and covered with a movable cover, and planting cups for planting plants are arranged on the movable cover; a flow hold which is provided on at least one side of the planting water tank, and a lid which is set to close the flow hole; a light group, which is suspended or fixed above the planting water tank; a controller which provides an output port, the light group connect to the output port. Multiple planting water tanks can be spliced through the flow holes to form a complete indoor planting system, which can facilitate users to flexibly arrange and design the connection of the planting water tanks according to the home or furniture settings to achieve adaptation, thereby improving the existing indoor planting system.

Abstract: In a method of manufacturing a lithographic mask of an integrated circuit for semiconductor device manufacturing an optical proximity correction (OPC) process to a layout pattern of the integrated circuit is performed to produce a corrected layout pattern. An inverse lithographic technology (ILT) process to the corrected layout pattern is also performed to enhance the corrected layout pattern to produce an OPC-ILT-enhanced layout pattern of the lithographic mask. A first contour image associated with the OPC-ILT-enhanced layout pattern is generated when the OPC-ILT-enhanced layout pattern of the lithographic mask is projected on a wafer. The features of the generated first contour image are extracted. And a second contour image of a developed photo resist pattern on the wafer associated with the OPC-ILT-enhanced layout pattern as an output of a deep neural network is generated.

Abstract: A lossless data compressor prevents normalization overruns on-the-fly as symbol occurrence counts are rounded to generate symbol frequencies, allowing an encoding table generator to generate encoding table entries without waiting for the symbol frequency table to finish filling. Rounding errors are accumulated as symbols are normalized and compensated for by reducing a symbol frequency when the symbol frequency is at least 2 and the accumulated errors have exceeded a threshold. The symbol frequency is also reduced when the number of remaining states in the encoding table is insufficient for a number of remaining unprocessed symbols and states for a current encoding table entry. Since error compensation occurs as symbols are being normalized, encoding table generation is not forced to wait for all symbols in the block to be processed, reducing latency. Three pipeline stages can operate on three input blocks: symbol counting, normalization/error compensation/encoding table generation, and data encoding.

Abstract: An application of feature gene TRIM22 in preparing reagent for regulating expression of breast cancer-related genes is provided. The feature gene TRIM22 disclosed in the present disclosure upregulates the expression of breast cancer-related genes SIX3, GATA6, PTX3, MMP1 and DMBT1 through overexpression, and downregulates the expression of the breast cancer-related genes SOX4, CXCL10, TNF, TP63 and CXCL16 through overexpression. Therefore, the feature gene TRIM22 provided in the present disclosure can be used as a reagent product to regulate the expression of breast cancer-related genes GATA6, SIX3, SOX4, CXCL10, PTX3, TNF, TP63, MMP1, CXCL16 and DMBT1 through overexpression.

Abstract: Embodiments of the present disclosure provide a multimedia playing method and a device. The method includes: displaying a first interface; playing a segment of a first playing object on the first interface, where the first interface includes prompt information, and the prompt information is used to prompt that the segment of the first playing object is being played.

Abstract: Disclosed are a cis-platinum cross-linked protein hydrogel and a preparation method thereof. Main components of the cis-platinum cross-linked protein hydrogel comprise the following ingredients in percentage by mass: 0.5% to 5.0% drug, 6.0% to 50.0% serum albumin and 47.0% to 93.0% solvent medium; a carboxyl group on a surface of the serum albumin and the drug form a coordinate bond; and the drug is cis-platinum. A hydrogel preparation is simple in structure and easy to prepare, and the used cis-platinum has dual effects: a cross-linking agent for promoting the formation of protein hydrogels and an antitumor drug for exerting a tumor inhibition curative effect. The strategy simplifies the carrier design and reduces potential toxic side effects. The protein carboxyl limits the release of cis-platinum through a coordination effect so that reduce the burst release of the loaded drugs drastically.

Abstract: The present application relates to the technical field of pharmaceutical chemistry, and particularly relates to compounds with ALK inhibitory activity and preparation method and use thereof. The compounds with ALK inhibitory activity provided by the present application are ALK inhibitors for treating diseases responsive to the inhibition of ALK kinase, can be used for treating ALK-positive diseases, such as tumors and cancers, and have broad application prospects.

Abstract: An optical fiber array device, where the optical fiber array device comprises a fiber base flange, enabled to hold an integrated positioning sheet. The integrated positioning sheet comprises a plurality of channels, with each formed by at least a positioning hole and a tapered hole. A plurality of fibers or fiber bundles are fixed in the positioning holes of the integrated positioning sheet. The device further comprises a lens array, with each lens of the lens array aligned with one channel of the plurality of channels.

Abstract: A system for breast cancer detection using co-localized ultrasound-mammography is disclosed. The system includes an examination box having a cavity connected to a side opening. A compression plate is connected to an actuator, the actuator configured to advance a surface of the compression plate towards a breast positioned within the cavity from the side opening to compress and stabilize the breast. An x-ray device is configured to generate at least one mammography image. An ultrasound probe is configured to generate at least one ultrasound image. A controller is operably connected to the x-ray device and ultrasound probe, the controller configured generate an image based on co-localization of the at least one mammography image and at the least one ultrasound image. A method of performing breast cancer detection and methods of breast imaging are also disclosed.

Abstract: A display substrate and a display device. The display substrate includes: a first pixel structure including a first sub-pixel and a second sub-pixel; and a pixel defining layer including first openings and second openings, where the first sub-pixel includes the first opening, and the second sub-pixel includes the second opening. In the first pixel structure, a pattern of an orthographic projection of the first opening of the at least one first sub-pixel on the base substrate has a maximum size in the first direction, a pattern of an orthographic projection of the second opening of the at least one second sub-pixel on the base substrate has a maximum size in the second direction, an angle is formed between the second direction and the first direction, and a ratio of the maximum size of the first opening to the maximum size of the second opening ranges from 0.2 to 2.