Abstract: Provided are a compound of formula (I), a stereoisomer, a deuterated compound, a solvate, a prodrug, a metabolite, a pharmaceutically acceptable salt or a eutectic thereof, or a pharmaceutical composition comprising same, and use thereof as a ketohexokinase inhibitor in the preparation of drugs for treating related diseases. Each group in formula (I) is as defined in the description.

Abstract: Music pushing method, apparatus, electronic device, and storage medium are provided by the embodiments of the present disclosure, for the method, firstly, a user end displays user information that satisfies a preset association relationship with music currently on a music playing interface in response to an operation acting on the music playing interface. In the present embodiments, upon inputting an operation instruction on target music by a user, information of other users who have taken an associated operation instruction to the target music and have an unrestricted friend relationship with the user is displayed, and by presenting music lists corresponding to other users, the user is guided to acquire music pushing information, and thus, ways for the user to acquire the music pushing information are expanded, and problems that music pushing is single and centralized as well as the pushing depends on a friend relationship are overcome.

Abstract: A compact optical imaging device with short optical length and low sensitivity, for use in an imaging module and an electronic device, comprises first to fifth lenses and a filter. An image-side surface of the fourth lens is convex near an optical axis of the optical imaging device. An image-side surface of the fifth lens is concave near the optical axis. The optical imaging device satisfies formulas 0.03 mm/°<TL5/FOV<0.1 mm/° and 2.4 mm<TL4/FNO<2.9 mm, TL5 being a distance from an object-side surface of the fifth lens to an image plane of the optical imaging device along the optical axis, FOV being a maximum field of view, TL4 being a distance from an object-side surface of the fourth lens to the image plane along the optical axis, and FNO being a F-number of the optical imaging device.

Abstract: Described herein are biomimetic Janus particles useful as artificial antigen presenting cells capable of activating T cells in vitro. “Bull's eye” ligand patterns mimicking either the native or reverse organization of the T cell immunological synapse are provided on the surface of nano- or micro-sized particles. Methods for activating T cells in vitro using biomimetic Janus particles described herein are also provided. T cells activated by the biomimetic Janus particles can be used in adoptive immunotherapies for treating cancer, tolerance induction in autoimmune disease, autologous immune enhancement therapy, and viral infection immunotherapy. Also described herein are methods for producing a biomimetic Janus particle.

Abstract: An electronic air cleaner includes a control housing including an ion generation device and a brush array having at least one brush assembly extending therefrom. The brush array is connectable to the control housing in both a first configuration and a second configuration.

Abstract: An engaging mechanism includes a casing, a first engaging member and a second engaging member. The casing has a first engaging recess and a second engaging recess. The first engaging member is slidably disposed in the casing and has a first engaging portion. The second engaging member is rotatably disposed in the casing and has a second engaging portion. When the first engaging member is located at a first lock position, the second engaging member is able to rotate between a second lock position and a second unlock position. When the second engaging member is located at the second unlock position and the first engaging member slides from the first lock position to a first unlock position, the first engaging member pushes the second engaging member to rotate toward the second lock position, such that the second engaging portion blocks the second engaging recess.

Abstract: Music pushing method, apparatus, electronic device, and storage medium are provided by the embodiments of the present disclosure, for the method, firstly, a user end displays user information that satisfies a preset association relationship with music currently on a music playing interface in response to an operation acting on the music playing interface. In the present embodiments, upon inputting an operation instruction on target music by a user, information of other users who have taken an associated operation instruction to the target music and have an unrestricted friend relationship with the user is displayed, and by presenting music lists corresponding to other users, the user is guided to acquire music pushing information, and thus, ways for the user to acquire the music pushing information are expanded, and problems that music pushing is single and centralized as well as the pushing depends on a friend relationship are overcome.

Abstract: Described herein are biomimetic Janus particles useful as artificial antigen presenting cells capable of activating T cells in vitro. “Bull's eye” ligand patterns mimicking either the native or reverse organization of the T cell immunological synapse are provided on the surface of nano- or micro-sized particles. Methods for activating T cells in vitro using biomimetic Janus particles described herein are also provided. T cells activated by the biomimetic Janus particles can be used in adoptive immunotherapies for treating cancer, tolerance induction in autoimmune disease, autologous immune enhancement therapy, and viral infection immunotherapy. Also described herein are methods for producing a biomimetic Janus particle.

Abstract: A resin composition includes 100 parts by weight of a vinyl group-containing polyphenylene ether resin, 10 parts by weight to 20 parts by weight of a polyolefin, 15 parts by weight to 45 parts by weight of a first phosphorus-containing compound and 5 parts by weight to 15 parts by weight of a second phosphorus-containing compound, wherein the polyolefin includes a styrene-butadiene-maleic anhydride terpolymer or a butadiene-maleic anhydride copolymer, the first phosphorus-containing compound includes a compound of Formula (I), and the second phosphorus-containing compound includes a compound of Formula (II), a compound of Formula (III) or a combination thereof.

Abstract: The disclosure is related to the field of preparation of nanometer materials, and, in particular, to a method for synthesizing a 2D ultrathin zeolitic imidazolate framework-67 (ZIF-67) with a hierarchical porous structure, the method converting ZIF-67 from nanoparticles into 2D ultrathin nanosheets with a hierarchical porous structure by controlling a dropping amount of water and the reaction time. With the method, the 2D ultrathin ZIF-67 with a hierarchical porous structure can be made from readily available starting materials in a one pot synthesis. The method is feasible on industrial scale and has both economic and environmental benefits due to the simple process and low cost.

Abstract: Systems and methods according to aspects of the invention verify requests for information over a network. Computing devices communicating over a network transmit numerous signals with various types of information including spatial information, temporal information, device-specific information, and transmission specific information. This information may be used to generate statistical records of valid request for information. Various combinations of these signals may be used to determine whether a request for information is a valid request based on the statistical records associated with the signals. Where a request for information has been verified, the system and method may provide the information. Where the request for information has not been verified, the system and method may deny the request for information. Thus the system and method may be used to prevent and block scraping and spamming attacks.

Abstract: Disclosed is an ?-phase nickel hydroxide and a preparation method and use thereof. The method for preparing an ?-phase nickel hydroxide comprises the following steps: subjecting a biomass calcium source to a calcination to obtain a porous calcium oxide; under a protective atmosphere, mixing the porous calcium oxide with a first methanol-ethanol solvent to obtain a calcium oxide heterogeneous solution; under a protective atmosphere, mixing the calcium oxide heterogeneous solution with a nickel source homogeneous solution to obtain a mixture, and subjecting the mixture to a coprecipitation to obtain a nickel calcium hydroxide precursor, wherein the nickel source homogeneous solution is prepared with a nickel source containing crystal water as a solute and a second methanol-ethanol solvent as a solvent; and subjecting the nickel calcium hydroxide precursor to a calcium hydroxide removal treatment to obtain the ?-phase nickel hydroxide.

Abstract: The disclosure provides a porous manganese-containing Fenton catalytic material and a preparation method and use thereof. The porous manganese-containing Fenton catalytic material according to the disclosure includes particles with a cluster structure and the particles with the cluster structure include a porous-structure calcium oxide and two-dimensional nanosheets of a Mn—Ca compound on a surface of the porous-structure calcium oxide.

Abstract: Organic photoelectric device comprises a first electrode, a first carrier transfer layer, an active layer, a second carrier transfer layer and a second electrode. The first electrode is a transparent electrode. The active layer includes at least one organic semiconductor material including a structure such as Formula I: The second carrier transfer layer is composed between the active layer and the second electrode. When X1 and X2 are selected from one of Si, Ge and derivatives thereof, the active layer further includes an organic solvent, and the solubility of the organic solvent to the active layer is not less than 5 mg/mL. When X1 and X2 are selected from one of C and its derivatives, the active layer further includes an additive. The power conversion efficiency of the organic photoelectric device of the present invention can be up to more than 14%.

Abstract: A method for detecting positions of wafers includes: rotating a rotation table with a wafer thereon in a first direction at a first speed; detecting a contour of the wafer rotating in the first direction at the first speed to provide contour data; rotating the rotation table in a second direction at a second speed when an aiming feature of the wafer passes the detector in the first direction at the first speed; detecting the contour of the wafer rotating in the second direction at the second speed to provide new contour data; and stopping the rotation of the rotation table and the detection of the wafer according to an accumulation of contour data and corresponding rotation angles, to estimate an eccentric position of the wafer and a position of the aiming feature when the aiming feature passes the detector in the second direction at the second speed.

Abstract: The present invention relates to an electrode material comprising at least one sulfur-limonene sulfide component or a composite of the sulfur-limonene sulfide component with a first conductive component; electrodes, in particular cathodes, containing the electrode material; half-cells, cells, and batteries containing the electrodes; and processes for obtaining the electrode material, the electrode, the half-cell, the cell, and the battery comprising electrode material and/or electrodes of the present invention.

Abstract: Devices, apparatuses, methods, and computer program products are provided for hemorrhage detection. An example sensing device for hemorrhage detection includes a blood selective layer that includes a permeable film and an iron selective conductive circuit supported by the permeable film. The sensing device further includes a controller operably coupled with the blood selective layer. The controller is configured to supply a current to the iron selective conductive circuit, determine an impedance of the iron selective conductive circuit responsive to blood received by the blood selective layer, and determine an amount of blood received by the blood selective layer based upon the determined impedance. The controller may further compare the determined impedance with an alert threshold and generate an alert signal in an instance in which the determined impedance satisfies the alert threshold.

Abstract: A redundant network IP smart failover method and system based on a redundant computer. Each computer in any computer group comprises an IP address switching module, a network status detecting module, and a peer fault detecting module. The IP address switching module is configured to smoothly switch an IP address in the redundant network. The peer fault detecting module is configured to mutually exclusively and stably acquire operation statuses of peer computers and quickly obtain a correct redundant network IP when necessary. The network status detecting module is configured to determine statuses of local and remote networks to facilitate the IP address switching module to smartly switch the IP address. Configuring a network status detecting module and a peer fault detecting module to aid the IP address switching module to allocate IP addresses more smartly can significantly improve reliability of the redundant network and effectively reduce IP conflicts during the redundant network failover process.

Abstract: Disclosed are a nitrogen-containing heterocyclic compound as shown in formula (I), or a stereoisomer, a solvate, a deuterated form, a pharmaceutically acceptable salt, or a cocrystal thereof or a pharmaceutical composition containing same, and the use thereof in the preparation of a drug for treating/preventing diseases mediated by autotaxin. Each group in formula (I) is as defined in the description.

Abstract: The disclosure is related to the field of preparation of nanometer materials, and, in particular, to a method for synthesizing a 2D ultrathin zeolitic imidazolate framework-67 (ZIF-67) with a hierarchical porous structure, the method converting ZIF-67 from nanoparticles into 2D ultrathin nanosheets with a hierarchical porous structure by controlling a dropping amount of water and the reaction time. With the method, the 2D ultrathin ZIF-67 with a hierarchical porous structure can be made from readily available starting materials in a one pot synthesis. The method is feasible on industrial scale and has both economic and environmental benefits due to the simple process and low cost.