Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) programmed cell death protein 1 (PD-1), and methods of use thereof. In one aspect, the animals have an insertion of a sequence encoding a human or humanized programmed cell death protein 1 (PD-1) at an endogenous PD-1 gene locus. This animal model can express a PD-1 protein containing a functional domain of the human PD-1 protein, and can be used as an animal model for developing therapeutics for human diseases and disorders, and assessing the toxicity and/or the efficacy of these human therapeutics.

Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD137, and methods of use thereof.

Abstract: The present document provides image processing methods and apparatus. One claim recites: obtaining a signal to be encoded in color image data, the signal comprising a plural-bit payload; predicting a resulting color of overprinting several inks on a substrate, the overprinting representing the color image data encoded with the signal; using the resulting color for both i) visibility evaluation of the overprinting, and ii) signal robustness evaluation of the overprinting as seen by an imaging device. Other claims and combinations are provided.

Abstract: This disclosure relates to advanced signal processing technology including steganographic embedding and digital watermarking.

Abstract: This disclosure relates to advanced signal processing technology including signal encoding and digital watermarking. Image areas are selected in an encoded digital design, and corresponding areas from a printed version of the encoded digital design are evaluated to determined signal robustness after printing.

Abstract: The present disclosure relates to the genetically modified non-human animals that express a human or chimeric (e.g., humanized) T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), and methods of use thereof.

Abstract: Provided is a method for preparing a PD-1 gene-modified humanized animal model. The method utilizes the CRIPSR/Cas9 technique to replace partial fragments of a mouse PD-1 gene with fragments of a human PD-1 gene using homologous recombination by constructing a targeting vector, thereby preparing a gene-modified humanized mouse. This mouse can normally express a PD-1 protein containing the functional domain of the human PD-1 protein, and can be used as an animal model for mechanism research regarding PD-1, PD-L1 and other signals, for screening regulators, and for toxicological research. The method has an important and high application value in studies on functions of the PD-1 gene and in the development of new drugs.

Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) IL15, and methods of use thereof.

Abstract: A vehicle interior component configured to provide an illuminated display/image and comprising a composite structure is disclosed. The component may comprise a cover providing a surface for the illuminated display/image and a substrate; the cover may comprise a cover layer, bottom layer and/or intermediate layer. The cover layer may comprise a surface layer and a base layer. The base layer and/or bottom layer may comprise a reinforcing layer. The surface layer, cover layer and/or base layer may comprise a pigment. The surface layer, cover layer and/or bottom layer may comprise a colorant (or pigment, dye, etc.). The bottom layer may comprise a pattern region comprising the image, a mask and/or light-blocking layer. The composite structure may comprise the cover, a functional layer, spacer/buffer layer, diffuser layer, sensor grid, capacitive sensor, textile and/or base/substrate. The cover surface may comprise a skin.

Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) IL6R and/or IL6, and methods of use thereof.

Abstract: The present invention relates to a drilling fluid for enhancing stratum pressure bearing capacity, and a method of preparing and using the drilling fluid. The drilling fluid comprises water, bentonite, low adhesive aggregation anionic cellulose, lignite resin, high temperature resistant and salt resistant filtrate reducer, silanol inhibitor, inorganic micrometer-nanometer rigid particles and emulsified asphalt. The bentonite is 2-9 parts by weight, the low adhesive aggregation anionic cellulose is 0.1-1 parts by weight, the lignite resin is 1-5 parts by weight, the high temperature resistant and salt resistant filtrate reducer is 0.1-2 parts by weight, the silanol inhibitor is 0.1-2 parts by weight, the inorganic micrometer-nanometer rigid particles are 0.5-5 parts by weight, and the emulsified asphalt is 1-10 parts by weight, based on 100 parts by weight of water.

Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) IL4R and/or IL4, and methods of use thereof.

Abstract: The present disclosure relates to genetically modified animals that express a canine or chimeric (e.g., caninized) programmed cell death protein 1 (PD-1), and methods of use thereof.

Abstract: A method for suppressing a common mode impulse current for an inverter generated when an alternating current switch is switched on and a device for applying the method are provided. Before the alternating current switch is switched on for the inverter, a target value of a common mode voltage between the inverter and ground is calculated based on at least one of a voltage between an alternating current port and ground, a voltage between the inverter and ground and a voltage across the alternating current switch sampled in real time. Then, a compensation power supply arranged between a main circuit of the inverter and ground is controlled to change the common mode voltage to the target value, so that a common mode voltage difference between two ends of the alternating current switch is zero. Subsequently, the inverter is controlled to switch on the alternating current switch.

Abstract: The present disclosure relates generally to image signal processing, including encoding signals for image data or artwork. A color blend/print model is used to predict signal detectability and visibility as is printed on a particular substrate, which facilitates object grading prior to print runs.

Abstract: A nanometer plugging water-based drilling fluid and preparation method and use thereof are within this disclosure. The nanometer plugging water-based drilling fluid comprise a nanometer plugging agent. The nanometer plugging agent may be surface modified SiO2 powder with the surfactant. The surfactant may be sodium dodecyl benzene sulfonate and/or sodium dodecyl sulfate. The nanometer plugging water-based drilling fluid may perform effective anti-collapse of stratum and maintain the stability of stratum.

Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD137, and methods of use thereof.

Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) IL4R and/or IL4, and methods of use thereof.

Abstract: A method for calculating the quantity of goods based on weighing includes the following steps: Step 1, Weight Conversion; accurately convert the weighing reading to the corresponding weight value W; Step 2, Weight Scaling; that is, the conversion of weight units; Step 3, Zero Point Correction; calibrate the weight reading; Step 4, Tare; remove the weight of non-goods objects in the weight value; Step 5, Anti-Mutation Filtering; anti-mutation filtering on the weight value; Step 6, Quantity Conversion; convert the weight value after calibration and correction of steps 1 to 5 above into the approximate (rough) quantity of the goods; Step 7, Quantity Calibration; calibrate the rough quantity of the above-mentioned goods.

Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD3e (T-cell surface glycoprotein CD3 epsilon chain), and methods of use thereof.