Abstract: The instant invention provides for compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.

Abstract: A digital signature generation apparatus includes memory to store finite field Fq and section D(ux(s, t), uy(s, t), s, t) as secret key, section being one of surfaces of three-dimensional manifold A(x, y, s, t) which is expressed by x-coordinate, y-coordinate, parameter s, and parameter t and is defined on finite field Fq, x-coordinate and y-coordinate of section being expressed by functions of parameter s and parameter t, calculates hash value of message m, generates hash value polynomial by embedding hash value in 1-variable polynomial h(t) defined on finite field Fq, and generates digital signature Ds(Ux(t), Uy(t), t) which is curve on section, the x-coordinate and y-coordinate of curve being expressed by functions of parameter t, by substituting hash value polynomial in parameter s of section.

Abstract: The invention relates to compounds of a general formula (I): wherein Ar1 is an optionally-substituted aryl or heteroaromatic group; R1 is an optionally-substituted lower alkyl, lower alkenyl, lower alkynyl or cyclo-lower alkyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R2 is a hydrogen atom, a lower alkyl group, a lower alkenyl group or a lower alkynyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R3 is a hydrogen atom or a lower alkyl group; R4 is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a group of —N(R1k)R1m; T and U are a nitrogen atom or a methine group, etc. The compounds of the invention have excellent Weel kinase-inhibitory effect and are therefore useful in the field of medicines, especially treatment of various cancers.

Abstract: The present invention relates to a compound of formula I: wherein: R1 is C1-6 alkyl, C3-8 cycloalkyl, aryl, heterocyclyl, or —COR1x, where the C1-6 alkyl, C3-8 cycloalkyl, aryl, and heterocyclyl may be substituted; and R1x is C3-8 cycloalkyl, aryl, or heterocyclyl, any of which may be substituted; R2, R3, R4, R5, R6, and R7 are each independently hydrogen, halogen, C1-6 alkyl, or aryl, where the C1-6 alkyl or aryl may be substituted; R8 is hydrogen, C1-6 alkyl, aryl, or heterocyclyl, any of which may be substituted; or a pharmaceutically acceptable salt or ester thereof.

Abstract: The invention relates to compounds of a general formula (I): wherein Ar1 is an optionally-substituted aryl or heteroaromatic group; R1 is an optionally-substituted lower alkyl, lower alkenyl, lower alkynyl or cyclo-lower alkyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R2 is a hydrogen atom, a lower alkyl group, a lower alkenyl group or a lower alkynyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R3 is a hydrogen atom or a lower alkyl group; R4 is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a group of —N(R1k)R1m; T and U are a nitrogen atom or a methine group, etc. The compounds of the invention have excellent Weel kinase-inhibitory effect and are therefore useful in the field of medicines, especially treatment of various cancers.

Abstract: The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms, preferably Akt1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity especially Akt1 by administering the compound to a patient in need of treatment of cancer.

Abstract: The instant invention provides for substituted [1,2,4]triazolo[4,3-a]-1,5-naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms, preferably Akt1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity, especially Akt1 by administering the compound to a patient in need of treatment of cancer.

Abstract: A digital signature generation apparatus includes memory to store finite field Fq and section D(ux(s, t), uy(s, t), s, t) as secret key, section being one of surfaces of three-dimensional manifold A(x, y, s, t) which is expressed by x-coordinate, y-coordinate, parameter s, and parameter t and is defined on finite field Fq, x-coordinate and y-coordinate of section being expressed by functions of parameter s and parameter t, calculates hash value of message m, generates hash value polynomial by embedding hash value in 1-variable polynomial h(t) defined on finite field Fq, and generates digital signature Ds(Ux(t), Uy(t), t) which is curve on section, the x-coordinate and y-coordinate of curve being expressed by functions of parameter t, by substituting hash value polynomial in parameter s of section.

Abstract: An encryption apparatus includes a plaintext embedding unit that embeds a message m as a coefficient of a three-variable plaintext polynomial m(x,y,t), an identification polynomial generating unit that generates a three-variable identification polynomial f(x,y,t), a polynomial generating unit that randomly generates three-variable polynomials r1(x,y,t), r2(x,y,t), s1(x,y,t), and s2(x,y,t), and an encrypting unit that generates encrypted texts F1 and F2 by performing an arithmetic operation with respect to these three-variable polynomials.

Abstract: The carbon fibers of this invention is characterized in that irreducible inorganic material particles in a mean primary particle size below 500 nm and reducible inorganic material particles in a mean primary particle size below 500 nm were mixed by pulverizing and then, the mixture was heat treated under the reducing atmosphere and metal particles in a mean particle size below 1 ?m were obtained, and the mixed powder of the thus obtained metal particles with the irreducible inorganic material particles are included in the carbon fibers.

Abstract: The invention relates to compounds of a general formula (I): wherein Ar1 is an optionally-substituted aryl or heteroaromatic group; R1 is an optionally-substituted lower alkyl, lower alkenyl, lower alkynyl or cyclo-lower alkyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R2 is a hydrogen atom, a lower alkyl group, a lower alkenyl group or a lower alkynyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R3 is a hydrogen atom or a lower alkyl group; R4 is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a group of —N(R1k)R1m; T and U are a nitrogen atom or a methine group, etc. The compounds of the invention have excellent Weel kinase-inhibitory effect and are therefore useful in the field of medicines, especially treatment of various cancers.

Abstract: A digital signature generation apparatus includes memory to store finite field Fq and section D(ux(s, t), uy(s, t), s, t) as secret key, section being one of surfaces of three-dimensional manifold A(x, y, s, t) which is expressed by x-coordinate, y-coordinate, parameter s, and parameter t and is defined on finite field Fq, x-coordinate and y-coordinate of section being expressed by functions of parameter s and parameter t, calculates hash value of message m, generates hash value polynomial by embedding hash value in 1-variable polynomial h(t) defined on finite field Fq, and generates digital signature Ds(Ux(t), Uy(t), t) which is curve on section, the x-coordinate and y-coordinate of curve being expressed by functions of parameter t, by substituting hash value polynomial in parameter s of section.

Abstract: A decryption apparatus includes a section assignment unit which assigns a section D to a plurality of encrypted texts Fi(x,y,t) (i=1, . . . , k), a one-variable polynomial arithmetic unit which subtracts L pairs of polynomials he(t) and hw(t) after the assignment, and a greatest common divisor arithmetic unit which obtains the greatest common divisor ?(t) of L polynomials gj(t)(=he(t)?hw(t)) (j=1, . . . , L) as a result of the subtraction.

Abstract: A key generating apparatus generates a fibration X(x, y, t)=0 of an algebraic surface X serving as a part of a public key and defined on a finite field Fq (where q=pr [p is a prime number and r is an extended degree]) and a private key which is two sections D1 and D2 corresponding to the fibration X(x, y, t)=0. The fibration X(x, y, t) is generated such that a term (cij(t)xiyj) of xiyj having a 1-variable polynomial cij(t) of t as a coefficient is included in the fibration X(x, y, t).

Abstract: A method whereby an encryption apparatus encrypts a message on the basis of a fibration X(x, y, t) serving as a public key when private keys are two or more sections corresponding to fibration X(x, y, t)=0 of an algebraic surface X, the method comprises embedding plaintext M obtained by concatenating the message to a random number as the coefficients of plaintext polynomial M(t) of degree l?1 or less, and generating encrypted text F=Epk(M, p, q, f, X) from the plaintext polynomial M(t) by an encrypting process of performing operations including at least one of addition, subtraction, and multiplication of random polynomials p(x, y, t), q(x, y, t), a random irreducible polynomial f(t) of degree l or more, and the fibration X(x, y, t) with respect to the plaintext polynomial M(t).

Abstract: According to each embodiment of this invention, an encryption apparatus, decryption apparatus, and key generation apparatus based on a public-key cryptographic scheme whose security is based on the divisor finding problem of obtaining a divisor on an algebraic surface which is a difficult problem that has not been solved by contemporary mathematics are realized by an arrangement using, as a private key, a section D of algebraic curves (divisors) on a fibration X(x, y, t) of an algebraic surface X. This makes it possible to create a public-key cryptographic scheme which can ensure security even in the advent of a quantum computer, can be securely realized by even current computers, and can be realized in a low-power environment.

Abstract: The invention relates to compounds of a general formula (I): wherein Ar1 is an optionally-substituted aryl or heteroaromatic group; R1 is an optionally-substituted lower alkyl, lower alkenyl, lower alkynyl or cyclo-lower alkyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R2 is a hydrogen atom, a lower alkyl group, a lower alkenyl group or a lower alkynyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R3 is a hydrogen atom or a lower alkyl group; R4 is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a group of —N(R1k)R1m; T and U are a nitrogen atom or a methine group, etc. The compounds of the invention have excellent Weel kinase-inhibitory effect and are therefore useful in the field of medicines, especially treatment of various cancers.

Abstract: The present invention aims to provide a fuel cell anode, a membrane electrode assembly and a fuel cell, so as to obtain high electric power. The fuel cell anode has an electrode catalyst layer, and the electrode catalyst layer comprises a supported catalyst comprises electrically conductive carriers and fine catalytic particles supported thereon, a proton-conductive inorganic oxide supporting SiO2 on its surface, and a proton-conductive organic polymer binder. The SiO2 supported on the inorganic oxide prevents the oxide particles from growing, to ensure the high electric power. It is necessary to control the mixing ratios among the supported catalyst, the proton-conductive oxide and the proton-conductive binder in particular ranges.

Abstract: In a molding method and a mold therefore, a fluid flows through an ejector pin including a front end surface movable with respect to the mold to release or remove from the mold at least a part of a product made from a melted material so that the front end surface of the ejector pin movable with respect to the mold is cooled by the fluid.

Abstract: An encryption apparatus includes a plaintext embedding unit that embeds a message m as a coefficient of a three-variable plaintext polynomial m(x,y,t), an identification polynomial generating unit that generates a three-variable identification polynomial f(x,y,t), a polynomial generating unit that randomly generates three-variable polynomials s1(x,y,t), s2(x,y,t), r11(x,y,t), . . . , r22(x,y,t), w11(x,y,t), . . . , w22(x,y,t), and an encrypting unit that generates encrypted texts F11, F12, F21, and F22 by performing an arithmetic operation with respect to three-variable essential polynomials G1(x,y,t) and G2(x,y,t) as part of public keys and these three-variable polynomials.