Abstract: A sealing device which includes an annular exterior sealing member; a reinforcing ring disposed in a housing hole to surround an outer circumference of a rotating shaft and to press a fitting portion of the exterior sealing member against an inner circumference surface of the housing hole; a retainer mounted in the reinforcing ring; an auxiliary sealing member having one end portion that is pinched and retained between the retainer and the reinforcing ring and the other end portion that is pressed against the outer circumference surface of the rotating shaft; and an elastic tongue piece and an engagement portion that are provided between the retainer and the reinforcing ring.

Abstract: This document provides methods and materials related to differentiating iPS cells into glucose-responsive, insulin-secreting progeny. For example, methods and material for using indolactam V (ILV) and glucagon like peptide-1 (GLP-1) to produce glucose-responsive, insulin-secreting progeny from iPS cells are provided.

Abstract: Provided is a signal transfer circuit which uses a low cost circuit board with a high packing density but is capable of reducing a crosstalk noise between signal lines and also reducing a reflection noise due to a stub. A signal transfer circuit of the present invention is configured such that lead terminals of electronic components and through-hole vias are connected to each other by surface wirings, respectively, to allow no branching from the middle of the through-hole vias. Further, first wirings connecting a first electronic component are each arranged between a corresponding pair of second wirings connecting a second electronic component, and signals are transmitted through the first wirings and the second wirings by interleaved transmission.

Abstract: The present invention provides novel methods for treating diseases associated with apoptotic degeneration in ocular tissue cells by effective administration of pigment epithelium derived factor (PEDF). The present inventors studied PEDF as a means to prevent ganglion cell death, the final pathology of glaucoma. The present invention is particularly focused on SIV vectors for effective methods for delivering PEDF, and constructed an SIV-PEDF vector. When the SIV-PEDF vector was administered subretinally to an ischemia reperfusion model and NMDA-induced model, a significant suppression effect on ganglion cell death was observed. The present inventors therefore discovered that the SIV-PEDF vector is an effective pharmaceutical agent for treating diseases associated with apoptotic degeneration in ocular tissue cells, such as glaucoma.

Abstract: A wire-grid polarizer comprising a light-transmitting substrate 14 having a surface on which a plurality of ridges 12 are formed in parallel with one another at a predetermined pitch with flat portions 13 formed between the ridges 12, each of the ridges 12 having a width narrowing from the bottom toward the top; and a metal layer 20 covering at least one side surface of each ridge 12, the maximum covering thickness of the metal layer on a lower half of the ridge being smaller than the maximum covering thickness of the metal layer on an upper half of the ridge; and a process for producing the first metal layer 20 by vapor-depositing a metal from a direction satisfying tan(?R1±10)=(Pp?Dpb/2)/Hp on the first side surface 16 side, and subsequently vapor-depositing the metal from a direction at an angle satisfying ?R1+5??R2??R1+25.

Abstract: A data transmission system is provided in which it is possible to perform both of suppressing the degrading of the slew rate and suppressing the ringing even if load capacitance of an input buffer is changed. The data transmission system transmitting data from an output buffer to the input buffer through a trace is provided with first RC parallel circuits connected in series to the trace on a first Printed Circuit Board (PCB) on which the output buffer is mounted, and second RC parallel circuits connected in series to the trace on a second Printed Circuit Board (PCB) on which the input buffer is mounted, and which can be connected and separated to and from the first Printed Circuit Board (PCB).

Abstract: A seal device where a seal lip reliably maintains shaft sealing relative to high-pressure fluid that is to be sealed and where the equivalent Mises stress occurring in the seal lip is reduced to extend the durable term of the seal lip longer. A backup ring has a tapered section continuously extending from a fixation section of the backup ring and also has a forward end section. A rounded surface (E) with a curvature radius (R-1) is formed at least at a boundary where a surface (D) of the tapered section changes to a surface (F) of the forward end section. A portion of the surface (D) of the tapered surface, which portion is in contact with the rounded surface (E) at the boundary, is a projected curvature surface having a curvature radius greater than the curvature radius (R-1) of the boundary.

Abstract: Provided are a wire-grid polarizer, which has not only a high degree of polarization, a high p-polarized light transmittance and a high s-polarized light reflectance but also a low angle dependency and a low wavelength dependency in terms of optical properties in a visible light region, and a process for producing the same.

Abstract: [PROBLEMS] A seal device where a seal lip reliably maintains shaft sealing relative to high-pressure fluid that is to be sealed and where the equivalent Mises stress occurring in the seal lip is reduced to extend the durable term of the seal lip longer. [MEANS FOR SOLVING PROBLEMS] A backup ring (2) has a tapered section (23) continuously extending from a fixation section (21) of the backup ring (2) and also has a forward end section (24). A rounded surface (E) with a curvature radius (R-1) is formed at least at a boundary (26) where a surface (D) of the tapered section (23) changes to a surface (F) of the forward end section (24). A portion of the surface (D) of the tapered surface (23), which portion is in contact with the rounded surface (E) at the boundary (26), is a projected curvature surface having a curvature radius greater than the curvature radius (R-1) of the boundary (26).

Abstract: The invention relates to materials and methods for improved vaccination strategies and in particular to the use of lentivirus comprising nucleic acid encoding an antigen, or antigen presenting cells transduced with such lentivirus, to stimulate immune responses against the encoded antigen, in heterologous prime-boost vaccination regimes.

Abstract: An integrally-rotating cylindrical sieve 1 includes a hollow rotating shaft 2, which a driveshaft 21 is inserted into and fixed to, support members 3 radially extended from the rotating shaft 2, a cylindrical sieve body 4 made from a thin plate with a large number of apertures 5 formed therein, such as punching metal, and coupled with the support members 3, and sieve frames 6a and 6b attached to axial ends of the sieve body 4. The rotating shaft 2, the support members 3, the sieve body 4, the sieve frames 6a and 6b, and the driveshaft 21 are coaxially rotated together. The sieve body 4 is a cylindrical corrugated plate having wave crests and wave troughs arranged along its circumference and has a large number of apertures 5 formed in the corrugated plate. This arrangement improves the sieving efficiency of the granular material and effectively prevents potential destruction and cracking of the granular material, thus enhancing the commercial value of the sieved granular material.

Abstract: This document provides methods and materials related to induced pluripotent stem cells. For example, induced pluripotent stem cells, compositions containing induced pluripotent stem cells, methods for obtaining induced pluripotent stem cells, and methods for using induced pluripotent stem cells are provided. In addition, methods and materials for using induced pluripotent stem cells to repair tissue (e.g., cardiovascular tissue) in vivo as well as methods and materials for using induced pluripotent stem cells to assess their therapeutic potential in appropriate animal models are provided.

Abstract: Provided is a wire grid polarizer showing a high degree of polarization, a high p-polarized light transmittance and a high s-polarized light reflectivity for light incident from a front surface and showing a low s-polarized light reflectivity for light incident from its rear surface, in the visible light region, and a process for producing such a polarizer.

Abstract: Provided is a process for easily producing a wire grid polarizer showing a high polarization separation ability in the visible light region and having an improved transmittance in a short wavelength region. On a light-transmitting substrate 14 having a surface on which a plurality of ridges 12 are formed, an underlayer 22, first fine metallic wires 24 and second fine metallic wires 30 are formed by a vapor deposition method satisfying the conditions (A) to (F). (A) The underlayer material was vapor-deposited on a top face 16 and a first side face 18 of each ridge 12 from a direction of an angle ?L. (B) The underlayer material is vapor-deposited on the top face of a first underlayer 22a and a second side face 20 from a direction of an angle of ?R on the opposite side to that of the condition (A). (C) ?L and ?R are from 60° to 90°. (D) The height Hma1 of the underlayer 22 is from 1 to 20 nm.

Abstract: Included are an exterior sealing member (20) that is annularly molded using an elastomer; a reinforcing ring (10) that is disposed in a housing hole (B) so as to surround an outer circumference of a rotating shaft (C) and to press a fitting portion (21) of the exterior sealing member (20) against an inner circumference surface of the housing hole (B); a retainer (40) that is mounted in the reinforcing ring (10); an auxiliary sealing member (30) having one end portion that is pinched and retained between the retainer (40) and the reinforcing ring (10) and the other end portion that is pressed against the outer circumference surface of the rotating shaft (C); and an elastic tongue piece (42) and an engagement portion (13) that is provided between the retainer (40) and the reinforcing ring (10).

Abstract: The present invention provides novel methods for treating diseases associated with apoptotic degeneration in ocular tissue cells by effective administration of pigment epithelium derived factor (PEDF). The present inventors studied PEDF as a means to prevent ganglion cell death, the final pathology of glaucoma. The present invention is particularly focused on SIV vectors for effective methods for delivering PEDF, and constructed an SIV-PEDF vector. When the SIV-PEDF vector was administered subretinally to an ischemia reperfusion model and NMDA-induced model, a significant suppression effect on ganglion cell death was observed. The present inventors therefore discovered that the SIV-PEDF vector is an effective pharmaceutical agent for treating diseases associated with apoptotic degeneration in ocular tissue cells, such as glaucoma.

Abstract: Provided herein is a retroviral vector comprising, and capable of expressing, a nucleotide of interest (NOI), wherein the NOI encodes an RNA or protein which is harmful to a cell.

Abstract: [PROBLEMS] A seal device where a seal lip reliably maintains shaft sealing relative to high-pressure fluid that is to be scaled and where the equivalent Mises stress occurring in the seal lip is reduced to extend the durable term of the seal lip longer. [MEANS FOR SOLVING PROBLEMS] A backup ring (2) has a tapered section (23) continuously extending from a fixation section (21) of the backup ring (2) and also has a forward end section (24). A rounded surface (E) with a curvature radius (R-1) is formed at least at a boundary (26) where a surface (D) of the tapered section (23) changes to a surface (F) of the forward end section (24). A portion of the surface (D) of the tapered surface (23), which portion is in contact with the rounded surface (E) at the boundary (26), is a projected curvature surface having a curvature radius greater than the curvature radius (R-1) of the boundary (26).

Abstract: The lip-type seal of the present invention includes a seal ring made of an elastic material so as to have an annular fitted part that is fitted to a housing and a lip part that extends from the fitted part inwardly in a radial direction in the shape of a substantially conical ring and that is brought into contact with a shaft, and a support ring including an annular joint part joined to the fitted part and an annular supporting part that defines a hole through which the shaft passes, that extends from a side of the joint part to a halfway area of the lip part, and that supports the lip part from inside in a radial direction. The lip part is tapered in cross section from an area from which non-contact with the supporting part starts toward an end thereof.

Abstract: Provided herein is a retroviral vector comprising, and capable of expressing, a nucleotide of interest (NOI), wherein the NOI encodes an RNA or protein which is harmful to a cell.