Abstract: The object of the present invention is to provide a preventive and/or therapeutic agent for pressure ulcers comprising a conditioned medium of immortalized mesenchymal stem cells to which specific genes are introduced as an active ingredient. The present invention provides the preventive and/or therapeutic agent for pressure ulcers comprising the conditioned medium of immortalized mesenchymal stem cells, to which hTERT or pTERT gene, bmi-1 gene, HPV-E6 gene, and HPV-E7 gene are introduced, as an active ingredient. Here, the mesenchymal stem cells are preferably obtained from either human or swine.

Abstract: An ultrasonic diagnosis system includes a reaction force detection sensor that detects a reaction force acting on an ultrasonic probe when the ultrasonic probe is pressed against a body surface of a subject. Then, the ultrasonic diagnosis system estimates the push-in amount of the ultrasonic probe with respect to the subject by using the reaction force detection sensor during the ultrasonic diagnosis to output a display or a warning of the estimated push-in amount of the ultrasonic probe to the output device.

Abstract: An ultrasonic diagnostic system includes an ultrasonic diagnostic device having a probe, a moving device configured to move the probe, and a control device. When ultrasonic diagnosis is performed on a subject, the control device controls the moving device such that the probe is pressed against a body surface of the subject, and in a case where a specific pattern is designated as a movement pattern of the probe, controls the moving device such that the pressing of the probe on the body surface is canceled or alleviated, then controls the moving device such that the probe is moved with the specific pattern, and when the movement with the specific pattern is ended, performs a specific control for controlling the moving device such that the probe is pressed against the body surface.

Abstract: An electrode structure includes an insulator and a first electrode that is in the shape of a line, where the first electrode is disposed on a first surface of the insulator, and the first surface is on an opposite side of the insulator relative to a surface of the insulator that faces a core metal of a steering wheel. The insulator includes an engagement portion that engages an engagement-target portion included in the core metal. After the electrode structure is engaged with the core metal, a foam is shaped into a mold to form the steering wheel.

Abstract: A multi-joint robot includes: a base; a first arm connected to the base via a first joint shaft and configured to pivot in a horizontal direction with respect to the base; a second arm connected to the first arm via a second joint shaft and configured to pivot in a horizontal direction with respect to the first arm; a first rotation driving device configured to rotationally drive the first joint shaft; a second rotation driving device configured to rotationally drive the second joint shaft; a moving device configured to move the base in an axial direction of the first joint shaft; and a control device configured to control the first driving device, the second driving device, and the moving device.

Abstract: An electrode structure disposed on the outer circumference of a core metal of a steering wheel provided in a vehicle includes an insulator and a first electrode disposed on a first surface of the insulator that is on an opposite side of the insulator relative to a surface of the insulator that faces the core metal of the steering wheel. The insulator includes an engagement portion that engages a first engagement-target portion included in the core metal.

Abstract: The electrode structure is an electrode structure disposed in a steering wheel provided in a vehicle, the electrode structure including: an insulator; a first electrode disposed on a first surface of the insulator, the first surface being a surface facing a core metal of the steering wheel; a second electrode disposed on a second surface, the second surface being a surface opposite to the first surface of the insulator; a protrusion protruding from the insulator toward the core metal; and an engagement portion that is engaged with the core metal.

Abstract: A pattern inspection apparatus includes an illumination optical system to illuminate an inspection substrate on which a pattern is formed, an offset calculation circuit to calculate an offset amount which depends on an image accumulation time of each of a plurality of photo sensor elements arrayed two-dimensionally, a time delay integration (TDI) sensor to include the plurality of photo sensor elements, to acquire an image of the inspection substrate by receiving a transmitted light or a reflected light from the inspection substrate by the plurality of photo sensor elements, to correct, using the offset amount, a pixel value of optical image data of an acquired image, and to output the optical image data having been corrected, and a comparison circuit to compare an optical image formed by the optical image data output from the TDI sensor with a reference image.

Abstract: An image acquisition method includes storing a coefficient of a relational expression between a parameter corresponding to a light quantity incident on an imaging sensor including a photo sensor element and an output value of the imaging sensor in the case of the light incident on the imaging sensor which employs a reference image accumulation time, inputting a desired image accumulation time, and calculating a parameter for obtaining a desired output value of the imaging sensor by using a corrected relational expression obtained by correcting using an output value of the imaging sensor employing the desired image accumulation time in the case of the incident light quantity being zero, adjusting the light quantity incident on the imaging sensor to be a calculated parameter, and acquiring a target image by the imaging sensor on which an adjusted light quantity is incident, and outputting data of the acquired image.

Abstract: An ultrasonic diagnosis system includes a reaction force detection sensor that detects a reaction force acting on an ultrasonic probe when the ultrasonic probe is pressed against a body surface of a subject. Then, the ultrasonic diagnosis system estimates the push-in amount of the ultrasonic probe with respect to the subject by using the reaction force detection sensor during the ultrasonic diagnosis to output a display or a warning of the estimated push-in amount of the ultrasonic probe to the output device.

Abstract: A system for detecting a position of a long medical device includes a model acquisition portion that acquires a blood vessel model, a correspondence detection portion 1 that detects a position of a long medical device inserted into a blood vessel and detects a correspondence between the blood vessel model and the position of the long medical device, and a display portion that displays the position of the long medical device in association with the blood vessel model on the basis of a detection result of the correspondence detection portion.

Abstract: A system for operating an ultrasound probe that is provided with sensor operation portions for operating the ultrasound probe that acquires ultrasound echo images of a blood vessel, and a control portion that controls operations of the sensor operation portions. The control portion may switch the arrangement of the ultrasound probe using the sensor operation portions between a first arrangement for acquiring an image of a cross section in the transverse direction of the blood vessel and a second arrangement for acquiring an image of a cross section in the longitudinal direction of the blood vessel.

Abstract: The present invention addresses the problem of providing an endocytosis enhancer comprising associates formed from a fluorescent protein. The fluorescent protein is preferably any one selected from the group consisting of a white fluorescent protein, a red fluorescent protein, a yellow fluorescent protein, a blue fluorescent protein and a green fluorescent protein. The endocytosis enhancer according to the present invention can enhance the cellular uptake of a drug, which is encapsulated in micelles each formed from a fluorescent-protein-supported carbosilane dendrimer, through endocytosis.

Abstract: A robot control device executes assist control for generating an assist force in a direction of an external force applied to a robot in a case where a position of the robot is located in a first area set in a work area of the robot when the external force is applied to the robot. The robot control device stops the execution of the assist control in a case where the position of the robot is located in a second area set outside the work area of the robot. The robot control device restricts the execution of the assist control in a case where the position of the robot is located in a third area set outside the first area and inside the second area.

Abstract: The present disclosure relates to a laminated body including at least a base material layer containing at least a flexible base material and an inorganic thin film layer, in which a distribution curve of IO2/ISi has at least one maximum value (IO2/ISi)maxBD in a region BD between a depth B and a depth D, where ionic strengths of Si?, C?, and O2? are each denoted as ISi, IC, and IO2 in a depth profile measured from a surface of the laminated body on an inorganic thin film layer side in a thickness direction using a time-of-flight secondary ion mass spectrometer (TOF-SIMS), an average ionic strength in a region A1 in which an absolute value of a coefficient of variation of an ionic strength value on a base material layer side is within 5% is denoted as ICA1, a depth that is closest to the region A1 on a surface side of the inorganic thin film layer with respect to the region A1 and exhibits an ionic strength to be 0.

Abstract: The present invention relates to a targeting-type capsule for drug delivery systems. The present invention addresses the problem of providing a capsule for drug delivery systems by utilizing the reactivity of a thiol with an alkyl halide, wherein the capsule comprises a silole-containing carbosilane dendrimer and a labeling protein containing a target recognition site (e.g., green fluorescent protein), can include a biological polymer or another molecule therein, and can deliver the biological polymer or the like selectively into a target cell.

Abstract: The electrode connection structure includes: a first base material; a first electrode layer and a second electrode layer that are located on the first base material; a second base material; a first fastening member and a second fastening member; and an insulating member, wherein the first fastening member includes: a shaft portion inserted in a first through hole penetrating the first electrode layer and the insulating member; and two clamping portions that clamp a periphery of the first through hole in each of the first electrode layer and the insulating member, and the second fastening member includes: a shaft portion inserted in a second through hole penetrating the second electrode layer and the insulating member; and two clamping portions that clamp a periphery of the second through hole in each of the second electrode layer and the insulating member.

Abstract: The purpose of the present invention is to provide immortalized stem cells for producing culture supernatant that can be used in the treatment of human diseases. Provided is a method for producing immortalized stem cells, the method being provided with: a step for producing a DNA fragment that includes a telomerase reverse transcriptase and at least one gene selected from the group consisting of Bmi-1, human papilloma virus E6, and human papilloma virus E7; a step for producing a viral vector that incorporates the DNA fragment including the gene; a step for transfecting the viral vector into mammalian stem cells and introducing the gene into the stem cells; and a step for culturing the stem cells into which the gene was introduced and using a drug to select immortalized stem cells.

Abstract: The object of the present invention is to provide an aggregatable carrier material for drug delivery system and a micelle formed thereof. The present invention provides an aggregatable carrier material for drug delivery system, which is formed by utilizing the reaction between thiol group and alkyl halide. It is formed by using carbosilane dendrimers containing silole and labeled proteins such as green fluorescent protein in aqueous solvent or in mixed solvent of the aqueous solvent and organic solvent. The micelle composed of the material may incorporate compounds having a variety of molecular weight and biopolymers in the aqueous solvent.

Abstract: An object of the present invention is to provide a laminate film excellent in heat resistance. The present invention relates to a laminate film including: a second primer layer, a flexible substrate, a first primer layer, a first organic layer, and a first inorganic thin film layer in this order, in which the first primer layer and the second primer layer each have a softening temperature of 130° C. or higher; when a thermal expansion displacement in the MD is defined as A (?m) and a heating temperature is defined as T (° C.) when the laminate film is heated while being pulled at a tensile load of 29.4 mN and a temperature elevation rate of 20° C./min, the laminate film constantly satisfies a relationship dA/dT>0 where T is 50 to 200° C.; and a dimensional change rate in the MD when the laminate film is heated from 25° C. to 200° C., left to stand at 200° C. for 20 minutes, and cooled to 25° C. is ?0.3 to 0.5%.