Abstract: The purpose of the present invention is to provide immortalized stem cells for producing culture supernatant that can be used in the treatment of human diseases. Provided is a method for producing immortalized stem cells, the method being provided with: a step for producing a DNA fragment that includes a telomerase reverse transcriptase and at least one gene selected from the group consisting of Bmi-1, human papilloma virus E6, and human papilloma virus E7; a step for producing a viral vector that incorporates the DNA fragment including the gene; a step for transfecting the viral vector into mammalian stem cells and introducing the gene into the stem cells; and a step for culturing the stem cells into which the gene was introduced and using a drug to select immortalized stem cells.

Abstract: The present invention is related to a targeted type shell for drug delivery system. The object of the present invention is to provide the targeted type shell for DDS, which comprises a carbosilane dendrimer containing a silole produced by which is formed by utilizing the reaction between thiol group and alkyl halide, and a targeted protein containing a labeled proteins such as green fluorescent protein with a target recognition site. The shell may incorporate compounds having a variety of molecular weight and biopolymers, and selectively deliver them into targeted cells.

Abstract: The electrostatic detection sensor has a first electrode, a second electrode, and a third electrode. A controller connects the first electrode and the second electrode, and applies a first drive voltage thereto to obtain a first intensity. The controller applies a second drive voltage to the first electrode while keeping the second electrode and the third electrode at a ground potential to obtain a second intensity. The controller applies a third drive voltage to the third electrode while grounding the first electrode to the ground potential and keeping the second electrode open to obtain a third intensity. Then, the controller determines whether an object is approaching based on first, second, and third computed values which are computed temporal changes in the first, second, and third intensities, respectively.

Abstract: A robot system for performing drive control of a robot arm with respect to a target object according to information obtained by a camera, including a robot having a working section, a camera mounted in the vicinity of the working section, and a control device for controlling the driving of the robot while confirming the target object based on image data of the camera, is provided. The control device performs image-capture control, which executes image-capturing of the target object with the camera a plurality of times when moving the working section with respect to the target object according to a predetermined trajectory, and focus control, in which predetermined images within a plurality of images captured by image-capture control are in focus.

Abstract: An object of the present invention is to provide a gas barrier laminated film having high adhesion under a high-temperature working environment.

Abstract: A laser irradiation method sets scan lines in an x direction in parallel, and in a y direction to be separate by an inter-scan-line distance Py corresponding to laser irradiation areas of a processing target object, orients a length direction of a linear laser spot with length Wy and width Wx in the y direction, and irradiates target object with the laser spot in each of irradiation positions arranged at width direction intervals ? while moving the laser spot relative to the target object along the scan lines. The method includes determining the inter-scan-line distance Py, the width direction interval ?, and a position shift quantity ?x (where, 0<?x<?) so that the irradiation positions on adjacent scan lines are shifted in the x direction by the position shift quantity ?x and a cumulative value of the applied laser intensity is substantially equalized.

Abstract: The purpose of the present invention is to provide a sheet-like piece comprising; a base sheet comprising an elastic material; a reservoir layer provided on the surface of said base sheet which contains a physiologically active substance and comprises micro needles; a adhesion layer which is formed in a mesh form on said base sheet and; a adhesion assisting layer which is formed on the surface of opposite side of said base sheet to the surface formed said reservoir layer. As a result, the sheet for promoting hair growth which may restore the state of thin hair to a state before thinning, a whitening and wrinkle ameliorating agent having whitening effect and wrinkle improving effect, and sheet-like piece used for these are provided.

Abstract: A semiconductor device includes: a semiconductor element; a case; a terminal made of a conductive material and embedded in the case, a part of the terminal being exposed to the outside, having an outermost surface that includes a first film, and having a base portion; a bonding wire that is connected to the first film and electrically connects the semiconductor element and the terminal; and a protection member that is more flexible than the case and covers a contact portion of the terminal contacting with the bonding wire. The first film is removed from an area around the contact portion with the bonding wire in the part of the terminal being exposed to the outside, causing the base portion to be exposed. An exposed portion of the base portion and the protection member adhere to each other.

Abstract: A rotation angle detection device of the present disclosure includes, a rotating body having a cylinder and configured to rotate with rotation of a rotating shaft coupled to an inside of the cylinder, an engagement protrusion provided inside of the cylinder of the rotating body and protruding in a first direction serving as a direction in which the rotating shaft extends, an elastic member mounted to the engagement protrusion and having an elastic holding part, a case having a rotation supporting part that rotatably supports the rotating body, and a rotation angle detector configured to detect a rotation angle of the rotating body. A predetermined gap is provided between the rotation supporting part of the case and an outer periphery of the cylinder of the rotating body. A fitting part protruding in a second direction perpendicular to the first direction is formed on an outer periphery of the engagement protrusion.

Abstract: This invention provides a gas barrier film, which can suppress blocking and winding deviation, and an optical film using the gas barrier film. The gas barrier film includes a flexible substrate and an inorganic thin film layer formed on at least one surface of the flexible substrate. A static friction coefficient between one surface of the gas barrier film and the other surface is not less than 0.85 and not more than 2.0, and when a 50 mm-square portion cut from the gas barrier film is placed on a horizontal surface such that a central portion of the 50 mm-square portion is in contact with the horizontal surface, an average value of distances from the horizontal surface to four corners of the 50 mm-square portion is not more than 2 mm.

Abstract: A manufacturing method for a laminated body having a laminated film and an adhesive layer, the manufacturing method including a step of forming the adhesive layer on one surface of the laminated film, wherein the laminated film is a laminated film on which at least a substrate, and a thin film layer containing at least silicon are laminated; and the step of forming the adhesive layer includes forming the adhesive layer on a surface of a laminated film material in which the thin film layer is laminated, while conveying the laminated film material in which the laminated film is continuous in strip shape in a lengthwise direction, and while applying a tensile force of at least 0.5 N/mm2 and less than 50 N/mm2 per unit of cross-sectional area, in the lengthwise direction, to the laminated film material.

Abstract: The object of the present invention is to provide an aggregatable carrier material for drug delivery system and a micelle formed thereof. The present invention provides an aggregatable carrier material for drug delivery system, which is formed by utilizing the reaction between thiol group and alkyl halide. It is formed by using carbosilane dendrimers containing silole and labeled proteins such as green fluorescent protein in aqueous solvent or in mixed solvent of the aqueous solvent and organic solvent. The micelle composed of the material may incorporate compounds having a variety of molecular weight and biopolymers in the aqueous solvent.

Abstract: The invention provides a gas barrier laminated film having high impact resistance when a heterolayer is formed on a thin film layer. The laminated film includes a flexible substrate and a thin film layer formed on at least one surface of the substrate, wherein the thin film layer contains Si, O, and C, and the ratio of the number of carbon atoms to the number of silicon atoms which is calculated using peaks each corresponding to each binding energy of 2p of Si, 1s of O, 1s of N, and 1s of C obtained from wide scan spectrums is in the range defined by the following formula (1) when the surface of the thin film layer is subjected to X-ray photoelectron spectrometry, and a intensity ratio of a peak intensity (I2) at 1240 to 1290 cm?1 to a peak intensity (Ii) at 950 to 1050 cm?1 is in the range defined by the following formula (2) when the surface of the thin film layer is measured by an ATR method in infrared spectrometry: 0.01<C/Si?0.02??(1) 0.01?I2/I1<0.

Abstract: An object of the present invention is to provide a gas barrier laminated film having high adhesion under a high-temperature working environment.

Abstract: A rotation angle detection device includes a lever, a cylindrical part, a magnet, and a magnetic sensing element. The lever includes a base and a shaft projecting in the direction of the rotation axis of the base and integrated with the base. The cylindrical part has a first end close to or in contact with the base, and a second end opposite to the first end and farther from the base than the first end. The shaft is inserted in the cylindrical part and is rotatably supported by the cylindrical part. The magnet is attached to the end of the shaft. The magnetic sensing element faces the magnet with a predetermined gap therebetween.

Abstract: A rotation angle detection device includes a lever, a cylindrical part, a magnet, and a magnetic sensing element. The lever includes a base and a shaft projecting in the direction of the rotation axis of the base and integrated with the base. The cylindrical part has a first end close to or in contact with the base, and a second end opposite to the first end and farther from the base than the first end. The shaft is inserted in the cylindrical part and is rotatably supported by the cylindrical part. The magnet is attached to the end of the shaft. The magnetic sensing element faces the magnet with a predetermined gap therebetween.

Abstract: A semiconductor device includes: a semiconductor element; a case; a terminal made of a conductive material and embedded in the case, a part of the terminal being exposed to the outside, having an outermost surface that includes a first film, and having a base portion; a bonding wire that is connected to the first film and electrically connects the semiconductor element and the terminal; and a protection member that is more flexible than the case and covers a contact portion of the terminal contacting with the bonding wire. The first film is removed from an area around the contact portion with the bonding wire in the part of the terminal being exposed to the outside, causing the base portion to be exposed. An exposed portion of the base portion and the protection member adhere to each other.

Abstract: A laminated film includes a flexible base material, and at least one thin film layer formed on at least one of surfaces of the base material, and the at least one thin film layer satisfies all of the following conditions (i) and (ii): (i) a silicon atom (Si), an oxygen atom (O) and a nitrogen atom (N) are contained, (ii) when X-ray photoelectron spectrometry is conducted for a surface of the thin film layer, an atomic number ratio of carbon atoms to silicon atoms calculated from a wide scan spectrum satisfies a condition represented by the following formula (1): 0<C/Si?0.2??(1).

Abstract: A laminated film includes a flexible base material, a first thin film layer formed on at least one of surfaces of the base material, and a second thin film layer formed on the first thin film layer, and the first thin film layer contains a silicon atom (Si), an oxygen atom (O) and a carbon atom (C), the second thin film layer contains a silicon atom, an oxygen atom and a nitrogen atom (N), and the first thin film layer and the second thin film layer are formed by using glow discharge plasma.