Patents by Inventor Yasuteru Urano
Yasuteru Urano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20110098475Abstract: A fluorescent probe which is represented by the following formula (wherein R1 and R2 represent hydrogen atom, or a substituent for trapping proton, a metal ion, or an active oxygen species; R3 represents a monovalent substituent other than hydrogen atom, carboxy group, or sulfo group; R4 and R5 represent hydrogen atom, a halogen atom, or an alkyl group; R6 to R9 represent an alkyl group; R10 and R11 represent hydrogen atom, a halogen atom, or an alkyl group; M? represents a counter ion; and the combination of R1, R2, and R3 (1) imparts a substantially high electron density to the benzene ring to which they bond so that the compound can be substantially non-fluorescent before trapping proton, a metal ion, or an active oxygen species, and (2) substantially reduces electron density of the benzene ring to which they bond so that the compound after trapping proton, a metal ion, or an active oxygen species can be highly fluorescent after the trapping.Type: ApplicationFiled: October 28, 2010Publication date: April 28, 2011Applicants: SEKISUI MEDICAL CO., LTD.Inventors: Tetsuo NAGANO, Yoko WADA, Yasuteru URANO
-
Patent number: 7897787Abstract: A compound represented by the following general formula (I): [wherein R1 and R2 independently represent hydrogen atom, or a group represented by the following formula (A): (wherein X1 and X2 represent hydrogen atom, an alkyl group, an alkoxy group, or a halogen atom), provided that R1 and R2 do not simultaneously represent hydrogen atom; R3 and R6 represent an alkyl group; R4 and R7 represent hydrogen atom, an alkyl group, carboxy group, an alkoxycarbonyl group, or sulfo group; and R5 and R8 represents an alkyl group, an aryl group, an alkoxycarbonyl group, a vinyl group, a thienyl group, or a pyrrolyl group], or a salt thereof, which is usable for efficient screening for a chemical substance having applicability as a catalyst of the reaction of Michael addition.Type: GrantFiled: September 13, 2006Date of Patent: March 1, 2011Assignee: The University of TokyoInventors: Takuya Matsumoto, Takuji Shoda, Yasuteru Urano, Tetsuo Nagano
-
Publication number: 20110033944Abstract: A method for measuring hypochlorite ion, which comprises the steps of: (A) reacting, with hypochlorite ion, a compound represented by the following general formula (I): wherein R1 represents a 2-carboxyphenyl group which may be substituted; R2 represents a phenyl group which is substituted with a substituted or unsubstituted amino group; X1 and X2 each independently represents either hydrogen atom or a halogen atom; or a salt thereof; and (B) measuring fluorescence of a dearylated compound generated in the aforementioned step (A) or a salt thereof.Type: ApplicationFiled: October 22, 2010Publication date: February 10, 2011Applicants: SEKISUI MEDICAL CO., LTD.Inventors: Ken-ichi SETSUKINAI, Yasuteru URANO, Tetsuo NAGANO
-
Patent number: 7868147Abstract: A fluorescent probe which is represented by the following formula (I): (wherein, R1 represents a monovalent substituent other than hydrogen atom, carboxy group, or sulfo group; R2 represents hydrogen atom, or a monovalent substituent; R3 and R4 each independently represents hydrogen atom or a halogen atom; and R5 represents a monovalent group which is cleaved by contact with a measuring object, provided that a combination of R1 and R2 is selected so that the oxidation potential of the benzene ring to which they bind makes (1) the compound represented by the formula (I) substantially no fluorescent before the cleavage, and (2) a compound after the cleavage, which is derived from the compound represented by the formula (I), substantially highly fluorescent after the cleavage).Type: GrantFiled: September 3, 2004Date of Patent: January 11, 2011Assignees: Sekisui Medical Co., Ltd.Inventors: Tetsuo Nagano, Mako Kamiya, Yasuteru Urano
-
Publication number: 20100297681Abstract: A fluorescent probe for measurement of UDP-glucuronosyltransferase, which comprises a fluorescein derivative, wherein in the fluorescein derivative, the 2-carboxy group on the benzene ring of fluorescein is replaced with another monovalent substituent, provided that said substituent is a substituent other than sulfo group, and the substituent does not have carboxy group or sulfo group, and wherein the fluorescein derivative may have an arbitrary substituent at a position on the benzene ring other than the 2-position, and the fluorescein derivative may have a substituent selected from the group consisting of an alkoxy group and a halogen atom at the 2-position and/or the 7-position of fluorescein.Type: ApplicationFiled: February 26, 2008Publication date: November 25, 2010Applicant: THE UNIVERSITY OF TOKYOInventors: Tetsuo Nagano, Yasuteru Urano, Rie Tomiyasu
-
Publication number: 20100120160Abstract: A compound represented by the formula (I) wherein R1 and R2 represent amino groups that substitute at adjacent positions on the benzene ring, wherein one of the amino groups may have one alkyl group; R3 and R4 represent hydrogen atom, a C1-6 alkyl group, or a C1-6 alkoxy group, R9 and R8 independently represent a C1-6 alkyl group, R6 and R9 represent a carboxy-substituted C1-6 alkyl group, an alkoxycarbonyl-substituted C1-6 alkyl group, a sulfo-substituted C1-6 alkyl group, or an alkyl sulfonate-substituted C1-6 alkyl group, and R7 and R10 represent a C1-6 alkyl group, an aryl group, a C1-6 alkoxycarbonyl group, a vinyl group, a thienyl group, or a pyrrolyl group, and an agent for measurement of nitrogen monoxide containing the compound. Said compound can give a fluorescent substance that is free from change in fluorescence intensity in a wide pH range.Type: ApplicationFiled: January 15, 2010Publication date: May 13, 2010Applicants: Daiichi Pure Chemicals Co., Ltd.Inventors: Tetsuo NAGANO, Yu Gabe, Yasuteru Urano
-
Publication number: 20100068733Abstract: A compound represented by the following general formula (I): wherein R1 represents an amino group which may be substituted with one or two alkyl groups; R2, R3, R4 and R5 independently represent an alkyl group; and R6 and R7 independently represent a monocarboxyalkyl group, a salt thereof, or an ester thereof, which is useful as a pH-sensitive fluorescent probe which emits intense fluorescence in an acidic region.Type: ApplicationFiled: November 15, 2007Publication date: March 18, 2010Applicant: THE UNIVERSITY OF TOKYOInventors: Tetsuo Nagano, Yasuteru Urano, Daisuke Asanuma
-
Publication number: 20090317914Abstract: A compound represented by the following general formula (I): [R1 represents hydrogen atom, or 1 to 4 monovalent substituents; R2, R4, R5, and R7 represent hydrogen atom, or a monovalent substituent; R3 represents ?O or ?N+(R8)(R9).M? (R8 and R9 represent an alkyl group, and M? represents a counter ion); R6 represents —OH or —N(R10)(R11) (R10 and R11 represent an alkyl group); n represents an integer of 1 to 3; and X represents —SH or —OH], which is useful for selective measurement of hypochlorite ion and the like.Type: ApplicationFiled: March 1, 2007Publication date: December 24, 2009Applicant: THE UNIVERSITY OF TOKYOInventors: Tetsuo Nagano, Yasuteru Urano, Suguru Kenmoku
-
Publication number: 20090318707Abstract: A compound represented by the following general formula (I): [wherein R1 and R2 independently represent hydrogen atom, or a group represented by the following formula (A): (wherein X1 and X2 represent hydrogen atom, an alkyl group, an alkoxy group, or a halogen atom), provided that R1 and R2 do not simultaneously represent hydrogen atom; R3 and R6 represent an alkyl group; R4 and R7 represent hydrogen atom, an alkyl group, carboxy group, an alkoxycarbonyl group, or sulfo group; and R5 and R8 represents an alkyl group, an aryl group, an alkoxycarbonyl group, a vinyl group, a thienyl group, or a pyrrolyl group], or a salt thereof, which is usable for efficient screening for a chemical substance having applicability as a catalyst of the reaction of Michael addition.Type: ApplicationFiled: September 13, 2006Publication date: December 24, 2009Applicant: THE UNIVERSITY OF TOKYOInventors: Takuya Matsumoto, Takuji Shoda, Yasuteru Urano, Tetsuo Nagano
-
Publication number: 20090263910Abstract: A method for measuring hypochlorite ion, which comprises the steps of: (A) reacting, with hypochlorite ion, a compound represented by the following general formula (I): wherein R1 represents a 2-carboxyphenyl group which may be substituted; R2 represents a phenyl group which is substituted with a substituted or unsubstituted amino group; X1 and X2 each independently represents either hydrogen atom or a halogen atom; or a salt thereof; and (B) measuring fluorescence of a dearylated compound generated in the aforementioned step (A) or a salt thereof.Type: ApplicationFiled: June 29, 2009Publication date: October 22, 2009Applicants: DAIICHI PURE CHEMICALS CO., LTDInventors: Ken-Ichi Setsukinai, Yasuteru Urano, Tetsuo Nagano
-
Publication number: 20090258434Abstract: A compound represented by the following general formula (I): {R1, R3, R6 and R8 are methyl groups and the like, R2 and R7 are cyano groups and the like, R4 and R5 are fluorine atoms and the like, and X is a group represented by the formula (A) [R11 is a monocarboxy-substituted C1-8 alkoxy group and the like, R12, R14 and R15 are hydrogen atoms and the like, and R13 is hydroxy group and the like], provided that the combination of the aforementioned substituents is such a combination that the compound represented by the formula (I) can be substantially non-fluorescent before reacting with peroxynitrite, and the compound represented by the formula (I) in which the group represented by the formula (A) is nitrated after reacting with peroxynitrite can be substantially highly fluorescent}, or a salt thereof, which is useful as a fluorescent probe for peroxynitrite measurement.Type: ApplicationFiled: November 14, 2006Publication date: October 15, 2009Applicant: THE UNIVERSITY OF TOKYOInventors: Tetsuo Nagano, Yasuteru Urano, Tasuku Ueno
-
Publication number: 20090118471Abstract: A compound represented by the following general formula (I) or a salt thereof [R1 represents hydrogen atom, or a C1-12 alkyl group; R2 represents a C1-12 alkyl group having one or more maleimide groups, an aryl group having two or more maleimide groups, a group represented by the formula (A): —(CH2)n—CO—N(R11)(R12) (R11 and R12 represent hydrogen atom, a C1-12 alkyl group, a C1-12 alkyl group having one or more maleimide groups, or an aryl group having one or more maleimide groups, and n represents an integer of 1 to 6), or a group represented by the formula (B): —(CH2)m—NH—CO—R13 (R13 represents a C1-12 alkyl group having one or more maleimide groups, or an aryl group having one or more maleimide groups, and m represents an integer of 1 to 6); R3 and R5 represent hydrogen atom, or a halogen atom; R4 represents hydroxyl group, a C1-12 acyloxy group, a C1-12 acyloxymethyloxy group, or an amino group], which is useful as a novel fluorescent labeling agent having a property of emitting intense fluorescence onlyType: ApplicationFiled: December 17, 2008Publication date: May 7, 2009Applicant: The University of TokyoInventors: Tetsuo NAGANO, Yasuteru Urano, Takuji Shoda
-
Patent number: 7524974Abstract: A fluorescent probe which is represented by the following formula (I): (wherein, R1 and R2 represent hydrogen atom, or a substituent for trapping proton, a metal ion, or an active oxygen species, or the like; R3 represents a monovalent substituent; R4 and R5 represent hydrogen atom or a halogen atom; R6 represents hydrogen atom, an alkylcarbonyl group, or an alkylcarbonyloxymethyl group, provided that a combination of R1, R2, and R3 provides (1) substantially high electron density of the benzene ring to which said groups bind, so that the compound represented by the formula (I) is substantially no fluorescent before the trapping of proton, or the like, and (2) substantially reduced electron density of the benzene ring to which said groups bind, so that a compound after the trapping, which is derived from the compound represented by the formula (I) is substantially highly fluorescent after the trapping of proton or the like). A fluorescent probe having an excellent fluorescence property is provided.Type: GrantFiled: July 7, 2003Date of Patent: April 28, 2009Assignees: Daiichi Pure Chemicals Co., Ltd.Inventors: Tetsuo Nagano, Yasuteru Urano, Suguru Kenmoku, Kohjiro Kanda
-
Patent number: 7524876Abstract: A compound represented by the following general formula (I) or a salt thereof: [wherein R1 and R2 represent hydrogen atom, a C1-6 alkyl group, or a group represented by the following formula (A): [wherein X1 and X2 represent hydrogen atom, or a group represented as —N(R3)(R4) (R3 and R4 represent hydrogen atom, a C1-6 alkyl group, a C1-6 alkylcarbonyl group, or a C1-6 alkyloxycarbonyl group); and n represents an integer of 1 to 6 ], provided that R1 and R2 do not simultaneously represent hydrogen atom), which is a novel luciferin derivative that serves as a luciferase substrate.Type: GrantFiled: July 27, 2006Date of Patent: April 28, 2009Assignee: The University of TokyoInventors: Hideo Takakura, Yasuteru Urano, Tetsuo Nagano
-
Patent number: 7482473Abstract: A compound represented by the following general formula (I) or a salt thereof [R1 represents hydrogen atom, or a C1-12 alkyl group; R2 represents a C1-12 alkyl group having one or more maleimide groups, an aryl group having two or more maleimide groups, a group represented by the formula (A): —(CH2)n—CO—N(R11)(R12) (R11 and R12 represent hydrogen atom, a C1-12 alkyl group, a C1-12 alkyl group having one or more maleimide groups, or an aryl group having one or more maleimide groups, and n represents an integer of 1 to 6), or a group represented by the formula (B): —(CH2)m—NH—CO—R13 (R13 represents a C1-12 alkyl group having one or more maleimide groups, or an aryl group having one or more maleimide groups, and m represents an integer of 1 to 6); R3 and R5 represent hydrogen atom, or a halogen atom; R4 represents hydroxyl group, a C1-12 acyloxy group, a C1-12 acyloxymethyloxy group, or an amino group], which is useful as a novel fluorescent labeling agent having a property of emitting intense fluorescence onlyType: GrantFiled: September 7, 2006Date of Patent: January 27, 2009Assignee: The University of TokyoInventors: Tetsuo Nagano, Yasuteru Urano, Takuji Shoda
-
Publication number: 20080249321Abstract: A fluorescent probe which is represented by the following formula (wherein R1 and R2 represent hydrogen atom, or a substituent for trapping proton, a metal ion, or an active oxygen species; R3 represents a monovalent substituent other than hydrogen atom, carboxy group, or sulfo group; R4 and R5 represent hydrogen atom, a halogen atom, or an alkyl group; R6 to R9 represent an alkyl group; R10 and R11 represent hydrogen atom, a halogen atom, or an alkyl group; M? represents a counter ion; and the combination of R1, R2, and R3 (1) imparts a substantially high electron density to the benzene ring to which they bond so that the compound can be substantially non-fluorescent before trapping proton, a metal ion, or an active oxygen species, and (2) substantially reduces electron density of the benzene ring to which they bond so that the compound after trapping proton, a metal ion, or an active oxygen species can be highly fluorescent after the trapping.Type: ApplicationFiled: March 3, 2005Publication date: October 9, 2008Applicants: Sekisui Medical Co., Ltd.Inventors: Tetsuo Nagano, Yoko Wada, Yasuteru Urano
-
Publication number: 20080188006Abstract: A method for measuring hypochlorite ion, which comprises the steps of. (A) reacting, with hypochlorite ion, a compound represented by the following general formula (I): wherein R1 represents a 2-carboxyphenyl group which may be substituted; R2 represents a phenyl group which is substituted with a substituted or unsubstituted amino group; X1 and X2 each independently represents either hydrogen atom or a halogen atom; or a salt thereof; and (B) measuring fluorescence of a dearylated compound generated in the aforementioned step (A) or a salt thereof.Type: ApplicationFiled: April 9, 2008Publication date: August 7, 2008Applicants: TETSUO NAGANO, DAIICHI PURE CHEMICALS CO., LTD.Inventors: Ken-ichi SETSUKINAI, Yasuteru URANO, Tetsuo NAGANO
-
Patent number: 7378282Abstract: A method for measuring hypochlorite ion, which comprises the steps of: (A) reacting, with hypochlorite ion, a compound represented by the following general formula (I): wherein R1 represents a 2-carboxyphenyl group which may be substituted; R2 represents a phenyl group which is substituted with a substituted or unsubstituted amino group; X1 and X2 each independently represents either hydrogen atom or a halogen atom; or a salt thereof; and (B) measuring fluorescence of a dearylated compound generated in the aforementioned step (A) or a salt thereof.Type: GrantFiled: May 14, 2003Date of Patent: May 27, 2008Assignees: Daiichi Pure Chemicals Co., Ltd.Inventors: Ken-ichi Setsukinai, Yasuteru Urano, Tetsuo Nagano
-
Publication number: 20080014147Abstract: A tumor cell or tumor tissue-selective fluorescent staining agent comprising a compound represented by the following general formula (I): wherein R1 and R2 independently represent a C1-C4 alkyl group which may be substituted, a C2-C4 alkenyl group which may be substituted, a C2-C4 alkynyl group which may be substituted, an aryl group which may be substituted, or a heteroaryl group which may be substituted.Type: ApplicationFiled: February 23, 2007Publication date: January 17, 2008Applicant: The University of TokyoInventors: Tetsuo Nagano, Yasuteru Urano, Hirotatsu Kojima, Yuuta Fujikawa, Tetsuro Takamatsu, Yoshinori Harada
-
Publication number: 20080014602Abstract: A fluorescent probe which is represented by the following formula (I): (wherein, R1 represents a monovalent substituent other than hydrogen atom, carboxy group, or sulfo group; R2 represents hydrogen atom, or a monovalent substituent; R3 and R4 each independently represents hydrogen atom or a halogen atom; and R5 represents a monovalent group which is cleaved by contact with a measuring object, provided that a combination of R1 and R2 is selected so that the oxidation potential of the benzene ring to which they bind makes (1) the compound represented by the formula (I) substantially no fluorescent before the cleavage, and (2) a compound after the cleavage, which is derived from the compound represented by the formula (I), substantially highly fluorescent after the cleavage).Type: ApplicationFiled: September 3, 2004Publication date: January 17, 2008Inventors: Tetsuo Nagano, Mako Kamiya, Yasuteru Urano