Abstract: A multi-chamber container for storing and applying eye drops. A container body (1) of the multi-chamber container has at least two chambers: a first chamber (3) and a second chamber (4), which are completely separated by means of a separable seal portion, wherein the first chamber and the second chamber independently encapsulate different types of medicaments; and a weak weld (2) is provided between the first chamber and the second chamber, so as to avoid changes over time when these agents are mixed together. The seal portion in the multi-chamber container can be separated upon application of an external force to one of the chambers of the container, such that the separately encapsulated different medicaments are mixed together in a sterile state, and a mixed solution that can be applied directly to the eye can be formed. The first chamber is provided with an outflow port (5).

Abstract: The present invention belongs to the technical field of chemical synthesis. Provided are a catalyst for an sp3-carbon-hydrogen-bond primary amination reaction, and a method for preparing a primary amine compound. The structure of the catalyst is as represented by formula (I). The method for preparing a primary amine compound by using the catalyst in the present invention has high general applicability and wide substrate applicability for reaction, is environmentally friendly; the reaction conditions are mild and not harsh, and the reaction operation is simple and convenient; and the method has potential industrial application prospects.

Abstract: A method includes: determining whether a first uplink transmission resource overlaps a first sidelink transmission resource in time domain; when the first uplink transmission resource overlaps the first sidelink transmission resource in time domain, determining a first configured maximum output power based on a first maximum power reduction, where the first maximum power reduction is a maximum power reduction corresponding to a con-current mode; and determining a transmitted power for a first uplink transmission and a transmitted power for a first sidelink transmission based on the first configured maximum output power.

Abstract: Provided are gene constructs that encode a microdystrophin protein for use in gene therapy. The microdystrophin gene constructs and expression cassettes were engineered for improved therapy with respect to efficacy, potency and safety to the subject when expressed by a viral vector in muscle cells and/or CNS cells.

Abstract: The present invention relates to carbohydrate esterase family 1 (CE1) polypeptides having ferulic acid esterase and/or acetyl xylan esterase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. The invention also relates to compositions comprising a CE1 family polypeptide having ferulic acid esterase and/or acetyl xylan esterase activity and use of the compositions for solubilizing hemicellulosic fiber.

Abstract: A hybrid transactional/analytical processing (HTAP) database includes an online transaction processing (OLTP) engine, an online analytical processing (OLAP) engine provided separately from the OLTP engine, and a shared storage holding data of multiple tenants. The shared storage is configured to receive a request for a first scan from a first tenant and a request for a second scan from a second tenant, execute the first scan, and after a predetermined first period of time has elapsed without the first scan finishing, pause the first scan and execute the second scan.

Abstract: A communication apparatus includes a first duplexer, a second duplexer, and a switch. In a first switch position, a first output end of the switch is connected to a first branch at which the first duplexer is located. In a second switch position, a second output end of the switch is connected to a second branch at which the second duplexer is located. A transmit filter of the first duplexer corresponds to a first uplink band. A receive filter of the first duplexer corresponds to a first downlink band. A bandwidth of the first downlink band is greater than a bandwidth of the first uplink band. A transmit filter of the second duplexer corresponds to a second uplink band. A receive filter of the second duplexer corresponds to a second downlink band. A bandwidth of the second downlink band is greater than a bandwidth of the second uplink band.

Abstract: Disclosed herein is an aminopyrazine compound of Formula (I), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions comprising thereof. Also disclosed is a method of treating HPK1 related disorders or diseases by using the compound disclosed herein.

Abstract: Disclosed probes comprise metal nanoparticle cores associated with magnetic particles that allow probes associated with targets to be concentrated by an applied magnetic field to increase detection sensitivity and provide sufficient spacing between concentrated probes to avoid signal quenching. The probe may comprise at least one recognition receptor, and may further comprise at least one reporter molecule, such as a fluorescent tag, a Raman reporter, or combinations thereof. Concentrating probe-target composites substantially enhances a sensing signal, such as from 5 to 10 times, compared to detection without concentrating the probes. The method may be used to detect, for example, interleukins at concentrations at least as low as 25 pg/ml in sputum or blood from a subject for early and precise profiling of viral infections, such as SARS-CoV-2 infections.

Abstract: A session processing method, a related apparatus, and a medium are provided. The session processing method includes: displaying an entry control of a target virtual scene; displaying the target virtual scene in response to the entry control being triggered by a first object, the target virtual scene comprising a first virtual object representing the first object and a second virtual object representing a second object, and the second object being not associated with the first object; displaying a first session start control for the second virtual object; displaying a first session region in response to the first session start control being triggered, the first session region being configured for supporting a session hold by the first virtual object and the second virtual object; and establishing an association relationship between the first object and the second object.

Abstract: A hybrid transactional/analytical processing (HTAP) database is provided, which includes an online transaction processing (OLTP) engine, an online analytical processing (OLAP) engine provided separately from the OLTP engine, and a shared storage holding data. The shared storage includes an OLTP storage holding data in row format for responding to queries of the OLTP engine, and an OLAP storage holding data in column format for responding to queries of the OLAP engine. The OLAP storage includes a delta store configured to record changes made to the OLTP storage in an update, and a base store configured to implement the update from the delta store on data in persistent storage in a flush. The HTAP database further includes a table metadata service configured to generate and perform operations on table metadata of the data that is updated in the flush.

Abstract: A hybrid transactional/analytical processing (HTAP) database is provided, which includes an online transaction processing (OLTP) engine, an online analytical processing (OLAP) engine provided separately from the OLTP engine, and a shared storage holding data. The shared storage includes an OLTP storage holding data in row format for responding to queries of the OLTP engine, and an OLAP storage holding data in column format for responding to queries of the OLAP engine. The OLAP storage includes a delta store configured to record changes made to the OLTP storage in an update, and a base store configured to implement the update from the delta store on data in persistent storage in a flush. The HTAP database further includes a table metadata service configured to generate and perform operations on table metadata of the data that is updated in the flush.

Abstract: Embodiments described herein provide a method for a unified code and natural language search system that integrates both natural language and programming language queries and documents. The method includes receiving a training dataset comprising natural language and programming language queries and documents, and training a neural network-based embedding model in two stages: first, by adapting the model with natural language query-document pairs, and then further adapting it with combined programming and natural language query-document pairs. The updated parameters from each stage are integrated into the model to enhance retrieval capabilities. In response to a search query, the trained embedding model retrieves relevant documents from a collection based on the similarity between the query and document embeddings.

Abstract: Embodiments described herein provide systems and methods for retrieval augmented generation. A neural network based language model may be provided a question as a user input. Based on the user input, semantically diverse queries may be generated for retrieval from diverse data sources. For example, a structured data source (e.g., database or knowledge base) and unstructured data (e.g., text articles) may be used to retrieve information relevant to the user input. The retrieve information may be ranked so that the most relevant information is used by the language model in generating an answer to the question in the user input. A non-retrieval based answer generated by the language model may be utilized in some embodiments in generating the final answer.

Abstract: A communication method includes reporting fourth and fifth band sets. The fourth band set and the fifth band set include a twelfth band and a thirteenth band. A maximum quantity of layers supported by uplink transmission on the twelfth band of the fourth band set is 1. A maximum quantity of layers supported by uplink transmission on the thirteenth band of the fourth band set is 2. A maximum quantity of layers supported by uplink transmission on the twelfth band of the fifth band set is 2. A maximum quantity of layers supported by uplink transmission on the thirteenth band of the fifth band set is 2. The method also includes receiving fourth information that indicates transmitter (Tx) switching on the twelfth band and the thirteenth band. The method further includes performing Tx switching on the twelfth band and the thirteenth band based on parameters of a sounding reference signal.

Abstract: The present invention relates to recombinant adeno-associated viruses (rAAVs) having capsid proteins engineered to include amino acid sequences that confer and/or enhance desired properties. In particular, the invention provides engineered capsid proteins comprising peptide insertions from heterologous proteins inserted within or near variable region IV (VR-IV) of the virus capsid, such that the insertion is surface exposed on the AAV particle. The invention also provides capsid proteins that direct rAAVs to target tissues, in particular, capsid proteins comprising peptides that are inserted into surface-exposed variable regions using a method for replacing a stop codon in the capsid gene with such peptide insert. The invention provides such methods for making the rAAV vectors into vector libraries and selecting the rAAV vectors having peptide inserts that target the rAAV to particular tissues of interest, and thus deliver therapeutics for treating disorders.

Abstract: A hybrid transactional/analytical processing (HTAP) database includes an online transaction processing (OLTP) engine, an online analytical processing (OLAP) engine provided separately from the OLTP engine, and a shared storage holding data of multiple tenants. The shared storage is configured to receive a request for a first scan from a first tenant and a request for a second scan from a second tenant, execute the first scan, and after a predetermined first period of time has elapsed without the first scan finishing, pause the first scan and execute the second scan.

Abstract: A method for building an artificial intelligence (AI) agent. The method includes: receiving a training query; generating, by a first neural network based language model, a training dataset comprising a correct solution and an incorrect solution to the training query; generating, by a second neural network based language model, a first candidate score in response to the correct solution and a second candidate score in response to the incorrect solution; and training the second neural network based language model, based on a training objective. The method also includes building, at a server, an AI agent through a first application programming interface (API) to a third neural network based language model configured to generate a plurality of candidate solutions in response to the user utterance, and through a second API to the trained second neural network based language model configured to generate scores conditioned on the plurality of candidate solutions; ranking.