Abstract: Provided are methods of treating or ameliorating the symptoms of dystrophinopathies, such as Duchenne muscular dystrophy and Becker muscular dystrophy by administration of therapeutically effective doses of recombinant adeno-associated viruses (rAAV) containing a transgene encoding a microdystrophin.

Abstract: The present invention relates to nucleic acid expression cassettes that are engineered to include polynucleotide sequences useful as inert stuffer (or filler) sequences in expression cassettes, particularly useful for transgene expression delivered as viral vectors, incorporating the engineered expression cassettes described herein, including rAA Vs, for use in therapy.

Abstract: Embodiments described herein provide systems and methods for training a text retrieval model. A system may generate queries associated with provided documents. The queries may be generated in one or more different manners. Examples of query generation may include extracting relevant spans of text from the documents, prompting a language model for a topic, title, abstractive summary, and/or extractive summary based on the documents. Metadata such as title or other HTML tags may be used as queries. Using the one or more queries, the text retrieval model may be trained using contrastive learning, using the generated query, and positive and negative sample documents. A fine-tuning training phase may be performed using domain-specific data which may also be done with generated query pairs, or may be done in a supervised fashion with provided queries. The text retrieval model may be used to locate documents given an input query.

Abstract: A page interaction method in provided, where the method includes: displaying a first page in response to a jump instruction for the first page, where the first page includes a first image layer and a second image layer in an expanded state, and the second image layer includes a wishing pool area; in response to detecting that the first page meets a preset entrance condition, displaying the first image layer on the second image layer, and playing a preset entrance special effect in the first image layer; and after the preset entrance special effect is played, canceling display of the first image layer, and playing interactive bullet-screen comments in the wishing pool area of the second image layer through scrolling.

Abstract: Described herein are surface treatment methods for removing one or more surface defect layers from polycrystalline films, polycrystalline films that are free of one or more defect surface layers, and use of the films in solar cells. In certain embodiments, the method is conducted by means of an adhesive tape or mechanical polishing. As described herein, solar cells containing the surface treated perovskite films show enhanced efficiency and stability.

Abstract: Embodiments described herein provide a semantic parsing framework which may be referred to as Uni-Parser. The Uni-Parser framework may be applied to question answering on both knowledge bases and databases. The three main stages of the Uni-Parser framework are enumeration, ranking, and generation. At the enumeration stage, primitives are enumerated based on matching the question to the data structure. After enumerating primitives, the Uni-Parser framework may rank the primitives used a trained ranker model. The top ranked primitives may then be used as inputs to a generator which is a learned sequence to sequence model which produces a logical form.

Abstract: A computer-implemented method for performing application data consistency management among a plurality of computing devices within a communication network includes retrieving by a first device, application data from a second device. The application data includes an app ID and a first application version number of an app residing on the second device. A first database table is updated using an object type associated with the app ID and the first application version number. The object type identifies a database table schema of a data object used by the app and a plurality of data fields of the data object. Data stored by one or more of the plurality of data fields is synchronized with a third device based on a second application version number of the app residing on the third device and the first database table.

Abstract: A metal 3D printing device comprises a building platform, a first powder spreading arm, a second powder spreading arm, a gas stream unit and a scanning module. The building platform is for supporting the powder. The first and second powder spreading arms are spaced and configured for spreading powder. The gas stream unites comprises a gas blowing port and a gas suction port, the gas blowing port is provided in the first powder spreading arm, and the gas suction port is provided in the second powder spreading arm. The scanning module is for emitting a laser to the powder preplaced between the first and second powder spreading arms to solidify the powder to form the product.

Abstract: A fan control system for use in a server system is disclosed. The fan control system includes a first monitoring and protection chip, a second monitoring and protection chip, a switch, a plurality of fans and a complex programmable logic device (CPLD). In a shutdown state of the server system, the switch is switched under control of the CPLD so that the fans are connected to the second monitoring and protection chip, receive standby power therefrom and run at a standby power level. When the server system is switched to a working state, the switch is switched under control of the CPLD so that the fans are connected to the first monitoring and protection chip, receive operating power therefrom and run at a higher working power level. This design can address different heat dissipation needs of various applications.

Abstract: Novel polypeptides having lysozyme activity, polynucleotides encoding polypeptides having lysozyme activity, and nucleic acid constructs, vectors, and host cells comprising polynucleotides that encode polypeptides having lysozyme activity, as well as methods of producing and using such polypeptides, polynucleotides, constructs, vectors, and host cells, including, but not limited to, animal feed and animal feed additives comprising polypeptides having lysozyme activity.

Abstract: Compositions and methods are described for the delivery of a fully human post-translationally modified therapeutic monoclonal antibody that binds to CGRP or CGRP receptor to a human subject for the treatment or prevention of migraines and cluster headaches. The antibodies may be delivered by gene therapy vectors, particularly rAAV vectors. Also provided are dual transgene constructs for the delivery of anti-CGRP and anti-CGRP receptor antibodies or antigen binding fragments thereof.

Abstract: The present invention relates to a method for producing a protein hydrolysate using a polypeptide having endopeptidase activity and a polypeptide having carboxypeptidase activity and the use of these enzymes for hydrolysing a protein substrate. In addition, the present invention relates to polypeptides having carboxypeptidase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

Abstract: A method for fabricating semiconductor devices is disclosed. The method includes forming a gate trench over a semiconductor channel, the gate trench being surrounded by gate spacers. The method includes sequentially depositing a work function metal, a glue metal, and an electrode metal in the gate trench. The method includes etching respective portions of the electrode metal and the glue metal to form a gate electrode above a metal gate structure. The metal gate structure includes a remaining portion of the work function metal and the gate electrode includes a remaining portion of the electrode metal. The gate electrode has an upper surface extending away from a top surface of the metal gate structure.

Abstract: Disclosed herein are methods and compositions for treating or preventing bacterial infection. In particular, the methods and compositions are directed towards C. difficile infection. In particular aspects, the compositions are vaccines containing multimeric polypeptides containing portions of multiple toxins from bacteria. The polypeptides induce effective immune responses thus treating or preventing infection.

Abstract: The present invention relates to a ?LED light-emitting and display device without electrical contact, external carrier injection and mass transfer and a preparation method thereof. The ?LED light-emitting and display device includes one or more light-emitting pixels, and each light-emitting pixel includes a pixel lower electrode, a lower insulation layer, a ?LED chip, an upper insulation layer and a pixel upper electrode from bottom to top, wherein the upper insulation layer and the lower insulation layer prevent the ?LED chip from being in direct electrical contact with the pixel lower electrode and the pixel upper electrode, and the ?LED chip is lit by an alternating electric field through electromagnetic coupling.

Abstract: The present invention relates animal feed or animal feed additives comprising one or more polypeptides having lysozyme activity. The invention also relates to polypeptides having lysozyme activity, polynucleotides encoding the polypeptides nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

Abstract: Provided are animal feed or animal feed additives comprising one or more polypeptides having lysozyme activity. Provided are polypeptides having lysozyme activity, polynucleotides encoding the polypeptides nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

Abstract: The present invention relates animal feed or animal feed additives comprising one or more polypeptides having lysozyme activity. The invention also relates to polypeptides having lysozyme activity, polynucleotides encoding the polypeptides nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

Abstract: A communication method includes reporting fourth and fifth band sets. The fourth band set and the fifth band set include a twelfth band and a thirteenth band. A maximum quantity of layers supported by uplink transmission on the twelfth band of the fourth band set is 1. A maximum quantity of layers supported by uplink transmission on the thirteenth band of the fourth band set is 2. A maximum quantity of layers supported by uplink transmission on the twelfth band of the fifth band set is 2. A maximum quantity of layers supported by uplink transmission on the thirteenth band of the fifth band set is 2. The method also includes receiving fourth information that indicates transmitter (Tx) switching on the twelfth band and the thirteenth band. The method further includes performing Tx switching on the twelfth band and the thirteenth band based on parameters of a sounding reference signal.

Abstract: Provided are a lipase mutant and use thereof. The amino acid sequence of the lipase mutant has a sequence shown in SEQ ID NO: 1, that is, sites at which amino acid mutations occur include a V154L site.