Patents by Inventor Yi Qiang

Yi Qiang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220016180
    Abstract: Disclosed are compositions comprising umbilical tissue, wherein the umbilical tissue comprises one or more engineered channels. Also disclosed are compositions comprising a previously cryopreserved umbilical tissue, wherein after cryopreservation and subsequent thawing the umbilical tissue comprises: a) viable cells native to the umbilical tissue; b) tissue integrity of native umbilical tissue; c) one or more growth factors that are native to the umbilical tissue; and d) depleted amounts of one or more types of functional immunogenic cells. Disclosed are methods of producing compositions comprising umbilical tissue, wherein the umbilical tissue comprises one or more engineered channels. Also disclosed are methods of treating damaged tissue comprising administering to the site of the damaged tissue compositions comprising umbilical tissue, wherein the umbilical tissue comprises one or more engineered channels.
    Type: Application
    Filed: August 12, 2021
    Publication date: January 20, 2022
    Inventors: Alla DANILKOVITCH, Yi DUAN-ARNOLD, Matthew MOORMAN, Anne LERCH, Jin-Qiang KUANG
  • Publication number: 20220000437
    Abstract: An embodiment of a computed tomography apparatus includes an x-ray source and scan control circuity configured to control the x-ray source to expose a subject with x-rays over a scan having a plurality of views. A detector is disposed to receive x-rays from the x-ray source, has a plurality of anodes arranged in groups, and a common conductive strip between the anodes. Photon counting circuits are respectively provided for each of the anodes and have adjustable operating parameters. Connection circuitry is configured to adaptively connect, in a first mode, each anode to one of the photon counting circuits and, in a second mode, each anode in a group to a same one of the photon counting circuits. Processing circuitry, connected to the connection circuitry and the photon counting circuits, is configured to, for each of the views, select the first mode or the second mode and adjust the operating parameters based upon exposure data obtained from exposing the subject with the x-rays from the x-ray source.
    Type: Application
    Filed: July 2, 2020
    Publication date: January 6, 2022
    Applicant: Canon Medical Systems Corporation
    Inventors: Xiaochun LAI, Liang CAI, Yi QIANG, Xiaohui ZHAN
  • Publication number: 20210335023
    Abstract: The present disclosure relates to an apparatus for estimating scatter in positron emission tomography, comprising processing circuitry configured to acquire an emission map and an attenuation map, each representing an initial image reconstruction of a positron emission tomography scan, calculate, using a radiative transfer equation (RTE) method, a scatter source map of a subject of the positron emission tomography scan based on the emission map and the attenuation map, estimate, using the RTE method and based on the emission map, the attenuation map, and the scatter source map, scatter, and perform an iterative image reconstruction of the positron emission tomography scan based on the estimated scatter and raw data from the positron emission tomography scan of the subject.
    Type: Application
    Filed: April 28, 2020
    Publication date: October 28, 2021
    Inventors: Wenyuan QI, Yujie LU, Evren ASMA, Yi QIANG, Jeffrey KOLTHAMMER, Zhou YU
  • Publication number: 20210327106
    Abstract: A method of grouping detection events in an imaging apparatus is described herein. The detection events can include primary detection events and secondary scattered events, which are frequently discarded due to the secondary scattered events, thus reducing sensitivity of the dataset for eventual image reconstruction. The method includes cell modules cascaded with identical parametrized cells, in a pipeline fashion, having the last cell in the chain circle back to the first cell. A rotating data pointer indicates the location of the first entry in the cell pipeline. The described method enables the grouping of multiple samples of detector data in real time with no loss of information, based on a time and location of the detected event. The method can be implemented in an FPGA as a hardware-based real time process.
    Type: Application
    Filed: June 21, 2021
    Publication date: October 21, 2021
    Applicant: CANON MEDICAL SYSTEMS CORPORATION
    Inventors: Ehod ELRAN, Yi QIANG, Vishnu BALARAMAN
  • Publication number: 20210329756
    Abstract: The invention provides a light management information system for an outdoor lighting network system, having a plurality of outdoor light units each including at least one sensor type, where each of the light units communicates with at least one other light unit, at least one user input/output device in communication with at one or more of said outdoor light units, a central management system in communication with light units, said central management system sends control commands and/or information to one or more of said outdoor light units, in response to received outdoor light unit status/sensor information from one or more of said outdoor light units or received user information requests from said user input/output device, a resource server in communication with said central management system, wherein the central management system uses the light unit status/sensor information and resources from the resource server to provide information to the user input/output device and/or reconfigure one or more of the l
    Type: Application
    Filed: April 30, 2021
    Publication date: October 21, 2021
    Inventors: HONGXIN CHEN, DAVE ALBERTO TAVARES CAVALCANTI, MARCIN GRAMZA, LIANG JIA, QING LI, DANIEL J. PIOTROWSKI, MAREK ZBIGNIEW SZCZERBA, MARCIN KRZYSZTOF SZCZODRAK, QIN ZHAO, HONGQIANG ZHAI, MICHAEL ALEX VAN HARTSKAMP, MARTIN ELIXMANN, ZHONG HUANG, FULONG MA, XIANNENG PENG, JIANFENG WANG, YI QIANG YU, KIRAN SRINIVAS CHALLAPALI
  • Patent number: 11149062
    Abstract: Disclosed herein are novel HDAC inhibitors. The HDAC inhibitors may be used in methods of treating cancer. The HDAC inhibitors may be used in methods of treating a neurological disorder.
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: October 19, 2021
    Assignee: UWM Research Foundation, Inc.
    Inventors: Yi-Qiang Cheng, M. Mahmun Hossain, Douglas Steeber, Karyn Frick, Steven Clark, Joseph Ulicki
  • Publication number: 20210282732
    Abstract: A method and apparatus is provided to perform dead-time correction in a positron emission tomography (PET) by estimating a full singles spectrum using a scatter model. The scatter model can use a Monte Carlo method, a radiation transfer equation method, an artificial neural network, or an analytical expression. The scatter model simulates scatter based on an emission image/map and an attenuation image/map to estimate Compton scattering. In the full singles spectrum, the singles counts with energies less than 511 keV are determined from the simulated scatter. The attenuation image can be generated based on X-ray computed tomography or based on applying a joint-estimation to PET data.
    Type: Application
    Filed: March 12, 2020
    Publication date: September 16, 2021
    Applicant: Canon Medical Systems Corporation
    Inventors: Wenyuan QI, Yi Qiang, Karthikayan Balakrishnan, Yujie Lu
  • Patent number: 11096633
    Abstract: A positron emission tomography scanner includes a plurality of gamma-ray detector rings that form a bore through which an imaging subject is translated, each of the plurality of gamma-ray detector rings being in a first axial position, and processing circuitry configured to receive attenuation data associated with a plurality of transaxial slices of the imaging subject, determine a second axial position of each of the plurality of gamma-ray detector rings based on the received attenuation data, and adjust a position of each of the plurality of gamma-ray detector rings from the first axial position to the second axial position. The processing circuitry may further be configured to calculate an attenuation metric based on the received attenuation data, and determine the second axial position such that the attenuation metric calculated for each pair of adjacent gamma-ray detector rings is equal.
    Type: Grant
    Filed: May 27, 2020
    Date of Patent: August 24, 2021
    Assignee: CANON MEDICAL SYSTEMS CORPORATION
    Inventors: Wenyuan Qi, Yi Qiang, Evren Asma, Jeffrey Kolthammer
  • Publication number: 20210247530
    Abstract: A method and apparatus are provided for nonlinear energy correction of a gamma-ray detector using a calibration spectrum acquired from the background radiation of lutetium isotope 176 (Lu-176) present in scintillators in the gamma-ray detector. Further, by periodically acquiring Lu-176 spectra using the background radiation from the scintillators, the nonlinear energy correction can be monitored to detect when changes in the gamma-ray detector cause the detector to go out of calibration, and then use a newly acquired Lu-176 spectrum to update the calibration of the nonlinear energy correction as needed. The detector calibration is performed by comparing a reference histogram to a calibration histogram generated using the nonlinear energy correction, and adjusting the parameters of the nonlinear energy correction until the two histograms match.
    Type: Application
    Filed: February 12, 2020
    Publication date: August 12, 2021
    Applicant: CANON MEDICAL SYSTEMS CORPORATION
    Inventors: Xiaoli LI, Yi QIANG, Kent C. BURR
  • Patent number: 11069097
    Abstract: A method of grouping detection events in an imaging apparatus is described herein. The detection events can include primary detection events and secondary scattered events, which are frequently discarded due to the secondary scattered events, thus reducing sensitivity of the dataset for eventual image reconstruction. The method includes cell modules cascaded with identical parametrized cells, in a pipeline fashion, having the last cell in the chain circle back to the first cell. A rotating data pointer indicates the location of the first entry in the cell pipeline. The described method enables the grouping of multiple samples of detector data in real time with no loss of information, based on a time and location of the detected event. The method can be implemented in an FPGA as a hardware-based real time process.
    Type: Grant
    Filed: April 20, 2020
    Date of Patent: July 20, 2021
    Assignee: CANON MEDICAL SYSTEMS CORPORATION
    Inventors: Ehod Elran, Yi Qiang, Vishnu Balaraman
  • Publication number: 20210208293
    Abstract: A method of normalizing detector elements in an imaging system is described herein. The method includes a line source that is easier to handle for a user, and decouples the normalization of the detector elements into a transaxial domain and an axial domain in order to isolate errors due to positioning of the line source. Additional simulations are performed to augment the real scanner normalization. A simulation of a simulated line source closely matching the real line source can be performed to isolate errors due to physical properties of the crystals and position of the crystals in the system, wherein the simulated detector crystals are otherwise modeled uniformly. A simulation of a simulated cylinder source can be performed to determine errors due to other effects stemming from gaps between the detector crystals.
    Type: Application
    Filed: May 5, 2020
    Publication date: July 8, 2021
    Applicant: CANON MEDICAL SYSTEMS CORPORATION
    Inventors: Wenyuan QI, Yi QIANG, Evren ASMA, Xiaoli LI, Li YANG, Peng PENG, Jeffrey KOLTHAMMER
  • Publication number: 20210199823
    Abstract: A method and system for providing improved timing calibration information for use with apparatuses performing Time of Flight Positron Emission Tomography scans. Relative timing offset, including timing walk, within a set of processing units in the scanner are obtained and corrected using a stationary limited extent positron-emitting source, and timing offset between the set of processing units is calibrated using an internal radiation source, for performing calibration.
    Type: Application
    Filed: June 22, 2020
    Publication date: July 1, 2021
    Applicant: CANON MEDICAL SYSTEMS CORPORATION
    Inventors: Xiaoli LI, Yi QIANG, Kent C. BURR, Peng PENG
  • Publication number: 20210192647
    Abstract: A system and method of providing nutritional data for a user is disclosed herein. The method includes receiving a selected restaurant from a health tracking device, and providing menu data for the user based on the selected restaurant. The method further includes receiving a selected menu item from the health tracking device, associating the selected menu item with a plurality of food items in a database, and providing the plurality of food items for the user. Furthermore, the method includes receiving a selected one of the plurality of food items from the health tracking device, and providing nutritional data based on the selected one of the plurality of food items.
    Type: Application
    Filed: March 4, 2021
    Publication date: June 24, 2021
    Inventors: CHUL LEE, YI QIANG
  • Publication number: 20210194177
    Abstract: A soft neural interface connector apparatus includes a PCB having a two-dimensional array of solder balls, a transparent top board, a cushioning layer on one side of the transparent top board, and a soft neural interface including a flexible and/or stretchable microelectrode array (MEA) through which neural signals are obtained or delivered. The MEA includes a two-dimensional array of contact pads corresponding to the array of solder balls. The PCB, the transparent top board, the cushioning layer, and the MEA are stacked together such that the MEA is between the cushioning layer and the PCB, and the contact pads are aligned with and in electrical contact with associated solder balls. A magnetic connector system having at least one magnetic connector component on the transparent top board is magnetically connected with at least one magnetic connector component on the PCB to press the contact pads and associated solder balls together.
    Type: Application
    Filed: November 24, 2020
    Publication date: June 24, 2021
    Inventors: Hui Fang, Yi Qiang, Xun Han, Kyung Jin Seo
  • Patent number: 11026317
    Abstract: The invention provides a light management information system for an outdoor lighting network system, having a plurality of outdoor light units each including at least one sensor type, where each of the light units communicates with at least one other light unit, at least one user input/output device in communication with at one or more of said outdoor light units, a central management system in communication with light units, said central management system sends control commands and/or information to one or more of said outdoor light units, in response to received outdoor light unit status/sensor information from one or more of said outdoor light units or received user information requests from said user input/output device, a resource server in communication with said central management system, wherein the central management system uses the light unit status/sensor information and resources from the resource server to provide information to the user input/output device and/or reconfigure one or more of the l
    Type: Grant
    Filed: October 22, 2019
    Date of Patent: June 1, 2021
    Assignee: SIGNIFY HOLDING B.V.
    Inventors: Hongxin Chen, Dave Alberto Tavares Cavalcanti, Marcin Gramza, Liang Jia, Qing Li, Daniel J. Piotrowski, Marek Zbigniew Szczerba, Marcin Krzysztof Szczodrak, Qin Zhao, Hongqiang Zhai, Michael Alex Van Hartskamp, Martin Elixmann, Zhong Huang, Fulong Ma, Xianneng Peng, Jianfeng Wang, Yi Qiang Yu, Kiran Srinivas Challapali
  • Patent number: 10962662
    Abstract: A method and apparatus are provided for positron emission imaging to calibrate timing of a pixelated gamma detector using multi-channel events. The apparatus can include processing circuitry configured to obtain calibration data representing a time and a position at which gamma rays are detected at a plurality of detector elements, and determine which gamma-ray detections of the calibration data correspond to multi-channel detections in which energy of a respective gamma ray is shared and detected by two or more of the plurality of detector elements. Additionally, the processing circuitry can be configured to determine a timing calibration of the plurality of detector elements by optimizing an objective representing agreement between time data of the multi-channel detections in the calibration data and the timing calibration.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: March 30, 2021
    Assignee: CANON MEDICAL SYSTEMS CORPORATION
    Inventors: Yi Qiang, Xiaoli Li, Kent C. Burr
  • Patent number: 10943312
    Abstract: A system and method of providing nutritional data for a user is disclosed herein. The method includes receiving a selected restaurant from a health tracking device, and providing menu data for the user based on the selected restaurant. The method further includes receiving a selected menu item from the health tracking device, associating the selected menu item with a plurality of food items in a database, and providing the plurality of food items for the user. Furthermore, the method includes receiving a selected one of the plurality of food items from the health tracking device, and providing nutritional data based on the selected one of the plurality of food items.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: March 9, 2021
    Assignee: MyFitnessPal, Inc.
    Inventors: Chul Lee, Yi Qiang
  • Patent number: 10807147
    Abstract: A platform for constraining a workpiece includes x-y stage connected to a base, wherein the x-y stage includes a floor and a y-axis datum and a x-axis datum aligned along a first axis and a second axis perpendicular to the first axis, respectively, and a primary constraint mechanism on the x-y stage. The primary constraint mechanism includes an x-axis wedge, a primary y-axis wedge and a primary z-axis clamp, and a primary linear actuator with a rod extendable and retractable parallel to the second axis. A primary linear actuator slides the x-axis wedge away from the x-axis datum, slides the primary y-axis wedge away from the y-axis datum, and rotates the primary z-axis clamp away from the workpiece. The primary z-axis clamp is attached to a cam with a pinion gear that engages a rack gear connected to the rod of the primary linear actuator.
    Type: Grant
    Filed: January 4, 2018
    Date of Patent: October 20, 2020
    Assignees: KORVIS ASIA PRIVATE LIMITED, KORVIS AUTOMATION (SHANGHAI) CO. LTD
    Inventor: Yi Qiang Yang
  • Patent number: 10782429
    Abstract: A method and apparatus are provided for positron emission imaging to calibrate energy measurements of a pixilated gamma-ray detector using energy sharing events between channels of the detector. Due to conservation of energy, when the energy of a single gamma ray shared among multiple channels, the sum of measured energies across the respective channel must equal the original energy of the incident gamma ray. Further, the fractions of the original energy distributed to the respective channels can span the entire range of zero to the original energy. Thus, a single gamma-ray source (e.g., cesium isotope 137) can be used to continuously calibrate the nonlinear energy response of the detector over an entire range of interest.
    Type: Grant
    Filed: February 6, 2019
    Date of Patent: September 22, 2020
    Assignee: CANON MEDICAL SYSTEMS CORPORATION
    Inventors: Yi Qiang, Xiaoli Li, Kent C. Burr
  • Patent number: 10768318
    Abstract: A method and apparatus are provided for positron emission imaging to correct a recorded energy of a detected gamma ray, when the gamma ray is scattered during detection. When scattering occurs, the energy of a single gamma ray can be distributed across multiple detector elements—a multi-channel detection. Nonlinearities in the detection process and charge/light sharing among adjacent channels can result in the summed energies from the multiple crystals of a multi-channel detection deviating from the energy that would be measured in single-channel detection absent scattering. This deviation is corrected by applying one or more correction factors (e.g., multiplicative or additive) that shifts the summed energies of multi-channel detections to agree with a known predefined energy (e.g., 511 keV). The correction factors can be stored in a look-up-table that is segmented to accommodate variations in the multi-channel energy shift based on the level of energy sharing.
    Type: Grant
    Filed: October 17, 2018
    Date of Patent: September 8, 2020
    Assignee: Canon Medical Systems Corporation
    Inventors: Yi Qiang, Huini Du, Kent C. Burr