Abstract: Disclosed herein are compositions and methods for increasing the stability of recombinant nanobodies. Also disclosed herein are recombinant nanobodies comprising an IL-2 polypeptide that bind serum albumin and uses thereof for treating cancers.

Abstract: In some embodiments, pick and place tools can pick and place multiple dies with different die sizes from different source wafers at a time to increase the throughput. In addition, some of these tools may incorporate non-contact die handling during pick and place processes. In some examples, the non-contact mechanisms can use Bernoulli effects or acoustic wave or vibration techniques to hold and release dies.

Abstract: Heat sink incorporation in integrated circuit layers using high accuracy bonding is described. In an example, an integrated circuit structure includes a first device layer. A second device layer is below the first device layer. An interconnect structure is between the first device layer and the second device layer. A heat sink material layer is between the interconnect structure and the second device layer.

Abstract: Device stacking in integrated circuit layers using high accuracy bonding is described. In an example, an integrated circuit structure includes a first device layer above a first interconnect structure, the first device layer including nanowire-based transistors or fin-based transistors. The integrated circuit structure includes a second device layer below a second interconnect structure, the second device layer including nanowire-based transistors or fin-based transistors, and the second interconnect structure bonded directly to the first interconnect structure.

Abstract: This application provides a single-stage voltage-adjustable rectification system with multi-output full-wave rectification, including a rectifier and a control module. The rectifier includes a producing module, an idling switch component, a first transistor component, a second transistor component, a load, and a third transistor component in electrical connection. The producing module is configured for producing alternating input voltage. The first transistor component and the second transistor component are configured for generating, based on the alternating input voltage, DC output voltage. The load is configured for obtaining the DC output voltage.

Abstract: The present disclosure provides a growth method of a high-temperature phase lanthanum borosilicate crystal, where the high-temperature phase lanthanum borosilicate crystal is a ?-La1-yLnyBSiO5 crystal prepared by a high-temperature flux method; a composite flux system is (La1-yLny)BO3—LiMoO4—SiO2—B2O3, and (La1-yLny)BO3, LiMoO4, SiO2, and B2O3 in the system have molar percentages of x1, x2, x3, and x4, respectively; 0<x1<0.3, 0.7?x2<1, 0<x3<0.3, x1+x2+x3=1, x1:x4=2:1 to 4:1. In the present disclosure, a difficulty is overcome in the crystal growth of ?-LaBSiO5 due to phase transition. The crystal is an optical function material that does not undergo the phase transition during annealing and can exist stably at room temperature. The crystal is widely used in laser, terahertz, and other fields.

Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.

Abstract: The disclosure provides novel solid state forms of Compound I selected from ethanol solvate Form A, ethanol solvate Form B, citric acid cocrystal Form A, and Form B, compositions comprising the same, and methods of making and using the same, including use in treating APOL1 mediated kidney disease. (I).

Abstract: A smart helmet system, a helmet, and a transportation vehicle are provided. The smart helmet system includes a helmet body, a first detection module, a second detection module, and a third detection module. The helmet body includes a first lock part of a helmet lock and retention straps; a second lock part of the helmet lock is mounted on the transportation vehicle. The first detection module is configured to detect a connection state between the first lock part and the second lock part and send information of the connection state to a control module. The second detection module is configured to detect a wearing state of the helmet and send information of the wearing state to the control module. The third detection module is configured to detect an engagement state of the helmet buckle and send information of the engagement state to the control module.

Abstract: A scooter is provided, including a wheel(s), a gas tank, and a pressure gauge. Each wheel includes a hub and a tire. The gas tank is disposed on the hub. The pressure gauge includes a pressure measurement assembly, a valve assembly, and a pressure control assembly. The pressure measurement assembly is connected with a lumen of the tire to detect a target pressure of air in the lumen. The valve assembly is connected with the lumen and the gas tank and includes a second gas channel. The pressure control assembly is electrically connected with the pressure measurement assembly and the valve assembly, is in communication connection with a control unit of the scooter, and is configured to periodically transmit the target pressure to the control unit and control the valve assembly to open or close the second gas channel based on a target instruction sent by the control unit.

Abstract: Embodiments relate to a method and apparatus for determining lane level localization of a vehicle with global coordinates. An automotive vehicle includes a vehicle navigation system, a database comprising standard-definition map data corresponding to road level latitude and longitude coordinates for a plurality of roadway features, at least one image sensor, and a processor in communication with the vehicle navigation system, the database, and the at least one image sensor. The processor is configured to determine an initial location of the vehicle, estimate a current location of the vehicle based on a dead reckoning process, detect, based on image data from the at least one image sensor, a lateral position of the vehicle within a lane of a road, and update the current location of the vehicle based on a difference between the estimated current location and the lateral position of the vehicle within the lane.

Abstract: Crystalline forms of salts of Compound I are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

Abstract: Microelectronic assemblies, related devices and methods, are disclosed herein. In some embodiments, a microelectronic assembly may include a first die having a surface; a template structure having a first surface and an opposing second surface, wherein the first surface of the template structure is coupled to the surface of the first die, and wherein the template structure includes a cavity at the first surface and a through-template opening extending from a top surface of the cavity to the second surface of the template structure; and a second die within the cavity of the template structure and electrically coupled to the surface of the first die by interconnects having a pitch of less than 10 microns between adjacent interconnects.

Abstract: A receiver circuit for double data rate memory is shown, which is operative to receive an input signal. The receiver circuit has two separated input circuits and a load-stage circuit. The first input circuit and the second input circuit in the input stage handle signals of non-overlapping signal swings. The input signal is received by an enabled input circuit of the first and the second input circuits. The load-stage circuit is coupled to the enabled input circuit to form a hybrid cascode circuit of a common-source and common-gate design.

Abstract: A decision feedback equalizer for double data rate memory is shown, which uses a sampling circuit and an adder circuit with parallel-to-serial conversion. The sampling circuit separates the sampling of a sampling object into even bits and odd bits, to output even-bit data on an even-bit channel, and to output odd-bit data on an odd-bit channel. The adder circuit with parallel-to-serial conversion is coupled to the sampling circuit to receive the even-bit data and the odd-bit data, and to combine the even-bit data with the odd-bit data to generate full-rate data.

Abstract: Disclosed herein are to peptide bundlemers that possess one or more hydrophobic groups on the surface that are capable of assembling into lattice nanostructures, amorphous networks and liquid crystalline structures in solution. Methods of creating these structures and articles formed from these structures are also disclosed.

Abstract: In an artificial intelligence (AI)-based method for generating a building block in a commercial district, geographic information data of a target district and surrounding districts is acquired to construct a three-dimensional space sand table, then design conditions in various planning files and local legal regulations are translated and extracted to generate a three-dimensional building block of the district, and then a training sample library of three-dimensional contour lines of the district is constructed, a machine learning model is loaded to generate three-dimensional building heights of the district and optimize building forms, to generate a plurality of schemes for the building block of the district, and finally simulated display of the schemes and display of scheme indexes are performed by using a holographic display device, and the schemes are outputted.

Abstract: A decision-making method and system for a residential outdoor environment based on landscape approach motivation are provided.

Abstract: Microelectronic assemblies, related devices and methods, are disclosed herein. In some embodiments, a microelectronic assembly may include a first die and a through-dielectric via (TDV) surrounded by a dielectric material in a first layer, where the TDV has a greater width at a first surface and a smaller width at an opposing second surface of the first layer; a second die, surrounded by the dielectric material, in a second layer on the first layer, where the first die is coupled to the second die by interconnects having a pitch of less than 10 microns, and the dielectric material around the second die has an interface seam extending from a second surface of the second layer towards an opposing first surface of the second layer with an angle of less than 90 degrees relative to the second surface; and a substrate on and coupled to the second layer.

Abstract: Crystalline forms of Compound I: pharmaceutically acceptable salts thereof, and solvates and hydrates thereof are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.