Abstract: An orally deliverable pharmaceutical composition comprises as a sole or first active ingredient a compound of Formula I defined herein or a pharmaceutically acceptable salt thereof, for example ABT-263 free base or ABT-263 bis-HCl salt, dispersed, in a free base equivalent amount of at least about 2.5% by weight of the composition, in a pharmaceutically acceptable carrier; wherein said active ingredient is in solid-state form and/or the composition further comprises, dispersed in the carrier, a pharmaceutically acceptable heavier-chalcogen antioxidant in an amount effective to inhibit oxidation of the active ingredient at a thioether linkage thereof. The composition is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

Abstract: A kind of growth method of non-polarized-plane InN which is growing m-plane InN and In-rich m-plane InGaN on LiA1O2 (100) substrate by the metal organic chemical vapor deposition (MOCVD), and m-plane is one kind of non-polarized-plane, In-rich denotes that the component of In x is higher than 0.3 in InxGa1?xN. The invention synthetically grows m-plane InN and In-rich m-plane InGaN using LiA1O2 (100) as substrate which will be disposed and the buffer by MOCVD. And the non-polarized-plane InN would be produced through choosing appropriate substrate and the technique condition of growth as well as using the design of buffer by MOCVD.

Abstract: An orally deliverable pharmaceutical composition comprises (a) a pharmaceutically acceptable acid addition salt of ABT-263 in solid particulate form, and (b) a plurality of pharmaceutically acceptable excipients including at least a solid diluent and a solid disintegrant; wherein the salt is formed from more than one equivalent of acid per equivalent of ABT-263. The composition is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

Abstract: The invention describes methods of pulmonary delivery of a TNF? inhibitor to a subject having a disorder in which TNF? is detrimental, such that the disorder is treated. Also included is a method of achieving systemic circulation of a TNF? inhibitor in a subject comprising administering the TNF? inhibitor to the central lung region or the peripheral lung region of the subject via inhalation, such that systemic circulation of the TNF? inhibitor is achieved.

Abstract: The present invention provides compostions and methods useful for treating and preventing neurodegenerative disease and neurologically related disorders by inhibition of Lp-PLA2. The compositions and methods are useful for treating and preventing diseases and disorders with abnormal blood brain barrier (BBB) function, for example neurodegenerative diseases with a permeable BBB, such as but not limited to, Alzheimer's Disease, Huntington's Disease, Parkinson's Disease and Vascular Dementia.

Abstract: The present invention provides compostions and methods useful for treating and preventing metabolic bone diseases and disorders by inhibition of Lp-PLA2. The compositions and methods are useful for treating and preventing metabolic bone diseases and disorders such as, for example osteoporosis, osteopenia and osteopenia related diseases and abnormal bone marrow.

Abstract: Parenteral formulations of peptides which are useful for sustained release are disclosed. Also disclosed are methods of preparation for the formulations.

Abstract: A retaining device for retaining expansion cards (60) with cover plates (62) includes a rear panel (20), a retaining bar (40), and a clip (50). The rear panel includes a pair of hooks (24), and a card rack (30). The card rack includes a supporting plate (32) for supporting the bent portions (624) of the expansion cards, and a pair of mounting plates (36) extending upwardly at two ends of the supporting flange. A pivot hole (362) is defined in each of the mounting plates and includes a round portion (366), and an entry (364) communicating with the round portion and an edge of a corresponding mounting plate. The retaining bar includes a pair of neck portions (48) rotatably engaging in the pivot holes. The clip is attached to the retaining bar and includes a pair of catching parts (54) engaging with the hooks.

Abstract: A fingerprint identification data accessing device comprises a fingerprint detector for detecting the fingerprint applied thereon as inputted the fingerprint data; a memory unit; a verification and coding module having a verification unit for verifying the inputted fingerprint data with the predetermined fingerprint data, if the inputted fingerprint data is identical to the predetermined fingerprint data, an authorization is given, if fails, the data accessing device is closed or the user is requested to re-input the fingerprint data; and a coding chip; as the authorization is given, the coding chip will be actuate to allow to access the data stored in the memory unit; otherwise the data in the memory unit cannot be read. The data accessing device is capable of being connected to an external computer for performing mathematical operation required in the verification and receiving input encrypted codes from users.

Abstract: The present invention relates to a process of extracting haw pits by dry distillation and the device used therein. The process includes the following steps: removing the impurities of haw pits and drying them; immersing haw pits in water and then dripping and charging the dried pit into the furnace for dry distillation; gradually raising the temperature and dry distilling the haw pits at two temperature ranges of 105-195° C. and 305-380° C. respectively and collecting the distillate; mixing together the distillate, allowing them to separate into layers by specific gravity difference and separating out the final brownish red transparent liquor by siphon. The method of the present invention can provide high yield of extraction and the present device is simple in structure. Further, the present invention is easy to be employed on the industrial scale.

Abstract: Parenteral formulations of peptides which are useful for sustained release are disclosed. Also disclosed are methods of preparation for the formulations.

Abstract: Parenteral formulations of peptides which are useful for sustained release are disclosed. Also disclosed are methods of preparation for the formulations.

Abstract: A method for fabricating oxide layers with different thicknesses on a substrate is described. A field oxide layer is formed on the substrate to define a first active region and a second active region therebetween. A first oxide layer is formed over the first active region. A thin oxynitride layer is formed on the first oxide layer.

Abstract: The present invention relates to a process of extracting haw pits by dry distillation and the device used therein. The process includes the following steps: removing the impurities of haw pits and drying them; immersing haw pits in water and then dripping and charging the dried pit into the furnace for dry distillation; gradually raising the temperature and dry distilling the haw pits at two temperature ranges of 105-195° C. and 305-380° C. respectively and collecting the distillate; mixing together the distillate, allowing them to separate into layers by specific gravity difference and separating out the final brownish red transparent liquor by siphon. The method of the present invention can provide high yield of extraction and the present device is simple in structure. Further, the present invention is easy to be employed on the industrial scale.

Abstract: This invention provides an autonomous random dynamic cryptogram lock system which comprises a lock body and a key body. There are non-volatile memories in both the lock body and key body respectively and each memory stores a set of cryptogram corresponding. When unlocking the microprocessor in the lock body checks the cryptograms. If matching, the lock is unlocked, otherwise it gives up alarm. After unlocking, the microprocessor renews a set of the corresponding real random cryptogram in both memories for unlocking next time. It accomplishes one cryptoguard function every time.

Abstract: A method for fabricating oxide layers with different thicknesses on a substrate is described. A field oxide layer is formed on the substrate to define a first active region and a second active region therebetween. A first oxide layer is formed over the first active region. A thin oxynitride layer is formed on the first oxide layer.

Abstract: The present invention is directed to a method for the prophylactic and therapeutic treatment of diseases or disorders associated with the abnormal proliferation and extracellular matrix synthesis of smooth muscle cells (SMC) and fibroblasts due to activation of NAD(P)H and/or increased ROS generation. The method involves the administration of an NAD(P)H oxidase inhibitor(s) and/or antioxidant(s) to a mammal in an amount sufficient to treat the disease or disorder prophylactically or therapeutically. The NAD(P)H oxidase inhibitor inhibits the synthesis or translocation of NAD(P)H subunits, thereby blocking the generation of intracellular reactive oxygen species (ROS) and thus the proliferation and extracellular matrix synthesis of SMC and fibroblasts. Similarly, the administration of antioxidants blocks the generation of intracellular ROS, thereby inhibiting SMC and fibroblast proliferation and extracellular matrix synthesis.

Abstract: A method and compounds are provided for inhibiting the synthesis of extracellular matrix proteins. Compounds of the invention comprise oligonucleotides specific for nuclear proto-oncogenes. Preferably, oligonucleotides of the invention are selected from the group consisting of c-myc and c-myb and are locally administered. The invention finds use in the treatment of a variety of disorders, including sclerotic disorders and restenosis, associated with the inappropriate synthesis of extracellular matrix proteins, particularly collagen.

Abstract: A fabrication process of forming a semiconductor device with elevated source/drain regions on a substrate is disclosed. The elevated portion of the source/drain regions is provided as a reactant for a later metallization process, thereby preventing the consumption of too much silicon contained in the source/drain regions. First, an elevated silicon layer is formed on portions of a substrate for forming source/drain regions of a semiconductor device. Next, a gate dielectric layer and a gate electrode layer are formed on the elevated silicon layer successively to construct a gate structure. Then, a lightly doped ion implantation process, a process of forming a sidewall spacer and a heavily doped ion implantation process are performed successively. Thus, the elevated silicon layer can be used as a reactant while performing a self-aligned silicidization process.

Abstract: A method for forming self-aligned raised source and drain regions on a semiconductor wafer includes the steps of defining a substrate, growing a first layer of dielectric material over the substrate, depositing a layer of polysilicon over the first layer of dielectric material, patterning and forming at least one gate, depositing a second layer of dielectric material over the gate and the first dielectric layer and masking the second dielectric layer to define a source region and a drain region. The method also includes the steps of anisotropically etching to form sidewall spacers contiguous with the gate, collimated sputtering to deposit a layer of silicon, and implanting ions into the deposited silicon.