Abstract: Iron garnet nanoparticles and or iron garnet particles containing various activatable nuclides, such as holmium-165 (165Ho) and dysprosium-164 (164Dy), are disclosed in this application. The iron garnet (e.g., HoIG and DyIG) nanoparticles and iron garnet particles can prepared using hydroxide co-precipitation methods. In some embodiments, radiosensitizers can be loaded on radioactive magnetic nanoparticles or radioactive iron garnet particles and, optionally, coated with suitable lipid bilayers. Methods of using the disclosed nanoparticles and particles for mediating therapeutic benefit in diseases responsive to radiation therapy are also provided. Another aspect of the invention provides films, electrospun fabrics or bandage coverings for the delivery of radiation to the site of a skin lesion amenable to treatment with radiation (e.g., skin cancers or psoriasis).

Abstract: The present disclosure relates to a sprayable gel composition, comprising (a) from about 0.08% to about 1.8% by weight of a polysaccharide, (b) from about 0.002% to about 0.08% by weight of a divalent alkaline earth cation, (c) from about 0.1% to about 30% by weight of a humectant, (d) from 0% to about 30% by weight of an emollient, and (e) from about 40% to about 95% by weight of a cosmetically acceptable carrier, wherein the weight percentages are based on the total weight of all components of the sprayable gel composition, and to a method of treating hair in need of a conditioning treatment.

Abstract: The present disclosure relates to a sprayable gel composition for hair conditioning, comprising (a) from about 0.01% to about 0.35% by weight of an acrylate/alkyl-acrylate cross-polymer, (b) from about 0.1% to about 30% by weight of a silicone oil selected from dimethylpolysiloxane, cyclic polysiloxanes, hydroxyl-terminated polydimethylsiloxanes, polysiloxane-polyalkylene copolymers, alkyl methyl polysiloxanes, phenylmethylpolysiloxane, hydroxyl-terminated polydimethylsiloxanes, divinyldimethicone/dimethicone copolymer, and combination thereof, (c) from about 0.1% to about 30% by weight of a monohydric alcohol containing from about 2 to about 8 carbon atoms, and (d) from about 40% to about 99.

Abstract: Humanized antibodies specific to the protofibrillar form of the beta-amyloid peptide are provided. Methods of using antibodies specific to the protofibrillar form of the beta-amyloid peptide in the field of Alzheimer's disease are also provided.

Abstract: The present disclosure relates to solid dosage forms comprising antiviral compounds and methods of using such dosage forms to treat antiviral infection.

Abstract: Disclosed is a method for depositing ultrathin C8-BTBT, PTCDA and their heterojunctions with precise control of the molecular layers. In the method, source of the organic semiconductor material to grow (C8-BTBT or PTCDA) and a support are spaced from each other in a vacuum chamber with a temperature gradient, and ultrathin organic semiconductor crystal can be deposited on the support in crystalline form and with precisely controlled molecular layers. The as-deposited C8-BTBT or PTCDA crystals can be one-molecular-layer or two-molecular-layer in thickness and has full coverage on the support without any additional layers or voids. Ultrathin heterojunctions of these two-dimensional organic semiconductors can also be achieved.

Abstract: The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula I or II: wherein the variables are as defined herein.

Abstract: The further advancement of membrane separation processes requires the development of more selective membranes. In this study, membranes that take inspiration from biological systems and use multiple functionalities of unique chemical design to control solute transport through chemical factors in addition to steric factors are detailed. Specifically, copolymer materials tailor-made for the generation of nanofilters that possess a high density of well-defined pores lined by azido moieties allowed for the generation of chemically-patterned mosaic membranes in a rapid manner through the use of printing devices. By engineering the composition of the reactive ink solutions used for chemical functionalization, large areas of patterned membranes were generated in seconds rather than hours. Charge mosaic membranes were used as an example of this novel platform.

Abstract: A DNA molecule comprising the sequence set forth in SEQ ID NO: 1, a recombinant Pichia plasmid into which the DNA molecule is inserted, and a recombinant Pichia strain obtained by the transformation of the recombinant Pichia plasmid into a competent Pichia cell and efficiently expressing the PprI protein of Deinococcus radiodurans.

Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.

Abstract: The embodiments of the present invention disclose a data transmission method. A specific solution is as follows: A processor sends, by using a first resource block, a first MAC PDU that carries a first reservation indicator field used to instruct to reserve the first resource block; a receiver receives a second MAC PDU sent by using a second resource block by a set of second terminal devices, where the second MAC PDU carries a first resource feedback field used to indicate that the first resource block is successfully reserved; a processor determines, according to the first resource feedback field and that is sent by a second terminal device in the set of second terminal devices, that the first resource block is a resource block used to send a new MAC PDU; and the transmitter sends the new MAC PDU by using the first resource block.

Abstract: Iron garnet nanoparticles and or iron garnet particles containing various activatable nuclides, such as holmium-165 (165Ho) and dysprosium-164 (164Dy), are disclosed in this application. The iron garnet (e.g., HoIG and DyIG) nanoparticles and iron garnet particles can prepared using hydroxide co-precipitation methods. In some embodiments, radiosensitizers can be loaded on radioactive magnetic nanoparticles or radioactive iron garnet particles and, optionally, coated with suitable lipid bilayers. Methods of using the disclosed nanoparticles and particles for mediating therapeutic benefit in diseases responsive to radiation therapy are also provided. Another aspect of the invention provides films, electrospun fabrics or bandage coverings for the delivery of radiation to the site of a skin lesion amenable to treatment with radiation (e.g., skin cancers or psoriasis).

Abstract: A definition method for urban dynamic spatial structure circle comprising steps of: collecting the location data of mobile phone users for cleaning and handling to obtain a matched location data of mobile phone user; incorporating the matched location data of mobile phone user at various moments into a daily location data of mobile phone according to the date with a base station being the unit; locating spatially each base station with different users in a whole city through Tyson polygon processing method addressing the incorporated base station information; distributing the data of user number in each polygon into each land plot contained therein; obtaining mobile phone user distribution multi-circle numerical law on each moment and workday and finding the critical point of value, delineating the urban dynamic spatial structure circle distribution map after combining the circles in the same plot area.

Abstract: The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula I or II: wherein the variables are as defined herein.

Abstract: A method for serving node establishment includes sending, by a network device, information about a micro network time-frequency resource pool to a terminal; and sending measurement configuration information to the terminal. The measurement configuration information instructs the terminal to serve, when the terminal determines that the terminal meets a preset condition of a first measurement event, as a first serving node to send exclusive information of the first serving node on a first time-frequency resource in the micro network time-frequency resource pool according to the information about the micro network time-frequency resource pool, and the first measurement event is any one of the at least one measurement event.

Abstract: The present disclosure relates to solid dosage forms comprising antiviral compounds and methods of using such dosage forms to treat antiviral infection.

Abstract: Embodiments of the present invention provide a communication method and a related device. The method in the embodiments of the present invention includes: determining, by a vehicular device, configuration information, where the configuration information includes a first periodic status message sending parameter and a trigger condition for reporting a network congestion measurement event; determining, by the vehicular device, a network congestion indication parameter, where the network congestion indication parameter is used to indicate a congestion degree of a network environment of the vehicular device; reporting, by the vehicular device, network congestion information to the base station when the network congestion indication parameter meets the trigger condition for reporting a network congestion measurement event; receiving, by the vehicular device, a second periodic status message sending parameter that is sent by the base station according to the network congestion information.

Abstract: The present disclosure provides a backhaul link establishment method, a base station, and a device. The method includes: sending, by a base station, an offloading bearer request message to a first LPN according to a backhaul offloading establishment request message; receiving, by the base station, an offloading bearer acknowledgement message sent by the first LPN; sending, by the base station, an offloading bearer configuration message to a first UE-relay; and sending, by the base station, a received ID of a service bearer and received second S1 configuration information of the service bearer to a core network element by using an MME. In this way, backhaul load on uplink/downlink resources of the base station is reduced.

Abstract: Disclosed is a modified activated sludge-based two-compartment treatment method for processing nitrate-contaminated drinking water. Raw water is firstly sent to a first TiO2-modified denitrifying activated sludge bioreactor (2), wherein organic carbon source is added in a controlled amount, and nitrate is partly reduced with nitrite being accumulated. Then, the effluent from the first bioreactor is sent to a second TiO2-modified denitrifying activated sludge bioreactor (3), wherein organic carbon source and hydrogen gas are supplemented, and remaining nitrate and accumulated nitrite are reduced to nitrogen gas. The denitrified effluent from the second bioreactor is sent to a settling tank (4), and TiO2-containing precipitates collected from the settling tank receive sequential alkaline and acidic treatment before being injected into the first bioreactor (2) for TiO2 recycling.

Abstract: Iron garnet nanoparticles and or iron garnet particles containing various activatable nuclides, such as holmium-165 (165Ho) and dysprosium-164 (164Dy), are disclosed in this application. The iron garnet (e.g., HoIG and DyIG) nanoparticles and iron garnet particles can prepared using hydroxide co-precipitation methods. In some embodiments, radiosensitizers can be loaded on radioactive magnetic nanoparticles or radioactive iron garnet particles and, optionally, coated with suitable lipid bilayers. Methods of using the disclosed nanoparticles and particles for mediating therapeutic benefit in diseases responsive to radiation therapy are also provided. Another aspect of the invention provides films, electrospun fabrics or bandage coverings for the delivery of radiation to the site of a skin lesion amenable to treatment with radiation (e.g., skin cancers or psoriasis).