Patents by Inventor Yi Shi

Yi Shi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150126545
    Abstract: A composition comprises a kinase inhibitory compound, e.g., N-(4-{4-amino-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl}phenyl)-N?-(3-fluorophenyl)urea, in a mixture comprising (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. The composition is suitable for dilution with an IV solution for administration to a subject in need thereof for treatment of a cancer.
    Type: Application
    Filed: December 14, 2012
    Publication date: May 7, 2015
    Applicant: AbbVie Inc.
    Inventors: Yi Shi, Josh M. Lipari, Brian E. Padden, Lloyd S. Dias, Julie K. Spence
  • Patent number: 8962633
    Abstract: The present invention provides compostions and methods useful for treating and preventing metabolic bone diseases and disorders by inhibition of Lp-PLA2. The compositions and methods are useful for treating and preventing metabolic bone diseases and disorders such as, for example osteoporosis, osteopenia and osteopenia related diseases and abnormal bone marrow.
    Type: Grant
    Filed: May 12, 2008
    Date of Patent: February 24, 2015
    Assignee: Thomas Jefferson University
    Inventors: Yi Shi, Theresa Freeman
  • Patent number: 8867254
    Abstract: This invention describes the structure and the fabrication method of a flexible memory. The flexible memory includes eight layers. The three function layers are a flexible layer of hall unit, a flexible layer of horizontal lines, and a flexible layer of vertical lines. The main fabrication process of the flexible memory includes the following: the function layers are made on the hard substrates by the traditional nano-micro methods, and then the function layers are transferred on the flexible substrates, finally the whole layers are packaged to form the flexible memory.
    Type: Grant
    Filed: July 31, 2013
    Date of Patent: October 21, 2014
    Assignee: Nanjing University
    Inventors: Yi Zhao, Yi Shi, Xiangdong Ye
  • Publication number: 20140169081
    Abstract: This invention describes the structure and the fabrication method of a flexible memory. The flexible memory includes eight layers. The three function layers are a flexible layer of hall unit, a flexible layer of horizontal lines, and a flexible layer of vertical lines. The main fabrication process of the flexible memory includes the following: the function layers are made on the hard substrates by the traditional nano-micro methods, and then the function layers are transferred on the flexible substrates, finally the whole layers are packaged to form the flexible memory.
    Type: Application
    Filed: July 31, 2013
    Publication date: June 19, 2014
    Applicant: Nanjing University
    Inventors: Yi ZHAO, Yi Shi, Xiangdong YE
  • Publication number: 20140113921
    Abstract: The present disclosure relates to pharmaceutical compositions of pyrimidinedione derivative compounds and methods of preparing and uses thereof. The disclosure also relates to methods of enhancing bioavailability of pyrimidinedione derivative compounds in pharmaceutical compositions administered to a subject and methods of reducing the amount of a pyrimidinedione derivative compound in a pharmaceutical composition while achieving the same bioavailability in a subject.
    Type: Application
    Filed: October 18, 2013
    Publication date: April 24, 2014
    Inventors: Yanxia Li, Ping Gao, Yi Shi, Yi Gao, Jianwei Wu
  • Publication number: 20140105890
    Abstract: The present application relates to humanized antibodies specific to the protofibrillar form of the beta-amyloid peptide, and to the use of said antibodies in the field of Alzheimer's disease.
    Type: Application
    Filed: October 1, 2013
    Publication date: April 17, 2014
    Applicant: SANOFI
    Inventors: Nicolas BAURIN, Francis BLANCHE, Beatrice CAMERON, Marc DUCHESNE, Vincent MIKOL, Souad NAIMI, Laurent PRADIER, Yi SHI
  • Publication number: 20140042121
    Abstract: The present invention provides a method for removing burrs of battery electrode plates using inductively coupled plasma (ICP) dry etching, in which an induction coil is used for ionizing reaction gas. A DC bias is applied to accelerate the ionized reaction gas to bombard the burrs of electrode plate, removing burrs that formed in machining processes using physical bombardment. The equipment used in the present invention is an ICP etch system. The method according to the present invention can completely remove the burrs of electrode plate, thereby effectively preventing short circuits caused by burrs penetrating the membrane separator in the battery.
    Type: Application
    Filed: April 2, 2013
    Publication date: February 13, 2014
    Applicant: Nanjing University
    Inventors: RONG ZHANG, TING ZHI, TAO TAO, ZHILI XIE, ZHIGUO YU, BING LIU, PENG CHEN, XIANGQIAN XIU, YI LI, PING HAN, YI SHI, YOUDOU ZHENG
  • Patent number: 8614299
    Abstract: The present application relates to humanized antibodies specific to the protofibrillar form of the beta-amyloid peptide, and to the use of said antibodies in the field of Alzheimer's disease.
    Type: Grant
    Filed: May 11, 2010
    Date of Patent: December 24, 2013
    Assignee: Sanofi
    Inventors: Nicolas Baurin, Francis Blanche, Beatrice Cameron, Marc Duchesne, Vincent Mikol, Souad Naimi, Laurent Pradier, Yi Shi
  • Patent number: 8604409
    Abstract: The present invention relates to a photosensitive detector with a composite dielectric gate MOSFET structure and its signal readout method. The MOSFET structure detector is formed on a p-type semiconductor substrate. N-type semiconductor regions locate on the two sides of the top part of the p-type semiconductor substrate to form a source and a drain. An underlying dielectric layer, a photo-electron storage layer, a top dielectric layer, and a control gate are stacked on the substrate in sequence. The top insulating dielectric layer can prevent the photoelectrons stored in the photo-electron storage layer from leaking into the control gate. The source and the drain are floating when photoelectrons are collected and injected into the photoelectron storing layer to be held therein. There is a transparent or semi-transparent window for detecting incident light forming on the substrate or gate surface.
    Type: Grant
    Filed: February 10, 2010
    Date of Patent: December 10, 2013
    Assignees: Nanjing University
    Inventors: Feng Yan, Rong Zhang, Yi Shi, Lin Pu, Yue Xu, Fuwei Wu, Xiaofeng Bo, Haoguang Xia
  • Patent number: 8598216
    Abstract: The invention relates to ritonavir bis-hydrochloride, processes for the preparation of the ritonavir bis-hydrochloride, pharmaceutical compositions containing the ritonavir bis-hydrochloride and made from it, and methods of using the ritonavir bis-hydrochloride to inhibit HIV protease or enhance the pharmacokinetics of compounds which are metabolized by cytochrome P450 3A4.
    Type: Grant
    Filed: December 16, 2011
    Date of Patent: December 3, 2013
    Assignee: Abbvie Inc.
    Inventors: Maurizio Acquasaliente, Didier Houllemare, Geoff Zhang, Pulla Singam, John Morris, Kennan Marsh, Martin Babcock, John Pavlina, Yi Shi, Yuchuan Gong
  • Publication number: 20130184292
    Abstract: The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula I or II: wherein the variables are as defined herein.
    Type: Application
    Filed: September 28, 2012
    Publication date: July 18, 2013
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Jean-Damien Charrier, John Studley, Francoise Yvonne Theodora Marie Pierard, Steven John Durrant, Benjamin Joseph Littler, Robert Michael Hughes, David Andrew Siesel, Paul Angell, Armando Urbina, Yi Shi
  • Publication number: 20130171338
    Abstract: The present invention provides a conducting polymer, a synthesis method thereof, and an electroactive electrode covered with the said conducting polymer. The conducting polymer is synthesized as follows: use the polybasic acid as dopant and crosslinking agent, and polymerize monomers into conducting polymer hydrogel. The monomers are selected one or more from pyrrole or its derivatives, thiophene or its derivatives, aniline or its derivatives. The acid group of the polybasic acid contains phosphate or polybasic acid which contains at least two substituents per molecule selected from sulfate, nitrate or carboxylic in which the molecular weight of at least one acid group is no more than 800. The mole ratio of the acid group in polybasic acid to monomers of the conducting polymer is 1:12-12:1. The preparation applied in the invention is simple, and need not to import any impurity. The conducting polymer hydrogel has high ionic conductivity, super hydrophilicity, and good biocompatibility.
    Type: Application
    Filed: March 31, 2011
    Publication date: July 4, 2013
    Applicant: NANJING UNIVERSITY
    Inventors: Lijia Pan, Dongyuan Zhai, Yi Shi, Hao Qiu
  • Publication number: 20130150379
    Abstract: The present invention provides compostions and methods useful for treating and preventing neurodenerative disease and neurologically related disorders by inhibition of Lp-PLA2. The compositions and methods are useful for treating and preventing diseases and disorders with abnormal blood brain barrier (BBB) function, for example neurodegenerative diseases with a permeable BBB, such as but not limited to, Alzheimer's Disease, Huntington's Disease, Parkinson's Disease and Vascular Dementia.
    Type: Application
    Filed: March 14, 2011
    Publication date: June 13, 2013
    Applicants: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY, THOMAS JEFFERSON UNIVERSITY
    Inventors: Yi SHI, Robert NAGELE
  • Patent number: 8263777
    Abstract: The present invention relates to anhydrous and hydrated forms of Compound 1, which are useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising compounds of formula I and methods of using the compositions in the treatment of proliferative disorders.
    Type: Grant
    Filed: May 24, 2011
    Date of Patent: September 11, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: David J. Lauffer, Pan Li, Stefanie Roeper, Shereen Ibrahim, Anuj K. Kuldipkumar, Yi Shi, David B. Miller, Jr.
  • Publication number: 20120177639
    Abstract: The present application relates to humanized antibodies specific to the protofibrillar form of the beta-amyloid peptide, and to the use of said antibodies in the field of Alzheimer's disease.
    Type: Application
    Filed: May 11, 2010
    Publication date: July 12, 2012
    Applicant: SANOFI
    Inventors: Nicolas Baurin, Francis Blanche, Beatrice Cameron, Marc Duchesne, Vincent Mikol, Souad Naimi, Laurent Pradier, Yi Shi
  • Publication number: 20110294849
    Abstract: The present invention relates to anhydrous and hydrated forms of Compound 1, which qre useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising compounds of formula I and methods of using the compositions in the treatment of proliferative disorders.
    Type: Application
    Filed: May 24, 2011
    Publication date: December 1, 2011
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: David J. Lauffer, Pan Li, Stefanie Roeper, Shereen Ibrahim, Anuj K. Kuldipkumar, Yi Shi, David B. Miller, JR.
  • Patent number: 8059395
    Abstract: A mounting apparatus for attaching a data storage device to a chassis includes a latching member, first and second elastic members and a button. The latching member defines a through hole therein and forms a latching pin at a first end thereof. The button includes an abutting portion and a pressing portion extending up from the abutting portion. When the mounting apparatus is mounted to the chassis, the button is placed on a bottom side of the latching member, the latching member is movably mounted to the chassis, the first elastic member is compressed between the second end of the latching member and a baffle formed on the chassis, the second elastic member is compressed between the button and the chassis, the pressing portion of the button extends through the through hole and extending out of a top surface of the latching member.
    Type: Grant
    Filed: March 19, 2010
    Date of Patent: November 15, 2011
    Assignees: Hong Fu Jin Precision Industry (ShenZhen) Co., Ltd., Hon Hai Precision Industry Co., Ltd.
    Inventors: Guang-Yi Zhang, Xiao-Zheng Li, De-Yi Shi
  • Publication number: 20110215227
    Abstract: The present invention relates to a photosensitive detector with a composite dielectric gate MOSFET structure and its signal readout method. The MOSFET structure detector is formed on a p-type semiconductor substrate. N-type semiconductor regions locate on the two sides of the top part of the p-type semiconductor substrate to form a source and a drain. An underlying dielectric layer, a photo-electron storage layer, a top dielectric layer, and a control gate are stacked on the substrate in sequence. The top insulating dielectric layer can prevent the photoelectrons stored in the photo-electron storage layer from leaking into the control gate. The source and the drain are floating when photoelectrons are collected and injected into the photoelectron storing layer to be held therein. There is a transparent or semi-transparent window for detecting incident light forming on the substrate or gate surface.
    Type: Application
    Filed: February 10, 2010
    Publication date: September 8, 2011
    Applicants: NANJING UNIVERSITY
    Inventors: Feng Yan, Rong Zhang, Yi Shi, Lin Pu, Yue Xu, Fuwei Wu, Xiaofeng Bo, Haoguang Xia
  • Publication number: 20110128693
    Abstract: A mounting apparatus for attaching a data storage device to a chassis includes a latching member, first and second elastic members and a button. The latching member defines a through hole therein and forms a latching pin at a first end thereof. The button includes an abutting portion and a pressing portion extending up from the abutting portion. When the mounting apparatus is mounted to the chassis, the button is placed on a bottom side of the latching member, the latching member is movably mounted to the chassis, the first elastic member is compressed between the second end of the latching member and a baffle formed on the chassis, the second elastic member is compressed between the button and the chassis, the pressing portion of the button extends through the through hole and extending out of a top surface of the latching member.
    Type: Application
    Filed: March 19, 2010
    Publication date: June 2, 2011
    Applicants: HONG FU JIN PRECISION INDUSTRY (ShenZhen) CO., LTD, HON HAI PRECISION INDUSTRY CO., LTD.
    Inventors: GUANG-YI ZHANG, XIAO-ZHENG LI, DE-YI SHI
  • Publication number: 20100323020
    Abstract: A liquid pharmaceutical composition comprises an aqueous medium having suspended therein a solid particulate Bc1-2 family protein inhibitory compound such as ABT-263, having a D90 particle size not greater than about 3 ?m; wherein the aqueous medium further comprises at least one pharmaceutically acceptable surfactant and at least one pharmaceutically acceptable basifying agent such as sodium bicarbonate in amounts that are effective together to inhibit particle size increase. The composition is suitable for oral or parenteral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bc1-2 family proteins, for example cancer.
    Type: Application
    Filed: June 17, 2010
    Publication date: December 23, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Rajeev Gokhale, Kennan C. Marsh, Yi Shi