Patents by Inventor Yi Yan

Yi Yan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIMICROBIAL GUANIDINIUM AND THIOURONIUM FUNCTIONALIZED POLYMERS
    Publication number: 20200085059
    Abstract: Antimicrobial cationic polycarbonates and polyurethanes have been prepared comprising one or more pendent guanidinium and/or isothiouronium groups. Additionally, antimicrobial particles were prepared having a silica core linked to surface groups comprising a guanidinium and/or isothiouronium group. The cationic polymers and cationic particles can be potent antimicrobial agents against Gram-negative microbes, Gram-positive microbes, and/or fungi.
    Type: Application
    Filed: November 16, 2019
    Publication date: March 19, 2020
    Inventors: Willy Chin, James L. Hedrick, Nor Lizawati Ibrahim, Ashlynn L.Z. Lee, Robert J. Ono, Qingxing Xu, Yi Yan Yang
  • ANTIMICROBIAL GUANIDINIUM AND THIOURONIUM FUNCTIONALIZED POLYMERS
    Publication number: 20200077660
    Abstract: Antimicrobial cationic polycarbonates and polyurethanes have been prepared comprising one or more pendent guanidinium and/or isothiouronium groups. Additionally, antimicrobial particles were prepared having a silica core linked to surface groups comprising a guanidinium and/or isothiouronium group. The cationic polymers and cationic particles can be potent antimicrobial agents against Gram-negative microbes, Gram-positive microbes, and/or fungi.
    Type: Application
    Filed: November 16, 2019
    Publication date: March 12, 2020
    Inventors: Willy Chin, James L. Hedrick, Nor Lizawati Ibrahim, Ashlynn L. Z. Lee, Robert J. Ono, Qingxing Xu, Yi Yan Yang
  • PREVENTION OF BIOFILM FORMATION
    Publication number: 20200071542
    Abstract: Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.
    Type: Application
    Filed: November 8, 2019
    Publication date: March 5, 2020
    Inventors: Amos Cahan, Hariklia Deligianni, Xin Ding, Mareva B. Fevre, James L. Hedrick, Pei-Yun S. Hsueh, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
  • TAILORABLE SURFACE TOPOLOGY FOR ANTIFOULING COATINGS
    Publication number: 20200071541
    Abstract: Embodiments are directed to a method of making an antifouling and bactericidal coating with tailorable surface topology. The method includes depositing a layer of branched polyethyleneimine (BPEI) and diamino-functionalized poly(propylene oxide) (PPO) in a mixture of water and organic solvent on a substrate to form a layer of BPEI/PPO. The method includes depositing a layer of glyoxal in a water-containing solution on the layer of BPEI/PPO. The method further includes curing the layer of BPEI/PPO and layer of glyoxal to form a homogenous, glyoxal crosslinked BPEI/PPO coating, where the curing induces local precipitation and alteration of the glyoxal crosslinked BPEI/PPO coating to provide a textured surface.
    Type: Application
    Filed: November 6, 2019
    Publication date: March 5, 2020
    Inventors: Amos Cahan, Xin Ding, Mareva B. Fevre, James L. Hedrick, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
  • PREVENTION OF BIOFILM FORMATION
    Publication number: 20200071543
    Abstract: Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.
    Type: Application
    Filed: November 8, 2019
    Publication date: March 5, 2020
    Inventors: Amos Cahan, Hariklia Deligianni, Xin Ding, Mareva B. Fevre, James L. Hedrick, Pei-Yun S. Hsueh, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
  • Star polymers with enhanced antimicrobial activity in response to light
    Patent number: 10561146
    Abstract: Techniques regarding star polymers with enhanced antimicrobial functionality are provided. For example, a polymer is provided that can comprise a core that can have a singlet oxygen generator and that can generate a singlet oxygen species upon irradiation with light. The polymer can also comprise a plurality of polycarbonate arms covalently bonded to the core. The plurality of polycarbonate arms can be degradable and can comprise a cation. Further, the plurality of polycarbonate arms can have antimicrobial functionality.
    Type: Grant
    Filed: November 28, 2017
    Date of Patent: February 18, 2020
    Assignee: International Business Machines Corporation
    Inventors: Willy Chin, James L. Hedrick, Noah Frederick Fine Nathel, Victoria A. Piunova, Zhi Xiang Voo, Yi Yan Yang
  • Prevention of biofilm formation
    Patent number: 10563069
    Abstract: Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: February 18, 2020
    Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, Institute of Bioengineering and Nanotechnology
    Inventors: Amos Cahan, Hariklia Deligianni, Xin Ding, Mareva B. Fevre, James L. Hedrick, Pei-Yun S. Hsueh, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
  • HIGHLY HYDROPHOBIC ANTIFOULING COATINGS FOR IMPLANTABLE MEDICAL DEVICES
    Publication number: 20200046886
    Abstract: Antibacterial coatings and methods of making the antibacterial coatings are described herein. In particular, a method for forming an organocatalyzed polythioether coating is provided in which a first solution including a bis-silylated dithiol and a fluoroarene is prepared. A second solution including an organocatalyst is prepared. The first solution and the second solution are mixed to form a mixed solution. The mixed solution is applied to a substrate, and the substrate is cured.
    Type: Application
    Filed: October 14, 2019
    Publication date: February 13, 2020
    Inventors: Amos Cahan, Mareva B. Fevre, James L. Hedrick, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
  • PRINTED REPASSIVATION FOR WAFER CHIP SCALE PACKAGING
    Publication number: 20200043878
    Abstract: Described examples provide integrated circuits and methods, including forming a conductive seed layer at least partially above a conductive feature of a wafer, forming a conductive structure on at least a portion of the conductive seed layer, performing a printing process that forms a polymer material on a side of the wafer proximate a side of the conductive structure, curing the deposited polymer material, and attaching a solder ball structure to a side of the conductive structure.
    Type: Application
    Filed: August 2, 2018
    Publication date: February 6, 2020
    Applicant: Texas Instruments Incorporated
    Inventors: Daiki Komatsu, Makoto Shibuya, Yi Yan, Hau Nguyen, Luu Thanh Nguyen, Anindya Poddar
  • BIODEGRADABLE POLYIONENES
    Publication number: 20200040136
    Abstract: Synthesis of polyionenes with built-in degradable linkers through addition polymerization of a novel class of degradable A2-type monomers (d-A2), and their use as antimicrobial agents are disclosed. A library of biodegradable polyionenes and Gemini-surfactants made from d-A2 monomers are also disclosed. These materials have potent and broad spectrum of antimicrobial activity with high selectivity over mammalian cells.
    Type: Application
    Filed: February 19, 2018
    Publication date: February 6, 2020
    Inventors: Yi Yan Yang, Shrinivas Venkataraman, Pang Kern Jeremy Tan
  • Printed repassivation for wafer chip scale packaging
    Patent number: 10541220
    Abstract: Described examples provide integrated circuits and methods, including forming a conductive seed layer at least partially above a conductive feature of a wafer, forming a conductive structure on at least a portion of the conductive seed layer, performing a printing process that forms a polymer material on a side of the wafer proximate a side of the conductive structure, curing the deposited polymer material, and attaching a solder ball structure to a side of the conductive structure.
    Type: Grant
    Filed: August 2, 2018
    Date of Patent: January 21, 2020
    Assignee: TEXAS INSTRUMENTS INCORPORATED
    Inventors: Daiki Komatsu, Makoto Shibuya, Yi Yan, Hau Nguyen, Luu Thanh Nguyen, Anindya Poddar
  • ANTIMICROBIAL GUANIDINIUM MACROMOLECULES WITH BACTERIA TARGETING MOIETIES
    Publication number: 20190388460
    Abstract: Compositions and methods regarding antimicrobial guanidinium macromolecules with one or more targeting moieties for selectively targeting bacteria are provided. According to an embodiment, an antimicrobial macromolecule is provided that comprises a polymer backbone and one or more guanidinium moieties that extend from the polymer backbone. The antimicrobial macromolecule further comprises a targeting moiety that extends from the polymer backbone. The targeting moiety can comprise a substance favored for consumption by bacteria, such as a monosaccharide.
    Type: Application
    Filed: June 20, 2018
    Publication date: December 26, 2019
    Inventors: James L. Hedrick, Yi Yan Yang, Nathaniel H. Park, Victoria A. Piunova, Zhi Xiang Voo
  • ANTIMICROBIAL POLYCARBONATES FOR MULTIDRUG RESISTANT BACTERIA
    Publication number: 20190390005
    Abstract: Compositions and methods regarding guanidinium functionalized polycarbonates that provide potent antimicrobial activity against multidrug resistant (MDR) bacteria, including Klebsiella pneumoniae (K. pneumoniae) are provided. According to an embodiment, an antimicrobial guanidinium-functionalized polymer is provided that comprises a hydrophobic molecular backbone with cationic guanidinium moieties respectively bound to the hydrophobic molecular backbone via butyl spacer groups. The antimicrobial guanidinium-functionalized polymer self-assembles into a micelle structure with hydrophobic residuals of the antimicrobial guanidinium-functionalized polymer buried inside the micelle structure and the cationic guanidinium moieties exposed on an external surface of the micelle structure to target pathogens.
    Type: Application
    Filed: June 20, 2018
    Publication date: December 26, 2019
    Inventors: James L. Hedrick, Yi Yan Yang, Chuan Yang
  • Highly hydrophobic antifouling coatings for implantable medical devices
    Patent number: 10507267
    Abstract: Antibacterial coatings and methods of making the antibacterial coatings are described herein. In particular, a method for forming an organocatalyzed polythioether coating is provided in which a first solution including a bis-silylated dithiol and a fluoroarene is prepared. A second solution including an organocatalyst is prepared. The first solution and the second solution are mixed to form a mixed solution. The mixed solution is applied to a substrate, and the substrate is cured.
    Type: Grant
    Filed: April 25, 2017
    Date of Patent: December 17, 2019
    Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Amos Cahan, Mareva B. Fevre, James L. Hedrick, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
  • Cationic polyamines for treatment of viruses
    Patent number: 10485824
    Abstract: Antiviral cationic polyamines were prepared by modifying polyethylenimines with N-acylating agents that introduce a side chain comprising one or more carbons and at least one alcohol hydroxy group. The cationic polyamines can have a linear or branched polyethylenimine backbone structure. Preferably, the cationic polyamines comprise pendant monosaccharide groups, which can be introduced via a cyclic carbonate comprising a pendant protected monosaccharide (e.g., mannose) group. The cationic polyamines can be active and selective against a broad spectrum of viruses at low concentrations, and are generally non-toxic.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: November 26, 2019
    Assignees: International Business Machines Corporation, Agency For Science, Technology And Research, National University of Singapore
    Inventors: James L. Hedrick, Ichiyama Koji, Naoki Yamamoto, Chuan Yang, Yi Yan Yang
  • CURVED-SURFACE COATED PLATE, PREPARATION METHOD THEREOF AND SOLAR MODULE
    Publication number: 20190348547
    Abstract: A curved-surface coated plate is provided. The curved-surface coated plate includes a curved-surface light-transmitting substrate and a film layer arranged on one side of the curved-surface light-transmitting substrate. The film layer is a full dielectric film and includes a high refractive index material film whose refractive index is higher than that of the curved-surface light-transmitting substrate. A method for preparing the curved-surface coated plate and a solar module including the curved-surface coated plate are also provided.
    Type: Application
    Filed: September 6, 2018
    Publication date: November 14, 2019
    Inventors: Zhenyu Wu, Junpeng Wan, Lisong Tao, Yi Yan, Shizhong Yang, Zhenlei Fang
  • SOLAR MODULE
    Publication number: 20190348555
    Abstract: A solar module is provided, comprising a front plate, a film, a solar cell and a back plate which are arranged in sequence, or comprising a front plate, a film, a solar cell, a film and a back plate which are arranged in sequence, wherein the front plate is a colored light-transmitting front plate.
    Type: Application
    Filed: August 1, 2018
    Publication date: November 14, 2019
    Inventors: Zhenyu Wu, Lisong Tao, Junpeng Wan, Yi Yan, Shizhong Yang, Zhenlei Fang
  • COATED PLATE, PREPARATION METHOD THEREOF AND SOLAR MODULE
    Publication number: 20190348557
    Abstract: A coated plate is provided. The coated plate includes a light-transmitting substrate and a film layer arranged on one side of the light-transmitting substrate. The film layer is a full dielectric film, and the film layer includes a high refractive index material film. The refractive index of the high refractive index material film is higher than that of the light-transmitting substrate. A preparation method of the coated plate and a solar module are also provided.
    Type: Application
    Filed: September 4, 2018
    Publication date: November 14, 2019
    Inventors: Zhenyu Wu, Lisong Tao, Junpeng Wan, Yi Yan, Shizhong Yang, Zhenlei Fang
  • VIRTUAL PROP ALLOCATION METHOD, SERVER, CLIENT, AND STORAGE MEDIUM
    Publication number: 20190342620
    Abstract: A server may divide a map into a grid comprising a plurality of cells, each of the cells corresponding to different geographic areas represented on the map. The server may determine geographic locations for a plurality of virtual props, respectively. The server may determine cells for the virtual props based on the geographic locations for placement of the virtual props. The server may obtain a current geographic location of a client. The server may identify a cell of the grid corresponding to the current geographic location of the client. The server may determine the identified cell is associated a virtual prop included in the virtual props. The server may allocate in response to the identified cell being associated with the virtual prop, the virtual prop to the client. The client receive prompt information indicative of the virtual prop being allocated to the client.
    Type: Application
    Filed: July 15, 2019
    Publication date: November 7, 2019
    Applicant: Tencent Technology (Shenzhen) Company Limited
    Inventor: Yi YAN
  • Preparation of robust polythioaminal carriers
    Patent number: 10457772
    Abstract: The present disclosure relates to polythioaminals with applications as carriers or delivery vehicles for therapeutic agents or other small molecule cargo. Polythioaminal block copolymer coupled to a therapeutic agent is a polymer-therapeutic conjugate that exhibits higher stability and longer life time in aqueous environments. The polythioaminal block copolymer coupled to a therapeutic agent can be synthesized by reacting hexahydrotriazines with a hydrophobic block precursor, a hydrophilic block precursor, a particle stabilizing segment precursor, and a cargo, such as a therapeutic agent, in a one pot synthesis. The ease of synthesizing the resulting polythioaminal block copolymer coupled to the therapeutic agent while offering the extended stability and polymer life time in aqueous environments make the polythioaminal block copolymer particularly attractive for therapeutic carriers.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: October 29, 2019
    Assignee: International Business Machines Corporation
    Inventors: Dylan J. Boday, Willy Chin, Jeannette M. Garcia, James L. Hedrick, Eunice Leong Jiayu, Shrinivas Venkataraman, Zhi Xiang Voo, Rudy J. Wojtecki, Yi Yan Yang