Abstract: In an embodiment, a magnetic assembly includes: an inner permeance annulus; and an outer permeance annulus connected to the inner permeance annulus via magnets, wherein the outer permeance annulus comprises a peak region with a thickness greater than other regions of the outer permeance annulus.

Abstract: Water-soluble, fluorescent particles and compositions, kits, and methods of making and using such particles are disclosed. Processes for preparing fluorescent particles and for controlling the size, polydispersity and optical properties of such particles also are provided.

Abstract: The present disclosure relates to a method for inhibiting a binding of a SARS-CoV-2 spike protein of a SARS-CoV-2 to an angiotensin-converting enzyme 2 including contacting the SARS-CoV-2 with a sufficient concentration of disulfiram, a method for inhibiting an activity of a main protease (Mpro) of SARS-CoV-2 including contacting a SARS-CoV-2 with a sufficient concentration of disulfiram, and a method for inhibiting an activity of a papain-like protease (PLpro) of SARS-CoV-2 including contacting a SARS-CoV-2 with a sufficient concentration of disulfiram. A method for inhibiting a replication or an infection of a SARS-CoV-2 in a cell includes contacting the cell with a sufficient concentration of disulfiram and a medical composition for use in a treatment of an infection of SARS-CoV-2 including a therapeutically effective amount of disulfiram are also provided.

Abstract: Systems and methods are disclosed for question generation to obtain more related medical information based on observed symptoms from a patient. In embodiments, possible diseases associated with the observed symptoms are generated by querying a knowledge graph. In embodiments, candidate symptoms associated with the possible diseases are also identified and are combined with the observed symptoms to obtain combined symptom sets. In embodiments, discriminative scores for the candidate symptom sets are determined and candidate symptoms with top discriminative scores are selected. In embodiments, these selected candidate symptoms may be checked for conflicts with observed symptoms and removed from further consideration if a conflict exists. In embodiments, one or more questions may be generated based on the remaining selected candidate systems to aid in collecting information about the patient. In embodiments, the process may be repeated with the updated observed symptoms.

Abstract: Presented are systems and methods that allow healthcare providers and governments to infer demand for healthcare resources to ensure effective and timely healthcare services to patients by reducing healthcare supply shortages, emergencies, and healthcare costs. In embodiments, this is accomplished by gathering data from a number of sources to generate labeled records from which entity features and relationships between entities are extracted, correlates, and/or combined with other external healthcare data. In embodiments, this information is used to train a model that predicts healthcare resource demands given a set of input conditions or factors.

Abstract: Water-soluble, fluorescent particles and compositions, kits, and methods of making and using such particles are disclosed. Processes for preparing fluorescent particles and for controlling the size, polydispersity and optical properties of such particles also are provided.

Abstract: The present disclosure relates to a method for preventing or inhibiting a synthesis of viral RNA of SARS-CoV-2 in a cell including contacting the cell with a sufficient concentration of tafenoquine, boceprevir or narlaprevir and a method for inhibiting an activity of a main protease (Mpro) of SARS-CoV-2 including contacting a SARS-CoV-2 with a sufficient concentration of tafenoquine, boceprevir or narlaprevir. A medical composition for use in a treatment of an infection of SARS-CoV-2 including a therapeutically effective amount of tafenoquine, boceprevir or narlaprevir is also provided.

Abstract: Various embodiments relate to a method and non-transitory computer readable medium for genome spelling correction, the method including the steps of performing pre-processing on a sentence, storing a first adjacent word to an unknown word and a second adjacent word to the unknown word, generating a plurality of candidate words for the unknown word, forming a plurality of trigrams with the first adjacent word to the unknown word and the second adjacent word to the unknown word and each of the plurality of candidate words, searching a trigram table for each of the plurality of trigrams and outputting the candidate word from the trigram with a highest trigram count in the trigram table.

Abstract: Silicon-substituted rhodamine compounds are disclosed herein. Also described herein are SiR dyes comprising at least one vinyl group attached to the Si atom (10 position) of the SiR dye. Derivatives, functionalized versions, conjugates, kits, related synthetic methods and uses of SiR compounds also are provided. Silicon-rhodamine (SiR) dyes can provide bright fluorescence at far red wavelengths and exhibit good photostability. The compounds described herein can be useful for fluorescent labeling and detection of biological samples.

Abstract: A method of forming foam material is provided, which includes mixing 100 parts by weight of a compound having cyclic carbonate groups and a foaming agent to form a foaming composition, wherein the foaming agent includes 3 to 13 parts by weight of carbamate salt and 15 to 65 parts by weight of amino compound. The foaming composition is heated to 100° C. to 170° C. for decomposing the carbamate salt into CO2 and amino compound, and the amino compound is reacted with the compound having cyclic carbonate groups to form the foam material.

Abstract: The disclosed embodiments provide a system for identifying root causes of performance issues. During operation, the system obtains a call graph containing a set of call paths for a set of services. Next, the system determines, based on a load test of the set of services, severity scores for the set of services, wherein the severity scores represent levels of abnormal behavior in the set of services. The system then groups the severity scores by the set of call paths and identifies, based on the grouped severity scores, one or more services as potential root causes of performance issues in the set of services. Finally, the system outputs the identified one or more services as the potential root causes of the performance issues.

Abstract: The composition includes a cyclic, unsaturated compound, preferably a polyphenol derivative. It reduces the synthesis of melanin by inhibiting the activity and expression levels of tyrosinase and related proteins, thereby preventing and limiting the content and distribution of melanin in mammalian skin. It also induces autophagy of melanosome, thereby restricting the synthesis, storage and transfer of melanin from melanocyte to keratinocyte. The dual modes of action allow for the efficacy of the composition at low dosage without causing toxicity to lighten skin and treat disorders associated with hyperpigmentation.

Abstract: The present disclosure relates to a visual field testing method, system, and testing apparatus based on head-mounted testing equipment. The method includes: transmitting, by the testing apparatus in electronic equipment, a start notification for starting monitoring of a movement trajectory of a pupil of a current eye to be tested to an eye movement tracking system after receiving a start test instruction transmitted from a controller; receiving, by the testing apparatus, movement state information of the pupil that is transmitted from the eye movement tracking system; and determining, by the testing apparatus, the movement trajectory of the pupil according to the movement state information, wherein the controller is a component that is associated with the head-mounted testing equipment and communicatively connected to the testing apparatus of the electronic equipment.

Abstract: The disclosed embodiments provide a system for identifying root causes of performance issues. During operation, the system obtains a call graph containing a set of call paths for a set of services. Next, the system determines, based on a load test of the set of services, severity scores for the set of services, wherein the severity scores represent levels of abnormal behavior in the set of services. The system then groups the severity scores by the set of call paths and identifies, based on the grouped severity scores, one or more services as potential root causes of performance issues in the set of services. Finally, the system outputs the identified one or more services as the potential root causes of the performance issues.

Abstract: Retina digital imaging system, instrument and method A retina digital imaging system includes: an illumination module (1), a main optical assembly (3), and an image sensor module (2); the illumination module (1) includes light-emitting diodes capable of emitting light with different wavelengths, and each light-emitting diode emits light to enter the retina through the main optical assembly (3) to form an illumination optical path; the light reflected by the retina passes through the main optical assembly (3) and forms an image on the image sensor module (2) to form an imaging optical path. The various spectral bands formed by light-emitting diodes may form a wider spectrum, so different layers of the retina may be imaged to provide valuable medical and diagnostic data.

Abstract: A polyurethane urea composition and a preparation method thereof are provided. The method includes mixing and reacting an urea and an amine compound to obtain a polyurea oligomer, and mixing and reacting the polyurea oligomer and a cyclic carbonate compound to obtain a polyurethane urea composition having a repeating unit represented by formula I: —R2—U2—U1—U2—R2—, wherein ??[formula I] U1 is a is an integer of 1 to 10000, each U2 is independently each R1 is independently a C1 to C20 alkylene group, a C3 to C20 cycloalkylene group, a C8 to C20 alkylarylene group, a polyether group having a weight-average molecular weight of 100 g/mol to 10000 g/mol, or a combination thereof, and each R2 is independently an aliphatic group, a cycloaliphatic group, an aromatic group substituted by an alkyl or an unsubstituted aromatic group, an oligo polyether group, an oligo polyester group, or a combination thereof.

Abstract: The present disclosure relates to a visual field testing method, system, and testing apparatus based on head-mounted testing equipment (02). The method includes: transmitting, by the testing apparatus in electronic equipment (01), a start notification for starting monitoring of a movement trajectory of a pupil of a current eye to be tested to an eye movement tracking system (03) after receiving a start test instruction transmitted from a controller; receiving, by the testing apparatus, movement state information of the pupil (202) that is transmitted from the eye movement tracking system (03); and determining, by the testing apparatus, the movement trajectory (203) of the pupil according to the movement state information, wherein the controller is a component that is associated with the head-mounted testing equipment (02) and communicatively connected to the testing apparatus of the electronic equipment (01). The method can reduce the testing complexity and may also improve the testing accuracy and comfort.

Abstract: In an embodiment, a magnetic assembly includes: an inner permeance annulus; and an outer permeance annulus connected to the inner permeance annulus via magnets, wherein the outer permeance annulus comprises a peak region with a thickness greater than other regions of the outer permeance annulus.

Abstract: Water-soluble, conjugated polymers containing one or more dibenzosilole monomer residues, as well as compositions, kits, and methods of making and using such polymers are disclosed. Also disclosed are dibenzosilole derivatives substituted with one or more water-solubilizing groups, and methods of making and using such derivatives to prepare water-soluble dibenzosilole polymers.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable media for automated profile image generation based on scheduled video conferences. A profile image generation system generates, based on image data captured during a first video conference, a first facial feature data set for a first identified face identified from the image data. The first facial feature data set includes numeric values representing the first identified face. The profile image generation system calculates, based on the first facial feature data set and historic facial feature data sets generated from image data captured during previous video conferences, a first value indicating a likelihood that the first identified face is a first meeting participant that participated in the first video conference. The profile image generation system determines that the first value meets or exceeds a threshold value, and in response, determines that the first identified face is the first meeting participant.