Abstract: Systems and methods are disclosed to identify entities that have a similar meaning, and may, in embodiments, be grouped into entity groups for knowledge base construction. In embodiments, the entity relations of similarity or non-similarity for an entity pair are predicted as a binary relationship. In embodiments, the prediction may be based upon similarity score between the entities and the entity features, which features are constructed using an entity feature or representation model. In embodiments, the prediction may be an iterative process involving minimum human checking and existing knowledge update. In embodiments, one or more entity groups are formed using graph search from the predicted entity pairs. In embodiments, a group centroid entity may be selected to represent each group based on one or more factors, such as its generality or popularity.

Abstract: Provided herein are compounds, compositions, kits, uses, and methods for assessing the viability of cells and/or quantifying the amount of live and dead cells in a mixture using differential stains. In some embodiments, the compounds are used in culture media or can function independently of fixation and/or permeabilization. In some embodiments, the compounds comprise a platinum atom. In some embodiments, the compounds comprise a nitrogen mustard moiety.

Abstract: Water-soluble, fluorescent particles and compositions, kits, and methods of making and using such particles are disclosed. Processes for preparing fluorescent particles and for controlling the size, polydispersity and optical properties of such particles also are provided.

Abstract: A polyurethane urea composition and a preparation method thereof are provided. The method includes mixing and reacting an urea and an amine compound to obtain a polyurea oligomer, and mixing and reacting the polyurea oligomer and a cyclic carbonate compound to obtain a polyurethane urea composition having a repeating unit represented by formula I: —R2—U2—U1—U2—R2, wherein ??[formula I] U1 is a is an integer of 1 to 10000, each U2 is independently each R1 is independently a C1 to C20 alkyl group, a C3 to C20 cycloalkyl group, a C8 to C20 alkylaryl group, a polyether group having a weight-average molecular weight of 100 g/mol to 10000 g/mol, or a combination thereof, and each R2 is independently an aliphatic group, a cycloaliphatic group, an aromatic group substituted by an alkyl or an unsubstituted aromatic group, an oligo polyether group, an oligo polyester group, or a combination thereof.

Abstract: The composition includes a cyclic, unsaturated compound, preferably a polyphenol derivative. It reduces the synthesis of melanin by inhibiting the activity and expression levels of tyrosinase and related proteins, thereby preventing and limiting the content and distribution of melanin in mammalian skin. It also induces autophagy of melanosome, thereby restricting the synthesis, storage and transfer of melanin from melanocyte to keratinocyte. The dual modes of action allow for the efficacy of the composition at low dosage without causing toxicity to lighten skin and treat disorders associated with hyperpigmentation.

Abstract: Methods, systems, and computer programs are presented for calculating a hyperparameter value set for training a machine-learning program (MLP). One method includes an operation for identifying a model for the MLP that comprises hyperparameter value sets to be tested based on a dataset that has performance data for features of the MLP. The method further includes operations for breaking the dataset into fragments for evaluating the model with a graphics processing unit (GPU) and for loading the cores of the GPU with the model and a respective hyperparameter value set. Each fragment of the dataset is streamed to a GPU memory, and the cores of the GPU evaluate, in parallel, the fragment based on the model and the respective hyperparameter value set. Further, the method includes operations for determining, storing, and presenting the best hyperparameter value set for the MLP.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable media for automated profile image generation based on scheduled video conferences. A profile image generation system generates, based on image data captured during a first video conference, a first facial feature data set for a first identified face identified from the image data. The first facial feature data set includes numeric values representing the first identified face. The profile image generation system calculates, based on the first facial feature data set and historic facial feature data sets generated from image data captured during previous video conferences, a first value indicating a likelihood that the first identified face is a first meeting participant that participated in the first video conference. The profile image generation system determines that the first value meets or exceeds a threshold value, and in response, determines that the first identified face is the first meeting participant.

Abstract: The disclosed embodiments provide a system for managing the execution of a statistical model. During operation, the system tracks a distribution of one or more metrics related to a performance of a first version of a statistical model. When a deviation in the distribution is detected, the system outputs an alert of an anomaly in the performance of the statistical model. The system also triggers a rollback to a second version of the statistical model.

Abstract: Water-soluble, conjugated polymers containing one or more dibenzosilole monomer residues, as well as compositions, kits, and methods of making and using such polymers are disclosed. Also disclosed are dibenzosilole derivatives substituted with one or more water-solubilizing groups, and methods of making and using such derivatives to prepare water-soluble dibenzosilole polymers.

Abstract: Water-soluble, conjugated polymers containing one or more dibenzosilole monomer residues, as well as compositions, kits, and methods of making and using such polymers are disclosed. Also disclosed are dibenzosilole derivatives substituted with one or more water-solubilizing groups, and methods of making and using such derivatives to prepare water-soluble dibenzosilole polymers.

Abstract: Presented are systems and methods that allow healthcare providers and governments to infer demand for healthcare resources to ensure effective and timely healthcare services to patients by reducing healthcare supply shortages, emergencies, and healthcare costs. In embodiments, this is accomplished by gathering data from a number of sources to generate labeled records from which entity features and relationships between entities are extracted, correlates, and/or combined with other external healthcare data. In embodiments, this information is used to train a model that predicts healthcare resource demands given a set of input conditions or factors.

Abstract: Systems and methods are disclosed to identify entities that have a similar meaning, and may, in embodiments, be grouped into entity groups for knowledge base construction. In embodiments, the entity relations of similarity or non-similarity for an entity pair are predicted as a binary relationship. In embodiments, the prediction may be based upon similarity score between the entities and the entity features, which features are constructed using an entity feature or representation model. In embodiments, the prediction may be an iterative process involving minimum human checking and existing knowledge update. In embodiments, one or more entity groups are formed using graph search from the predicted entity pairs. In embodiments, a group centroid entity may be selected to represent each group based on one or more factors, such as its generality or popularity.

Abstract: Systems and methods are disclosed provide improved automated extraction of medical-related information. In embodiments, finer-grained medical-related data, such as medical entities, including symptoms, diseases, dimensions, and temporal information, can be extracted. In embodiments, by extracted finer level medical-related information from an input statement and generating visual displays of that information, a medical professional can readily see relevant medical information that provides medical entities and associated dimension information, as well as evolving history.

Abstract: Systems and methods are disclosed for question generation to obtain more related medical information based on observed symptoms from a patient. In embodiments, possible diseases associated with the observed symptoms are generated by querying a knowledge graph. In embodiments, candidate symptoms associated with the possible diseases are also identified and are combined with the observed symptoms to obtain combined symptom sets. In embodiments, discriminative scores for the candidate symptom sets are determined and candidate symptoms with top discriminative scores are selected. In embodiments, these selected candidate symptoms may be checked for conflicts with observed symptoms and removed from further consideration if a conflict exists. In embodiments, one or more questions may be generated based on the remaining selected candidate systems to aid in collecting information about the patient. In embodiments, the process may be repeated with the updated observed symptoms.

Abstract: A catalyst and a method for synthesizing cyclic carbonate using the catalyst are provided. The catalyst includes a metal complex shown in formula (I): wherein R1, R2, R4, and R5 are independently a C1-C25 alkyl group, a C1-C25 alkoxy group, a C3-C8 cycloalkyl group, a C6-C25 aryl group, a C6-C25 aryloxy group, a C7-C25 aralkyl group, a C7-C25 aralkoxy group, or halogen; R3 is hydrogen, a C1-C25 alkyl group, a C3-C8 cycloalkyl group, a C6-C25 aryl group, a C6-C25 aryloxy group, a C7-C25 aralkyl group, or a C7-C25 aralkoxy group; M is Sn or Ti; X is Cl, Br, I, or OAc; and L represents ether or furan.

Abstract: A catalyst system includes a transition metal salt containing a halo group, an acetate group, or a combination thereof, and an organic phosphine ligand. The molar ratio of the organic phosphine ligand to the transition metal salt is greater than 0 and less than or equal to 50.

Abstract: Water-soluble, conjugated polymers containing one or more dibenzosilole monomer residues, as well as compositions, kits, and methods of making and using such polymers are disclosed. Also disclosed are dibenzosilole derivatives substituted with one or more water-solubilizing groups, and methods of making and using such derivatives to prepare water-soluble dibenzosilole polymers.

Abstract: Provided herein are heptamethine cyanine dyes having a large Stokes shift, and the salts and conjugates thereof. Also provided are methods of using and making such large Stokes shift dyes as fluorescence resonance energy transfer (FRET) acceptors or donors.

Abstract: Disclosed herein are compounds, compositions, methods, and kits for detecting reactive oxygen species (ROS) by conventional fluorescence microscopy, fluorescence spectroscopy, flow cytometry, and/or high content imaging. The compounds disclosed herein are novel reduced nucleic acid binding cyanine dyes, which dyes are probes for detecting ROS and measuring oxidative stress in cells either in vitro and/or in vivo. Also described herein are processes for preparing novel reduced dyes, i.e., ROS probes, for use in the disclosed compositions, methods and kits.

Abstract: Provided herein are heptamethine cyanine dyes having a large Stokes shift, and the salts and conjugates thereof. Also provided are methods of using and making such large Stokes shift dyes as fluorescence resonance energy transfer (FRET) acceptors or donors.