Abstract: A large-field-of-view high-resolution imaging device includes an imaging array formed by splicing and combining a plurality of imaging units and a CSI phosphor screen. Each imaging unit is formed by coupling an array of light cones in series and an enhanced CCD. The series light cone array is formed by connecting a large light cone and a small light cone in series such that a small end face of the large light cone is connected with a large end face of the small light cone, a large end face of the large light cone is attached to the CSI phosphor screen, and a small end face of the small light cone serves as an input window of an image enhancer. The enhanced CCD is formed by coupling the image enhancer and a CCD camera. A photosensitive screen of the CCD camera serves as an output window of the image enhancer.

Abstract: Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, or a stereoisomer thereof; and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

Abstract: A method and apparatus for breaking a unit dose package in a chamber within a post located in a basket of a laundry washing machine. The method includes filling the basket and the chamber, increasing a rotation speed of the basket and/or the post to raise the water level in the basket and lower the water level in the chamber to cause a unit dose package within the chamber to move downwards; reducing the rotation speed to lower the water level in the basket and raise the water level in chamber to cause the unit dose package within the chamber to move upwards; and repeating the steps of increasing and reducing the rotational speed to cause the unit dose package to break open and at least partially dissolve. A laundry washing machine configured to perform this process is also provided.

Abstract: A packet loss processing method and a network device are provided. The method includes: A first node obtains a first forwarding label of a first packet, where the first packet is a discarded packet. The first node determines, based on the first forwarding label, that the first node does not have a LSP corresponding to the first forwarding label. The first node sends a first message to a second node, where the first message includes the first forwarding label, and the first message is used to indicate that the first node does not have the LSP corresponding to the first forwarding label. The second node may be, for example, a peer node of the first node. The first node sends the message to the peer node, to indicate that the first node does not have the LSP corresponding to the forwarding label.

Abstract: A laundry washing machine and a method for operating the washing machine offer ways to load a unit dose package into a compartment of the washing machine. A control unit controls the washing machine to add water to a compartment having a unit dose package. The tub is then filled with hot or cold water depending on the temperature of the water in the tub, or whether a sanitizing cycle of a washing program has been selected.

Abstract: A method and apparatus for breaking a unit dose package in a chamber within a post located in a basket of a laundry washing machine. The method includes filling the basket and the chamber, increasing a rotation speed of the basket and/or the post to raise the water level in the basket and lower the water level in the chamber to cause a unit dose package within the chamber to move downwards; reducing the rotation speed to lower the water level in the basket and raise the water level in chamber to cause the unit dose package within the chamber to move upwards; and repeating the steps of increasing and reducing the rotational speed to cause the unit dose package to break open and at least partially dissolve. A laundry washing machine configured to perform this process is also provided.

Abstract: A method for controlling a laundry washing machine. The method includes: performing a tub loading process comprising operating supply valve(s) to provide a first volume of water through a detergent supply system and into a tub to fill the tub with wash liquid; performing a washing process comprising rotating a drum to agitate laundry in in the presence of the wash liquid; performing a static rinsing process comprising operating a pump to remove any free volume of wash liquid from the tub without rotating the drum; and performing one or more rinsing processes comprising: operating the supply valve(s) to provide a volume of clean rinse water to the tub, operating the pump to remove the rinse water from the drum, and operating the motor to spin the drum at high speed to extract rinse water from the laundry, while continuing to operate the pump.

Abstract: A method for controlling a laundry washing machine. The method includes: performing a tub loading process comprising operating supply valve(s) to provide a first volume of water through a detergent supply system and into a tub to fill the tub with wash liquid; performing a washing process comprising rotating a drum to agitate laundry in the presence of the wash liquid; performing a static rinsing process comprising operating a pump to remove any free volume of wash liquid from the tub without rotating the drum; and performing one or more rinsing processes comprising: operating the supply valve(s) to provide a volume of clean rinse water to the tub, operating the pump to remove the rinse water from the drum, and operating the motor to spin the drum at high speed to extract rinse water from the laundry, while continuing to operate the pump.

Abstract: A laundry washing machine and a method for operating the washing machine offer ways to load a unit dose package into a compartment of the washing machine. A control unit controls the washing machine to add water to a compartment having a unit dose package. The tub is then filled with hot or cold water depending on the temperature of the water in the tub, or whether a sanitizing cycle of a washing program has been selected.

Abstract: A laundry washing machine having: a casing, a washing tub located within the casing, a drum mounted within the washing tub and configured to rotate relative to the casing, a door attached to the casing and being openable to provide access to the drum, an additive loading and supply system configured to receive loose detergent, one or more valves configured to selectively provide water to the additive loading and supply system, a tub supply pipe fluidly connecting the additive loading and supply system to the drum, a receptacle configured to receive a unit dose package comprising a water soluble pouch containing a dose of cleaning product, and means for breaking the unit dose package outside the additive loading and supply system.

Abstract: A laundry washing machine having a casing, a washing tub within the casing, a drum within the washing tub, a door to provide access to the drum, an additive loading and supply system configured to receive one or more cleaning products, a soaking chamber configured to receive and hold a unit dose package and at least a first volume of liquid, a tub supply pipe connecting the soaking chamber to the washing tub and/or drum, valves to dispense water into the soaking chamber, and a control unit operatively connected to the valves. The control unit has instructions that, when executed: cause the valves to supply the first volume of liquid to the soaking chamber, allow the first volume of liquid to reside in the soaking chamber for a predetermined amount of time, and subsequently release the first quantity of liquid from the soaking chamber to the tub supply pipe.

Abstract: A laundry washing machine having a casing, a washing tub within the casing, a drum within the washing tub, a door to provide access to the drum, an additive loading and supply system configured to receive one or more cleaning products, a soaking chamber configured to receive and hold a unit dose package and at least a first volume of liquid, a tub supply pipe connecting the soaking chamber to the washing tub and/or drum, valves to dispense water into the soaking chamber, and a control unit operatively connected to the valves. The control unit has instructions that, when executed: cause the valves to supply the first volume of liquid to the soaking chamber, allow the first volume of liquid to reside in the soaking chamber for a predetermined amount of time, and subsequently release the first quantity of liquid from the soaking chamber to the tub supply pipe.

Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: Compounds are provided having the structure of Formula (I): or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein A, B, L, R3, R4, R5, R6, R8, m and n are as defined herein. Such compounds modulate the opioid receptor, particulare the mu-opioid receptor (MOR) and/or the kappa-opioid receptor (KOR), and/or the delta-opioid receptor (DOR). Products containing such compounds, as well as methods for their use and preparation, are also provided.

Abstract: Compounds are provided having the structure of Formula (I): or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein A, B, L, R3, R4, R5, R6, R8, m and n are as defined herein. Such compounds modulate the opioid receptor, particulate the mu-opioid receptor (MOR) and/or the kappa-opioid receptor (KOR), and/or the delta-opioid receptor (DOR). Products containing such compounds, as well as methods for their use and preparation, are also provided.

Abstract: A laundry washing machine having: a casing, a washing tub located within the casing, a drum mounted within the washing tub and configured to rotate relative to the casing, a door attached to the casing and being openable to provide access to the drum, an additive loading and supply system configured to receive loose detergent, one or more valves configured to selectively provide water to the additive loading and supply system, a tub supply pipe fluidly connecting the additive loading and supply system to the drum, a receptacle configured to receive a unit dose package comprising a water soluble pouch containing a dose of cleaning product, and means for breaking the unit dose package outside the additive loading and supply system.

Abstract: Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, or a stereoisomer thereof; and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

Abstract: A method and apparatus for breaking a unit dose package in a chamber within a post located in a basket of a laundry washing machine. The method includes filling the basket and the chamber, increasing a rotation speed of the basket and/or the post to raise the water level in the basket and lower the water level in the chamber to cause a unit dose package within the chamber to move downwards; reducing the rotation speed to lower the water level in the basket and raise the water level in chamber to cause the unit dose package within the chamber to move upwards; and repeating the steps of increasing and reducing the rotational speed to cause the unit dose package to break open and at least partially dissolve. A laundry washing machine configured to perform this process is also provided.

Abstract: A laundry washing machine having a casing, a washing tub within the casing, a drum within the washing tub, a door to provide access to the drum, an additive loading and supply system configured to receive one or more cleaning products, a soaking chamber configured to receive and hold a unit dose package and at least a first volume of liquid, a tub supply pipe connecting the soaking chamber to the washing tub and/or drum, valves to dispense water into the soaking chamber, and a control unit operatively connected to the valves. The control unit has instructions that, when executed: cause the valves to supply the first volume of liquid to the soaking chamber, allow the first volume of liquid to reside in the soaking chamber for a predetermined amount of time, and subsequently release the first quantity of liquid from the soaking chamber to the tub supply pipe.

Abstract: A laundry washing machine and a method for operating the washing machine offer ways to load a unit dose package into a compartment of the washing machine. A control unit controls the washing machine to add water to a compartment having a unit dose package. The tub is then filled with hot or cold water depending on the temperature of the water in the tub, or whether a sanitizing cycle of a washing program has been selected.