Abstract: The present invention provides compounds, pharmaceutical compositions and methods for the treatment of specific cancers. Such compositions may generally comprise a compound of formula (I): wherein R1-R3 are as defined herein, or pharmaceutically acceptable salts or esters thereof; and a pharmaceutically acceptable carrier.

Abstract: We provide compounds given by Formula I, which is shown in FIG. 3, or pharmaceutically acceptable salts thereof, as well as formulations thereof and methods of use of those compounds and formulations for treatment of cancer.

Abstract: The present invention provides compounds, pharmaceutical compositions and methods for the treatment of specific cancers. Such compositions may generally comprise a compound of formula (I): wherein R1-R3 are as defined herein, or pharmaceutically acceptable salts or esters thereof; and a pharmaceutically acceptable carrier.

Abstract: The present invention provides compounds, pharmaceutical compositions and methods for the treatment of specific cancers. Such compositions may generally comprise a compound of formula (I): wherein R1-R3 are as defined herein, or pharmaceutically acceptable salts or esters thereof; and a pharmaceutically acceptable carrier.

Abstract: The present invention provides compounds having formula (I): wherein R1, R2, R3 and n are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of inflammatory or autoimmune and proliferative disorders and as inhibitors of cell adhesion molecule expression and inflammatory cytokine signal transduction generally.

Abstract: A digital communications system and method to transmit and receive a digital communications signal wherein the digital signal has a plurality of frames, wherein at least two modulations are supported, and wherein each of the plurality of frames has the same number of symbols.

Abstract: The present invention provides compounds, pharmaceutical compositions and methods for the treatment of specific cancers. Such compositions may generally comprise a compound of formula (I): wherein R1-R3 are as defined herein, or pharmaceutically acceptable salts or esters thereof; and a pharmaceutically acceptable carrier.

Abstract: The present invention provides compounds, pharmaceutical compositions and methods for the treatment of specific cancers. Such compositions may generally comprise a compound of formula (I): wherein R1-R3 are as defined herein, or pharmaceutically acceptable salts or esters thereof; and a pharmaceutically acceptable carrier.

Abstract: The present invention provides compounds, methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis.

Abstract: The present invention provides methods for the use of compounds having formula (I) in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, t, X, Y, Z, and n are as defined herein.

Abstract: An approach is provided for supporting carrier synchronization in a digital broadcast and interactive system. A carrier synchronization module receives one or more signals representing a frame that includes one or more overhead fields (e.g., preamble and optional pilot blocks and one or multiple segments separated by pilot blocks). The module estimates carrier frequency and phase on a segment by segment basis and tracks frequency between segments. Carrier phase of the signal is estimated based upon the overhead field. Estimates carrier phase of random data field are determined based upon the estimated phase values from the overhead fields, and upon both the past and future data signals. Further, the frequency of the signal is estimated based upon the overhead fields and/or the random data field. The above arrangement is particularly suited to a digital satellite broadcast and interactive system.

Abstract: A method and apparatus for providing an asymmetrical backwards compatible communications signal that is capable of being decoded by QPSK and OQPSK receivers as well as PSK and QAM receivers is provided. The invention comprises a timing error accumulator coupled to a first bit stream. The first bit stream includes content that is common to the QPSK/OQPSK receiver and to the PSK/QAM receiver. A phase error accumulator is coupled to a second bit stream and adjusts the phase of symbols in the second bit stream. A phase and timing error compensator is coupled to the phase error accumulator and the timing error accumulator and adjusts the first and second bit streams received from the phase error accumulator and the timing error accumulator in order to reduce timing and phase errors. A higher order modulator coupled to the phase- and timing error compensator is also provided. The higher order modulator processes the first and second bit streams to provide the asymmetrical backwards compatible signal.

Abstract: The present invention provides methods for the use of compounds having formula (I) in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, t, X, Y, Z, and n are as defined herein.

Abstract: The present invention provides compounds having formula (I): wherein R1, R2, R3 and n are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of inflammatory or autoimmune and proliferative disorders and as inhibitors of cell adhesion molecule expression and inflammatory cytokine signal transduction generally.

Abstract: A digital communications system and method to transmit and receive a digital communications signal wherein the digital signal has a plurality of frames, wherein at least two modulations are supported, and wherein each of the plurality of frames has the same number of symbols.

Abstract: An approach is provided for supporting carrier synchronization in a digital broadcast and interactive system. A carrier synchronization module receives one or more signals representing a frame that includes one or more overhead fields (e.g., preamble and optional pilot blocks and one or multiple segments separated by pilot blocks). The module estimates carrier frequency and phase on a segment by segment basis and tracks frequency between segments. Carrier phase of the signal is estimated based upon the overhead field. Estimates carrier phase of random data field are determined based upon the estimated phase values from the overhead fields, and upon both the past and future data signals. Further, the frequency of the signal is estimated based upon the overhead fields and/or the random data field. The above arrangement is particularly suited to a digital satellite broadcast and interactive system.

Abstract: As discussed above, there remains a need for the development of novel therapeutic agents useful for treating inflammatory or autoimmune and proliferative diseases. The present invention provides novel compounds of general formula (I), and pharmaceutical compositions thereof, as described generally and in classes and subclasses herein, as well as methods of making and using such compounds.

Abstract: A digital communication system and method using a digital signal having a plurality of frames to transmit data, including a first frame and a second frame, wherein each of the plurality of frames has a frame structure; and wherein the first frame has, a plurality of codewords comprising user data, and a Next Frame Composition Table to set the structure for the second frame, and wherein the second frame has at least one codeword.

Abstract: An approach is provided for supporting carrier synchronization in a digital broadcast and interactive system. A carrier synchronization module receives one or more signals representing a frame that includes one or more overhead fields (e.g., preamble and optional pilot blocks and one or multiple segments separated by pilot blocks). The module estimates carrier frequency and phase on a segment by segment basis and tracks frequency between segments. Carrier phase of the signal is estimated based upon the overhead field. Estimates carrier phase of random data field are determined based upon the estimated phase values from the overhead fields, and upon both the past and future data signals. Further, the frequency of the signal is estimated based upon the overhead fields and/or the random data field. The above arrangement is particularly suited to a digital satellite broadcast and interactive system.

Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, X, Y, Z, and n are as defined herein.