Abstract: The present invention provides compounds having formula (1): wherein R1-R6, A, J, D, A, G, Q, w, x, y, and z are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of cancer and/or inflammatory disorders, and more generally as proteasome inhibitors.

Abstract: The present invention provides compounds having formula (1): wherein R1-R6, A, J, D, E, G, Q, w, x, y, and z are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of cancer and/or inflammatory disorders, and more generally as proteasome inhibitors.

Abstract: The present invention provides compounds, pharmaceutical compositions and methods for the treatment of specific cancers. Such compositions may generally comprise a compound of formula (I): wherein R1-R3 are as defined herein, or pharmaceutically acceptable salts or esters thereof; and a pharmaceutically acceptable carrier.

Abstract: An approach is provided for supporting carrier synchronization in a digital broadcast and interactive system. A carrier synchronization module receives one or more signals representing a frame that includes one or more overhead fields (e.g., preamble and optional pilot blocks and one or multiple segments separated by pilot blocks). The module estimates carrier frequency and phase on a segment by segment basis and tracks frequency between segments. Carrier phase of the signal is estimated based upon the overhead field. Estimates carrier phase of random data field are determined based upon the estimated phase values from the overhead fields, and upon both the past and future data signals. Further, the frequency of the signal is estimated based upon the overhead fields and/or the random data field. The above arrangement is particularly suited to a digital satellite broadcast and interactive system.

Abstract: An approach is provided for supporting carrier synchronization in a digital broadcast and interactive system. A carrier synchronization module receives one or more signals representing a frame that includes one or more overhead fields (e.g., preamble and optional pilot blocks and one or multiple segments separated by pilot blocks). The module estimates carrier frequency and phase on a segment by segment basis and tracks frequency between segments. Carrier phase of the signal is estimated based upon the overhead field. Estimates carrier phase of random data field are determined based upon the estimated phase values from the overhead fields, and upon both the past and future data signals. Further, the frequency of the signal is estimated based upon the overhead fields and/or the random data field. The above arrangement is particularly suited to a digital satellite broadcast and interactive system.

Abstract: As discussed above, there remains a need for the development of novel therapeutic agents useful for treating inflammatory or autoimmune and proliferative diseases.

Abstract: The present invention provides compounds having formula (I), wherein R1, R2, R3 and n are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of inflammatory or autoimmune and proliferative disorders and as inhibitors of cell adhesion molecule expression and inflammatory cytokine signal transduction generally

Abstract: A method and apparatus for providing an asymmetrical backwards compatible communications signal that is capable of being decoded by QPSK and OQPSK receivers as well as PSK and QAM receivers is provided. The invention comprises a timing error accumulator coupled to a first bit stream. The first bit stream includes content that is common to the QPSK/OQPSK receiver and to the PSK/QAM receiver. A phase error accumulator is coupled to a second bit stream and adjusts the phase of symbols in the second bit stream. A phase and timing error compensator is coupled to the phase error accumulator and the timing error accumulator and adjusts the first and second bit streams received from the phase error accumulator and the timing error accumulator in order to reduce timing and phase errors. A higher order modulator coupled to the phase- and timing error compensator is also provided. The higher order modulator processes the first and second bit streams to provide the asymmetrical backwards compatible signal.

Abstract: A method and apparatus for providing an asymmetrical backwards compatible communications signal that is capable of being decoded by QPSK and OQPSK receivers as well as PSK and QAM receivers is provided. The invention comprises a timing error accumulator coupled to a first bit stream. The first bit stream includes content that is common to the QPSK/OQPSK receiver and to the PSK/QAM receiver. A phase error accumulator is coupled to a second bit stream and adjusts the phase of symbols in the second bit stream. A phase and timing error compensator is coupled to the phase error accumulator and the timing error accumulator and adjusts the first and second bit streams received from the phase error accumulator and the timing error accumulator in order to reduce timing and phase errors. A higher order modulator coupled to the phase and timing error compensator is also provided. The higher order modulator processes the first and second bit streams to provide the asymmetrical backwards compatible signal.

Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, X, Y, Z, and n are as defined herein.

Abstract: A video encoding/decoding system based on 3D wavelet decomposition and the human perceptual model is implemented. JND is applied in quantizer design to improve the subjective quality of compressed video. The 3D wavelet decomposition helps to remove spatial and temporal redundancy and provides scalability of video quality. In order to conceal the errors that may, occur under bad wireless channel conditions, a slicing method and a joint source channel coding scenario, that combines RCPC with CRC and utilizes the distortion information to allocate convolutional coding rates are proposed. A new subjective quality index based on JND is presented and used to evaluate the overall system performance at different signal to noise rations (SNR) and at different compression ratios. Due to the wide use of arithmetic coding (AC) in data compression, it is considered as a readily available unit in the video codec system for broadcasting.

Abstract: The present invention provides compounds having formula (I), wherein R1, R2, R3 and n are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of inflammatory or autoimmune and proliferative disorders and as inhibitors of cell adhesion molecule expression and inflammatory cytokine signal transduction generally.

Abstract: The present invention provides compounds haviang formula (1): wherein R1-R6, A, J, D, E, G, Q, w, x, y, and z are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of cancer and/or inflammatory disorders, and more generally as proteasome inhibitors.

Abstract: An approach is provided estimating non-linear characteristics of an amplifier (such as a Travelling Wave Tube Amplifier) used to amplify a composite signal in a radio communication system. The composite signal, which includes a plurality of inbound signals overlay on an outbound signal, is sampled. The outbound signal is utilized as a training signal. Coarse estimates of the response of the amplifier is generated based on the samples of the composite signal and the training signal. Further, the interference associated with the inbound signals are removed from the estimation of the response of the amplifier by curve-fitting and estimating interference characteristics of the composite signal. An estimated response of the amplifier is thus output, and can be utilized to provide accurate non-linearity compensation and cancellation.

Abstract: An approach is provided for supporting carrier synchronization in a digital broadcast and interactive system. A carrier synchronization module receives one or more signals representing a frame that includes one or more overhead fields (e.g., preamble and optional pilot blocks and one or multiple segments separated by pilot blocks). The module estimates carrier frequency and phase on a segment by segment basis and tracks frequency between segments. Carrier phase of the signal is estimated based upon the overhead field. Estimates carrier phase of random data field are determined based upon the estimated phase values from the overhead fields, and upon both the past and future data signals. Further, the frequency of the signal is estimated based upon the overhead fields and/or the random data field. The above arrangement is particularly suited to a digital satellite broadcast and interactive system.

Abstract: Circuit and method for controlling circuitry in a power converter device during a soft-start process is provided. Synchronous rectifier control circuitry is adapted to gradually apply a gate drive signal derived from the main switch of the power converter device to a freewheeling synchronous rectifier of the switching circuitry during the soft-start process. The control circuitry gradually releases the amplitude or the pulse-width of the gate drive signal to the freewheeling synchronous rectifier to avoid a large duty ratio in the synchronous rectifier during start-up so that a negative current does not build up in the output inductor.

Abstract: An approach for identifying a particular carrier among a plurality of carriers in a satellite communication system is disclosed. A transmitter multiplies an encoded signal by a prescribed periodic sequence to form a watermarked signal and transmits the watermarked signal associated with a particular carrier over a communication channel. A receiver tunes to one of the carriers and extracts a data sequence from the one carrier. The receiver multiplies the data sequence with the prescribed periodic sequence to form another watermarked signal and determines whether the watermarked signals match.

Abstract: A power converter device using synchronous rectifiers and method for controlling operation thereof are provided. A first synchronous rectifier is coupled to the secondary transformer winding to pass a voltage induced at the secondary winding in response to an input voltage supplied to the primary transformer winding during an on-state of a main power switch. A first drive circuit is coupled to the gate terminal of the first synchronous rectifier to selectively activate and deactivate the first rectifier in correspondence with the respective on and off states of the main power switch based on a gate voltage supplied by the first drive circuit, with at least one circuit parameter being selected in the first drive circuit for maintaining the gate voltage within a predefined range regardless of variation in the level of the input voltage.

Abstract: A power distribution system is provided including current sharing circuitry, current sensing and over-current protection. The system includes a plurality of power converter modules each having a current sharing signal terminal on an input side and power output terminals on an output side, the corresponding power output terminals of the several modules being connected together and adapted to power a common load; an interconnecting signal bus coupled across the current sharing signal terminals on the input side; a plurality of feedback circuits, each of which is associated with one of said modules, each feedback circuit including a comparator (error amplifier) for comparing a feedback voltage on the output side with a reference voltage to provide an error signal to the input side; the error signal conditioned to provide a current command signal to said signal bus, wherein the signal bus provides a common current command signal to drive the power converter modules.

Abstract: A power distribution system is provided including current sharing circuitry, current sensing and over-current protection. The system includes a plurality of power converter modules each having a current sharing signal terminal on an input side and power output terminals on an output side, the corresponding power output terminals of the several modules being connected together and adapted to power a common load; an interconnecting signal bus coupled across the current sharing signal terminals on the input side; a plurality of feedback circuits, each of which is associated with one of said modules, each feedback circuit including a comparator (error amplifier) for comparing a feedback voltage on the output side with a reference voltage to provide an error signal to the input side; the error signal conditioned to provide a current command signal to said signal bus, wherein the signal bus provides a common current command signal to drive the power converter modules.