Patents by Inventor Yin To Chiu

Yin To Chiu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12319909
    Abstract: This invention relates to the isolation, concentration and/or purification of ribonucleic acid (RNA) in aqueous two-phase phase systems. In some embodiments, the present invention provides sample preparation methods, compositions and kit components for the isolation, concentration and/or purification of RNA from fluid mixtures comprising biological materials.
    Type: Grant
    Filed: March 19, 2021
    Date of Patent: June 3, 2025
    Assignee: Phase Scientific International, Ltd.
    Inventors: Yin To Chiu, Harsha Madan Kittur, Cheuk Yiu Tenny Chung, Garrett Lee Mosley
  • Publication number: 20250170498
    Abstract: The present invention relates to a method and/or device for improving the separation behaviors and performance of aqueous two-phase system (ATPS) for the isolation and/or concentration of one or more target analytes from a sample. In one embodiment, the present method and device comprise ATPS components within a porous material and one or more phase separation behavior modifying agents that improve the separation behavior and performance characteristics of ATPS, including but not limited to the increasing the stability or reducing fluctuations of ATPS thought the adjustment of total volume of a sample solution that undergoes phase separation, volume ratio of the two phases of the ATPS, fluid flow rates, and concentrations of ATPS components.
    Type: Application
    Filed: January 17, 2025
    Publication date: May 29, 2025
    Inventors: Yin To CHIU, Brian Sangwoo LEE, Garrett Lee MOSLEY, Beatrice S. LIM
  • Patent number: 12258616
    Abstract: The present disclosure relates to methods, compositions, and kits for concentrating and purifying at least one target analyte from a clinical biological sample. In some embodiments, the methods involve one or more aqueous two-phase system (ATPS) compositions and at least one solid phase medium. Some embodiments provide a kit comprising one or more ATPS compositions, a binding buffer; and a solid phase medium. Other embodiments provide methods of treating cancers or infectious diseases in a patient in need thereof.
    Type: Grant
    Filed: September 19, 2024
    Date of Patent: March 25, 2025
    Assignee: PHASE SCIENTIFIC INTERNATIONAL, LTD.
    Inventors: Cheuk Yiu Tenny Chung, Vasu Saini, Daniel William Bradbury, Harsha Madan Kittur, Masae Kobayashi Wen, Cheuk Yin Lam, Kar Kee Tse, Kit Cheung, Wing Yee Ng, Yin To Chiu, Garrett Lee Mosley
  • Patent number: 12253519
    Abstract: The present invention relates to a method for improving the detection and diagnosis targeting biomarkers using an aqueous two-phase system (ATPS). In one embodiment, the present invention provides a method for improving a diagnostic procedure involving the detection or quantification of one or more biomarkers in liquid biopsy, the method comprises contacting a porous material embedded with ATPS components with a liquid biopsy containing the biomarkers, purifying and concentrating the target biomarkers, and providing a product comprising the target biomarkers for performing the diagnostic procedure.
    Type: Grant
    Filed: January 14, 2024
    Date of Patent: March 18, 2025
    Assignee: PHASE SCIENTIFIC INTERNATIONAL, LTD.
    Inventor: Yin To Chiu
  • Publication number: 20250027137
    Abstract: The present disclosure relates to methods, compositions, and kits for concentrating and purifying at least one target analyte from a clinical biological sample. In some embodiments, the methods involve one or more aqueous two-phase system (ATPS) compositions and at least one solid phase medium. Some embodiments provide a kit comprising one or more ATPS compositions, a binding buffer; and a solid phase medium. Other embodiments provide methods of treating cancers or infectious diseases in a patient in need thereof.
    Type: Application
    Filed: September 19, 2024
    Publication date: January 23, 2025
    Inventors: Cheuk Yiu Tenny CHUNG, Vasu SAINI, Daniel William BRADBURY, Harsha Madan KITTUR, Masae Kobayashi WEN, Cheuk Yin LAM, Kar Kee TSE, Kit CHEUNG, Wing Yee NG, Yin To CHIU, Garrett Lee MOSLEY
  • Publication number: 20250027138
    Abstract: The present disclosure relates to methods, compositions, and kits for concentrating and purifying at least one target analyte from a clinical biological sample. In some embodiments, the methods involve one or more aqueous two-phase system (ATPS) compositions and at least one solid phase medium. Some embodiments provide a kit comprising one or more ATPS compositions, a binding buffer; and a solid phase medium. Other embodiments provide methods of treating cancers or infectious diseases in a patient in need thereof.
    Type: Application
    Filed: September 19, 2024
    Publication date: January 23, 2025
    Inventors: Cheuk Yiu Tenny CHUNG, Vasu SAINI, Daniel William BRADBURY, Harsha Madan KITTUR, Masae Kobayashi WEN, Cheuk Yin LAM, Kar Kee TSE, Kit CHEUNG, Wing Yee NG, Yin To CHIU, Garrett Lee MOSLEY
  • Publication number: 20250019686
    Abstract: The present invention relates to methods of using aqueous two-phase system (ATPS) for the isolation, concentration and/or purification of short nucleic acid fragment having about or less than 250 base pairs (bp). In one embodiment, the present invention provides a composition and kit for the purification of short nucleic acid fragments having about or less than 250 base pairs from nucleic acid-containing biological materials. In another embodiment, the present invention provides uses of certain salts and/or polymers in a two-phase system for the purification of short nucleic acid fragments having about or less than 250 base pairs from nucleic acid containing biological materials.
    Type: Application
    Filed: September 25, 2024
    Publication date: January 16, 2025
    Inventor: Yin To CHIU
  • Publication number: 20250011838
    Abstract: The present disclosure relates to methods, compositions, and kits for concentrating and purifying at least one target analyte from a clinical biological sample. In some embodiments, the methods involve one or more aqueous two-phase system (ATPS) compositions and at least one solid phase medium. Some embodiments provide a kit comprising one or more ATPS compositions, a binding buffer; and a solid phase medium. Other embodiments provide methods of treating cancers or infectious diseases in a patient in need thereof.
    Type: Application
    Filed: September 19, 2024
    Publication date: January 9, 2025
    Inventors: Cheuk Yiu Tenny CHUNG, Vasu SAINI, Daniel William BRADBURY, Harsha Madan KITTUR, Masae Kobayashi WEN, Cheuk Yin LAM, Kar Kee TSE, Kit CHEUNG, Wing Yee NG, Yin To CHIU, Garrett Lee MOSLEY
  • Patent number: 12129459
    Abstract: The present invention relates to methods of using aqueous two-phase system (ATPS) for the isolation, concentration and/or purification of short nucleic acid fragment having about or less than 250 base pairs (bp). In one embodiment, the present invention provides a composition and kit for the purification of short nucleic acid fragments having about or less than 250 base pairs from nucleic acid-containing biological materials. In another embodiment, the present invention provides uses of certain salts and/or polymers in a two-phase system for the purification of short nucleic acid fragments having about or less than 250 base pairs from nucleic acid containing biological materials.
    Type: Grant
    Filed: May 16, 2023
    Date of Patent: October 29, 2024
    Assignee: PHASE SCIENTIFIC INTERNATIONAL, LTD.
    Inventor: Yin To Chiu
  • Patent number: 12129511
    Abstract: The present disclosure relates to methods, compositions, and kits for concentrating and purifying at least one target analyte from a clinical biological sample. In some embodiments, the methods involve one or more aqueous two-phase system (ATPS) compositions and at least one solid phase medium. Some embodiments provide a kit comprising one or more ATPS compositions, a binding buffer; and a solid phase medium. Other embodiments provide methods of treating cancers or infectious diseases in a patient in need thereof.
    Type: Grant
    Filed: September 8, 2023
    Date of Patent: October 29, 2024
    Assignee: PHASE SCIENTIFIC INTERNATIONAL, LTD.
    Inventors: Cheuk Yiu Tenny Chung, Vasu Saini, Daniel William Bradbury, Harsha Madan Kittur, Masae Kobayashi Wen, Cheuk Yin Lam, Kar Kee Tse, Kit Cheung, Wing Yee Ng, Yin To Chiu, Garrett Lee Mosley
  • Patent number: 12043826
    Abstract: The present disclosure relates to a novel material and composition to perform purification and concentration of biological sample or nucleic acid in single step. The present disclosure also relates to a method to use of the same in two phase system to purify and concentrate the target biological materials and/or nucleic acids with an improved detection accuracy for diagnostics performance.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: July 23, 2024
    Assignee: PHASE SCIENTIFIC INTERNATIONAL, LTD.
    Inventor: Yin To Chiu
  • Publication number: 20240173648
    Abstract: The present invention relates to a method and/or device for improving the separation behaviors and performance of aqueous two-phase system (ATPS) for the isolation and/or concentration of one or more target analytes from a sample. In one embodiment, the present method and device comprise ATPS components within a porous material and one or more phase separation behavior modifying agents that improve the separation behavior and performance characteristics of ATPS, including but not limited to the increasing the stability or reducing fluctuations of ATPS thought the adjustment of total volume of a sample solution that undergoes phase separation, volume ratio of the two phases of the ATPS, fluid flow rates, and concentrations of ATPS components.
    Type: Application
    Filed: February 8, 2024
    Publication date: May 30, 2024
    Inventors: Yin To CHIU, Brian Sangwoo LEE, Garrett Lee MOSLEY, Beatrice S. LIM
  • Publication number: 20240151716
    Abstract: The present invention relates to a method for improving the detection and diagnosis targeting biomarkers using an aqueous two-phase system (ATPS). In one embodiment, the present invention provides a method for improving a diagnostic procedure involving the detection or quantification of one or more biomarkers in liquid biopsy, the method comprises contacting a porous material embedded with ATPS components with a liquid biopsy containing the biomarkers, purifying and concentrating the target biomarkers, and providing a product comprising the target biomarkers for performing the diagnostic procedure.
    Type: Application
    Filed: January 14, 2024
    Publication date: May 9, 2024
    Inventor: Yin To CHIU
  • Publication number: 20240141409
    Abstract: The present disclosure relates to methods, compositions, and kits for concentrating and purifying at least one target analyte from a clinical biological sample. In some embodiments, the methods involve one or more aqueous two-phase system (ATPS) compositions and at least one solid phase medium. Some embodiments provide a kit comprising one or more ATPS compositions, a binding buffer; and a solid phase medium. Other embodiments provide methods of treating cancers or infectious diseases in a patient in need thereof.
    Type: Application
    Filed: September 8, 2023
    Publication date: May 2, 2024
    Inventors: Cheuk Yiu Tenny CHUNG, Vasu SAINI, Daniel William BRADBURY, Harsha Madan KITTUR, Masae Kobayashi WEN, Cheuk Yin LAM, Kar Kee TSE, Kit CHEUNG, Wing Yee NG, Yin To CHIU, Garrett Lee MOSLEY
  • Publication number: 20240141316
    Abstract: The present disclosure relates to methods, compositions, and kits for isolating target nucleic acids below a target size from a sample comprising nucleic acid components. In some embodiments, the methods involve one or more aqueous two-phase system (ATPS) compositions, at least one solid phase medium, and at least one buffer. Some embodiments provide a kit comprising one or more ATPS compositions, at least one solid phase medium, and at least one buffer. Other embodiments provide methods for diagnosing a disease or condition using the methods described herein.
    Type: Application
    Filed: September 8, 2023
    Publication date: May 2, 2024
    Inventors: Vasu SAINI, Cheuk Yiu Tenny CHUNG, Daniel William BRADBURY, Harsha Madan KITTUR, Cheuk Yin LAM, Kar Kee TSE, Kit CHEUNG, Yin To CHIU, Garrett Lee MOSLEY
  • Patent number: 11938419
    Abstract: The present invention relates to a method and/or device for improving the separation behaviors and performance of aqueous two-phase system (ATPS) for the isolation and/or concentration of one or more target analytes from a sample. In one embodiment, the present method and device comprise ATPS components within a porous material and one or more phase separation behavior modifying agents that improve the separation behavior and performance characteristics of ATPS, including but not limited to the increasing the stability or reducing fluctuations of ATPS thought the adjustment of total volume of a sample solution that undergoes phase separation, volume ratio of the two phases of the ATPS, fluid flow rates, and concentrations of ATPS components.
    Type: Grant
    Filed: March 13, 2023
    Date of Patent: March 26, 2024
    Assignee: PHASE DIAGNOSTICS, INC.
    Inventors: Yin To Chiu, Brian Sangwoo Lee, Garrett Lee Mosley, Beatrice S. Lim
  • Patent number: 11913948
    Abstract: The present invention relates to a method for improving the detection and diagnosis targeting biomarkers using an aqueous two-phase system (ATPS). In one embodiment, the present invention provides a method for improving a diagnostic procedure involving the detection or quantification of one or more biomarkers in liquid biopsy, the method comprises contacting a porous material embedded with ATPS components with a liquid biopsy containing the biomarkers, purifying and concentrating the target biomarkers, and providing a product comprising the target biomarkers for performing the diagnostic procedure.
    Type: Grant
    Filed: May 17, 2022
    Date of Patent: February 27, 2024
    Assignee: PHASE SCIENTIFIC INTERNATIONAL, LTD.
    Inventor: Yin To Chiu
  • Patent number: 11885803
    Abstract: In various embodiments devices and methods for the detection and/or quantification of clinically relevant pathogens (e.g., bacteria, fungi, viruses, etc.) are provided. In certain embodiments the device comprises a lateral-flow assay that detects the bacterium at a concentration of less than about 6×106 cells/mL, less than about 3×106 cells/ml, less than about 1×106 CFU/mL, or less than about 50 ?g/mL. In certain embodiments the device comprises an aqueous two-phase system (ATPS) comprising a mixed phase solution that separates into a first phase solution and a second phase solution; and a lateral-flow assay (LFA). In certain embodiments the device comprises a flow-through system comprising a concentration component comprising an aqueous two-phase system (ATPS) comprising a mixed phase solution that separates into a first phase solution and a second phase solution; and a detection component disposed beneath said concentration component.
    Type: Grant
    Filed: February 16, 2022
    Date of Patent: January 30, 2024
    Assignee: The Regents of the University of California
    Inventors: Daniel Takashi Kamei, Yin To Chiu, Benjamin Ming Wu, Garrett L. Mosley
  • Publication number: 20240003875
    Abstract: Disclosed herein are devices and methods that use aqueous two phase systems and lateral flow assays to detect target analytes in a sample. These devices and methods may be used to diagnose a disease or condition in a biological sample, such as blood or serum. In addition, these devices and methods may be used to detect allergens in a food samples or contaminants, such as environmental toxins, in water samples. Device and kit components may be conveniently assembled in a portable container and are amenable to actuation in most settings. The devices are simple to use, requiring a non-trained operator to simply add the sample to the device. Conveniently, the time it takes to detect the target analyte is very short. Thus, the devices and methods disclosed herein provide novel and useful means for point-of-care.
    Type: Application
    Filed: March 10, 2023
    Publication date: January 4, 2024
    Applicant: The Regents of the University of California
    Inventors: Daniel Takashi Kamei, Yin To Chiu, Benjamin Ming Wu, Garrett L. Mosley
  • Publication number: 20230287385
    Abstract: The present invention relates to methods of using aqueous two-phase system (ATPS) for the isolation, concentration and/or purification of short nucleic acid fragment having about or less than 250 base pairs (bp). In one embodiment, the present invention provides a composition and kit for the purification of short nucleic acid fragments having about or less than 250 base pairs from nucleic acid-containing biological materials. In another embodiment, the present invention provides uses of certain salts and/or polymers in a two-phase system for the purification of short nucleic acid fragments having about or less than 250 base pairs from nucleic acid containing biological materials.
    Type: Application
    Filed: May 16, 2023
    Publication date: September 14, 2023
    Inventor: Yin To CHIU