Abstract: An immunoconjugate includes an anti-Globo H antibody, or a binding fragment thereof, and a therapeutic agent or a label, having the formula: Ab?(L?D)m, wherein Ab is the anti-Globo H antibody or the binding fragment thereof, L is a linker or a direct bond, D is the therapeutic agent or the label, and m is an integer from 1 to 8. The antibody may be a monoclonal antibody, which may be a humanized antibody. A method for treating a cancer includes administering to a subject in need of such treatment a pharmaceutically effective amount of an immunoconjugate containing an antibody against Globo H, or a binding fragment thereof, and a therapeutic agent covalently conjugated with the antibody.

Abstract: A method fits reversing immune suppression or immune exhaustion or for treating a disease associated with immune suppression includes: administering a co position to a subject in need of such treatments wherein the composition contains a CD11b modulator that binds specifically to CD11b on a cell to inhibit PD-L1 expression. The CD11b modulator is an antibody or an antigen-binding portion thereof, or a compound as described.

Abstract: An integrated, multi-service network client for cellular mobile devices is described. The multi-service client includes a VPN handler having an interface programmed to exchange the network packets with the security manager for application of the security service, wherein the VPN handler is configurable to operate in one of an enterprise mode and in a non-enterprise mode, wherein in the enterprise mode the VPN handler establishes a VPN connection with a remote VPN security device and provides encryption services to securely tunnel the network packets between the cellular mobile device and the remote VPN security device, and wherein in the non-enterprise mode the VPN handler directs the network packets to the security manager without application of the encryption services and communicates the network packets to a packet-based network without tunneling the packets.

Abstract: The present invention illustrates a conductive composite material, and a negative electrode materials and a secondary battery containing the same. The conductive composite material includes a core, an inner coating layer and an outer coating layer. The core is made of a first material selected from a group consisting of WA element, metal, metal compound or alloy. The inner coating layer is existed on the core and made of oxide, nitride or carbide of the first material. The outer coating layer is existed on the inner coating layer and made of a carbon material and a second material containing halogen or VA element.

Abstract: A method for modulating an immunoresponse includes binding a TREM-like transcript 1 (TLT-1) polypeptide to an immune cell, wherein the binding of the TLT-1 polypeptide to the immune cell suppresses immunoresponse. A method for treating and/or preventing a disease associated with immune hyper-reactivity includes administering the TLT-1 polypeptide to a subject in need thereof.

Abstract: A DRAM circuit includes an array having a normal word line, a first redundant word line and a second redundant word line immediately adjacent to the first redundant word line. The second redundant word line is activated if the normal word line is assigned, by a memory controller external to the DRAM circuit, to be activated. A redundant refresh circuit is configured to determine that the first redundant word line is required to be refreshed in response to the second redundant word line being activated; and a row decoder is configured to, according to the determination of the redundant refresh circuit, refresh the first redundant word line.

Abstract: The present invention relates to benzoxazole derivatives having the following Formula (I): The compounds of the present invention are found to possess the ability to decrease PD-L1 level, suggesting that the compounds of the invention can be used in cancer immunotherapy and treatment or prevention of sepsis or septic shock.

Abstract: An integrated, multi-service virtual private network (VPN) network client for cellular mobile devices is described. The multi-service network client can be deployed as a single software package on cellular mobile network devices to provide integrated services including secure enterprise VPN connectivity, acceleration, security management including monitored and enforced endpoint compliance, and collaboration services. The multi-service client integrates with an operating system of the device to provide a VPN handler to establish a VPN connection with a remote VPN security device. The VPN network client includes to data acceleration module exchange network packets with the VPN handler and apply at least one acceleration service to the network packets, and a VPN control application that provides a unified user interface that allows a user to configure both the VPN handler and the data acceleration module.

Abstract: A display panel device includes a panel, a stand, at least one stand hinge, and at least one foot mechanism. The stand hinge is disposed at a first side of the stand, and the stand hinge is pivotally connecting the panel to the stand. The foot mechanism is disposed at a second side of the stand opposite to the first side. The foot mechanism includes a foot and an elastically pivot assembly. The elastically pivot assembly is pivotally connecting the foot to the stand. When the panel display device is in an opened status, the panel and the stand form a first angle, and one side of the foot lies on a plane. When the panel display device is in a closed status, the stand covers the panel and the foot mechanism is placed within an opening of the panel.

Abstract: A composite electrode and a lithium-based battery are disclosed, wherein the composite electrode comprises: a substrate and a conductive layer formed on the substrate, wherein the conductive layer comprises graphite powders, Si-based powders, Ti-based powders, or a combination thereof embedded in a conductive matrix and coated with diamond films, and the diamond films are formed of diamond grains. The novel electrodes of the present invention when used in the Li-based battery can provide superior performance including excellent chemical inertness, physical integrity, and charge-discharge cycling life-time, and exhibit high electric conductivity and excellent lithium ion permeability.

Abstract: An integrated, multi-service network client for cellular mobile devices is described. The multi-service network client can be deployed as a single software package on cellular mobile network devices to provide integrated services including secure enterprise virtual private network (VPN) connectivity, acceleration, security management including monitored and enforced endpoint compliance, and collaboration services. Once installed on the cellular mobile device, the multi-service client integrates with an operating system of the device to provide a single entry point for user authentication for secure enterprise connectivity, endpoint security services including endpoint compliance with respect to anti-virus and spyware software, and comprehensive integrity checks.

Abstract: Compounds represented by the formula (I) or pharmaceutically acceptable salts thereof: R2—Y—Z-Q-A-R1??Formula (I) wherein R1, R2, Y, Z, Q, and A are as defined. These compounds are inhibitors of tubulin polymerization by binding at colchicines binding site and are useful in the treatment of tumors or mitotic diseases such as cancers, gout, and other conditions associated with abnormal cell proliferation.

Abstract: A supporting structure includes a body, a first plate, a second plate, a first elastic assembly, and a second elastic assembly. The body has a groove used for accommodating a display panel. The first plate is disposed on a first side of the groove, and the second plate is disposed on a second side of the groove opposite to the first side. The first elastic assembly is pivotally connecting the first plate and the body, and the second elastic assembly is pivotally connecting the second plate and the body. The first elastic assembly and the second elastic assembly clamp the display panel when the display panel is inserted into the groove of the body. The first elastic assembly and the second elastic assembly together cover the groove when the display panel is detached from the body. An electronic device using the supporting structure is also disclosed.

Abstract: A display panel device includes a panel, a stand, at least one stand hinge, and at least one foot mechanism. The stand hinge is disposed at a first side of the stand, and the stand hinge is pivotally connecting the panel to the stand. The foot mechanism is disposed at a second side of the stand opposite to the first side. The foot mechanism includes a foot and an elastically pivot assembly. The elastically pivot assembly is pivotally connecting the foot to the stand. When the panel display device is in an opened status, the panel and the stand form a first angle, and one side of the foot lies on a plane. When the panel display device is in a closed status, the stand covers the panel and the foot mechanism is placed within an opening of the panel.

Abstract: A composite electrode and a lithium-based battery are disclosed, wherein the composite electrode comprises: a substrate and a conductive layer formed on the substrate, wherein the conductive layer comprises graphite powders, Si-based powders, Ti-based powders, or a combination thereof embedded in a conductive matrix and coated with diamond films, and the diamond films are formed of diamond grains. The novel electrodes of the present invention when used in the Li-based battery can provide superior performance including excellent chemical inertness, physical integrity, and charge-discharge cycling life-time, and exhibit high electric conductivity and excellent lithium ion permeability.

Abstract: An integrated, multi-service virtual private network (VPN) network client for cellular mobile devices is described. The multi-service network client can be deployed as a single software package on cellular mobile network devices to provide integrated services including secure enterprise VPN connectivity, acceleration, security management including monitored and enforced endpoint compliance, and collaboration services. The multi-service client integrates with an operating system of the device to provide a VPN handler to establish a VPN connection with a remote VPN security device. The VPN network client includes to data acceleration module exchange network packets with the VPN handler and apply at least one acceleration service to the network packets, and a VPN control application that provides a unified user interface that allows a user to configure both the VPN handler and the data acceleration module.

Abstract: An integrated, multi-service virtual private network (VPN) network client for cellular mobile devices is described. The multi-service network client can be deployed as a single software package on cellular mobile network devices to provide integrated services including secure enterprise VPN connectivity, acceleration, security management including monitored and enforced endpoint compliance, and collaboration services. The multi-service client integrates with an operating system of the device to provide a VPN handler to establish a VPN connection with a remote VPN security device. The VPN network client includes to data acceleration module exchange network packets with the VPN handler and apply at least one acceleration service to the network packets, and a VPN control application that provides a unified user interface that allows a user to configure both the VPN handler and the data acceleration module.

Abstract: An integrated, multi-service network client for cellular mobile devices is described. The multi-service network client can be deployed as a single software package on cellular mobile network devices to provide integrated services including secure enterprise virtual private network (VPN) connectivity, acceleration, security management including monitored and enforced endpoint compliance, and collaboration services. The VPN network client is programmed to receive a web-based home page from an enterprise VPN appliance, process the web-based home page to identify a bookmark embedded within the response that corresponds to an enterprise webmail for the user and dynamically construct a user interface to have an input control native to the cellular mobile device for launching a native email client of the cellular mobile device to access the email without launching a web browser.