Abstract: Provided herein are an indene compound, e.g., a compound of Formula (I), and a pharmaceutical composition thereof. Also provided herein is a method of their use for treating, preventing, or ameliorating one or more symptoms of a fibrotic disease.

Abstract: Disclosed herein are triterpenoid compounds, for example, a compound of Formula (I), and pharmaceutical compositions thereof. Also disclosed herein are methods of their use for treat.

Abstract: A central learning model is deployed as a user model and as an assistant model. Sensitive information utterances from a corpus of previously stored conversation language corresponding to user queries and chat agent responses thereto are used to train the user model to become an updated user model and to train the assistant model to become an updated assistant model, respectively. The user model provides user contexts corresponding to user queries to the assistant model and the assistant model provides assistant contexts corresponding to chat agent responses to the user model. During training, the user model does not provide plain-text queries to the assistant model and the assistant model does not provide plain-text responses to the user model. The updated assistant model may facilitate a federated training process produce an updated central model. An updated central model may be used to provide real-time chat agent responses to live user queries.

Abstract: A cooking method includes, in response to a cooking instruction, obtaining cooking parameters corresponding to a type of target food indicated by the cooking instruction, and controlling a first heating device, a second heating device, and a fan of a cooking appliance to operate based on the cooking parameters. The cooking parameters include a first heating temperature for the first heating device, a second heating temperature for the second heating device, and a set duration. The first heating device is arranged below a pot body of the cooking appliance. The second heating device is arranged above the pot body. The method further includes, in response to a heating duration being longer than the set duration, turning off the first heating device and the second heating device.

Abstract: The present disclosure provides a system for CO2 storage and utilization of a concrete mixing plant and a method thereof. The system includes a slurry making module, a cyclic grinding module and a material storage and application module. The cyclic grinding module can grind, in the presence of a gas containing CO2 and medium balls, a composite slurry prepared by the slurry making module, and can cyclically use the gas containing CO2, so as to realize continuous production of a carbon-mineralized slurry. The material storage and application module includes a material storage bin and a mixing machine connected with each other, and the material storage bin is configured to receive and store the carbon-mineralized slurry from a slurry bin. The mixing machine is configured to mix and prepare the carbon-mineralized slurry into a commodity concrete.

Abstract: The present disclosure provides a system for CO2 storage and utilization of a concrete mixing plant and a method thereof. The system includes a slurry making module, a cyclic grinding module and a material storage and application module. The cyclic grinding module can grind, in the presence of a gas containing CO2 and medium balls, a composite slurry prepared by the slurry making module, and can cyclically use the gas containing CO2, so as to realize continuous production of a carbon-mineralized slurry. The material storage and application module includes a material storage bin and a mixing machine connected with each other, and the material storage bin is configured to receive and store the carbon-mineralized slurry from a slurry bin. The mixing machine is configured to mix and prepare the carbon-mineralized slurry into a commodity concrete.

Abstract: The present disclosure discloses a method for training a gearbox fault diagnosis model, and a gearbox fault diagnosis method. The method includes: acquiring a motor current signal in an electromechanical system where a gearbox is located; calculating, based on the current signal, characteristic values representing complexity and degree of mutation of the current signal; filtering the characteristic values based on a random forest algorithm to generate a sample data set; and training, based on the data set, a deep reinforcement learning network model to generate the fault diagnosis model. By means of the method for training the gearbox fault diagnosis model according to the present disclosure, merely the current signal is acquired, no additional sensor is needed, and the defect of additional hardware in the prior art is overcome.

Abstract: The invention discloses a surgical smoking knife, which includes: a casing with a slide inside; a smoking tube slidably connected to the slide, with one part located inside the casing and the other part located outside the casing; and an electrode knife disposed on the smoking knives. on the pipe; a control circuit board is arranged on the housing; a flexible transmission circuit slat penetrates into the inside of the smoking pipe through a slide, and its two ends are connected to the control circuit board and the electrode knife respectively. The beneficial effect of the present invention is that it can effectively reduce the friction resistance during telescopic adjustment.

Abstract: The present disclosure relates to methods of treating melanoma in a patient in need thereof, comprising administering to the subject a therapeutically effective amount of ripretinib or a pharmaceutically acceptable salt thereof.

Abstract: The present invention discloses a method of preparing an alkali activation material by using red mud-based wet grinding and carbon sequestration and an application thereof. The preparation method includes: (1) adding water, red mud, a crystalline control agent, and a grinding aid into a wet grinding carbon sequestration apparatus to perform wet grinding, and simultaneously introducing CO2 until a slurry pH reaches 7 to 7.5; and removing wet grinding balls by a sieve to obtain a slurry A; (2) adding carbide slag, water and a water reducer to a wet planetary ball grinder tank for wet grinding, and removing wet grinding balls by a sieve to obtain a slurry B; (3) taking 50 to 80 parts of the slurry A and 20 to 50 parts of the slurry B and mixing them to obtain an alkali activation material.

Abstract: Provided herein are an indene compound, e.g., a compound of Formula (I), and a pharmaceutical composition thereof. Also provided herein is a method of their use for treating, preventing, or ameliorating one or more symptoms of a fibrotic disease.

Abstract: The present invention provides a method of preparing a recycled cementitious material by a phosphogypsum-assisted carbon sequestration pretreatment process. The method includes: (1) placing 100 mass parts of phosphogypsum, 1 to 2 mass parts of grinding aid, 10 to 20 mass parts of sodium-containing alkali component, 150 to 300 mass parts of zirconia balls, and 150 to 300 mass parts of water into a wet grinding tank for wet grinding. After 10 min to 30 min of wet grinding, introducing CO2 at a flow rate of 1.5 to 2.2 mass parts/min to keep a temperature of a wet grinding slurry below 40° C. When the wet grinding slurry reaches pH=10, ending the wet grinding and sieving out a wet grinding slurry; (2) mixing the wet grinding slurry with 700 to 1000 mass parts of slag and 100 to 350 mass parts of water to obtain a recycled cementitious material.

Abstract: Provided herein are retinoid X receptor alpha binders that specifically bind to an epitope of a retinoid X receptor alpha, wherein the epitope comprises a phosphorylated serine at position 56 or 70. Also provided herein are retinoid X receptor alpha/polo-like kinase 1 modulators that inhibit the interaction of a polo-like kinase 1 with a retinoid X receptor alpha comprising a phosphorylated serine at position 56 or 70.

Abstract: The present invention provides a method of preparing a recycled cementitious material by a phosphogypsum-assisted carbon sequestration pretreatment process. The method includes: (1) placing 100 mass parts of phosphogypsum, 1 to 2 mass parts of grinding aid, 10 to 20 mass parts of sodium-containing alkali component, 150 to 300 mass parts of zirconia balls, and 150 to 300 mass parts of water into a wet grinding tank for wet grinding. After 10 min to 30 min of wet grinding, introducing CO2 at a flow rate of 1.5 to 2.2 mass parts/min to keep a temperature of a wet grinding slurry below 40° C. When the wet grinding slurry reaches pH=10, ending the wet grinding and sieving out a wet grinding slurry; (2) mixing the wet grinding slurry with 700 to 1000 mass parts of slag and 100 to 350 mass parts of water to obtain a recycled cementitious material.

Abstract: The present invention discloses a method of preparing an alkali activation material by using red mud-based wet grinding and carbon sequestration and an application thereof. The preparation method includes: (1) adding water, red mud, a crystalline control agent, and a grinding aid into a wet grinding carbon sequestration apparatus to perform wet grinding, and simultaneously introducing CO2 until a slurry pH reaches 7 to 7.5; and removing wet grinding balls by a sieve to obtain a slurry A; (2) adding carbide slag, water and a water reducer to a wet planetary ball grinder tank for wet grinding, and removing wet grinding balls by a sieve to obtain a slurry B; (3) taking 50 to 80 parts of the slurry A and 20 to 50 parts of the slurry B and mixing them to obtain an alkali activation material.

Abstract: Provided herein are an indene compound, e.g., a compound of Formula (I), and a pharmaceutical composition thereof. Also provided herein is a method of their use for treating, preventing, or ameliorating one or more symptoms of a fibrotic disease.

Abstract: The present disclosure relates to a soup cooking control method for a pressure cooker, a pressure cooker, and a computer-readable storage medium. The method includes: a preheating and temperature-increasing stage, a medium-high temperature maintenance stage, a high pressure maintenance stage, and a decompression exhaust stage. The medium-high temperature maintenance stage includes: opening the pressure relief valve, to allow the pressure cooker to be in a non-closed state; controlling, under the non-closed state of the pressure cooker, the heating body to supply heat with a first preset heating power, and maintaining an internal temperature of the pressure cooker at a first preset temperature within a first preset duration. The present disclosure solves the problem that when the existing pressure cooker makes soup, insufficient oxidation of fat will cause large amounts of fat in the meat to dissolve, which affects people's health and the taste of the soup.

Abstract: A central learning model is deployed as a user model and as an assistant model. Sensitive information utterances from a corpus of previously stored conversation language corresponding to user queries and chat agent responses thereto are used to train the user model to become an updated user model and to train the assistant model to become an updated assistant model, respectively. The user model provides user contexts corresponding to user queries to the assistant model and the assistant model provides assistant contexts corresponding to chat agent responses to the user model. During training, the user model does not provide plain-text queries to the assistant model and the assistant model does not provide plain-text responses to the user model. The updated assistant model may facilitate a federated training process produce an updated central model. An updated central model may be used to provide real-time chat agent responses to live user queries.

Abstract: Disclosed is a method for evaluating cooking quality that includes: in response to receiving evaluation information of a food sent by a terminal, retrieving an assessment result corresponding to the food, the assessment result being an assessment result of the cooking quality of a cooking appliance; and determining an evaluation result of the cooking quality of the cooking appliance based on the assessment result, the evaluation information, and a preset evaluation rule. Also disclosed is a device for evaluating cooking quality. With this disclosure, both the assessment result and the evaluation information are weighted in computing the evaluation result of the cooking quality of the cooking appliance. Such an evaluation result not only reflects users' subjective evaluation of the cooking quality, but it also reflects an objective and tenable evaluation of the cooking quality, making the evaluation of the cooking quality more reasonable.

Abstract: The present invention provides a two-dimensional material nanosheets with a large area and a controllable thickness and a general preparation method therefor. As an intralayer heat transfer coefficient of a two-dimensional material is much higher than an interlayer heat transfer coefficient thereof, the two-dimensional material is uniformly heated and sublimated layer by layer by controlling the energy of the laser pulses, a thinning thickness is controlled by adjusting the action time of the laser pulses, and finally, a two-dimensional material film with a controllable thickness is obtained. At the same time, a sample displacement stage moving freely in a two-dimensional plane space can realize preparation of the two-dimensional material film with a large area. Compared with traditional methods, the present invention can control a sample thickness of the two-dimensional material film, has a high generality, and is suitable for all kinds two-dimensional materials.