Patents by Inventor Yingzhi Bi

Yingzhi Bi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRAZOLYLSULFONAMIDE COMPOUNDS AND THEIR USE IN THERAPY
    Publication number: 20240150321
    Abstract: The invention provides pyrazolylsulfonamide compounds, pharmaceutical compositions, their use for inhibiting mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), and their use in the treatment of a disease or condition, such as a proliferative disorder, inflammatory disorder, or autoimmune disorder.
    Type: Application
    Filed: August 25, 2023
    Publication date: May 9, 2024
    Inventors: Yingzhi Bi, Kenneth G. Carson, Geraldine Cirillo Harriman, Sundarapandian Thangapandian, Christian Josef Kuper, Sebastien Louis Degorce, Benjamin Paul Whittaker, Arwel Lewis, Maria Angel Palomero-Vazquez
  • PYRIDINYLSULFONAMIDE COMPOUNDS AND THEIR USE IN THERAPY
    Publication number: 20240150365
    Abstract: The invention provides pyridinylsulfonamide compounds, pharmaceutical compositions, their use for inhibiting mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), and their use in the treatment of a disease or condition, such as a proliferative disorder, inflammatory disorder, or autoimmune disorder.
    Type: Application
    Filed: August 25, 2023
    Publication date: May 9, 2024
    Inventors: Yingzhi BI, Kenneth G. CARSON, Geraldine Cirillo HARRIMAN, Sundarapandian THANGAPANDIAN, Christian Josef KUPER, Sebastien Louis DEGORCE, Arwel LEWIS, Maria Angel PALOMERO-VAZQUEZ, Robert Stuart Laurie CHAPMAN
  • SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME
    Publication number: 20230143612
    Abstract: The present invention includes substituted 1,1?-biphenyl compounds, analogues thereof, and compositions comprising the same. In one aspect, the compounds contemplated in the invention can be used to treat, ameliorate, or prevent hepatitis B virus (HBV) and/or hepatitis D virus (HDV) infections in a patient. In another aspect, the compounds contemplated in the invention can be used to treat, ameliorate, and/or prevent cancer in a patient.
    Type: Application
    Filed: February 1, 2021
    Publication date: May 11, 2023
    Inventors: Vijay Ahuja, Yingzhi Bi, Andrew G. Cole, Bruce D. Dorsey, Yi Fan, Ramesh Kakarla, Sharon Marie Kirk, Duyan Nguyen, Seyma Ozturk, Jorge G. Quintero, Michael J. Sofia
  • Substituted 2,3-dihydro-1H-indene analogs and methods using same
    Patent number: 11130740
    Abstract: The present invention includes substituted 2,3-dihydro-1H-indene analogs, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infections in a patient.
    Type: Grant
    Filed: April 24, 2018
    Date of Patent: September 28, 2021
    Assignee: Arbutus Biopharma Corporation
    Inventors: Yingzhi Bi, Bruce D. Dorsey, Christopher Brooks Moore
  • Substituted pyridinone-containing trycyclic compounds, and methods using same
    Patent number: 11013726
    Abstract: The present invention includes substituted pyridinone-containing tricyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infection in a patient. In certain embodiments, the compounds and compositions of the invention inhibit and/or reduce HBsAg secretion.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: May 25, 2021
    Assignee: Arbutus Biopharma Corporation
    Inventors: Laurèn Danielle Bailey, Yingzhi Bi, Shuai Chen, Bruce D. Dorsey, Dimitar B. Gotchev, Richard James Holland, Ramesh Kakarla, Duyan Nguyen, Mark Christopher Wood
  • SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS, ANALOGUES THEREOF, AND METHODS USING SAME
    Publication number: 20210052585
    Abstract: The present invention includes substituted 3,3?bis(phenoxymethyl)-1,1?-biphenyl compounds, analogues thereof, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) and/or hepatitis D virus (HDV) infections in a patient.
    Type: Application
    Filed: March 29, 2019
    Publication date: February 25, 2021
    Inventors: Yingzhi Bi, Bruce D. Dorsey, Yi Fan, Christopher Brooks Moore, Duyan Nguyen
  • Substituted pyridinone-containing trycyclic compounds, and methods using same
    Patent number: 10821103
    Abstract: The present invention includes substituted pyridinone-containing tricyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infection in a patient. In certain embodiments, the compounds and compositions of the invention inhibit and/or reduce HBsAg secretion.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: November 3, 2020
    Assignee: Arbutus Biopharma Corporation
    Inventors: Laurèn Danielle Bailey, Yingzhi Bi, Shuai Chen, Bruce D. Dorsey, Dimitar B. Gotchev, Richard James Holland, Ramesh Kakarla, Duyan Nguyen, Mark Christopher Wood
  • SUBSTITUTED PYRIDINONE-CONTAINING TRYCYCLIC COMPOUNDS, AND METHODS USING SAME
    Publication number: 20200261432
    Abstract: The present invention includes substituted pyridinone-containing tricyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infection in a patient. In certain embodiments, the compounds and compositions of the invention inhibit and/or reduce HBsAg secretion.
    Type: Application
    Filed: March 30, 2020
    Publication date: August 20, 2020
    Applicant: Arbutus Biopharma Corporation
    Inventors: Laurèn Danielle Bailey, Yingzhi Bi, Shuai Chen, Bruce D. Dorsey, Dimitar B. Gotchev, Richard James Holland, Ramesh Kakarla, Duyan Nguyen, Mark Christopher Wood
  • SUBSTITUTED 2,3-DIHYDRO-1H-INDENE ANALOGS AND METHODS USING SAME
    Publication number: 20200165213
    Abstract: The present invention includes substituted 2,3-dihydro-1H-indene analogs, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infections in a patient.
    Type: Application
    Filed: April 24, 2018
    Publication date: May 28, 2020
    Inventors: Yingzhi Bi, Bruce D. Dorsey, Christopher Brooks Moore
  • SUBSTITUTED PYRIDINONE-CONTAINING TRYCYCLIC COMPOUNDS, AND METHODS USING SAME
    Publication number: 20190314347
    Abstract: The present invention includes substituted pyridinone-containing tricyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infection in a patient. In certain embodiments, the compounds and compositions of the invention inhibit and/or reduce HBsAg secretion.
    Type: Application
    Filed: November 3, 2017
    Publication date: October 17, 2019
    Inventors: Danielle Lauren BAILEY, Yingzhi BI, Shuai CHEN, Bruce D. DORSEY, Dimitar B. GOTCHEV, Richard James HOLLAND, Ramesh KAKARLA, Duyan NGUYEN, Mark Christopher WOOD
  • Pyrazolo[1,5-a]pyrimidine-based compounds, compositions comprising them, and methods of their use
    Patent number: 9862724
    Abstract: Pyrazolo[1,5-a]pyrimidine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.
    Type: Grant
    Filed: May 3, 2016
    Date of Patent: January 9, 2018
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Yingzhi Bi, Michael Walter Gardyan, Michael Alan Green, Godwin Kumi, Yulian Zhang
  • Inhibitors of adapter associated kinase 1, compositions comprising them, and methods of their use
    Patent number: 9682982
    Abstract: The adaptor associated kinase 1 (AAK1) inhibitor 3-methyloxetan-3-yl-4-(3-(2-methoxypyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carboxylate: and pharmaceutically acceptable salts and solid forms thereof are disclosed. Compositions comprising the compound and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by AAK1 activity are also disclosed.
    Type: Grant
    Filed: March 16, 2015
    Date of Patent: June 20, 2017
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Yingzhi Bi, Godwin Kumi
  • PYRAZOLO[1,5-a]PYRIMIDINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE
    Publication number: 20170129896
    Abstract: Pyrazolo[1,5-a]pyrimidine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.
    Type: Application
    Filed: July 12, 2016
    Publication date: May 11, 2017
    Inventors: Yingzhi BI, Kenneth Gordon CARSON, Giovanni CIANCHETTA, Michael Alan GREEN, Godwin KUMI, Alan MAIN, Yulian ZHANG, Glenn Gregory ZIPP
  • PYRAZOLO[1,5-a]PYRIMIDINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE
    Publication number: 20170081330
    Abstract: Pyrazolo[1,5-a]pyrimidine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.
    Type: Application
    Filed: May 3, 2016
    Publication date: March 23, 2017
    Inventors: Yingzhi BI, Michael Walter GARDYAN, Michael Alan GREEN, Godwin KUMI, Yulian ZHANG
  • IMIDAZO[1,2-b]PYRIDAZINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE
    Publication number: 20170057964
    Abstract: Imidazo[1,2-b]pyridazine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.
    Type: Application
    Filed: April 26, 2016
    Publication date: March 2, 2017
    Inventors: Yingzhi BI, Kenneth Gordon CARSON, Giovanni CIANCHETTA, Michael Alan GREEN, Godwin KUMI, Zhi LIANG, Ying Jade LIU, Alan MAIN, Yulian ZHANG, Glenn Gregory ZIPP
  • Pyrazolo[1,5-a]pyrimidine-based compounds, compositions comprising them, and methods of their use
    Patent number: 9403832
    Abstract: Pyrazolo[1,5-a]pyrimidine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by adaptor associated kinase 1 activity are also disclosed.
    Type: Grant
    Filed: September 11, 2014
    Date of Patent: August 2, 2016
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Yingzhi Bi, Kenneth Gordon Carson, Giovanni Cianchetta, Michael Alan Green, Godwin Kumi, Alan Main, Yulian Zhang, Glenn Gregory Zipp
  • INHIBITORS OF ADAPTER ASSOCIATED KINASE 1, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE
    Publication number: 20160039824
    Abstract: The adaptor associated kinase 1 (AAK1) inhibitor 3-methyloxetan-3-yl-4-(3-(2-methoxypyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carboxylate: and pharmaceutically acceptable salts and solid forms thereof are disclosed. Compositions comprising the compound and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by AAK1 activity are also disclosed.
    Type: Application
    Filed: March 16, 2015
    Publication date: February 11, 2016
    Inventors: Yingzhi BI, Godwin KUMI
  • IMIDAZO[1,2-b]PYRIDAZINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE
    Publication number: 20160024093
    Abstract: Imidazo[1,2-b]pyridazine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.
    Type: Application
    Filed: February 25, 2015
    Publication date: January 28, 2016
    Inventors: Yingzhi BI, Kenneth Gordon CARSON, Giovanni CIANCHETTA, Michael Alan GREEN, Godwin KUMI, Zhi LIANG, Ying Jade LIU, Alan MAIN, Yulian ZHANG, Glenn Gregory ZIPP
  • PYRAZOLO[1,5-a]PYRIMIDINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE
    Publication number: 20150183792
    Abstract: Pyrazolo[1,5-a]pyrimidine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.
    Type: Application
    Filed: September 11, 2014
    Publication date: July 2, 2015
    Inventors: Yingzhi BI, Kenneth Gordon CARSON, Giovanni CIANCHETTA, Michael Alan GREEN, Godwin KUMI, Alan MAIN, Yulian ZHANG, Gregory Glenn ZIPP
  • IMIDAZO[1,2-b]PYRIDAZINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE
    Publication number: 20150183791
    Abstract: Imidazo[1,2-b]pyridazine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.
    Type: Application
    Filed: September 5, 2014
    Publication date: July 2, 2015
    Inventors: Yingzhi BI, Michael Walter GARDYAN, Michael Alan GREEN, Godwin KUMI, Yulian ZHANG